Details for: TRAJ11

Gene ID: 28744

Symbol: TRAJ11

Ensembl ID: ENSG00000211878

Description: T cell receptor alpha joining 11

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.8314
    Cell Significance Index: 23.1400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0515
    Cell Significance Index: 0.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0434
    Cell Significance Index: 0.9500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0159
    Cell Significance Index: 0.1800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0148
    Cell Significance Index: 0.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0044
    Cell Significance Index: 0.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0009
    Cell Significance Index: -0.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0024
    Cell Significance Index: -0.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0053
    Cell Significance Index: -0.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0065
    Cell Significance Index: -0.0900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0066
    Cell Significance Index: -0.0900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0071
    Cell Significance Index: -0.0900
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0080
    Cell Significance Index: -0.0900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0098
    Cell Significance Index: -0.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0099
    Cell Significance Index: -0.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0124
    Cell Significance Index: -0.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0147
    Cell Significance Index: -0.4800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0185
    Cell Significance Index: -0.3700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0274
    Cell Significance Index: -0.2000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0319
    Cell Significance Index: -0.4300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0322
    Cell Significance Index: -0.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0339
    Cell Significance Index: -0.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0344
    Cell Significance Index: -0.4100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0369
    Cell Significance Index: -0.4700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0370
    Cell Significance Index: -0.4100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0374
    Cell Significance Index: -0.4400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0374
    Cell Significance Index: -0.5000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0375
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0380
    Cell Significance Index: -0.3500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0393
    Cell Significance Index: -0.4700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0393
    Cell Significance Index: -0.4900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0395
    Cell Significance Index: -0.4800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0396
    Cell Significance Index: -0.5000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0454
    Cell Significance Index: -0.3900
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0455
    Cell Significance Index: -0.5200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0457
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0460
    Cell Significance Index: -0.4300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0500
    Cell Significance Index: -0.5600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0507
    Cell Significance Index: -0.5200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0510
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0517
    Cell Significance Index: -0.5300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0524
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0525
    Cell Significance Index: -0.5300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0533
    Cell Significance Index: -0.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0557
    Cell Significance Index: -0.5400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0571
    Cell Significance Index: -0.5300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0577
    Cell Significance Index: -0.5200
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0578
    Cell Significance Index: -0.5500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0603
    Cell Significance Index: -0.5200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0617
    Cell Significance Index: -0.5400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0628
    Cell Significance Index: -0.5300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0673
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0708
    Cell Significance Index: -0.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0807
    Cell Significance Index: -0.4400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0960
    Cell Significance Index: -0.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-specific expression:** TRAJ11 is expressed in a diverse range of cell types, including CD8+ and CD4+ T cells, alpha-beta T cell precursors, and B cells, suggesting its critical role in immune cell development and function. 2. **T cell receptor assembly:** TRAJ11 is involved in the assembly of the TCR complex, which is essential for T cell receptor signaling and recognition of antigen. 3. **Signaling regulation:** TRAJ11 may also regulate TCR signaling pathways, influencing the activation, proliferation, and differentiation of T cells. 4. **Potential for alternative splicing:** The gene's structure and expression profile suggest the possibility of alternative splicing, which could result in diverse isoforms with distinct functions. **Pathways and Functions:** 1. **T cell receptor signaling:** TRAJ11 is involved in the assembly and regulation of the TCR complex, which is essential for T cell receptor signaling and recognition of antigen. 2. **TCR assembly and modification:** TRAJ11 may contribute to the assembly and modification of the TCR complex, influencing the presentation of TCRs to the cell surface. 3. **Immune cell development:** TRAJ11 is expressed in early T cell precursors, suggesting its role in the development and maturation of T cells. 4. **Regulation of T cell responses:** TRAJ11 may also regulate T cell responses, influencing the activation, proliferation, and differentiation of T cells. **Clinical Significance:** Dysregulation of TRAJ11 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** TRAJ11 dysfunction may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** TRAJ11 alterations may also play a role in cancer, including T cell-based cancers, such as leukemia and lymphoma. 3. **Immunodeficiency disorders:** TRAJ11 dysfunction may contribute to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 4. **Tissue transplantation:** TRAJ11 may also influence the rejection of transplanted tissues, highlighting its potential as a therapeutic target in transplantation medicine. In conclusion, TRAJ11 is a critical gene that plays a pivotal role in T cell development, function, and regulation. Further research is necessary to fully elucidate the mechanisms of TRAJ11 and its implications in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.