Gene HOXB6 - ENSG00000108511 | NCBI Gene ID: 3216

Details for: HOXB6

Gene ID: 3216

Symbol: HOXB6

Ensembl ID: ENSG00000108511

Description: homeobox B6

Associated with

Anterior/posterior pattern specification
(GO:0009952)
Chromatin
(GO:0000785)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Embryonic skeletal system morphogenesis
(GO:0048704)
Erythrocyte homeostasis
(GO:0034101)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna binding
(GO:0003723)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.08
Marker Score: 4352
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.08
Marker Score: 5109
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 2.07
Marker Score: 606
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.87
Marker Score: 64758
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.83
Marker Score: 1462
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.61
Marker Score: 378
Cell Name: kidney cell (CL1000497)
Fold Change: 1.56
Marker Score: 1040
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.35
Marker Score: 264
Cell Name: motor neuron (CL0000100)
Fold Change: 1.21
Marker Score: 721
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.17
Marker Score: 15485
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4804
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.1
Marker Score: 350
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.08
Marker Score: 1215
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.08
Marker Score: 2535
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.06
Marker Score: 2670
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.02
Marker Score: 648
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.01
Marker Score: 1667
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71814
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48039
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 506
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.94
Marker Score: 813
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5320
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 372
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.9
Marker Score: 1824
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.89
Marker Score: 475
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.88
Marker Score: 1671.5
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.88
Marker Score: 303
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.87
Marker Score: 1237
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5293
Cell Name: germ cell (CL0000586)
Fold Change: 0.86
Marker Score: 1509
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.86
Marker Score: 2299
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.8
Marker Score: 250
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.79
Marker Score: 405.5
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.78
Marker Score: 357
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1266
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.77
Marker Score: 815
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 584
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 684
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.74
Marker Score: 693
Cell Name: neural cell (CL0002319)
Fold Change: 0.73
Marker Score: 351
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.71
Marker Score: 336
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.71
Marker Score: 266
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.69
Marker Score: 704
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.67
Marker Score: 282
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.63
Marker Score: 625
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.62
Marker Score: 980
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.6
Marker Score: 376
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.55
Marker Score: 267
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.55
Marker Score: 328
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.54
Marker Score: 360
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.54
Marker Score: 138.5
Cell Name: stem cell (CL0000034)
Fold Change: 0.54
Marker Score: 1289
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.53
Marker Score: 757
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.52
Marker Score: 1645
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.52
Marker Score: 120
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.51
Marker Score: 171
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.49
Marker Score: 1197
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 472
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.47
Marker Score: 115
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 276.5
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.46
Marker Score: 191
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 0.45
Marker Score: 115
Cell Name: granulocyte (CL0000094)
Fold Change: 0.45
Marker Score: 201
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.43
Marker Score: 592
Cell Name: goblet cell (CL0000160)
Fold Change: 0.43
Marker Score: 2858
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.43
Marker Score: 203
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.42
Marker Score: 98
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.41
Marker Score: 221
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.41
Marker Score: 2490
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.41
Marker Score: 261
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.4
Marker Score: 161
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.4
Marker Score: 225
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.39
Marker Score: 10091
Cell Name: male germ cell (CL0000015)
Fold Change: 0.39
Marker Score: 112
Cell Name: enterocyte (CL0000584)
Fold Change: 0.39
Marker Score: 1854
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.38
Marker Score: 6009
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.38
Marker Score: 237
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.38
Marker Score: 338
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.37
Marker Score: 166
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.37
Marker Score: 368.5
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.36
Marker Score: 167
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.36
Marker Score: 720
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.36
Marker Score: 244
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.36
Marker Score: 149
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.36
Marker Score: 430
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.36
Marker Score: 524
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.35
Marker Score: 927
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.35
Marker Score: 81
Cell Name: pericyte (CL0000669)
Fold Change: 0.35
Marker Score: 206
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.35
Marker Score: 91.5
Cell Name: paneth cell (CL0000510)
Fold Change: 0.34
Marker Score: 235
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.34
Marker Score: 790

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**Key characteristics:** * HOXB6 is a large gene with a complex structure. It contains a central region of DNA that is involved in homeobox DNA binding, and two flanking regions that are involved in tissue-specific regulation. * HOXB6 is expressed in a variety of cell types, including epithelial cells, endothelial cells, and neural cells. * It is involved in a number of important biological processes, including tissue specification, differentiation, and migration. **Pathways and functions:** * HOXB6 is involved in the specification of the anterior/posterior (A/P) axis of the body. * It is also involved in the differentiation of epithelial cells into various cell types. * HOXB6 is a key regulator of erythropoiesis, the process of blood cell production. * It is also involved in the development and maintenance of the cardiovascular system, the kidney, and the central nervous system. **Clinical significance:** * Mutations in HOXB6 have been linked to a number of human diseases, including leukemia, breast cancer, and heart disease. * These mutations can disrupt the normal function of HOXB6, leading to the development of these diseases. * As a result, HOXB6 is a promising target for the development of new cancer treatments. **Additional information:** * HOXB6 is a member of the HOX family of homeobox genes. * The HOX genes are expressed in a highly tissue-specific manner, with each gene being expressed in a specific cell type. * HOXB6 is a highly conserved gene, with a similar gene found in other vertebrates.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeobox protein Hox-B6

Genular Protein ID: 151178129

Symbol: HXB6_HUMAN

Name: Homeobox protein Hox-B6

UniProtKB Accession Codes:

P17509 A8K835 D3DTV5 P09068 Q9HB11 Q9UGH2

Database IDs:

Citations:

PubMed ID: 1672751

Title: Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues.

PubMed ID: 1672751

DOI: 10.1093/nar/19.3.539

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2573064

Title: Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.

PubMed ID: 2573064

DOI: 10.1073/pnas.86.21.8536

PubMed ID: 6091895

Title: Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.

PubMed ID: 6091895

DOI: 10.1016/0092-8674(84)90261-7

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

Length: 224
Mass: 25432
Checksum: F60292D4D664099C
Sequence:

MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFATSSYYP 
PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH PEPRKSDCAQ DKSVFGETEE 
QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA 
HALCLTERQI KIWFQNRRMK WKKESKLLSA SQLSAEEEEE KQAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HOXB6

Associated with

Cells (max top 100)

Other Information

Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues. PubMed ID: 1672751

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. PubMed ID: 2573064

Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. PubMed ID: 6091895

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330