Details for: TRAJ30

Gene ID: 28725

Symbol: TRAJ30

Ensembl ID: ENSG00000211859

Description: T cell receptor alpha joining 30

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 7.5251
    Cell Significance Index: 147.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2369
    Cell Significance Index: 29.9600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3261
    Cell Significance Index: 4.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1556
    Cell Significance Index: 2.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0007
    Cell Significance Index: 0.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0008
    Cell Significance Index: -0.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0057
    Cell Significance Index: -0.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0077
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0107
    Cell Significance Index: -0.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0110
    Cell Significance Index: -0.2200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0140
    Cell Significance Index: -0.1900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0154
    Cell Significance Index: -0.2600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0164
    Cell Significance Index: -0.2000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0167
    Cell Significance Index: -0.2300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0169
    Cell Significance Index: -0.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0173
    Cell Significance Index: -0.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0181
    Cell Significance Index: -0.2400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0186
    Cell Significance Index: -0.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0199
    Cell Significance Index: -0.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0214
    Cell Significance Index: -0.4000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0222
    Cell Significance Index: -0.2500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0223
    Cell Significance Index: -0.2700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0232
    Cell Significance Index: -0.2900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0235
    Cell Significance Index: -0.2700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0236
    Cell Significance Index: -0.2800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0241
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0253
    Cell Significance Index: -0.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0253
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0257
    Cell Significance Index: -0.2400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0262
    Cell Significance Index: -0.3100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0262
    Cell Significance Index: -0.3200
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0270
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0284
    Cell Significance Index: -0.3000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0288
    Cell Significance Index: -0.2700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0293
    Cell Significance Index: -0.3400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0294
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0302
    Cell Significance Index: -0.3100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0318
    Cell Significance Index: -0.3200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0323
    Cell Significance Index: -0.2700
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0323
    Cell Significance Index: -0.3700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0324
    Cell Significance Index: -0.2800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0338
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0338
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0345
    Cell Significance Index: -0.3500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0351
    Cell Significance Index: -0.2900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0351
    Cell Significance Index: -0.4100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0358
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0364
    Cell Significance Index: -0.3500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0377
    Cell Significance Index: -0.2900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0400
    Cell Significance Index: -0.3500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0403
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0404
    Cell Significance Index: -0.4400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0411
    Cell Significance Index: -0.3200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0411
    Cell Significance Index: -0.3500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0422
    Cell Significance Index: -0.2300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0494
    Cell Significance Index: -0.3400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0497
    Cell Significance Index: -0.3700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1214
    Cell Significance Index: -0.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** TRAJ30 is significantly expressed in multiple T cell subsets, including CD8-positive, alpha-beta T cells, naive thymus-derived CD4-positive, alpha-beta T cells, CD8-positive, alpha-beta memory T cells, CD4-positive, alpha-beta thymocytes, mature alpha-beta T cells, and B cells. This widespread expression suggests that TRAJ30 is a fundamental component of the immune system, contributing to the development and maintenance of various T cell populations. 2. **Gene Structure:** While the detailed gene structure of TRAJ30 is not provided, it is likely to be a small, non-coding gene that regulates the expression of adjacent or nearby genes. The presence of a joining domain, as indicated by the "alpha joining" nomenclature, suggests that TRAJ30 may play a role in the assembly or stabilization of the T cell receptor (TCR) complex. 3. **Evolutionary Conservation:** The conservation of TRAJ30 across different species implies that this gene has been retained throughout evolution, underscoring its importance in the development and function of the immune system. **Pathways and Functions:** 1. **TCR Assembly and Regulation:** TRAJ30 is likely to play a critical role in the assembly and regulation of the TCR complex, which is essential for the recognition and activation of antigens. The joining domain of TRAJ30 may facilitate the interaction between the alpha and beta chains of the TCR, ensuring proper assembly and function. 2. **T Cell Development and Maturation:** TRAJ30 may also contribute to the development and maturation of T cells by regulating the expression of adjacent or nearby genes involved in T cell development and differentiation. 3. **Immune Response and Regulation:** The expression of TRAJ30 in various T cell subsets suggests that this gene may play a role in regulating the immune response, modulating the activity of different T cell populations, and maintaining immune homeostasis. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Alterations in TRAJ30 expression or function may contribute to immunodeficiency disorders, such as impaired T cell development and function. Understanding the role of TRAJ30 in T cell development and regulation may provide insights into the pathogenesis of these disorders. 2. **Cancer Immunotherapy:** TRAJ30 may also play a role in cancer immunotherapy, as dysregulation of the TCR complex has been implicated in various types of cancer. Targeting TRAJ30 or other components of the TCR complex may provide a novel therapeutic strategy for cancer treatment. 3. **Autoimmune Diseases:** The expression of TRAJ30 in various T cell subsets suggests that this gene may also contribute to the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes. Understanding the role of TRAJ30 in autoimmune disease may provide insights into the pathogenesis of these disorders and the development of novel therapeutic strategies. In conclusion, TRAJ30 is a fascinating gene that plays a critical role in the development and function of various T cell subsets. Further research into the characteristics, pathways, and functions of TRAJ30 is necessary to fully appreciate its immunological significance and potential clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.