Details for: OR6V1

Gene ID: 346517

Symbol: OR6V1

Ensembl ID: ENSG00000225781

Description: olfactory receptor family 6 subfamily V member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.17
    Marker Score: 102506
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.83
    Marker Score: 160529
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.04
    Marker Score: 51816
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.26
    Marker Score: 7739
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 6.05
    Marker Score: 1568
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 5.02
    Marker Score: 1573
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 4.93
    Marker Score: 1561
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 4.88
    Marker Score: 1572
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.46
    Marker Score: 6305
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3155.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.98
    Marker Score: 1568
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.97
    Marker Score: 1565
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.8
    Marker Score: 1551
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 2.25
    Marker Score: 1166
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.16
    Marker Score: 1287
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.03
    Marker Score: 1563
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.76
    Marker Score: 1573
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.75
    Marker Score: 1571
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.6
    Marker Score: 1546
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.55
    Marker Score: 1569
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.44
    Marker Score: 1524
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.28
    Marker Score: 1018
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7689
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.13
    Marker Score: 1557
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.98
    Marker Score: 1573
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.98
    Marker Score: 70581
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.97
    Marker Score: 46806
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.97
    Marker Score: 1570
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.96
    Marker Score: 29855
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.91
    Marker Score: 828
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5071
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5271
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.69
    Marker Score: 1436
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1548
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.61
    Marker Score: 1452
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.56
    Marker Score: 1507
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.46
    Marker Score: 1573
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.43
    Marker Score: 1541
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.39
    Marker Score: 1571.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.05
    Marker Score: 1572
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.03
    Marker Score: 1570

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Other Information

**Key Characteristics:** OR6V1 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family, specifically subfamily V. It is expressed in various cell types, including glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, and connective tissue cells. The OR6V1 protein is characterized by its seven transmembrane domains, which allow it to bind to odorant molecules and trigger a signaling cascade. The gene is highly expressed in the olfactory epithelium, where it is thought to play a crucial role in detecting chemical stimuli. **Pathways and Functions:** The OR6V1 gene is involved in several signaling pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell**: OR6V1 is thought to be responsible for detecting odorant molecules in the olfactory epithelium, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Expression and translocation of olfactory receptors**: OR6V1 plays a role in the expression and translocation of olfactory receptors to the plasma membrane, where they can interact with odorant molecules. 3. **G protein-coupled receptor activity**: OR6V1 is a GPCR that activates G proteins, which in turn trigger a signaling cascade that regulates various cellular processes. 4. **G protein-coupled receptor signaling pathway**: OR6V1 is part of the G protein-coupled receptor signaling pathway, which is involved in regulating various cellular processes, including cell proliferation, differentiation, and survival. 5. **Olfactory receptor activity**: OR6V1 is an olfactory receptor that is responsible for detecting odorant molecules in the olfactory epithelium. 6. **Olfactory signaling pathway**: OR6V1 is part of the olfactory signaling pathway, which is responsible for transmitting signals from the olfactory epithelium to the central nervous system. **Clinical Significance:** The OR6V1 gene has significant clinical implications, particularly in the diagnosis and treatment of olfactory disorders. Mutations in the OR6V1 gene have been associated with anosmia, a condition characterized by the loss of smell. Furthermore, OR6V1 has been implicated in various other diseases, including: 1. **Neurodegenerative disorders**: OR6V1 has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where olfactory dysfunction is a common symptom. 2. **Cancer**: OR6V1 has been found to be overexpressed in certain types of cancer, including lung and breast cancer. 3. **Neurological disorders**: OR6V1 has been implicated in various neurological disorders, including epilepsy and migraines. In conclusion, the OR6V1 gene is a critical component of the olfactory system and plays a significant role in various cellular processes and signaling pathways. Its clinical significance lies in its involvement in various diseases, including olfactory disorders, neurodegenerative disorders, cancer, and neurological disorders. Further research is needed to fully understand the role of OR6V1 in human health and disease.

Genular Protein ID: 2979092370

Symbol: OR6V1_HUMAN

Name: Olfactory receptor 6V1

UniProtKB Accession Codes:

Q8N148 A4D2I0 B9EH48 Q6IF70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 313
  • Mass: 34902
  • Checksum: 2BA8B7A3A74048EF
  • Sequence:
    • MANLSQPSEF VLLGFSSFGE LQALLYGPFL MLYLLAFMGN TIIIVMVIAD THLHTPMYFF 
LGNFSLLEIL VTMTAVPRML SDLLVPHKVI TFTGCMVQFY FHFSLGSTSF LILTDMALDR 
FVAICHPLRY GTLMSRAMCV QLAGAAWAAP FLAMVPTVLS RAHLDYCHGD VINHFFCDNE 
PLLQLSCSDT RLLEFWDFLM ALTFVLSSFL VTLISYGYIV TTVLRIPSAS SCQKAFSTCG 
SHLTLVFIGY SSTIFLYVRP GKAHSVQVRK VVALVTSVLT PFLNPFILTF CNQTVKTVLQ 
GQMQRLKGLC KAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.