Details for: HOXB5

Gene ID: 3215

Symbol: HOXB5

Ensembl ID: ENSG00000120075

Description: homeobox B5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.08
    Marker Score: 3262
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.05
    Marker Score: 894
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.59
    Marker Score: 2905.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.5
    Marker Score: 840
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.21
    Marker Score: 1309
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.11
    Marker Score: 1328
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.97
    Marker Score: 930
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.97
    Marker Score: 4831
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.91
    Marker Score: 2042
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.88
    Marker Score: 1769
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.65
    Marker Score: 2874
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.34
    Marker Score: 46286
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.2
    Marker Score: 2496
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4802
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.07
    Marker Score: 251
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1
    Marker Score: 316.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.95
    Marker Score: 605.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.94
    Marker Score: 1356
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5312
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.88
    Marker Score: 2070
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.85
    Marker Score: 11200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.82
    Marker Score: 712
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.81
    Marker Score: 538
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 499.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.63
    Marker Score: 864
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.61
    Marker Score: 120
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.61
    Marker Score: 883
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.59
    Marker Score: 206
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.59
    Marker Score: 599
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.59
    Marker Score: 555
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.57
    Marker Score: 1520.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1101
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.54
    Marker Score: 288
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.54
    Marker Score: 1412
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.51
    Marker Score: 204
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.5
    Marker Score: 256
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.49
    Marker Score: 1246
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.48
    Marker Score: 910
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.47
    Marker Score: 177
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.47
    Marker Score: 194
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.45
    Marker Score: 446
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.45
    Marker Score: 104
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.44
    Marker Score: 537
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.44
    Marker Score: 212
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.42
    Marker Score: 120
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.41
    Marker Score: 2740
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.41
    Marker Score: 127
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4
    Marker Score: 259
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.4
    Marker Score: 498
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.39
    Marker Score: 207
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.39
    Marker Score: 191
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.39
    Marker Score: 176
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.39
    Marker Score: 262
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.37
    Marker Score: 884
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.37
    Marker Score: 517
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.37
    Marker Score: 103
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.36
    Marker Score: 96
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.36
    Marker Score: 445
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.35
    Marker Score: 202
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.35
    Marker Score: 550
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.34
    Marker Score: 364
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.34
    Marker Score: 343
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.33
    Marker Score: 554
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.33
    Marker Score: 1023
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 86
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 319
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.32
    Marker Score: 229
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.31
    Marker Score: 281
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.31
    Marker Score: 206
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.31
    Marker Score: 88
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.31
    Marker Score: 71
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.31
    Marker Score: 293
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3
    Marker Score: 138.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.3
    Marker Score: 547
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.3
    Marker Score: 76
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.3
    Marker Score: 287
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.3
    Marker Score: 318
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.29
    Marker Score: 711.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.29
    Marker Score: 202
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.27
    Marker Score: 122
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.26
    Marker Score: 69
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 155

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Other Information

**Key characteristics:** * HOXB5 is a transcription factor that is expressed in a variety of cell types. * It is a key regulator of embryonic skeletal system morphogenesis. * It is also involved in the specification of the anterior/posterior axis and the development of the cardiovascular system. **Pathways and functions:** * HOXB5 is a key regulator of the expression of a number of genes involved in embryonic skeletal system morphogenesis. * It is also involved in the specification of the anterior/posterior axis and the development of the cardiovascular system. * HOXB5 is a key regulator of the development of the lung and the surrounding tissues. **Clinical significance:** HOXB5 mutations are associated with a number of human diseases, including human immunodeficiency, cardiovascular disease, and cancer. These mutations can lead to the formation of tumors or the development of other diseases that are characterized by abnormal development. **Additional information:** * HOXB5 is a member of the homeobox gene family of transcription factors. * It is expressed in a variety of cell types, including embryonic stem cells, neural cells, and muscle cells. * It is a key regulator of cell differentiation and proliferation. * It is a target for a number of human cancers.

Genular Protein ID: 2535875935

Symbol: HXB5_HUMAN

Name: Homeobox protein Hox-B5

UniProtKB Accession Codes:

P09067 B2RC69 P09069 Q17RP4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1355360

Title: Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product.

PubMed ID: 1355360

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4075393

Title: Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.

PubMed ID: 4075393

DOI: 10.1016/0092-8674(85)90008-x

PubMed ID: 6091895

Title: Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.

PubMed ID: 6091895

DOI: 10.1016/0092-8674(84)90261-7

PubMed ID: 3453105

Title: A human homoeo box gene specifically expressed in spinal cord during embryonic development.

PubMed ID: 3453105

DOI: 10.1038/320763a0

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 269
  • Mass: 29434
  • Checksum: 58197F105DB0F8C4
  • Sequence:
    • MSSYFVNSFS GRYPNGPDYQ LLNYGSGSSL SGSYRDPAAM HTGSYGYNYN GMDLSVNRSS 
ASSSHFGAVG ESSRAFPAPA QEPRFRQAAS SCSLSSPESL PCTNGDSHGA KPSASSPSDQ 
ATSASSSANF TEIDEASASS EPEEAASQLS SPSLARAQPE PMATSTAAPE GQTPQIFPWM 
RKLHISHDMT GPDGKRARTA YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI 
WFQNRRMKWK KDNKLKSMSL ATAGSAFQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.