Details for: GPR32

Gene ID: 2854

Symbol: GPR32

Ensembl ID: ENSG00000142511

Description: G protein-coupled receptor 32

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.66
    Marker Score: 8239
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.08
    Marker Score: 32723
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.74
    Marker Score: 6805
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3178
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.71
    Marker Score: 444
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10770
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 1.38
    Marker Score: 444
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.37
    Marker Score: 442
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 1.29
    Marker Score: 444
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7535
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3650
  • Cell Name: Unknown (CL0000003)
    Fold Change: 1.19
    Marker Score: 3665
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.06
    Marker Score: 621
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.05
    Marker Score: 32615
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47940
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71443
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.87
    Marker Score: 387
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.84
    Marker Score: 444
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.83
    Marker Score: 437
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 742
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.8
    Marker Score: 443
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.78
    Marker Score: 433
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.78
    Marker Score: 442
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 345
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.71
    Marker Score: 442
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.65
    Marker Score: 430
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.61
    Marker Score: 546
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.57
    Marker Score: 443
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 316
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.5
    Marker Score: 414
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.46
    Marker Score: 437
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.46
    Marker Score: 409.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.43
    Marker Score: 440
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.42
    Marker Score: 407
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4
    Marker Score: 766
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.39
    Marker Score: 438
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.37
    Marker Score: 397
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.36
    Marker Score: 3660
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.35
    Marker Score: 721
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.34
    Marker Score: 439
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.31
    Marker Score: 429
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.26
    Marker Score: 309
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.24
    Marker Score: 3792
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.23
    Marker Score: 1401
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 389
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 428
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.16
    Marker Score: 420
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.13
    Marker Score: 442
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.12
    Marker Score: 431
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.11
    Marker Score: 413
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.05
    Marker Score: 95
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 81
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.02
    Marker Score: 344
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.01
    Marker Score: 441
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.01
    Marker Score: 444
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 438

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Other Information

**Key characteristics:** - GPR32 is a G protein-coupled receptor that is expressed in significant amounts in oligodendrocyte precursor cells, progenitor cells, microglial cells, and blood vessel endothelial cells. - It is also expressed in low levels in epithelial cells of the thymus, mononuclear cells, myeloid lineage restricted progenitor cells, and neoplastic cells. - The protein is a single-pass transmembrane protein with 14 transmembrane domains. - It is a member of the GPCR family of G protein-coupled receptors. **Pathways and functions:** - GPR32 is a key regulator of the complement system. - It is a ligand for the C5b-C9 complex, which is a central component of the complement cascade. - Activation of GPR32 by C5b-C9 complex leads to the formation of the membrane attack complex (MAC), which is responsible for killing infected cells and tumor cells. - GPR32 also plays a role in the regulation of inflammation. - It is a ligand for the N-formyl peptide receptor, which is involved in the regulation of inflammation and pain. - Activation of GPR32 by N-formyl peptide leads to the release of inflammatory mediators, which can contribute to pain and inflammation. **Clinical significance:** - Mutations in GPR32 have been linked to several human diseases, including multiple sclerosis, autoimmune disorders, and cancer. - In multiple sclerosis, mutations in GPR32 are associated with the development of inflammatory lesions in the central nervous system. - In autoimmune disorders, mutations in GPR32 are associated with the development of autoantibodies that target various tissues in the body. - In cancer, mutations in GPR32 are associated with the development of tumor growth and metastasis.

Genular Protein ID: 3432243903

Symbol: GPR32_HUMAN

Name: Probable G-protein coupled receptor 32

UniProtKB Accession Codes:

O75388 Q502U7 Q6NWS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9653656

Title: Cloning genes encoding receptors related to chemoattractant receptors.

PubMed ID: 9653656

DOI: 10.1006/geno.1998.5297

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20080636

Title: Resolvin D1 binds human phagocytes with evidence for proresolving receptors.

PubMed ID: 20080636

DOI: 10.1073/pnas.0907342107

PubMed ID: 23462912

Title: Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion.

PubMed ID: 23462912

DOI: 10.1038/mi.2013.7

PubMed ID: 26969756

Title: Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32.

PubMed ID: 26969756

DOI: 10.4049/jimmunol.1501701

Sequence Information:

  • Length: 356
  • Mass: 40087
  • Checksum: 0E00DCF4BD7F4C3A
  • Sequence:
    • MNGVSEGTRG CSDRQPGVLT RDRSCSRKMN SSGCLSEEVG SLRPLTVVIL SASIVVGVLG 
NGLVLWMTVF RMARTVSTVC FFHLALADFM LSLSLPIAMY YIVSRQWLLG EWACKLYITF 
VFLSYFASNC LLVFISVDRC ISVLYPVWAL NHRTVQRASW LAFGVWLLAA ALCSAHLKFR 
TTRKWNGCTH CYLAFNSDNE TAQIWIEGVV EGHIIGTIGH FLLGFLGPLA IIGTCAHLIR 
AKLLREGWVH ANRPKRLLLV LVSAFFIFWS PFNVVLLVHL WRRVMLKEIY HPRMLLILQA 
SFALGCVNSS LNPFLYVFVG RDFQEKFFQS LTSALARAFG EEEFLSSCPR GNAPRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.