Details for: LINC00112

Gene ID: 54089

Symbol: LINC00112

Ensembl ID: ENSG00000232401

Description: long intergenic non-protein coding RNA 112

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.3590
    Cell Significance Index: 14.0700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0419
    Cell Significance Index: 0.6900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0233
    Cell Significance Index: 0.2000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0148
    Cell Significance Index: 0.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0101
    Cell Significance Index: 0.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0022
    Cell Significance Index: 0.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0004
    Cell Significance Index: -0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0005
    Cell Significance Index: -0.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0021
    Cell Significance Index: -0.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0023
    Cell Significance Index: -0.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0058
    Cell Significance Index: -0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0075
    Cell Significance Index: -0.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0085
    Cell Significance Index: -0.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0090
    Cell Significance Index: -0.2600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0125
    Cell Significance Index: -0.1500
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0134
    Cell Significance Index: -0.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0161
    Cell Significance Index: -0.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0167
    Cell Significance Index: -0.2300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0171
    Cell Significance Index: -0.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0190
    Cell Significance Index: -0.2700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0206
    Cell Significance Index: -0.2200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0208
    Cell Significance Index: -0.3200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0230
    Cell Significance Index: -0.2300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0238
    Cell Significance Index: -0.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0238
    Cell Significance Index: -0.2800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0245
    Cell Significance Index: -0.2600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0248
    Cell Significance Index: -0.1800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0253
    Cell Significance Index: -0.2800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0254
    Cell Significance Index: -0.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0256
    Cell Significance Index: -0.6200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0262
    Cell Significance Index: -0.2500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0277
    Cell Significance Index: -0.3000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0284
    Cell Significance Index: -0.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0302
    Cell Significance Index: -0.5900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0307
    Cell Significance Index: -0.2900
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0308
    Cell Significance Index: -0.2900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0325
    Cell Significance Index: -0.3800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0325
    Cell Significance Index: -0.2700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0338
    Cell Significance Index: -0.3100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0342
    Cell Significance Index: -0.2100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0351
    Cell Significance Index: -0.4900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0388
    Cell Significance Index: -0.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0409
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0410
    Cell Significance Index: -0.4200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0425
    Cell Significance Index: -0.4700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0427
    Cell Significance Index: -0.5400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0430
    Cell Significance Index: -0.3400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0459
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0466
    Cell Significance Index: -0.4000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0490
    Cell Significance Index: -0.4000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0518
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0527
    Cell Significance Index: -0.5800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0529
    Cell Significance Index: -0.5300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0534
    Cell Significance Index: -0.3700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0534
    Cell Significance Index: -0.6100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0642
    Cell Significance Index: -0.5600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0773
    Cell Significance Index: -0.6000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0846
    Cell Significance Index: -0.6300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0894
    Cell Significance Index: -0.4800
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -0.2996
    Cell Significance Index: -0.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00112 is a 1,000 nucleotide long lincRNA, which is non-coding and lacks any known protein-coding potential. Despite its lack of protein-coding potential, LINC00112 has been shown to regulate various cellular processes through its role in modulating gene expression. It has been observed to interact with various nuclear and cytoplasmic proteins, which may influence its regulatory activity. The expression of LINC00112 is restricted to specific cell types, suggesting that it plays a crucial role in maintaining cellular identity and function. **Pathways and Functions:** The mechanisms by which LINC00112 regulates cellular processes are complex and multifaceted. Studies have shown that LINC00112 interacts with various signaling pathways, including the PI3K/AKT, MAPK, and Wnt/β-catenin pathways. These interactions can modulate gene expression, influencing cell proliferation, differentiation, and survival. LINC00112 has also been implicated in regulating the expression of genes involved in cellular stress responses, such as heat shock protein 70 (HSP70) and apoptosis-related genes. Furthermore, LINC00112 has been shown to regulate the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which are crucial for maintaining gene expression homeostasis. By modulating the expression of these regulatory RNAs, LINC00112 can influence cellular processes such as cell cycle progression, apoptosis, and differentiation. **Clinical Significance:** The clinical significance of LINC00112 is an area of active research, with studies suggesting its potential role in various human diseases. Cancer research has identified LINC00112 as a potential oncogene, with its overexpression observed in various types of cancer, including breast, lung, and colon cancer. LINC00112 has also been implicated in regulating the expression of genes involved in cancer progression, such as angiogenesis and metastasis. In addition to its role in cancer, LINC00112 has also been implicated in other human diseases, including cardiovascular disease, neurodegenerative disorders, and autoimmune diseases. Its expression has been observed to be altered in these diseases, suggesting a potential role in disease pathogenesis. In conclusion, LINC00112 is a complex lincRNA that plays a significant role in regulating cellular processes, including cell proliferation, differentiation, and survival. Its clinical significance is an area of active research, with studies suggesting its potential role in various human diseases, including cancer and other complex disorders. Further research is needed to fully elucidate the mechanisms by which LINC00112 regulates cellular processes and to explore its therapeutic potential.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.