Details for: H1 5

Gene ID: 3009

Symbol: H1 5

Ensembl ID: ENSG00000184357

Description: H1.5 linker histone, cluster member

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 9.56
    Marker Score: 96951.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.55
    Marker Score: 4222.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.27
    Marker Score: 863
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.13
    Marker Score: 11448.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.09
    Marker Score: 1913
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.98
    Marker Score: 270
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5180
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9
    Marker Score: 2673
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.9
    Marker Score: 675
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.89
    Marker Score: 1183
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.75
    Marker Score: 293
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 669
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 280
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 532.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2878.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.63
    Marker Score: 313
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.62
    Marker Score: 625
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.61
    Marker Score: 730.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.58
    Marker Score: 389
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.57
    Marker Score: 357
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.57
    Marker Score: 592
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.55
    Marker Score: 934
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.54
    Marker Score: 674
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.54
    Marker Score: 382
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.52
    Marker Score: 6076
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.5
    Marker Score: 178
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.48
    Marker Score: 349.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 445
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.46
    Marker Score: 656.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.46
    Marker Score: 303
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 249
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.44
    Marker Score: 188
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.43
    Marker Score: 847
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.42
    Marker Score: 443
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.42
    Marker Score: 124
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.41
    Marker Score: 203
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.4
    Marker Score: 140
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.39
    Marker Score: 207
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.39
    Marker Score: 104
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.39
    Marker Score: 248
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.38
    Marker Score: 187
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.38
    Marker Score: 455
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.37
    Marker Score: 2376
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.37
    Marker Score: 1010
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.37
    Marker Score: 153
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.34
    Marker Score: 248
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.33
    Marker Score: 311
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.33
    Marker Score: 295
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.33
    Marker Score: 316
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.32
    Marker Score: 177
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.32
    Marker Score: 154
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.32
    Marker Score: 199
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.32
    Marker Score: 448
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.31
    Marker Score: 157
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.31
    Marker Score: 134
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.31
    Marker Score: 107
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.29
    Marker Score: 1205
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.29
    Marker Score: 210
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.28
    Marker Score: 1054
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.28
    Marker Score: 192.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.28
    Marker Score: 200
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.28
    Marker Score: 171.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.28
    Marker Score: 81
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.28
    Marker Score: 111
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.27
    Marker Score: 683
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.27
    Marker Score: 184
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.27
    Marker Score: 158
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.27
    Marker Score: 93
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.26
    Marker Score: 77
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.26
    Marker Score: 125
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.25
    Marker Score: 162
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.25
    Marker Score: 294
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.25
    Marker Score: 63
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.24
    Marker Score: 161
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.24
    Marker Score: 260
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.24
    Marker Score: 136
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.23
    Marker Score: 195
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.23
    Marker Score: 357
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.22
    Marker Score: 173
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.21
    Marker Score: 606
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.21
    Marker Score: 96

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Other Information

**Key characteristics:** * H1.5 is a linker histone, which means that it helps to hold DNA fragments together in chromatin. * It is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * H1.5 is found in a variety of cell types, including neurons, muscle cells, and immune cells. * It is involved in a variety of cellular processes, including apoptosis, cell cycle regulation, and differentiation. **Pathways and functions:** * H1.5 is involved in apoptosis, the process by which cells die. * It is a key regulator of cell cycle regulation, and its expression is controlled by a variety of factors, including growth factors and cytokines. * H1.5 is also involved in differentiation, and its expression is upregulated in cells that are differentiating into a specific cell type. **Clinical significance:** * Mutations in the H1.5 gene have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * One such disease is Werner's syndrome, which is caused by a mutation in the H1.5 gene. In Werner's syndrome, the cells in the brain and other tissues become hyperactive and begin to divide uncontrollably. * H1.5 is also a target for cancer therapy, and inhibitors of the protein have been shown to be effective in inhibiting cancer growth. **Additional notes:** * The H1.5 gene is located on chromosome 1. * It is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * H1.5 is a multi-functional protein that plays a critical role in a variety of cellular processes.

Genular Protein ID: 2181496884

Symbol: H15_HUMAN

Name: Histone H1.5

UniProtKB Accession Codes:

P16401 Q14529 Q3MJ42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9031620

Title: Characterization of the H1.5 gene completes the set of human H1 subtype genes.

PubMed ID: 9031620

DOI: 10.1016/s0378-1119(96)00582-3

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2613692

Title: Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d.

PubMed ID: 2613692

DOI: 10.1093/oxfordjournals.jbchem.a122941

PubMed ID: 10997781

Title: The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.

PubMed ID: 10997781

DOI: 10.1023/a:1009262819961

PubMed ID: 11746507

Title: Distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin II: distribution in human adult fibroblasts.

PubMed ID: 11746507

DOI: 10.1002/jcb.1224

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16377619

Title: Histone H1 phosphorylation occurs site-specifically during interphase and mitosis: identification of a novel phosphorylation site on histone H1.

PubMed ID: 16377619

DOI: 10.1074/jbc.m508957200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19136008

Title: M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3.

PubMed ID: 19136008

DOI: 10.1016/j.jmb.2008.12.047

PubMed ID: 19552482

Title: Mapping of lysine monomethylation of linker histones in human breast and its cancer.

PubMed ID: 19552482

DOI: 10.1021/pr9000652

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 226
  • Mass: 22580
  • Checksum: 0BA1402101766FDF
  • Sequence:
    • MSETAPAETA TPAPVEKSPA KKKATKKAAG AGAAKRKATG PPVSELITKA VAASKERNGL 
SLAALKKALA AGGYDVEKNN SRIKLGLKSL VSKGTLVQTK GTGASGSFKL NKKAASGEAK 
PKAKKAGAAK AKKPAGATPK KAKKAAGAKK AVKKTPKKAK KPAAAGVKKV AKSPKKAKAA 
AKPKKATKSP AKPKAVKPKA AKPKAAKPKA AKPKAAKAKK AAAKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.