Details for: OR10G2

Gene ID: 26534

Symbol: OR10G2

Ensembl ID: ENSG00000255582

Description: olfactory receptor family 10 subfamily G member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1007
    Cell Significance Index: 1.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0440
    Cell Significance Index: 0.4800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0292
    Cell Significance Index: 0.3300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0280
    Cell Significance Index: 0.3000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0093
    Cell Significance Index: 0.1200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0133
    Cell Significance Index: -0.2700
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0169
    Cell Significance Index: -0.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0177
    Cell Significance Index: -0.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0196
    Cell Significance Index: -0.3300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0214
    Cell Significance Index: -0.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0255
    Cell Significance Index: -0.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0260
    Cell Significance Index: -0.6600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0293
    Cell Significance Index: -0.4700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0294
    Cell Significance Index: -0.3500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0295
    Cell Significance Index: -0.2900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0378
    Cell Significance Index: -0.4900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0389
    Cell Significance Index: -0.5200
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0396
    Cell Significance Index: -0.1800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0439
    Cell Significance Index: -0.5600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0464
    Cell Significance Index: -0.6000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0469
    Cell Significance Index: -0.5400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0507
    Cell Significance Index: -0.6700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0509
    Cell Significance Index: -0.6100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0529
    Cell Significance Index: -0.5700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0536
    Cell Significance Index: -0.6800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0550
    Cell Significance Index: -0.6100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0553
    Cell Significance Index: -0.6800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0558
    Cell Significance Index: -0.6700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0590
    Cell Significance Index: -0.5900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0617
    Cell Significance Index: -0.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0631
    Cell Significance Index: -0.6400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0638
    Cell Significance Index: -0.6400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0652
    Cell Significance Index: -0.6900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0653
    Cell Significance Index: -0.7600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0656
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0666
    Cell Significance Index: -0.6400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0675
    Cell Significance Index: -0.6800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0683
    Cell Significance Index: -0.6200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0692
    Cell Significance Index: -0.8200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0702
    Cell Significance Index: -0.6600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0711
    Cell Significance Index: -0.6200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0719
    Cell Significance Index: -0.7800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0724
    Cell Significance Index: -0.6800
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0733
    Cell Significance Index: -0.5300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0746
    Cell Significance Index: -0.8800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0785
    Cell Significance Index: -0.6400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0786
    Cell Significance Index: -0.7400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0788
    Cell Significance Index: -0.6800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0790
    Cell Significance Index: -0.7000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0791
    Cell Significance Index: -0.7500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0793
    Cell Significance Index: -0.6700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0835
    Cell Significance Index: -0.6200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0888
    Cell Significance Index: -0.9200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0989
    Cell Significance Index: -0.9200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1013
    Cell Significance Index: -0.8600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1056
    Cell Significance Index: -0.9300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1075
    Cell Significance Index: -0.8600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1253
    Cell Significance Index: -0.8300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1289
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1393
    Cell Significance Index: -1.4700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1509
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Olfactory Receptor Family**: OR10G2 belongs to the olfactory receptor subfamily G, which is distinct from other olfactory receptors that are primarily expressed in the olfactory epithelium. 2. **G Protein-Coupled Receptor (GPCR)**: The OR10G2 protein is predicted to be a GPCR, which is a large family of receptors that respond to a wide range of ligands, including hormones, neurotransmitters, and odorants. 3. **Broad Tissue Expression**: OR10G2 is expressed in various cell types, including pericytes, cardiac endothelial cells, and immune cells, suggesting a role in multiple physiological processes beyond olfaction. 4. **Signaling Pathways**: OR10G2 is involved in signaling pathways related to sensory perception, expression and translocation of olfactory receptors, G protein-coupled receptor activity, and G protein-coupled receptor signaling pathway. **Pathways and Functions** 1. **Detection of Chemical Stimuli**: OR10G2 is involved in detecting chemical stimuli involved in sensory perception of smell, which is mediated by its GPCR activity. 2. **Expression and Translocation of Olfactory Receptors**: OR10G2 may play a role in regulating the expression and translocation of olfactory receptors, which is essential for the development and maintenance of olfactory function. 3. **G Protein-Coupled Receptor Activity**: OR10G2 is predicted to be a GPCR, which is involved in signal transduction and cellular responses to chemical stimuli. 4. **G Protein-Coupled Receptor Signaling Pathway**: OR10G2 is involved in G protein-coupled receptor signaling pathway, which is a complex signaling cascade that regulates various cellular responses, including gene expression, cell proliferation, and differentiation. **Clinical Significance** 1. **Olfactory Dysfunction**: OR10G2 dysregulation may contribute to olfactory dysfunction, which is a common symptom of various neurological and psychiatric disorders, including Parkinson's disease, Alzheimer's disease, and schizophrenia. 2. **Cardiovascular Disease**: OR10G2 expression in cardiac endothelial cells and smooth muscle myoblasts suggests a possible role in cardiovascular disease, including hypertension and atherosclerosis. 3. **Immune System**: OR10G2 expression in immune cells, including pericytes and lymphoid lineage restricted progenitor cells, suggests a possible role in immune system regulation and disease. 4. **Cancer**: OR10G2 expression in fibroblasts of cardiac tissue and kidney epithelial cells suggests a possible role in cancer development and progression. In conclusion, OR10G2 is a complex gene that encodes for a GPCR involved in sensory perception, expression and translocation of olfactory receptors, and G protein-coupled receptor signaling pathway. Its dysregulation may contribute to various diseases, including olfactory dysfunction, cardiovascular disease, immune system disorders, and cancer. Further research is needed to fully elucidate the functional significance of OR10G2 and its potential therapeutic applications.

Genular Protein ID: 1369369264

Symbol: O10G2_HUMAN

Name: Olfactory receptor 10G2

UniProtKB Accession Codes:

Q8NGC3 B2RPD0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 EMBL 4 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 310
  • Mass: 34297
  • Checksum: 7F09580D7F31C405
  • Sequence:
    • MGKTKNTSLD AVVTDFILLG LSHPPNLRSL LFLVFFIIYI LTQLGNLLIL LTMWADPKLC 
ARPMYILLGV LSFLDMWLSS VTVPLLILDF TPSIKAIPFG GCVAQLYFFH FLGSTQCFLY 
TLMAYDRYLA ICQPLRYPVL MNGRLCTVLV AGAWVAGSMH GSIQATLTFR LPYCGPNQVD 
YFICDIPAVL RLACADTTVN ELVTFVDVGV VAASCFMLIL LSYANIVNAI LKIRTTDGRR 
RAFSTCGSHL IVVTVYYVPC IFIYLRAGSK DPLDGAAAVF YTVVTPLLNP LIYTLRNQEV 
KSALKRITAG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.