Details for: IGKV2 4

Gene ID: 28929

Symbol: IGKV2 4

Ensembl ID: ENSG00000253435

Description: immunoglobulin kappa variable 2-4 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.1384
    Cell Significance Index: 29.0100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.7644
    Cell Significance Index: 12.3800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.6880
    Cell Significance Index: 11.7600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4157
    Cell Significance Index: 5.7000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3284
    Cell Significance Index: 4.2500
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.2705
    Cell Significance Index: 3.5600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1421
    Cell Significance Index: 1.5100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0179
    Cell Significance Index: -0.2600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0255
    Cell Significance Index: -0.1700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0290
    Cell Significance Index: -0.4000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0465
    Cell Significance Index: -0.5200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0529
    Cell Significance Index: -0.4800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0544
    Cell Significance Index: -0.6000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0642
    Cell Significance Index: -0.8400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0660
    Cell Significance Index: -0.7600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0761
    Cell Significance Index: -0.8100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0804
    Cell Significance Index: -0.9500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0926
    Cell Significance Index: -0.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0936
    Cell Significance Index: -0.9500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1038
    Cell Significance Index: -1.6700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1049
    Cell Significance Index: -1.4900
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1061
    Cell Significance Index: -0.9400
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1102
    Cell Significance Index: -0.9600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1176
    Cell Significance Index: -0.9400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1184
    Cell Significance Index: -1.8000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1189
    Cell Significance Index: -1.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1198
    Cell Significance Index: -2.4100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1198
    Cell Significance Index: -1.0200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1276
    Cell Significance Index: -1.4800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1278
    Cell Significance Index: -1.5100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1289
    Cell Significance Index: -1.8100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1318
    Cell Significance Index: -1.6900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1372
    Cell Significance Index: -1.4600
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1382
    Cell Significance Index: -1.4400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1387
    Cell Significance Index: -1.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1398
    Cell Significance Index: -1.4500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1451
    Cell Significance Index: -1.7400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1518
    Cell Significance Index: -1.5500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1530
    Cell Significance Index: -1.3200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1552
    Cell Significance Index: -1.4400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1558
    Cell Significance Index: -2.1400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1589
    Cell Significance Index: -1.8300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1630
    Cell Significance Index: -1.5300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1665
    Cell Significance Index: -1.5500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1727
    Cell Significance Index: -1.9100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1772
    Cell Significance Index: -1.5100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1803
    Cell Significance Index: -2.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1860
    Cell Significance Index: -1.7600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2023
    Cell Significance Index: -1.8500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2103
    Cell Significance Index: -2.4200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2114
    Cell Significance Index: -1.9600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2121
    Cell Significance Index: -2.4100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2184
    Cell Significance Index: -1.3900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2184
    Cell Significance Index: -1.3700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2188
    Cell Significance Index: -2.2100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2200
    Cell Significance Index: -2.4100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2310
    Cell Significance Index: -2.1900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.2336
    Cell Significance Index: -2.2100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2619
    Cell Significance Index: -2.4500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3184
    Cell Significance Index: -1.8900
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.3311
    Cell Significance Index: -3.2400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.3359
    Cell Significance Index: -3.4100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3412
    Cell Significance Index: -2.2200
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.3463
    Cell Significance Index: -2.4500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.5545
    Cell Significance Index: -1.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2-4 is a pseudogene, meaning it has undergone mutations that render it non-functional and unable to produce a functional immunoglobulin. Despite this, it is significantly expressed in multiple cell types, including erythrocytes, double-negative thymocytes, megakaryocytes, and precursor B cells. Its expression is not limited to B cells, as it is also found in mast cells and plasma cells. The presence of IGKV2-4 in these cell types suggests that it may play a role in regulating gene expression or modulating immune responses. **Pathways and Functions:** While IGKV2-4 is devoid of coding potential, its expression is linked to various cellular processes. Research suggests that IGKV2-4 may act as a decoy or regulatory element, influencing the expression of nearby genes or modulating the activity of nearby transcription factors. Its expression in hematopoietic stem cells and megakaryocytes may contribute to the development and maturation of these cells. Furthermore, IGKV2-4's presence in plasma cells suggests that it may play a role in regulating the expression of genes involved in antibody production. **Clinical Significance:** IGKV2-4's expression in various cell types raises questions about its clinical significance. While its non-functional nature suggests that it may not directly contribute to immune function, its widespread expression across multiple cell types implies that it may be involved in regulating immune responses or modulating the activity of nearby genes. Future studies are needed to elucidate the functional implications of IGKV2-4 and its role in disease pathogenesis. In conclusion, IGKV2-4 is a pseudogene with significant expression across various cell types, including hematopoietic stem cells and mature B cells. While its non-functional nature suggests that it may not directly contribute to immune function, its expression in multiple cell types implies that it may play a role in regulating gene expression or modulating immune responses. Further research is necessary to fully elucidate the functional implications of IGKV2-4 and its clinical significance. **Potential Research Directions:** 1. Investigate the functional implications of IGKV2-4 in different cell types and tissues. 2. Explore the role of IGKV2-4 in regulating gene expression or modulating immune responses. 3. Investigate the clinical significance of IGKV2-4 in disease pathogenesis, such as autoimmune disorders or cancer. 4. Examine the expression patterns of IGKV2-4 in different tissues and cell types to better understand its regulation. By exploring these avenues, researchers can gain a deeper understanding of IGKV2-4's role in the immune system and its potential clinical implications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.