Details for: HOXB6

Gene ID: 3216

Symbol: HOXB6

Ensembl ID: ENSG00000108511

Description: homeobox B6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.1830
    Cell Significance Index: -10.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.5581
    Cell Significance Index: -9.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.0795
    Cell Significance Index: -9.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.5741
    Cell Significance Index: 44.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0876
    Cell Significance Index: -10.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6812
    Cell Significance Index: -10.5800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.2061
    Cell Significance Index: 12.5400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.0074
    Cell Significance Index: 23.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7997
    Cell Significance Index: 41.5800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.7731
    Cell Significance Index: 10.9700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.5357
    Cell Significance Index: 5.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4521
    Cell Significance Index: 793.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3994
    Cell Significance Index: 63.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2787
    Cell Significance Index: 19.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1435
    Cell Significance Index: 39.7400
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.0524
    Cell Significance Index: 2.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8853
    Cell Significance Index: 18.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6457
    Cell Significance Index: 583.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6291
    Cell Significance Index: 32.6800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.6284
    Cell Significance Index: 6.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4784
    Cell Significance Index: 28.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4763
    Cell Significance Index: 51.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4547
    Cell Significance Index: 73.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3336
    Cell Significance Index: 6.9200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.3222
    Cell Significance Index: 5.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1960
    Cell Significance Index: 1.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1728
    Cell Significance Index: 17.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1713
    Cell Significance Index: 2.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1700
    Cell Significance Index: 11.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1580
    Cell Significance Index: 5.0600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1525
    Cell Significance Index: 1.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1521
    Cell Significance Index: 27.4200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1425
    Cell Significance Index: 0.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1318
    Cell Significance Index: 25.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1300
    Cell Significance Index: 2.1800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0950
    Cell Significance Index: 0.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0869
    Cell Significance Index: 1.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0763
    Cell Significance Index: 2.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0524
    Cell Significance Index: 2.6500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0465
    Cell Significance Index: 0.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0363
    Cell Significance Index: 26.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0160
    Cell Significance Index: 1.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0139
    Cell Significance Index: 0.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0130
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0145
    Cell Significance Index: -1.4800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0160
    Cell Significance Index: -0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0173
    Cell Significance Index: -2.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0180
    Cell Significance Index: -10.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0301
    Cell Significance Index: -0.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0324
    Cell Significance Index: -2.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0387
    Cell Significance Index: -1.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0390
    Cell Significance Index: -5.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0447
    Cell Significance Index: -8.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0451
    Cell Significance Index: -7.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0483
    Cell Significance Index: -10.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0526
    Cell Significance Index: -10.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0741
    Cell Significance Index: -8.6300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0765
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0819
    Cell Significance Index: -9.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0830
    Cell Significance Index: -10.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0914
    Cell Significance Index: -10.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1025
    Cell Significance Index: -2.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1049
    Cell Significance Index: -6.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1293
    Cell Significance Index: -9.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1377
    Cell Significance Index: -10.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1626
    Cell Significance Index: -4.0600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1695
    Cell Significance Index: -3.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1713
    Cell Significance Index: -4.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1913
    Cell Significance Index: -2.0800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2017
    Cell Significance Index: -2.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2123
    Cell Significance Index: -9.9000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2123
    Cell Significance Index: -3.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2166
    Cell Significance Index: -10.1800
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: -0.2174
    Cell Significance Index: -0.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2193
    Cell Significance Index: -8.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2289
    Cell Significance Index: -2.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2311
    Cell Significance Index: -3.3100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2333
    Cell Significance Index: -2.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2444
    Cell Significance Index: -10.0100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2834
    Cell Significance Index: -4.2700
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.2869
    Cell Significance Index: -2.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2983
    Cell Significance Index: -10.4500
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.2985
    Cell Significance Index: -2.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3022
    Cell Significance Index: -5.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3157
    Cell Significance Index: -8.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3204
    Cell Significance Index: -8.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3303
    Cell Significance Index: -9.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3328
    Cell Significance Index: -9.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3444
    Cell Significance Index: -7.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3482
    Cell Significance Index: -9.3300
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.3495
    Cell Significance Index: -2.1800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3575
    Cell Significance Index: -2.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3744
    Cell Significance Index: -9.3500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3937
    Cell Significance Index: -10.0300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3953
    Cell Significance Index: -4.1700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.3969
    Cell Significance Index: -2.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** HOXB6 is a transcription factor that regulates the expression of target genes involved in embryonic development, tissue morphogenesis, and cellular differentiation. 2. **Cellular Specificity:** HOXB6 is expressed in various cell types, including epithelial cells, smooth muscle cells, neurons, and mesodermal cells. 3. **Developmental Processes:** HOXB6 is involved in the regulation of anterior/posterior pattern specification, embryonic skeletal system morphogenesis, and erythrocyte homeostasis. 4. **Pathway Involvement:** HOXB6 is associated with chromatin, DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulation, and sequence-specific DNA binding. **Pathways and Functions:** 1. **Anterior/Posterior Pattern Specification:** HOXB6 regulates the expression of target genes involved in the specification of anterior and posterior regions during embryonic development. 2. **Chromatin Regulation:** HOXB6 interacts with chromatin to regulate gene expression and maintain the integrity of the genome. 3. **Transcriptional Regulation by RNA Polymerase II:** HOXB6 regulates the expression of target genes by interacting with RNA polymerase II and modulating transcriptional activity. 4. **Sequence-Specific DNA Binding:** HOXB6 binds to specific DNA sequences to regulate the expression of target genes involved in embryonic development and tissue morphogenesis. **Clinical Significance:** 1. **Cancer Association:** Aberrant expression of HOXB6 has been linked to various types of cancer, including leukemia, lymphoma, and solid tumors. 2. **Developmental Disorders:** Mutations in HOXB6 have been associated with developmental disorders, such as craniosynostosis and limb abnormalities. 3. **Disease Modeling:** HOXB6 has been used as a model gene to study the mechanisms of embryonic development, tissue homeostasis, and disease. 4. **Therapeutic Targeting:** HOXB6 may serve as a therapeutic target for the treatment of cancer and developmental disorders. In conclusion, HOXB6 is a critical gene involved in various developmental processes, tissue homeostasis, and cellular differentiation. Its dysregulation has been linked to various diseases, including cancer and developmental disorders. Further research is needed to fully understand the regulatory role of HOXB6 in embryonic development and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 151178129

Symbol: HXB6_HUMAN

Name: Homeobox protein Hox-B6

UniProtKB Accession Codes:

P17509 A8K835 D3DTV5 P09068 Q9HB11 Q9UGH2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 12 Ensembl 2 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1672751

Title: Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues.

PubMed ID: 1672751

DOI: 10.1093/nar/19.3.539

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2573064

Title: Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.

PubMed ID: 2573064

DOI: 10.1073/pnas.86.21.8536

PubMed ID: 6091895

Title: Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.

PubMed ID: 6091895

DOI: 10.1016/0092-8674(84)90261-7

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

  • Length: 224
  • Mass: 25432
  • Checksum: F60292D4D664099C
  • Sequence:
    • MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFATSSYYP 
PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH PEPRKSDCAQ DKSVFGETEE 
QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA 
HALCLTERQI KIWFQNRRMK WKKESKLLSA SQLSAEEEEE KQAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.