Details for: DNAJA1

Gene ID: 3301

Symbol: DNAJA1

Ensembl ID: ENSG00000086061

Description: DnaJ heat shock protein family (Hsp40) member A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.17
    Marker Score: 4834
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.93
    Marker Score: 3353.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.84
    Marker Score: 4097.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.82
    Marker Score: 129956
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.62
    Marker Score: 1333
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.56
    Marker Score: 5480
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.35
    Marker Score: 1786
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.29
    Marker Score: 2491
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.07
    Marker Score: 8606
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.06
    Marker Score: 2575
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.06
    Marker Score: 2398.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.92
    Marker Score: 1833
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.92
    Marker Score: 7131
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.87
    Marker Score: 5730.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.84
    Marker Score: 1183.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.78
    Marker Score: 4560
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.78
    Marker Score: 1990
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.72
    Marker Score: 26949
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.71
    Marker Score: 1217
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.71
    Marker Score: 3534.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.7
    Marker Score: 4578
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.67
    Marker Score: 2810
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.66
    Marker Score: 1369
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.64
    Marker Score: 1099
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.62
    Marker Score: 22788.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.59
    Marker Score: 1766
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.58
    Marker Score: 89510
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.58
    Marker Score: 3099
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.57
    Marker Score: 1656
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.57
    Marker Score: 1719
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.56
    Marker Score: 1859
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.55
    Marker Score: 28720
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.53
    Marker Score: 1455
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.53
    Marker Score: 2267
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.53
    Marker Score: 2634.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.52
    Marker Score: 3643.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.5
    Marker Score: 10405
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.49
    Marker Score: 1071
  • Cell Name: neural cell (CL0002319)
    Fold Change: 2.49
    Marker Score: 1199
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.46
    Marker Score: 1107.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.46
    Marker Score: 1118
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.46
    Marker Score: 10601.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.46
    Marker Score: 5129
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.45
    Marker Score: 586
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.45
    Marker Score: 2872
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.44
    Marker Score: 3513
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.44
    Marker Score: 3447
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.42
    Marker Score: 4215
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.42
    Marker Score: 1108
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.42
    Marker Score: 1251
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.41
    Marker Score: 748
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.41
    Marker Score: 2621
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.41
    Marker Score: 934.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.4
    Marker Score: 1138
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.39
    Marker Score: 5044.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.39
    Marker Score: 4058
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.38
    Marker Score: 1227
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.38
    Marker Score: 1874
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.38
    Marker Score: 2555
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.37
    Marker Score: 4456
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.37
    Marker Score: 4815
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.36
    Marker Score: 8128
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.36
    Marker Score: 2225
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.35
    Marker Score: 2272.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.35
    Marker Score: 1174.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.35
    Marker Score: 8687.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.35
    Marker Score: 3224
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.33
    Marker Score: 5933
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.32
    Marker Score: 15123
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.32
    Marker Score: 8994
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.32
    Marker Score: 23486
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.32
    Marker Score: 6401
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.31
    Marker Score: 3406
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.31
    Marker Score: 59092
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.27
    Marker Score: 847
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.27
    Marker Score: 1652
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 2.27
    Marker Score: 952
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.26
    Marker Score: 126263
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.25
    Marker Score: 2723
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.25
    Marker Score: 1912
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.24
    Marker Score: 4369
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.24
    Marker Score: 5647.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.24
    Marker Score: 1535
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.24
    Marker Score: 846.5
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.23
    Marker Score: 5024
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.22
    Marker Score: 13191
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.22
    Marker Score: 3225
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2.21
    Marker Score: 1270
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.21
    Marker Score: 1904
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.21
    Marker Score: 1469
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.21
    Marker Score: 4200
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.21
    Marker Score: 585
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.2
    Marker Score: 545
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.2
    Marker Score: 29009
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 2.19
    Marker Score: 854.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.18
    Marker Score: 1148
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.17
    Marker Score: 1447
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 2.17
    Marker Score: 2174
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.16
    Marker Score: 2300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.16
    Marker Score: 753.5

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Other Information

**Key characteristics:** * DNAJA1 is a member of the DNAJA family of heat shock proteins, which are chaperones that protect proteins from damage by binding to misfolded or unfolded proteins. * It is a stress sensor that is activated by a variety of stimuli, including heat, oxidative stress, and protein misfolding. * Upon activation, DNAJA1 dissociates from its chaperone protein HSP90 and becomes a chaperone for other proteins, including those involved in protein folding and stress response. * It also binds to the C3hc4-type ring finger domain of the cytokine receptor complex, which is involved in inflammation. * It is also involved in the regulation of spermatogenesis, as it is expressed in high levels in sperm cells and is required for their function. **Pathways and functions:** * **Stress response:** DNAJA1 is activated by a variety of stress factors, including heat, oxidative stress, and protein misfolding. * **Cell cycle regulation:** DNAJA1 is involved in the regulation of cell cycle progression and apoptosis. * **Differentiation:** DNAJA1 is expressed in cells that are differentiating into myoblasts and neurons. * **Protein folding:** DNAJA1 is involved in the folding and refolding of proteins. * **Inflammation:** DNAJA1 is also involved in the regulation of inflammation, as it is expressed in inflammatory cells and is activated by inflammatory stimuli. **Clinical significance:** * Mutations in the DNAJA1 gene have been linked to a number of human diseases, including heat shock, stroke, and cancer. * Overexpression of DNAJA1 has been linked to the development of cancer, as it can promote the survival and proliferation of cancer cells. * Therefore, DNAJA1 is a promising target for the treatment of cancer.

Genular Protein ID: 2548126103

Symbol: DNJA1_HUMAN

Name: DnaJ homolog subfamily A member 1

UniProtKB Accession Codes:

P31689 Q5T7Q0 Q86TL9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 GO 35 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8334161

Title: Human cDNA encoding DnaJ protein homologue.

PubMed ID: 8334161

DOI: 10.1016/0167-4781(93)90104-l

PubMed ID: 8334160

Title: Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein.

PubMed ID: 8334160

DOI: 10.1016/0167-4781(93)90103-k

PubMed ID: 15595953

Title: Expression of a novel DnaJA1 alternative splicing in human testis and sperm.

PubMed ID: 15595953

DOI: 10.1111/j.1365-2605.2004.00492.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9192730

Title: HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria.

PubMed ID: 9192730

DOI: 10.1093/oxfordjournals.jbchem.a021670

PubMed ID: 10816573

Title: Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70.

PubMed ID: 10816573

DOI: 10.1074/jbc.m002021200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14752510

Title: hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria.

PubMed ID: 14752510

DOI: 10.1038/sj.cdd.4401369

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24318877

Title: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.

PubMed ID: 24318877

DOI: 10.1074/jbc.m113.521997

PubMed ID: 25281747

Title: RING finger protein RNF207, a novel regulator of cardiac excitation.

PubMed ID: 25281747

DOI: 10.1074/jbc.m114.592295

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 24512202

Title: Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer.

PubMed ID: 24512202

DOI: 10.1021/bi401329a

Sequence Information:

  • Length: 397
  • Mass: 44868
  • Checksum: A899C06F6BB32780
  • Sequence:
    • MVKETTYYDV LGVKPNATQE ELKKAYRKLA LKYHPDKNPN EGEKFKQISQ AYEVLSDAKK 
RELYDKGGEQ AIKEGGAGGG FGSPMDIFDM FFGGGGRMQR ERRGKNVVHQ LSVTLEDLYN 
GATRKLALQK NVICDKCEGR GGKKGAVECC PNCRGTGMQI RIHQIGPGMV QQIQSVCMEC 
QGHGERISPK DRCKSCNGRK IVREKKILEV HIDKGMKDGQ KITFHGEGDQ EPGLEPGDII 
IVLDQKDHAV FTRRGEDLFM CMDIQLVEAL CGFQKPISTL DNRTIVITSH PGQIVKHGDI 
KCVLNEGMPI YRRPYEKGRL IIEFKVNFPE NGFLSPDKLS LLEKLLPERK EVEETDEMDQ 
VELVDFDPNQ ERRRHYNGEA YEDDEHHPRG GVQCQTS

Genular Protein ID: 1789906521

Symbol: B7Z5C0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z5C0

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 5 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 240
  • Mass: 27543
  • Checksum: 5DAF46E51AEFFC8B
  • Sequence:
    • MQIRIHQIGP GMVQQIQSVC MECQGHGERI SPKDRCKSCN GRKIVREKKI LEVHIDKGMK 
DGQKITFHGE GDQEPGLEPG DIIIVLDQKD HAVFTRRGED LFMCMDIQLV EALCGFQKPI 
STLDNRTIVI TSHPGQIVKH GDIKCVLNEG MPIYRRPYEK GRLIIEFKVN FPENGFLSPD 
KLSLLEKLLP ERKEVEETDE MDQVELVDFD PNQERRRHYN GEAYEDDEHH PRGGVQCQTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.