Details for: HOXA2

Gene ID: 3199

Symbol: HOXA2

Ensembl ID: ENSG00000105996

Description: homeobox A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.0462
    Cell Significance Index: -4.0700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 8.8860
    Cell Significance Index: 87.9200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.3636
    Cell Significance Index: 22.4700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.2284
    Cell Significance Index: 7.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0677
    Cell Significance Index: 203.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.0466
    Cell Significance Index: -4.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7647
    Cell Significance Index: 75.6500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.7565
    Cell Significance Index: 4.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6365
    Cell Significance Index: 574.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6055
    Cell Significance Index: 12.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5443
    Cell Significance Index: 14.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4152
    Cell Significance Index: 67.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3957
    Cell Significance Index: 43.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2520
    Cell Significance Index: 15.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2311
    Cell Significance Index: 15.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1608
    Cell Significance Index: 7.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1247
    Cell Significance Index: 6.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1105
    Cell Significance Index: 3.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1053
    Cell Significance Index: 2.1900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0833
    Cell Significance Index: 1.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0825
    Cell Significance Index: 2.3100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0735
    Cell Significance Index: 0.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0686
    Cell Significance Index: 0.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0547
    Cell Significance Index: 0.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0401
    Cell Significance Index: 1.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0314
    Cell Significance Index: 3.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0222
    Cell Significance Index: 0.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0135
    Cell Significance Index: 0.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0064
    Cell Significance Index: 2.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0039
    Cell Significance Index: 0.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0038
    Cell Significance Index: 0.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0036
    Cell Significance Index: 0.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0021
    Cell Significance Index: 0.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0004
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.9200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0042
    Cell Significance Index: -2.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0048
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -3.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0073
    Cell Significance Index: -0.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0165
    Cell Significance Index: -1.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0167
    Cell Significance Index: -3.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0168
    Cell Significance Index: -2.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0170
    Cell Significance Index: -3.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0198
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0208
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0221
    Cell Significance Index: -3.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0240
    Cell Significance Index: -3.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0266
    Cell Significance Index: -1.8800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0271
    Cell Significance Index: -0.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0298
    Cell Significance Index: -3.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0307
    Cell Significance Index: -1.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0367
    Cell Significance Index: -2.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0413
    Cell Significance Index: -3.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0440
    Cell Significance Index: -1.3000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0458
    Cell Significance Index: -0.6700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0467
    Cell Significance Index: -0.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0496
    Cell Significance Index: -1.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0514
    Cell Significance Index: -1.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0521
    Cell Significance Index: -1.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0527
    Cell Significance Index: -3.9300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0568
    Cell Significance Index: -0.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0571
    Cell Significance Index: -2.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0598
    Cell Significance Index: -0.6500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0714
    Cell Significance Index: -1.2300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0718
    Cell Significance Index: -1.0900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0786
    Cell Significance Index: -0.8600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0929
    Cell Significance Index: -0.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0953
    Cell Significance Index: -2.0600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0984
    Cell Significance Index: -0.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1026
    Cell Significance Index: -2.0600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1072
    Cell Significance Index: -0.7700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1099
    Cell Significance Index: -1.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1111
    Cell Significance Index: -4.0800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1141
    Cell Significance Index: -1.2600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1160
    Cell Significance Index: -1.6500
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1174
    Cell Significance Index: -1.3900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1179
    Cell Significance Index: -1.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1195
    Cell Significance Index: -3.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1204
    Cell Significance Index: -2.4000
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.1216
    Cell Significance Index: -0.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1278
    Cell Significance Index: -1.8300
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1289
    Cell Significance Index: -1.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1315
    Cell Significance Index: -3.7700
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1343
    Cell Significance Index: -1.3200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1344
    Cell Significance Index: -2.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1365
    Cell Significance Index: -2.1900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1380
    Cell Significance Index: -0.8100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1401
    Cell Significance Index: -3.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1420
    Cell Significance Index: -3.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1422
    Cell Significance Index: -3.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1432
    Cell Significance Index: -3.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1440
    Cell Significance Index: -2.8100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.1453
    Cell Significance Index: -1.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1495
    Cell Significance Index: -1.0100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1525
    Cell Significance Index: -1.4700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1527
    Cell Significance Index: -2.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1535
    Cell Significance Index: -3.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXA2 is a transcription factor that belongs to the homeobox gene family, which consists of highly conserved DNA-binding proteins. The gene is characterized by its ability to bind to specific DNA sequences, thereby regulating the expression of target genes involved in various biological processes. HOXA2's expression is tightly regulated during embryonic development, where it plays a crucial role in anterior-posterior patterning, dorsal-ventral patterning, and segment specification. Additionally, HOXA2 is involved in the regulation of cell fate determination, axon guidance, and the development of specific cell types, such as neurons and osteoblasts. **Pathways and Functions:** HOXA2's involvement in various signaling pathways makes it a key player in regulating development, immune responses, and tissue homeostasis. Some of the key pathways and functions associated with HOXA2 include: 1. **Anterior-Posterior Pattern Specification:** HOXA2 regulates the expression of anterior and posterior genes, influencing the development of the hindbrain and the formation of the anterior-posterior axis. 2. **Dorsal-Ventral Pattern Formation:** HOXA2 is involved in the regulation of dorsal-ventral patterning, influencing the development of the neural tube and the formation of the dorsal and ventral regions. 3. **Segment Specification:** HOXA2 regulates the expression of genes involved in segment specification, influencing the development of the body plan and the formation of repeating structures. 4. **Axon Guidance:** HOXA2 is involved in the regulation of axon guidance, influencing the migration and targeting of neurons during development. 5. **Cell Fate Determination:** HOXA2 regulates the expression of genes involved in cell fate determination, influencing the development of specific cell types, such as neurons and osteoblasts. **Clinical Significance:** HOXA2's involvement in various developmental and immunological processes makes it a significant gene in the context of human disease. Some of the clinical implications of HOXA2 dysregulation include: 1. **Immunological Disorders:** Alterations in HOXA2 expression have been linked to various immunological disorders, including autoimmune diseases and cancer. 2. **Developmental Abnormalities:** Dysregulation of HOXA2 has been implicated in developmental abnormalities, including neural tube defects and congenital heart defects. 3. **Cancer:** HOXA2 is often overexpressed in various types of cancer, including breast, lung, and colon cancer. 4. **Neurological Disorders:** Alterations in HOXA2 expression have been linked to neurological disorders, including schizophrenia and autism spectrum disorder. In conclusion, HOXA2 is a complex gene that plays a crucial role in regulating developmental and immunological processes. Its involvement in various signaling pathways makes it a significant gene in the context of human disease. Further research is necessary to fully understand the mechanisms by which HOXA2 influences cell fate determination, patterning, and signaling pathways, and to explore its potential therapeutic applications in the treatment of various diseases.

Genular Protein ID: 2184616326

Symbol: HXA2_HUMAN

Name: Homeobox protein Hox-A2

UniProtKB Accession Codes:

O43364 A1L4K3 B2RMW3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23775976

Title: HOXA2 haploinsufficiency in dominant bilateral microtia and hearing loss.

PubMed ID: 23775976

DOI: 10.1002/humu.22367

PubMed ID: 18394579

Title: A mutation in HOXA2 is responsible for autosomal-recessive microtia in an Iranian family.

PubMed ID: 18394579

DOI: 10.1016/j.ajhg.2008.02.015

Sequence Information:

  • Length: 376
  • Mass: 41002
  • Checksum: 78EB388FE1EEAD72
  • Sequence:
    • MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 
PGSHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE KKAAKKTALL PAAAAAATAA 
ATGPACLSHK ESLEIADGSG GGSRRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL 
DLTERQVKVW FQNRRMKHKR QTQCKENQNS EGKCKSLEDS EKVEEDEEEK TLFEQALSVS 
GALLEREGYT FQQNALSQQQ APNGHNGDSQ SFPVSPLTSN EKNLKHFQHQ SPTVPNCLST 
MGQNCGAGLN NDSPEALEVP SLQDFSVFST DSCLQLSDAV SPSLPGSLDS PVDISADSLD 
FFTDTLTTID LQHLNY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.