Details for: TRAJ23

Gene ID: 28732

Symbol: TRAJ23

Ensembl ID: ENSG00000211866

Description: T cell receptor alpha joining 23

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0346
    Cell Significance Index: 0.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0012
    Cell Significance Index: 0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0027
    Cell Significance Index: -0.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0034
    Cell Significance Index: -0.1500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0053
    Cell Significance Index: -0.2000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0073
    Cell Significance Index: -0.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0078
    Cell Significance Index: -0.0900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0095
    Cell Significance Index: -0.1000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0107
    Cell Significance Index: -0.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0108
    Cell Significance Index: -0.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0111
    Cell Significance Index: -0.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0112
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0132
    Cell Significance Index: -0.1600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0134
    Cell Significance Index: -0.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0140
    Cell Significance Index: -0.1700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0165
    Cell Significance Index: -0.1900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0169
    Cell Significance Index: -0.2200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0176
    Cell Significance Index: -0.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0177
    Cell Significance Index: -0.2300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0183
    Cell Significance Index: -0.2000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0197
    Cell Significance Index: -0.2000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0197
    Cell Significance Index: -0.2400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0198
    Cell Significance Index: -0.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0204
    Cell Significance Index: -0.1100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0206
    Cell Significance Index: -0.2200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0210
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0214
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0217
    Cell Significance Index: -0.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0222
    Cell Significance Index: -0.2100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0224
    Cell Significance Index: -0.2300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0225
    Cell Significance Index: -0.1900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0226
    Cell Significance Index: -0.2100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0228
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0228
    Cell Significance Index: -0.2300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0228
    Cell Significance Index: -0.2400
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0230
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0232
    Cell Significance Index: -0.2000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0238
    Cell Significance Index: -0.2200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0245
    Cell Significance Index: -0.2500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0246
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0260
    Cell Significance Index: -0.2400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0263
    Cell Significance Index: -0.2300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0272
    Cell Significance Index: -0.2400
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0280
    Cell Significance Index: -0.2300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0284
    Cell Significance Index: -0.2300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0291
    Cell Significance Index: -0.2000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0303
    Cell Significance Index: -0.2500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0323
    Cell Significance Index: -0.2400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0787
    Cell Significance Index: -0.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRAJ23 gene is a non-coding gene that is highly conserved across species, suggesting its importance in maintaining cellular homeostasis. The gene is specifically expressed in cells of the adaptive immune system, including T cells, B cells, and NKT cells. The TRAJ23 gene is composed of a single exon and is located on chromosome 2p11.2. Its expression is restricted to specific cell types, including CD8+ T cells, B cells, and mature alpha-beta T cells. The gene's expression is dynamic, with changes observed in response to antigen exposure and during immune cell development. **Pathways and Functions:** The TRAJ23 gene plays a crucial role in the development and function of T cells, which are central to the adaptive immune response. The gene's product, TRAJ23, is involved in the formation of functional TCRs by interacting with other TCR components. This interaction is essential for the proper assembly, folding, and expression of TCRs on the surface of T cells. The TRAJ23 gene also regulates the expression of other genes involved in T cell development and function, such as cytokine genes and transcription factors. Furthermore, the TRAJ23 gene is involved in the regulation of the T cell receptor signaling pathway, which is critical for the activation and proliferation of T cells. **Clinical Significance:** Dysregulation of the TRAJ23 gene has been implicated in various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Alterations in TRAJ23 expression have also been observed in cancer, where it may contribute to the development and progression of tumors. Additionally, the TRAJ23 gene has been shown to play a role in the regulation of the immune response to infections, such as HIV and tuberculosis. Understanding the mechanisms by which TRAJ23 regulates T cell function and development may provide valuable insights into the development of novel therapeutic strategies for immune-related disorders. In conclusion, the TRAJ23 gene is a critical component of the immune system, playing a pivotal role in the development, function, and regulation of various immune cells. Further research into the mechanisms by which TRAJ23 regulates T cell function and development is necessary to fully appreciate its clinical significance and to explore its potential as a therapeutic target for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.