Details for: SEPTIN8

Gene ID: 23176

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SEPTIN8

Ensembl ID: ENSG00000164402

Description: septin 8

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 22.01
    rCSI 26.67%
    PRS 70.25
  • regulatory T cell CL0000815
    CSI 19.72
    rCSI 22.86%
    PRS 84.94
  • conventional dendritic cell CL0000990
    CSI 17.56
    rCSI 14.66%
    PRS 85.11
  • chondrocyte CL0000138
    CSI 13.11
    rCSI 20.85%
    PRS 84.56
  • neural progenitor cell CL0011020
    CSI 12.14
    rCSI 53.41%
    PRS 78.94
  • melanocyte of skin CL1000458
    CSI 11.19
    rCSI 15.25%
    PRS 59.91
  • basal cell of epidermis CL0002187
    CSI 7.93
    rCSI 14.06%
    PRS 60.45
  • placental villous trophoblast CL2000060
    CSI 6.22
    rCSI 9.61%
    PRS 87.79
  • suprabasal keratinocyte CL4033013
    CSI 5.94
    rCSI 9.7%
    PRS 60.26
  • retinal pigment epithelial cell CL0002586
    CSI 5.49
    rCSI 10.9%
    PRS 85.85
  • Bergmann glial cell CL0000644
    CSI 5.35
    rCSI 7.32%
    PRS 81.74
  • cytotoxic T cell CL0000910
    CSI 4.93
    rCSI 28.26%
    PRS 89.09
  • vascular associated smooth muscle cell CL0000359
    CSI 4.82
    rCSI 15.63%
    PRS 87.63
  • bronchus fibroblast of lung CL2000093
    CSI 3.83
    rCSI 3.11%
    PRS 88.75
  • kidney connecting tubule epithelial cell CL1000768
    CSI 3.68
    rCSI 9.33%
    PRS 82.78
  • perivascular cell CL4033054
    CSI 3.63
    rCSI 4.96%
    PRS 92.7
  • cerebral cortex endothelial cell CL1001602
    CSI 3.62
    rCSI 6.27%
    PRS 83.85
  • Mueller cell CL0000636
    CSI 3.46
    rCSI 7.9%
    PRS 82.73
  • retina horizontal cell CL0000745
    CSI 3.44
    rCSI 5.24%
    PRS 86.43
  • fibroblast of lung CL0002553
    CSI 3.25
    rCSI 3.03%
    PRS 90.71
  • glial cell CL0000125
    CSI 3.2
    rCSI 12.17%
    PRS 82.74
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 3.16
    rCSI 5.74%
    PRS 83.03
  • interstitial cell of Cajal CL0002088
    CSI 3.11
    rCSI 3.96%
    PRS 93.17
  • squamous epithelial cell CL0000076
    CSI 3.08
    rCSI 7.32%
    PRS 87.1
  • colonocyte CL1000347
    CSI 3.08
    rCSI 4.41%
    PRS 87.9
  • sncg GABAergic cortical interneuron CL4023015
    CSI 3.07
    rCSI 4.94%
    PRS 76.95
  • innate lymphoid cell CL0001065
    CSI 3.04
    rCSI 6.27%
    PRS 84.26
  • cerebral cortex neuron CL0010012
    CSI 3.03
    rCSI 12.36%
    PRS 82.26
  • lung pericyte CL0009089
    CSI 2.93
    rCSI 7.74%
    PRS 93.43
  • inhibitory interneuron CL0000498
    CSI 2.91
    rCSI 6.73%
    PRS 80.11
  • L6b glutamatergic cortical neuron CL4023038
    CSI 2.85
    rCSI 8.92%
    PRS 77.27
  • parietal epithelial cell CL1000452
    CSI 2.76
    rCSI 7.39%
    PRS 83.72
  • pancreatic A cell CL0000171
    CSI 2.76
    rCSI 2.89%
    PRS 91.53
  • hepatic stellate cell CL0000632
    CSI 2.71
    rCSI 10.16%
    PRS 84.53
  • vascular leptomeningeal cell CL4023051
    CSI 2.58
    rCSI 4.52%
    PRS 85.64
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.48
    rCSI 3.2%
    PRS 77.02
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.43
    rCSI 5.46%
    PRS 76.32
  • blood vessel smooth muscle cell CL0019018
    CSI 2.37
    rCSI 19.25%
    PRS 86.32
  • helper T cell CL0000912
    CSI 2.16
    rCSI 3.05%
    PRS 85.8
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.08
    rCSI 2.95%
    PRS 86.96
  • colon epithelial cell CL0011108
    CSI 2.05
    rCSI 2.15%
    PRS 87.07
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 2.04
    rCSI 7.34%
    PRS 73.85
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.97
    rCSI 2.45%
    PRS 73.71
  • retinal cone cell CL0000573
    CSI 1.85
    rCSI 2.98%
    PRS 81.58
  • central nervous system neuron CL2000029
    CSI 1.85
    rCSI 13.59%
    PRS 80.62
  • dopaminergic neuron CL0000700
    CSI 1.66
    rCSI 9.37%
    PRS 78.54
  • club cell CL0000158
    CSI 1.45
    rCSI 2.12%
    PRS 84.78
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.43
    rCSI 2.52%
    PRS 75.29
  • kidney epithelial cell CL0002518
    CSI 1.42
    rCSI 2.72%
    PRS 96.22
  • retinal ganglion cell CL0000740
    CSI 1.2
    rCSI 2.65%
    PRS 78.54
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.18
    rCSI 4.47%
    PRS 76.12
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.13
    rCSI 2.75%
    PRS 73.63
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.06
    rCSI 1.79%
    PRS 75.83
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.9
    rCSI 2.61%
    PRS 88.6
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.8
    rCSI 4.72%
    PRS 76.38
  • direct pathway medium spiny neuron CL4023026
    CSI 0.44
    rCSI 10.51%
    PRS 73.63
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.4
    rCSI 9.56%
    PRS 73.88

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SEPTIN8](/details-gene/23176) is a protein-coding gene that encodes a member of the septin family of GTP-binding proteins. These proteins are highly conserved cytoskeletal components that form heterooligomeric complexes and polymerize into filaments, rings, and gauzes. Functionally, [SEPTIN8](/details-gene/23176) is implicated in fundamental cellular processes, most notably cytoskeleton-dependent cytokinesis, protein localization, and the regulation of SNARE complex assembly. Expression data indicates that **Overall**, [SEPTIN8](/details-gene/23176) is a significant marker in diverse cell types, with particularly high relevance in immune cells such as '[CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203)' and '[regulatory T cell](/details-cell/CL0000815)', as well as in non-immune cells including '[conventional dendritic cell](/details-cell/CL0000990)', '[chondrocyte](/details-cell/CL0000138)', and '[neural progenitor cell](/details-cell/CL0011020)', suggesting a broad but specific role in cell division, differentiation, and specialized cellular functions. ## Cellular Roles and Expression Landscape The expression profile of [SEPTIN8](/details-gene/23176) reveals its importance across multiple biological systems, with a prominent role in the immune system. It demonstrates high significance in several T lymphocyte subsets, including '[CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203)' (CSI: 22.01), '[regulatory T cell](/details-cell/CL0000815)' (CSI: 19.72), and '[cytotoxic T cell](/details-cell/CL0000910)' (CSI: 4.93). Its high CSI in '[conventional dendritic cell](/details-cell/CL0000990)' (CSI: 17.56) further underscores its potential involvement in both innate and adaptive immune responses, possibly related to cell division during clonal expansion or cytoskeletal arrangements required for antigen presentation. Beyond the immune system, [SEPTIN8](/details-gene/23176) exhibits a significant presence in developmental and structural contexts. It is a notable marker in '[neural progenitor cell](/details-cell/CL0011020)' (CSI: 12.14) and '[Bergmann glial cell](/details-cell/CL0000644)' (CSI: 5.35), consistent with its annotated localization to axons and presynaptic terminals. Additionally, its high significance in '[chondrocyte](/details-cell/CL0000138)' (CSI: 13.11) and various epidermal cells like '[melanocyte of skin](/details-cell/CL1000458)' (CSI: 11.19) and '[basal cell of epidermis](/details-cell/CL0002187)' (CSI: 7.93) suggests a functional role in the maintenance and proliferation of these structural and barrier tissues. This widespread yet distinct expression pattern points to [SEPTIN8](/details-gene/23176) being a multifunctional cytoskeletal organizer essential for specialized cellular activities. ## Pathways and Molecular Function The functional annotations for [SEPTIN8](/details-gene/23176) are consistent with its role as a core member of the septin protein family. Its molecular functions are dominated by '[Gtp binding (GO:0005525)](https://www.ebi.ac.uk/QuickGO/term/GO:0005525)' and '[Gtpase activity (GO:0003924)](https://www.ebi.ac.uk/QuickGO/term/GO:0003924)', which are essential for the polymerization and depolymerization of septin filaments. Furthermore, its ability to engage in '[Protein binding (GO:0005515)](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)' is critical for its assembly into the '[Septin complex (GO:0031105)](https://www.ebi.ac.uk/QuickGO/term/GO:0031105)', as demonstrated by its known interactions with other septins ([Link](https://doi.org/10.1016/s0014-5793(02)02749-7), [Link](https://doi.org/10.1160/th03-09-0578)). At the biological process level, [SEPTIN8](/details-gene/23176) is centrally involved in '[Cytoskeleton-dependent cytokinesis (GO:0061640)](https://www.ebi.ac.uk/QuickGO/term/GO:0061640)', where it localizes to the '[Cell division site (GO:0032153)](https://www.ebi.ac.uk/QuickGO/term/GO:0032153)' and forms part of the '[Septin ring (GO:0005940)](https://www.ebi.ac.uk/QuickGO/term/GO:0005940)' that scaffolds the cleavage furrow. This function is likely vital in the highly proliferative cell types where it is prominently expressed, such as T cells and progenitor cells. Additionally, its involvement in the '[Regulation of snare complex assembly (GO:0035542)](https://www.ebi.ac.uk/QuickGO/term/GO:0035542)' and its localization to the '[Presynapse (GO:0098793)](https://www.ebi.ac.uk/QuickGO/term/GO:0098793)' and '[Synaptic vesicle membrane (GO:0030672)](https://www.ebi.ac.uk/QuickGO/term/GO:0030672)' provide a molecular basis for its significance in neural cells, suggesting a role in regulating neurotransmitter release. ## Research Directions The diverse expression pattern of [SEPTIN8](/details-gene/23176) across immune, neural, and structural cell types suggests it plays fundamental yet context-specific roles. Its core function in cytokinesis and cytoskeletal organization presents several avenues for future investigation. Based on the available data, several testable hypotheses can be proposed: 1. Given its high significance in multiple T cell subsets ([CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203), [regulatory T cell](/details-cell/CL0000815)) and its established role in cytokinesis, [SEPTIN8](/details-gene/23176) may be essential for the rapid clonal expansion of T cells following antigen stimulation. Its depletion would be expected to impair T cell proliferation and subsequent effector functions. 2. The high significance of [SEPTIN8](/details-gene/23176) in '[neural progenitor cell](/details-cell/CL0011020)' and its localization to presynaptic compartments suggest it plays a critical role in neurogenesis or synaptic maturation. It may function by scaffolding components of the synaptic vesicle release machinery or by regulating cytoskeletal dynamics during axon guidance. A key experiment to test the first hypothesis would be to use a CRISPR-Cas9 system to specifically knock out [SEPTIN8](/details-gene/23176) in primary human T cells. Following *in vitro* activation with anti-CD3/CD28 antibodies, the proliferative capacity of knockout versus control cells could be quantified using dye dilution assays (e.g., CFSE). Concurrently, effector cytokine production (e.g., IFN-γ, IL-2) could be measured by intracellular cytokine staining or ELISA to determine if its role extends beyond proliferation to effector function. As a therapeutic target, [SEPTIN8](/details-gene/23176) presents a complex profile. Its fundamental role in cell division makes it a potential target for anti-proliferative therapies, particularly in cancers characterized by high [SEPTIN8](/details-gene/23176) expression. **Inhibition** would be the therapeutic strategy. However, its broad expression across vital cell types in the immune and nervous systems raises significant concerns about potential on-target, off-tumor toxicity. Therefore, therapeutic strategies would likely require highly targeted delivery systems (e.g., antibody-drug conjugates) or focus on malignancies where [SEPTIN8](/details-gene/23176) or an interacting partner is uniquely dysregulated.

Genular Protein ID: 1703431496

Symbol: SEPT8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92599 A6NC65 A6NKP6 F6W7K9 Q8IX36 Q8IX37 Q9BVB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 5 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 6 SASBDB 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12023038

Title: Human septin-septin interaction: CDCrel-1 partners with KIAA0202.

PubMed ID: 12023038

DOI: 10.1016/s0014-5793(02)02749-7

PubMed ID: 12909369

Title: Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202).

PubMed ID: 12909369

DOI: 10.1016/s0378-1119(03)00635-8

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 10704283

Title: Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11.

PubMed ID: 10704283

DOI: 10.1006/geno.1999.6100

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12475938

Title: Mammalian septins nomenclature.

PubMed ID: 12475938

DOI: 10.1091/mbc.e02-07-0438

PubMed ID: 12098780

Title: KIAA0202, a human septin family member, interacting with hPFTAIRE1.

PubMed ID: 12098780

PubMed ID: 15116257

Title: The novel human platelet septin SEPT8 is an interaction partner of SEPT4.

PubMed ID: 15116257

DOI: 10.1160/th03-09-0578

PubMed ID: 15915442

Title: Expression profiling the human septin gene family.

PubMed ID: 15915442

DOI: 10.1002/path.1789

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27084579

Title: SEPT8 modulates beta-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.

PubMed ID: 27084579

DOI: 10.1242/jcs.185215

Sequence Information:

  • Length: 483
  • Mass: 55756
  • Checksum: 35E1ACF95F5DBA6B
  • Sequence:
    • MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL 
MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDESYRPI 
VDYIDAQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN 
IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV 
GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY 
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK 
EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP 
LRKDKDKKNR SDIGAHQPGM SLSSSKVMMT KASVEPLNCS SWWPAIQCCS CLVRDATWRE 
GFL

Genular Protein ID: 1458150327

Symbol: B7ZVZ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZVZ1

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 GO 9 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 427
  • Mass: 49564
  • Checksum: 8AF692ABE8C02138
  • Sequence:
    • MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL 
MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDERPIVD 
YIDAQFENYL QEELKIRRSL FDYHDTRIHV CLYFITPTGH SLKSLDLVTM KKLDSKVNII 
PIIAKADTIS KSELHKFKIK IMGELVSNGV QIYQFPTDDE AVAEINAVMN AHLPFAVVGS 
TEEVKVGNKL VRARQYPWGV VQVENENHCD FVKLREMLIR VNMEDLREQT HSRHYELYRR 
CKLEEMGFQD SDGDSQPFSL QETYEAKRKE FLSELQRKEE EMRQMFVNKV KETELELKEK 
ERELHEKFEH LKRVHQEEKR KVEEKRRELE EETNAFNRRK AAVEALQSQA LHATSQQPLR 
KDKDKKN

Genular Protein ID: 3116788273

Symbol: A6NFQ9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NFQ9

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 440
  • Mass: 50928
  • Checksum: 47EA668689A47D25
  • Sequence:
    • MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL 
MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDERPIVD 
YIDAQFENYL QEELKIRRSL FDYHDTRIHV CLYFITPTGH SLKSLDLVTM KKLDSKVNII 
PIIAKADTIS KSELHKFKIK IMGELVSNGV QIYQFPTDDE AVAEINAVMN AHLPFAVVGS 
TEEVKVGNKL VRARQYPWGV VQVENENHCD FVKLREMLIR VNMEDLREQT HSRHYELYRR 
CKLEEMGFQD SDGDSQPFSL QETYEAKRKE FLSELQRKEE EMRQMFVNKV KETELELKEK 
ERELHEKFEH LKRVHQEEKR KVEEKRRELE EETNAFNRRK AAVEALQSQA LHATSQQPLR 
KDKDKKKASG WSSIYSVTIP