Details for: BHLHE22
Gene ID: 27319
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: BHLHE22
Ensembl ID: ENSG00000180828
Description: basic helix-loop-helix family member e22
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 7.35rCSI 14.77%PRS 97.57
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CSI 5.89rCSI 12.52%PRS 96.96
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CSI 5.25rCSI 6.73%PRS 97.96
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CSI 3.42rCSI 4.68%PRS 97.86
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CSI 2.5rCSI 4.68%PRS 96.63
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CSI 2.49rCSI 10.94%PRS 94.29
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CSI 2.1rCSI 4.32%PRS 94.17
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CSI 1.27rCSI 4.36%PRS 94.03
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 913671577
Symbol: BHE22_HUMAN
Name: Class E basic helix-loop-helix protein 22
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12213201
Title: Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor.
PubMed ID: 12213201
PubMed ID: 14516699
Title: Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.
PubMed ID: 14516699
Sequence Information:
- Length: 381
- Mass: 36997
- Checksum: 7B17A9BD5C7F8569
- Sequence:
MERGMHLGAA AAGEDDLFLH KSLSASTSKR LEAAFRSTPP GMDLSLAPPP RERPASSSSS PLGCFEPADP EGAGLLLPPP GGGGGGSAGS GGGGGGGVGV PGLLVGSAGV GGDPSLSSLP AGAALCLKYG ESASRGSVAE SSGGEQSPDD DSDGRCELVL RAGVADPRAS PGAGGGGAKA AEGCSNAHLH GGASVPPGGL GGGGGGGSSS GSSGGGGGSG SGSGGSSSSS SSSSKKSKEQ KALRLNINAR ERRRMHDLND ALDELRAVIP YAHSPSVRKL SKIATLLLAK NYILMQAQAL EEMRRLVAYL NQGQAISAAS LPSSAAAAAA AAALHPALGA YEQAAGYPFS AGLPPAASCP EKCALFNSVS SSLCKQCTEK P
Genular Protein ID: 4261306001
Symbol: B4DF88_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 384
- Mass: 37197
- Checksum: A891DEC8C662C06A
- Sequence:
MERGMHLGAA AAGEDDLFLH KSLSASTAKR LEAAFRSTPP GMDLSLAPPP RERPASSSSS PQGCFEPADP EGAGLLLPPP GGGGGGSAGS GGGGGGGGVG VPGLLVGSAG VGGDPSLSSL PAGAALCLKY GESASRGSVA ESSGGEQSPD DDSDGRCELV LRAGVADPRA SPGAGGGGAK AAEGCSNAHL HGGASVPPGG LGGGGGGGSS SGSSGGGGGS GSGSGSGGSS SSSSSSSKKS KEQKALRLNI NARERRRMHD LNDALDELRA VIPYAHSPSV RKLSKIATLL LAKNYILMQA QALEEMRRLV AYLNQGQAIS AASLPSSAAA AAAAAALHPA LGAYEQAAGY PFSAGLPPAA SCPEKCALFN SVSSSLCKQC TEKP