Details for: TRBJ1 6

Gene ID: 28630

Symbol: TRBJ1 6

Ensembl ID: ENSG00000282780

Description: T cell receptor beta joining 1-6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 16.3893
    Cell Significance Index: 320.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.1751
    Cell Significance Index: 76.9100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.8645
    Cell Significance Index: 11.2900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1565
    Cell Significance Index: 2.6700
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1159
    Cell Significance Index: 1.5300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0715
    Cell Significance Index: 0.3900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0395
    Cell Significance Index: 0.4400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0320
    Cell Significance Index: 0.4000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0203
    Cell Significance Index: 0.2600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0038
    Cell Significance Index: 0.0400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0068
    Cell Significance Index: -0.1200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0111
    Cell Significance Index: -0.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0139
    Cell Significance Index: -0.2000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0145
    Cell Significance Index: -0.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0149
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0198
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0238
    Cell Significance Index: -0.1900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0253
    Cell Significance Index: -0.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0256
    Cell Significance Index: -0.3400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0263
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0266
    Cell Significance Index: -0.2800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0294
    Cell Significance Index: -0.2700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0304
    Cell Significance Index: -0.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0330
    Cell Significance Index: -0.6100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0372
    Cell Significance Index: -0.3200
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0390
    Cell Significance Index: -0.3200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0400
    Cell Significance Index: -0.3400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0424
    Cell Significance Index: -0.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0458
    Cell Significance Index: -0.4400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0476
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0496
    Cell Significance Index: -0.4700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0505
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0572
    Cell Significance Index: -0.5800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0582
    Cell Significance Index: -0.3100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0608
    Cell Significance Index: -0.7100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0621
    Cell Significance Index: -0.6200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0626
    Cell Significance Index: -0.6100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0630
    Cell Significance Index: -0.7300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0631
    Cell Significance Index: -0.6400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0666
    Cell Significance Index: -0.6200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0677
    Cell Significance Index: -0.8000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0684
    Cell Significance Index: -0.7600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0688
    Cell Significance Index: -0.7300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0695
    Cell Significance Index: -0.6000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0695
    Cell Significance Index: -0.8200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0695
    Cell Significance Index: -0.7100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0703
    Cell Significance Index: -0.7100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0705
    Cell Significance Index: -0.7100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0722
    Cell Significance Index: -0.7600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0742
    Cell Significance Index: -0.6200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0748
    Cell Significance Index: -0.7000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0857
    Cell Significance Index: -0.7500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0889
    Cell Significance Index: -0.7500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0902
    Cell Significance Index: -0.7300
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0909
    Cell Significance Index: -0.8400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0938
    Cell Significance Index: -0.7300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0981
    Cell Significance Index: -0.7300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1061
    Cell Significance Index: -0.7300
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1076
    Cell Significance Index: -0.8800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1414
    Cell Significance Index: -1.1300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2855
    Cell Significance Index: -0.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRBJ1-6 is significantly expressed in various immune cells, including natural killer cells, T cells, mast cells, and hematopoietic stem cells. 2. **Cell Type Specificity:** TRBJ1-6 is expressed in alpha-beta T cells, gamma-delta T cells, and some populations of natural killer cells. 3. **Function:** TRBJ1-6 is essential for the proper assembly and function of the TCR complex, allowing for the recognition and binding of specific antigens. 4. **Evolutionary Conservation:** TRBJ1-6 is conserved across different species, suggesting its critical role in the evolution of the adaptive immune system. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBJ1-6 plays a crucial role in the adaptive immune response by recognizing and binding to specific antigens, triggering an immune response. 2. **TCR Complex Assembly:** TRBJ1-6 is essential for the assembly and function of the TCR complex, which is composed of alpha, beta, and gamma chains. 3. **Immune Cell Development:** TRBJ1-6 is involved in the development and maturation of immune cells, including T cells, natural killer cells, and mast cells. 4. **Immune Homeostasis:** TRBJ1-6 helps maintain immune homeostasis by regulating the function and development of immune cells. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in TRBJ1-6 expression have been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, highlighting its potential as a therapeutic target. 2. **Cancer Immunotherapy:** TRBJ1-6 is being explored as a target for cancer immunotherapy, as it can be used to enhance the recognition and targeting of tumor cells by the immune system. 3. **Immunodeficiency Disorders:** TRBJ1-6 mutations have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID), emphasizing its importance in maintaining immune function. 4. **Vaccine Development:** TRBJ1-6 is being investigated as a potential component of vaccines, as it can be used to enhance the recognition and response to antigens. In conclusion, TRBJ1-6 is a critical component of the adaptive immune system, playing a pivotal role in the recognition and binding of specific antigens, the assembly and function of the TCR complex, and the development and function of immune cells. Its importance in maintaining immune homeostasis and preventing autoimmune diseases makes it a promising target for therapeutic interventions and vaccine development.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.