Details for: TRAJ24

Gene ID: 28731

Symbol: TRAJ24

Ensembl ID: ENSG00000211865

Description: T cell receptor alpha joining 24

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1288
    Cell Significance Index: 2.8200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0390
    Cell Significance Index: 0.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0053
    Cell Significance Index: 0.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0011
    Cell Significance Index: 0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0015
    Cell Significance Index: -0.3100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0047
    Cell Significance Index: -0.2100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0076
    Cell Significance Index: -0.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0082
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0086
    Cell Significance Index: -0.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0126
    Cell Significance Index: -0.1500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0132
    Cell Significance Index: -0.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0183
    Cell Significance Index: -0.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0185
    Cell Significance Index: -0.3400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0193
    Cell Significance Index: -0.1700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0204
    Cell Significance Index: -0.2300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0206
    Cell Significance Index: -0.2500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0208
    Cell Significance Index: -0.2600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0208
    Cell Significance Index: -0.2600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0208
    Cell Significance Index: -0.2800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0231
    Cell Significance Index: -0.2100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0236
    Cell Significance Index: -0.2700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0238
    Cell Significance Index: -0.2800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0248
    Cell Significance Index: -0.2500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0249
    Cell Significance Index: -0.3000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0258
    Cell Significance Index: -0.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0262
    Cell Significance Index: -0.3100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0266
    Cell Significance Index: -0.2700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0267
    Cell Significance Index: -0.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0267
    Cell Significance Index: -0.3400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0269
    Cell Significance Index: -0.3100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0269
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0276
    Cell Significance Index: -0.2800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0280
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0289
    Cell Significance Index: -0.2700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0292
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0297
    Cell Significance Index: -0.3000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0324
    Cell Significance Index: -0.2800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0331
    Cell Significance Index: -0.4200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0332
    Cell Significance Index: -0.2800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0351
    Cell Significance Index: -0.2700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0355
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0358
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0372
    Cell Significance Index: -0.4600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0379
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0386
    Cell Significance Index: -0.3600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0403
    Cell Significance Index: -0.2200
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0410
    Cell Significance Index: -0.3400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0417
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0427
    Cell Significance Index: -0.4500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0444
    Cell Significance Index: -0.4800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0474
    Cell Significance Index: -0.4100
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0492
    Cell Significance Index: -0.5200
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0518
    Cell Significance Index: -0.4700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0565
    Cell Significance Index: -0.5100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0603
    Cell Significance Index: -0.5100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0627
    Cell Significance Index: -0.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ24 is a gene that encodes a protein involved in the assembly of the T cell receptor (TCR) complex. The TCR is a heterodimeric receptor composed of an alpha chain (TRAJ24) and a beta chain, which together recognize and bind to specific antigens. TRAJ24 is specifically expressed in various immune cells, including CD8+ and CD4+ T cells, NK T cells, and B cells. These cells are essential for the adaptive immune response, which involves the activation of immune cells to recognize and eliminate pathogens. **Pathways and Functions:** The assembly of the TCR complex involves the interaction of TRAJ24 with other TCR components, including the alpha chain, beta chain, and gamma chain. This interaction triggers the activation of downstream signaling pathways, which ultimately lead to the activation of T cells. TRAJ24 plays a crucial role in the assembly and signaling of T cells, particularly in the activation of cytotoxic T cells and helper T cells. The gene is also involved in the development and differentiation of alpha-beta T cells, which are essential for the adaptive immune response. **Clinical Significance:** Dysregulation of TRAJ24 has been implicated in several immune-related disorders, including autoimmune diseases and cancer. For example, aberrant expression of TRAJ24 has been observed in patients with multiple sclerosis and rheumatoid arthritis, suggesting a potential role in the pathogenesis of these diseases. Additionally, TRAJ24 has been shown to be involved in the development of cancer, particularly in T cell-mediated cancers such as leukemia and lymphoma. Therefore, further research is needed to fully understand the clinical significance of TRAJ24 and its potential as a therapeutic target. In conclusion, TRAJ24 is a critical gene that plays a vital role in the assembly and signaling of T cells, which are central to the adaptive immune response. Further research is needed to fully understand the clinical significance of TRAJ24 and its potential as a therapeutic target for immune-related disorders. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which TRAJ24 regulates T cell signaling and function. 2. The potential role of TRAJ24 in autoimmune diseases and cancer should be further investigated. 3. Therapeutic strategies targeting TRAJ24 may offer new avenues for the treatment of immune-related disorders. **Future Directions:** 1. Investigate the role of TRAJ24 in the development of T cell-mediated cancers. 2. Examine the potential of TRAJ24 as a therapeutic target for autoimmune diseases. 3. Elucidate the mechanisms by which TRAJ24 regulates T cell signaling and function. By continuing to explore the functions of TRAJ24, we may uncover new insights into the regulation of the immune response and identify potential therapeutic targets for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.