Details for: H1 5

Gene ID: 3009

Symbol: H1 5

Ensembl ID: ENSG00000184357

Description: H1.5 linker histone, cluster member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.6015
    Cell Significance Index: -6.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.4336
    Cell Significance Index: -6.2700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 7.7148
    Cell Significance Index: -1.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.7034
    Cell Significance Index: -6.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.1583
    Cell Significance Index: -6.3600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 3.4237
    Cell Significance Index: 43.2600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.0038
    Cell Significance Index: 11.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6693
    Cell Significance Index: 107.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0764
    Cell Significance Index: 126.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7983
    Cell Significance Index: 16.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5974
    Cell Significance Index: 59.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5545
    Cell Significance Index: 60.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5202
    Cell Significance Index: 16.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4139
    Cell Significance Index: 11.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4035
    Cell Significance Index: 6.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3811
    Cell Significance Index: 61.9800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.3807
    Cell Significance Index: 3.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3532
    Cell Significance Index: 3.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3433
    Cell Significance Index: 8.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3148
    Cell Significance Index: 9.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3142
    Cell Significance Index: 14.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2935
    Cell Significance Index: 17.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2870
    Cell Significance Index: 54.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1680
    Cell Significance Index: 11.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1607
    Cell Significance Index: 9.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1592
    Cell Significance Index: 3.9800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.1429
    Cell Significance Index: 1.5200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.1162
    Cell Significance Index: 0.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1154
    Cell Significance Index: 22.9000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1069
    Cell Significance Index: 1.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0970
    Cell Significance Index: 3.4100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0894
    Cell Significance Index: 0.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0630
    Cell Significance Index: 1.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0598
    Cell Significance Index: 54.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0577
    Cell Significance Index: 1.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0428
    Cell Significance Index: 23.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0420
    Cell Significance Index: 0.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0339
    Cell Significance Index: 0.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0330
    Cell Significance Index: 14.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0249
    Cell Significance Index: 0.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0133
    Cell Significance Index: 0.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0043
    Cell Significance Index: -2.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0070
    Cell Significance Index: -1.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0085
    Cell Significance Index: -1.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0091
    Cell Significance Index: -1.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0098
    Cell Significance Index: -0.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0183
    Cell Significance Index: -6.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0203
    Cell Significance Index: -2.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0233
    Cell Significance Index: -0.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0243
    Cell Significance Index: -0.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0301
    Cell Significance Index: -3.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0321
    Cell Significance Index: -3.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0342
    Cell Significance Index: -6.8700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0410
    Cell Significance Index: -0.4000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0413
    Cell Significance Index: -0.3000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0451
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0506
    Cell Significance Index: -8.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0524
    Cell Significance Index: -3.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0529
    Cell Significance Index: -3.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0553
    Cell Significance Index: -7.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0566
    Cell Significance Index: -2.9500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0670
    Cell Significance Index: -1.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0893
    Cell Significance Index: -6.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0978
    Cell Significance Index: -7.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1046
    Cell Significance Index: -4.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1060
    Cell Significance Index: -3.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1203
    Cell Significance Index: -4.1800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1204
    Cell Significance Index: -1.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1301
    Cell Significance Index: -3.4200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1408
    Cell Significance Index: -1.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1424
    Cell Significance Index: -6.6400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1486
    Cell Significance Index: -2.1300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1625
    Cell Significance Index: -1.8400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1658
    Cell Significance Index: -1.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1739
    Cell Significance Index: -2.5300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1760
    Cell Significance Index: -2.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1841
    Cell Significance Index: -6.9700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1855
    Cell Significance Index: -1.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1861
    Cell Significance Index: -6.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1912
    Cell Significance Index: -6.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2027
    Cell Significance Index: -7.1000
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.2073
    Cell Significance Index: -2.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2119
    Cell Significance Index: -6.2400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2195
    Cell Significance Index: -2.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2199
    Cell Significance Index: -3.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2202
    Cell Significance Index: -2.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2225
    Cell Significance Index: -5.3900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2285
    Cell Significance Index: -1.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2355
    Cell Significance Index: -5.4400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2364
    Cell Significance Index: -3.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2442
    Cell Significance Index: -6.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2508
    Cell Significance Index: -6.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2559
    Cell Significance Index: -7.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2574
    Cell Significance Index: -2.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2643
    Cell Significance Index: -3.9600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2659
    Cell Significance Index: -3.3700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2668
    Cell Significance Index: -2.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** H1.5 linker histone is a member of the histone H1 family, characterized by its ability to bind to DNA and histone proteins, thereby regulating chromatin structure and function. Its expression is widespread, with significant levels found in various cell types, including glutamatergic neurons, large pre-B-II cells, proerythroblasts, and germ cells. H1.5 is also involved in the formation of senescence-associated heterochromatin foci (SAHFs) and heterochromatin, highlighting its role in maintaining genome stability. **Pathways and Functions:** H1.5 is implicated in several key pathways, including: 1. **Apoptosis and DNA Fragmentation**: H1.5 plays a crucial role in regulating chromatin structure and function during apoptosis, a process essential for maintaining genome stability. 2. **Cellular Responses to Stimuli**: H1.5 is involved in responding to cellular stress, including DNA damage and telomere stress-induced senescence. 3. **Chromatin Organization**: H1.5 regulates chromatin structure and function, ensuring proper DNA binding and transcription. 4. **Programmed Cell Death**: H1.5 is involved in the regulation of apoptosis, a process essential for eliminating damaged or unwanted cells. **Clinical Significance:** H1.5 has significant implications for various diseases and disorders, including: 1. **Immune Disorders**: H1.5 is involved in regulating immune responses, making it a potential target for the treatment of autoimmune diseases. 2. **Cancer**: H1.5 plays a role in maintaining genome stability, making it a potential therapeutic target for cancer treatment. 3. **Neurological Disorders**: H1.5 is involved in regulating chromatin structure and function in neurons, highlighting its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Conclusion:** In conclusion, H1.5 linker histone is a multifaceted protein involved in regulating chromatin structure and function, as well as immune responses. Its significant expression in various cell types and involvement in key pathways, including apoptosis and DNA fragmentation, highlights its importance in maintaining genome stability. Further research is needed to fully elucidate the role of H1.5 in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2181496884

Symbol: H15_HUMAN

Name: Histone H1.5

UniProtKB Accession Codes:

P16401 Q14529 Q3MJ42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9031620

Title: Characterization of the H1.5 gene completes the set of human H1 subtype genes.

PubMed ID: 9031620

DOI: 10.1016/s0378-1119(96)00582-3

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2613692

Title: Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d.

PubMed ID: 2613692

DOI: 10.1093/oxfordjournals.jbchem.a122941

PubMed ID: 10997781

Title: The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts.

PubMed ID: 10997781

DOI: 10.1023/a:1009262819961

PubMed ID: 11746507

Title: Distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin II: distribution in human adult fibroblasts.

PubMed ID: 11746507

DOI: 10.1002/jcb.1224

PubMed ID: 15911621

Title: H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain.

PubMed ID: 15911621

DOI: 10.1074/jbc.m501627200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16377619

Title: Histone H1 phosphorylation occurs site-specifically during interphase and mitosis: identification of a novel phosphorylation site on histone H1.

PubMed ID: 16377619

DOI: 10.1074/jbc.m508957200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19136008

Title: M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3.

PubMed ID: 19136008

DOI: 10.1016/j.jmb.2008.12.047

PubMed ID: 19552482

Title: Mapping of lysine monomethylation of linker histones in human breast and its cancer.

PubMed ID: 19552482

DOI: 10.1021/pr9000652

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 226
  • Mass: 22580
  • Checksum: 0BA1402101766FDF
  • Sequence:
    • MSETAPAETA TPAPVEKSPA KKKATKKAAG AGAAKRKATG PPVSELITKA VAASKERNGL 
SLAALKKALA AGGYDVEKNN SRIKLGLKSL VSKGTLVQTK GTGASGSFKL NKKAASGEAK 
PKAKKAGAAK AKKPAGATPK KAKKAAGAKK AVKKTPKKAK KPAAAGVKKV AKSPKKAKAA 
AKPKKATKSP AKPKAVKPKA AKPKAAKPKA AKPKAAKAKK AAAKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.