Details for: BHLHE22

Gene ID: 27319

Symbol: BHLHE22

Ensembl ID: ENSG00000180828

Description: basic helix-loop-helix family member e22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 3.4747
    Cell Significance Index: 4.0000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.5195
    Cell Significance Index: 19.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3843
    Cell Significance Index: 17.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9447
    Cell Significance Index: 26.9600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.6448
    Cell Significance Index: 5.6800
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.4604
    Cell Significance Index: 2.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4408
    Cell Significance Index: 29.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4287
    Cell Significance Index: 12.2900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.3672
    Cell Significance Index: 4.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3153
    Cell Significance Index: 139.3800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.2722
    Cell Significance Index: 3.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1815
    Cell Significance Index: 9.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1560
    Cell Significance Index: 2.2200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1502
    Cell Significance Index: 1.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1394
    Cell Significance Index: 7.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1297
    Cell Significance Index: 7.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1202
    Cell Significance Index: 2.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0653
    Cell Significance Index: 13.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0591
    Cell Significance Index: 3.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0393
    Cell Significance Index: 0.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0214
    Cell Significance Index: 7.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0176
    Cell Significance Index: 11.2000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0066
    Cell Significance Index: 0.0700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.0008
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0096
    Cell Significance Index: -2.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0111
    Cell Significance Index: -6.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0129
    Cell Significance Index: -5.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0142
    Cell Significance Index: -1.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0299
    Cell Significance Index: -4.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0322
    Cell Significance Index: -2.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0335
    Cell Significance Index: -6.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0339
    Cell Significance Index: -6.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0358
    Cell Significance Index: -6.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0382
    Cell Significance Index: -4.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0440
    Cell Significance Index: -5.6800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0441
    Cell Significance Index: -0.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0458
    Cell Significance Index: -6.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0492
    Cell Significance Index: -5.8000
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0562
    Cell Significance Index: -0.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0570
    Cell Significance Index: -0.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0683
    Cell Significance Index: -1.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0696
    Cell Significance Index: -1.6700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0738
    Cell Significance Index: -0.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0775
    Cell Significance Index: -6.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0835
    Cell Significance Index: -6.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0922
    Cell Significance Index: -1.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0953
    Cell Significance Index: -7.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1062
    Cell Significance Index: -4.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1122
    Cell Significance Index: -5.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1136
    Cell Significance Index: -5.9000
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1138
    Cell Significance Index: -1.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1190
    Cell Significance Index: -4.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1230
    Cell Significance Index: -1.3400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1295
    Cell Significance Index: -1.4300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1406
    Cell Significance Index: -1.6400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1439
    Cell Significance Index: -1.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1512
    Cell Significance Index: -6.6900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1512
    Cell Significance Index: -2.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1567
    Cell Significance Index: -1.7800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1649
    Cell Significance Index: -1.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1662
    Cell Significance Index: -5.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1691
    Cell Significance Index: -3.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1705
    Cell Significance Index: -6.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1731
    Cell Significance Index: -6.0200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1760
    Cell Significance Index: -1.6000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1778
    Cell Significance Index: -1.7200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1786
    Cell Significance Index: -4.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1790
    Cell Significance Index: -5.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1804
    Cell Significance Index: -6.8300
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1829
    Cell Significance Index: -1.7900
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1847
    Cell Significance Index: -2.0500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1902
    Cell Significance Index: -1.8100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1913
    Cell Significance Index: -2.5500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1940
    Cell Significance Index: -1.6800
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1969
    Cell Significance Index: -2.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1973
    Cell Significance Index: -5.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2005
    Cell Significance Index: -2.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2081
    Cell Significance Index: -2.6300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2196
    Cell Significance Index: -2.1300
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2204
    Cell Significance Index: -2.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2205
    Cell Significance Index: -5.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2213
    Cell Significance Index: -5.9100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2222
    Cell Significance Index: -3.8300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2236
    Cell Significance Index: -2.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2316
    Cell Significance Index: -3.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2350
    Cell Significance Index: -6.1800
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.2380
    Cell Significance Index: -2.2400
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.2381
    Cell Significance Index: -2.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2407
    Cell Significance Index: -6.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2414
    Cell Significance Index: -6.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2426
    Cell Significance Index: -4.8700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2491
    Cell Significance Index: -2.7300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2510
    Cell Significance Index: -3.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2525
    Cell Significance Index: -1.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2545
    Cell Significance Index: -6.1700
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.2640
    Cell Significance Index: -2.8500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2673
    Cell Significance Index: -1.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulation**: BHLHE22 functions as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. 2. **Cell-Type Specificity**: BHLHE22 is expressed in a range of cell types, including neural progenitor cells, intestinal crypt stem cells, goblet cells, and cerebral cortex GABAergic interneurons. 3. **Cell-Cell Communication**: BHLHE22 is involved in regulating cell-cell communication and adhesion, particularly through its interactions with cadherins and other cell adhesion molecules. 4. **Developmental Processes**: BHLHE22 plays a role in various developmental processes, including axon development, sensory organ development, and neuron fate commitment. **Pathways and Functions** BHLHE22 is involved in multiple signaling pathways, including: 1. **Adherens Junctions Interactions**: BHLHE22 regulates the expression and function of CDH11, a key component of adherens junctions, which are essential for maintaining tissue structure and integrity. 2. **Axon Development**: BHLHE22 is involved in regulating axon development, particularly through its interactions with other transcription factors and signaling molecules. 3. **Cell-Junction Organization**: BHLHE22 regulates the organization of cell junctions, including adherens junctions, tight junctions, and desmosomes, which are critical for maintaining tissue structure and function. 4. **Chromatin Remodeling**: BHLHE22 interacts with chromatin remodeling complexes to regulate gene expression and maintain tissue homeostasis. **Clinical Significance** Dysregulation of BHLHE22 has been implicated in various diseases, including: 1. **Neurological Disorders**: Mutations in BHLHE22 have been associated with neurological disorders, such as epilepsy and schizophrenia, highlighting its role in regulating neuronal development and function. 2. **Cancer**: BHLHE22 has been implicated in cancer development and progression, particularly in intestinal cancer, where it regulates cell proliferation and differentiation. 3. **Developmental Disorders**: BHLHE22 mutations have been associated with developmental disorders, such as congenital heart defects and neural tube defects, highlighting its role in regulating developmental processes. In conclusion, BHLHE22 is a critical transcription factor involved in regulating gene expression, cell-cell communication, and tissue development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its function and therapeutic applications.

Genular Protein ID: 913671577

Symbol: BHE22_HUMAN

Name: Class E basic helix-loop-helix protein 22

UniProtKB Accession Codes:

Q8NFJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12213201

Title: Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor.

PubMed ID: 12213201

DOI: 10.1006/geno.2002.6833

PubMed ID: 14516699

Title: Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.

PubMed ID: 14516699

DOI: 10.1016/s0925-4773(03)00130-8

Sequence Information:

  • Length: 381
  • Mass: 36997
  • Checksum: 7B17A9BD5C7F8569
  • Sequence:
    • MERGMHLGAA AAGEDDLFLH KSLSASTSKR LEAAFRSTPP GMDLSLAPPP RERPASSSSS 
PLGCFEPADP EGAGLLLPPP GGGGGGSAGS GGGGGGGVGV PGLLVGSAGV GGDPSLSSLP 
AGAALCLKYG ESASRGSVAE SSGGEQSPDD DSDGRCELVL RAGVADPRAS PGAGGGGAKA 
AEGCSNAHLH GGASVPPGGL GGGGGGGSSS GSSGGGGGSG SGSGGSSSSS SSSSKKSKEQ 
KALRLNINAR ERRRMHDLND ALDELRAVIP YAHSPSVRKL SKIATLLLAK NYILMQAQAL 
EEMRRLVAYL NQGQAISAAS LPSSAAAAAA AAALHPALGA YEQAAGYPFS AGLPPAASCP 
EKCALFNSVS SSLCKQCTEK P

Genular Protein ID: 4261306001

Symbol: B4DF88_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DF88

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 384
  • Mass: 37197
  • Checksum: A891DEC8C662C06A
  • Sequence:
    • MERGMHLGAA AAGEDDLFLH KSLSASTAKR LEAAFRSTPP GMDLSLAPPP RERPASSSSS 
PQGCFEPADP EGAGLLLPPP GGGGGGSAGS GGGGGGGGVG VPGLLVGSAG VGGDPSLSSL 
PAGAALCLKY GESASRGSVA ESSGGEQSPD DDSDGRCELV LRAGVADPRA SPGAGGGGAK 
AAEGCSNAHL HGGASVPPGG LGGGGGGGSS SGSSGGGGGS GSGSGSGGSS SSSSSSSKKS 
KEQKALRLNI NARERRRMHD LNDALDELRA VIPYAHSPSV RKLSKIATLL LAKNYILMQA 
QALEEMRRLV AYLNQGQAIS AASLPSSAAA AAAAAALHPA LGAYEQAAGY PFSAGLPPAA 
SCPEKCALFN SVSSSLCKQC TEKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.