Details for: MFNG

Gene ID: 4242

Symbol: MFNG

Ensembl ID: ENSG00000100060

Description: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.8317
    Cell Significance Index: -7.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.3410
    Cell Significance Index: -11.9200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 26.9937
    Cell Significance Index: -11.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.4004
    Cell Significance Index: -13.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.7550
    Cell Significance Index: -13.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.8429
    Cell Significance Index: -9.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 3.0752
    Cell Significance Index: -0.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9628
    Cell Significance Index: -9.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7822
    Cell Significance Index: 81.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7597
    Cell Significance Index: -10.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6277
    Cell Significance Index: 136.8800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.8329
    Cell Significance Index: 4.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9870
    Cell Significance Index: 63.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8838
    Cell Significance Index: 10.0400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.8211
    Cell Significance Index: 2.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7102
    Cell Significance Index: 135.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6719
    Cell Significance Index: 79.2400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5685
    Cell Significance Index: 5.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4511
    Cell Significance Index: 44.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4389
    Cell Significance Index: 396.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3760
    Cell Significance Index: 6.9500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.3378
    Cell Significance Index: 4.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3367
    Cell Significance Index: 5.9500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.3301
    Cell Significance Index: 2.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2128
    Cell Significance Index: 34.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2021
    Cell Significance Index: 40.1100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.1598
    Cell Significance Index: 1.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1410
    Cell Significance Index: 15.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.1008
    Cell Significance Index: -0.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0684
    Cell Significance Index: 4.7300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0513
    Cell Significance Index: 0.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0348
    Cell Significance Index: 0.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0246
    Cell Significance Index: 0.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0083
    Cell Significance Index: 0.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0049
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0059
    Cell Significance Index: -10.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -11.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0083
    Cell Significance Index: -0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0115
    Cell Significance Index: -6.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0129
    Cell Significance Index: -9.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0186
    Cell Significance Index: -13.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0190
    Cell Significance Index: -12.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0192
    Cell Significance Index: -0.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0192
    Cell Significance Index: -8.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0199
    Cell Significance Index: -11.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0218
    Cell Significance Index: -0.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0231
    Cell Significance Index: -0.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0273
    Cell Significance Index: -9.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0283
    Cell Significance Index: -12.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0322
    Cell Significance Index: -0.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0353
    Cell Significance Index: -10.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0453
    Cell Significance Index: -2.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0478
    Cell Significance Index: -9.5800
  • Cell Name: centroblast (CL0009112)
    Fold Change: -0.0557
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0575
    Cell Significance Index: -12.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0596
    Cell Significance Index: -6.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0605
    Cell Significance Index: -10.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0682
    Cell Significance Index: -11.6400
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0687
    Cell Significance Index: -0.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0744
    Cell Significance Index: -9.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0749
    Cell Significance Index: -10.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0854
    Cell Significance Index: -5.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0861
    Cell Significance Index: -10.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0893
    Cell Significance Index: -12.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0904
    Cell Significance Index: -10.3600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0917
    Cell Significance Index: -0.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0920
    Cell Significance Index: -11.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0974
    Cell Significance Index: -10.1400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1109
    Cell Significance Index: -0.9700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1156
    Cell Significance Index: -1.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1183
    Cell Significance Index: -6.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1228
    Cell Significance Index: -5.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1336
    Cell Significance Index: -9.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1381
    Cell Significance Index: -4.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1384
    Cell Significance Index: -10.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1566
    Cell Significance Index: -11.6700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1642
    Cell Significance Index: -1.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1653
    Cell Significance Index: -10.1600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1661
    Cell Significance Index: -2.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1700
    Cell Significance Index: -11.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1723
    Cell Significance Index: -10.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1901
    Cell Significance Index: -9.6100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1903
    Cell Significance Index: -1.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1942
    Cell Significance Index: -6.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1952
    Cell Significance Index: -8.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1986
    Cell Significance Index: -5.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1987
    Cell Significance Index: -10.3200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2058
    Cell Significance Index: -3.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2105
    Cell Significance Index: -8.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2156
    Cell Significance Index: -11.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2314
    Cell Significance Index: -10.7900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2479
    Cell Significance Index: -2.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2537
    Cell Significance Index: -11.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2573
    Cell Significance Index: -5.4800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2913
    Cell Significance Index: -4.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2958
    Cell Significance Index: -11.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2992
    Cell Significance Index: -7.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MFNG is a gene that encodes for an enzyme involved in the post-translational modification of proteins. Specifically, it catalyzes the addition of O-fucose residues to specific peptides, resulting in the formation of O-fucosylated proteins. This process is crucial for the regulation of immune cell function, development, and interactions. MFNG is predominantly expressed in various immune cells, including T cells, B cells, and natural killer cells, highlighting its central role in immune regulation. **Pathways and Functions:** MFNG is intricately involved in multiple signaling pathways, including the Notch signaling pathway, which is crucial for T cell development, differentiation, and function. The Notch signaling pathway is also essential for the regulation of immune responses, particularly in the context of tolerance and immunity. MFNG's involvement in this pathway suggests that it plays a critical role in the fine-tuning of immune responses, enabling the immune system to distinguish between self and non-self. Beyond its involvement in Notch signaling, MFNG is also implicated in the regulation of T cell differentiation and function. Specifically, it is involved in the development of T helper 22 (Th22) cells, which are characterized by their ability to produce IL-17 and IL-22, cytokines that play a key role in the defense against pathogens. **Clinical Significance:** MFNG's involvement in immune regulation and development has significant implications for our understanding of immune-related disorders. For instance, alterations in MFNG expression or function may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. Furthermore, MFNG's role in T cell differentiation and function highlights its potential as a target for immunotherapies aimed at modulating immune responses. In addition, MFNG's involvement in the Notch signaling pathway suggests that it may play a role in the development of cancer. Specifically, the Notch signaling pathway is often dysregulated in various cancers, leading to the development of malignant tumors. MFNG's involvement in this pathway may contribute to the development of cancer by promoting the survival and proliferation of cancer cells. In conclusion, MFNG is a gene that plays a critical role in immune regulation and development. Its involvement in multiple signaling pathways, including the Notch signaling pathway, highlights its importance in the fine-tuning of immune responses. As research continues to uncover the intricacies of MFNG's function, it is essential to consider its potential implications for our understanding of immune-related disorders and the development of novel immunotherapies. **Future Directions:** Further research is necessary to fully elucidate the mechanisms by which MFNG regulates immune responses and development. Specifically, studies aimed at understanding the molecular mechanisms underlying MFNG's involvement in the Notch signaling pathway and its role in T cell differentiation and function would be highly valuable. Additionally, the exploration of MFNG's potential as a therapeutic target in immune-related disorders and cancer would provide significant insights into the development of novel treatments.

Genular Protein ID: 898263663

Symbol: MFNG_HUMAN

Name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

UniProtKB Accession Codes:

O00587 B4DLT6 O43730 Q504S9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CTD 1 ChEBI 13 DNASU 1 EC 2 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9187150

Title: A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.

PubMed ID: 9187150

DOI: 10.1242/dev.124.11.2245

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 321
  • Mass: 36202
  • Checksum: 7CB847E7423DD0BC
  • Sequence:
    • MQCRLPRGLA GALLTLLCMG LLCLRYHLNL SPQRVQGTPE LSQPNPGPPK LQLHDVFIAV 
KTTRAFHRLR LELLLDTWVS RTREQTFVFT DSPDKGLQER LGSHLVVTNC SAEHSHPALS 
CKMAAEFDTF LASGLRWFCH VDDDNYVNPR ALLQLLRAFP LARDVYVGRP SLNRPIHASE 
PQPHNRTRLV QFWFATGGAG FCINRKLALK MAPWASGSRF MDTSALIRLP DDCTMGYIIE 
CKLGGRLQPS PLFHSHLETL QLLRTAQLPE QVTLSYGVFE GKLNVIKLQG PFSPEEDPSR 
FRSLHCLLYP DTPWCPQLGA R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.