Details for: HOXB5

Gene ID: 3215

Symbol: HOXB5

Ensembl ID: ENSG00000120075

Description: homeobox B5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 60.8826
    Cell Significance Index: -9.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.0779
    Cell Significance Index: -8.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.9993
    Cell Significance Index: -8.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7781
    Cell Significance Index: -9.5900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 6.3911
    Cell Significance Index: 39.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4.5244
    Cell Significance Index: 98.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4534
    Cell Significance Index: -11.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4303
    Cell Significance Index: -9.5900
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.6544
    Cell Significance Index: 17.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3859
    Cell Significance Index: 11.0700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.2814
    Cell Significance Index: 14.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1286
    Cell Significance Index: 39.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1193
    Cell Significance Index: 50.7400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.0908
    Cell Significance Index: 6.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0765
    Cell Significance Index: 24.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0661
    Cell Significance Index: 22.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9619
    Cell Significance Index: 868.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9527
    Cell Significance Index: 520.2700
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.7016
    Cell Significance Index: 1.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6642
    Cell Significance Index: 108.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6083
    Cell Significance Index: 66.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5602
    Cell Significance Index: 29.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4295
    Cell Significance Index: 6.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4104
    Cell Significance Index: 24.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3564
    Cell Significance Index: 24.6500
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.3376
    Cell Significance Index: 2.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3336
    Cell Significance Index: 6.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2761
    Cell Significance Index: 5.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2249
    Cell Significance Index: 22.2500
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.1476
    Cell Significance Index: 0.5500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1273
    Cell Significance Index: 1.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1271
    Cell Significance Index: 24.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0979
    Cell Significance Index: 17.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0948
    Cell Significance Index: 3.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0433
    Cell Significance Index: 2.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0152
    Cell Significance Index: 0.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0119
    Cell Significance Index: 8.7600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0081
    Cell Significance Index: 0.0800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0079
    Cell Significance Index: 0.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0062
    Cell Significance Index: 0.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0108
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0164
    Cell Significance Index: -9.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0170
    Cell Significance Index: -2.0900
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0244
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0304
    Cell Significance Index: -6.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0416
    Cell Significance Index: -8.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0469
    Cell Significance Index: -8.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0537
    Cell Significance Index: -5.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0646
    Cell Significance Index: -7.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0706
    Cell Significance Index: -8.0900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0818
    Cell Significance Index: -0.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0857
    Cell Significance Index: -1.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0898
    Cell Significance Index: -11.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0951
    Cell Significance Index: -7.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0957
    Cell Significance Index: -1.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1002
    Cell Significance Index: -1.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1032
    Cell Significance Index: -6.3300
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.1119
    Cell Significance Index: -0.8100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1288
    Cell Significance Index: -1.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1363
    Cell Significance Index: -10.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1520
    Cell Significance Index: -2.2900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1755
    Cell Significance Index: -1.0300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1779
    Cell Significance Index: -2.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1788
    Cell Significance Index: -3.4900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1805
    Cell Significance Index: -1.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1811
    Cell Significance Index: -7.4200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1924
    Cell Significance Index: -2.1000
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2176
    Cell Significance Index: -2.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2253
    Cell Significance Index: -2.0800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2311
    Cell Significance Index: -1.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2366
    Cell Significance Index: -6.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2379
    Cell Significance Index: -11.1800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.2405
    Cell Significance Index: -1.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2409
    Cell Significance Index: -6.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2468
    Cell Significance Index: -9.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2498
    Cell Significance Index: -6.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2532
    Cell Significance Index: -5.0500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2668
    Cell Significance Index: -1.9200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2726
    Cell Significance Index: -1.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2851
    Cell Significance Index: -6.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3013
    Cell Significance Index: -8.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3024
    Cell Significance Index: -4.3300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3142
    Cell Significance Index: -4.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3150
    Cell Significance Index: -8.4400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.3155
    Cell Significance Index: -2.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3163
    Cell Significance Index: -8.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3200
    Cell Significance Index: -3.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3253
    Cell Significance Index: -6.4300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3256
    Cell Significance Index: -4.1000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3287
    Cell Significance Index: -4.1700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.3440
    Cell Significance Index: -1.8100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.3474
    Cell Significance Index: -2.1500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3549
    Cell Significance Index: -2.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3603
    Cell Significance Index: -8.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3639
    Cell Significance Index: -9.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXB5 is a homeobox gene, which contains a highly conserved DNA-binding domain that allows it to regulate transcriptional activity. The gene exhibits a high degree of tissue specificity, with its expression being restricted to certain cell types and developmental stages. This specificity is crucial for the proper functioning of HOXB5 in developmental processes, as aberrant expression of this gene can lead to developmental abnormalities. Notably, HOXB5 is involved in the regulation of cell proliferation, differentiation, and survival, highlighting its role as a key regulator of developmental processes. **Pathways and Functions:** HOXB5 is involved in several key developmental pathways, including: 1. **Anatomical Structure Morphogenesis:** HOXB5 plays a crucial role in the development of embryonic structures, such as the skeletal system, by regulating the expression of other genes involved in morphogenesis. 2. **Anterior/Posterior Pattern Specification:** HOXB5 is involved in the specification of anterior-posterior patterns during embryonic development, which is essential for the proper formation of body axes. 3. **Chromatin Regulation:** HOXB5 interacts with chromatin to regulate gene expression, highlighting its role in the control of transcriptional activity. 4. **Endothelial Cell Differentiation:** HOXB5 is involved in the regulation of endothelial cell differentiation, which is critical for the development of vascular tissues. **Functions:** 1. **Transcriptional Regulation:** HOXB5 acts as a transcriptional activator, regulating the expression of target genes involved in developmental processes. 2. **Cell Proliferation and Differentiation:** HOXB5 regulates cell proliferation and differentiation by influencing the expression of genes involved in these processes. 3. **Apoptosis:** HOXB5 is involved in the regulation of apoptosis, ensuring the proper elimination of cells during development. **Clinical Significance:** Understanding the role of HOXB5 in developmental processes has significant implications for the treatment of various diseases. For example: 1. **Cancer:** Aberrant expression of HOXB5 has been observed in various types of cancer, including breast and lung cancer. This highlights the potential of HOXB5 as a therapeutic target for cancer treatment. 2. **Neurological Disorders:** HOXB5 has been implicated in the pathogenesis of neurological disorders, such as autism and schizophrenia. This underscores the importance of understanding the role of HOXB5 in the development of the nervous system. 3. **Regenerative Medicine:** HOXB5 has been shown to be involved in the regulation of stem cell differentiation and proliferation, highlighting its potential as a therapeutic target for regenerative medicine. In conclusion, HOXB5 is a critical gene involved in various developmental processes, including anatomical structure morphogenesis, anterior/posterior pattern specification, and endothelial cell differentiation. Its dysregulation has been implicated in various diseases, including cancer and neurological disorders. Further research is needed to fully elucidate the role of HOXB5 in developmental processes and its potential therapeutic applications.

Genular Protein ID: 2535875935

Symbol: HXB5_HUMAN

Name: Homeobox protein Hox-B5

UniProtKB Accession Codes:

P09067 B2RC69 P09069 Q17RP4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1355360

Title: Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product.

PubMed ID: 1355360

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4075393

Title: Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.

PubMed ID: 4075393

DOI: 10.1016/0092-8674(85)90008-x

PubMed ID: 6091895

Title: Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.

PubMed ID: 6091895

DOI: 10.1016/0092-8674(84)90261-7

PubMed ID: 3453105

Title: A human homoeo box gene specifically expressed in spinal cord during embryonic development.

PubMed ID: 3453105

DOI: 10.1038/320763a0

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 269
  • Mass: 29434
  • Checksum: 58197F105DB0F8C4
  • Sequence:
    • MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN GMDLSVNRSS 
ASSSHFGAVG ESSRAFPAPA QEPRFRQAAS SCSLSSPESL PCTNGDSHGA KPSASSPSDQ 
ATSASSSANF TEIDEASASS EPEEAASQLS SPSLARAQPE PMATSTAAPE GQTPQIFPWM 
RKLHISHDMT GPDGKRARTA YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI 
WFQNRRMKWK KDNKLKSMSL ATAGSAFQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.