Details for: OR6V1

Gene ID: 346517

Symbol: OR6V1

Ensembl ID: ENSG00000225781

Description: olfactory receptor family 6 subfamily V member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0440
    Cell Significance Index: 0.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0237
    Cell Significance Index: 0.3400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0211
    Cell Significance Index: 0.4200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0054
    Cell Significance Index: 0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0014
    Cell Significance Index: -0.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0020
    Cell Significance Index: -0.4000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0067
    Cell Significance Index: -0.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0080
    Cell Significance Index: -0.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0097
    Cell Significance Index: -0.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0126
    Cell Significance Index: -0.4000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0138
    Cell Significance Index: -0.4400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0184
    Cell Significance Index: -0.2400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0189
    Cell Significance Index: -0.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0202
    Cell Significance Index: -0.4000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0203
    Cell Significance Index: -0.2700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0210
    Cell Significance Index: -0.3400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0216
    Cell Significance Index: -0.2800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0218
    Cell Significance Index: -0.2500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0251
    Cell Significance Index: -0.3300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0276
    Cell Significance Index: -0.3300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0289
    Cell Significance Index: -0.3400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0289
    Cell Significance Index: -0.3900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0303
    Cell Significance Index: -0.3300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0314
    Cell Significance Index: -0.4300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0325
    Cell Significance Index: -0.4100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0326
    Cell Significance Index: -0.3500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0341
    Cell Significance Index: -0.4300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0343
    Cell Significance Index: -0.3800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0348
    Cell Significance Index: -0.3700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0348
    Cell Significance Index: -0.4000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0350
    Cell Significance Index: -0.4000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0351
    Cell Significance Index: -0.4400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0353
    Cell Significance Index: -0.4400
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0362
    Cell Significance Index: -0.4500
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.0374
    Cell Significance Index: -0.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0377
    Cell Significance Index: -0.4500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0400
    Cell Significance Index: -0.5400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0406
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0416
    Cell Significance Index: -0.4000
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0418
    Cell Significance Index: -0.3800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0422
    Cell Significance Index: -0.4000
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0448
    Cell Significance Index: -0.4700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0473
    Cell Significance Index: -0.4300
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0476
    Cell Significance Index: -0.3300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0480
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0483
    Cell Significance Index: -0.4900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0488
    Cell Significance Index: -0.5800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0503
    Cell Significance Index: -0.5100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0513
    Cell Significance Index: -0.5400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0533
    Cell Significance Index: -0.4400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0544
    Cell Significance Index: -0.5700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0569
    Cell Significance Index: -0.7400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0575
    Cell Significance Index: -0.5700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0637
    Cell Significance Index: -1.2500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0652
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0671
    Cell Significance Index: -0.6300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0697
    Cell Significance Index: -0.6400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0710
    Cell Significance Index: -0.8600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0715
    Cell Significance Index: -0.6300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0763
    Cell Significance Index: -0.9300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0815
    Cell Significance Index: -0.5300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0837
    Cell Significance Index: -0.7900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0938
    Cell Significance Index: -1.0000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0974
    Cell Significance Index: -1.0500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1230
    Cell Significance Index: -0.7300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1284
    Cell Significance Index: -0.8100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1320
    Cell Significance Index: -0.7100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1496
    Cell Significance Index: -0.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR6V1 is a G protein-coupled receptor that plays a pivotal role in the detection of chemical stimuli involved in sensory perception of smell. 2. **Expression and Translocation:** OR6V1 is expressed in various cell types, including glutamatergic neurons, progenitor cells, and mononuclear cells, suggesting a broader role beyond olfactory perception. 3. **Cellular Localization:** OR6V1 is primarily localized to the plasma membrane, where it can interact with odorant molecules and initiate signaling cascades. 4. **Signaling Pathways:** OR6V1 activates G protein-coupled receptor activity, leading to the activation of downstream signaling pathways involved in sensory perception and cellular response. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR6V1 recognizes and binds to specific odorant molecules, triggering the activation of G protein-coupled receptor activity and subsequent signaling cascades. 2. **Sensory Perception:** OR6V1 plays a crucial role in the sensory perception of smell, allowing individuals to detect and differentiate between various odors. 3. **Neurological Function:** OR6V1 is expressed in glutamatergic neurons, suggesting a potential role in neurological function and potentially even neurological disorders. 4. **Cancer Signaling:** Recent studies have implicated OR6V1 in cancer signaling pathways, suggesting a potential role in the development and progression of certain cancers. **Clinical Significance:** 1. **Olfactory Dysfunction:** OR6V1 has been implicated in olfactory dysfunction, a condition characterized by impaired smell perception. Understanding the role of OR6V1 in olfactory perception may lead to the development of novel therapeutic strategies for treating olfactory dysfunction. 2. **Neurological Disorders:** OR6V1's expression in glutamatergic neurons suggests a potential role in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. 3. **Cancer Research:** OR6V1's involvement in cancer signaling pathways has significant implications for understanding the development and progression of certain cancers, potentially leading to the development of novel therapeutic strategies. 4. **Immunological Significance:** OR6V1's expression in mononuclear cells and other immune cells suggests a potential role in immunological function and potentially even immunological disorders. In conclusion, OR6V1 is a multifunctional gene that plays a critical role in sensory perception, neurological function, and potentially even cancer. Further research is needed to fully elucidate the mechanisms by which OR6V1 functions and its clinical significance. As an expert immunologist, I believe that understanding the intricacies of OR6V1 has the potential to lead to the development of novel therapeutic strategies for a range of diseases, from olfactory dysfunction to cancer.

Genular Protein ID: 2979092370

Symbol: OR6V1_HUMAN

Name: Olfactory receptor 6V1

UniProtKB Accession Codes:

Q8N148 A4D2I0 B9EH48 Q6IF70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 313
  • Mass: 34902
  • Checksum: 2BA8B7A3A74048EF
  • Sequence:
    • MANLSQPSEF VLLGFSSFGE LQALLYGPFL MLYLLAFMGN TIIIVMVIAD THLHTPMYFF 
LGNFSLLEIL VTMTAVPRML SDLLVPHKVI TFTGCMVQFY FHFSLGSTSF LILTDMALDR 
FVAICHPLRY GTLMSRAMCV QLAGAAWAAP FLAMVPTVLS RAHLDYCHGD VINHFFCDNE 
PLLQLSCSDT RLLEFWDFLM ALTFVLSSFL VTLISYGYIV TTVLRIPSAS SCQKAFSTCG 
SHLTLVFIGY SSTIFLYVRP GKAHSVQVRK VVALVTSVLT PFLNPFILTF CNQTVKTVLQ 
GQMQRLKGLC KAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.