Details for: HOXA2

Gene ID: 3199

Symbol: HOXA2

Ensembl ID: ENSG00000105996

Description: homeobox A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1509
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.49
    Marker Score: 621.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7647
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.06
    Marker Score: 846
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.77
    Marker Score: 820
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.75
    Marker Score: 708
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 684
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1081
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.65
    Marker Score: 497.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1133
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.53
    Marker Score: 333
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 323
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.49
    Marker Score: 548
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.46
    Marker Score: 160
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 252
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.41
    Marker Score: 719
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.4
    Marker Score: 237
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 367
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.34
    Marker Score: 324
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.31
    Marker Score: 1165
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.31
    Marker Score: 445
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.29
    Marker Score: 97
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.26
    Marker Score: 3430
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 99
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.22
    Marker Score: 511.5
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.21
    Marker Score: 144
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 114
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.19
    Marker Score: 139
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.19
    Marker Score: 57
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.18
    Marker Score: 85
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.18
    Marker Score: 289
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.17
    Marker Score: 205
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.16
    Marker Score: 55
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 149
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.15
    Marker Score: 89
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.15
    Marker Score: 155
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.15
    Marker Score: 182
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.13
    Marker Score: 133
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.13
    Marker Score: 264
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 291
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.12
    Marker Score: 199
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.12
    Marker Score: 302
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.11
    Marker Score: 24
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.11
    Marker Score: 134
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.1
    Marker Score: 74.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1
    Marker Score: 71
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 117
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1
    Marker Score: 206
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.1
    Marker Score: 150
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.09
    Marker Score: 57
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.09
    Marker Score: 102

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Other Information

**Key characteristics:** - HOXA2 is a highly conserved gene with a predicted protein of 135 amino acids. - It is located on chromosome 17p13.3. - It is expressed in a wide range of cell types, including conventional dendritic cell, megakaryocyte-erythroid progenitor cell, granulocyte monocyte progenitor cell, goblet cell, enterocyte of epithelium of small intestine, pulmonary interstitial fibroblast, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and absorptive cell. **Pathways and functions:** - HOXA2 is a key activator of anterior hox genes during hindbrain development. - It binds to the Rna polymerase II-specific DNA-binding domain in the promoters of these genes and promotes their transcription. - It is also involved in the regulation of Rhombomere 2 development, Rhombomere 3 morphogenesis, and segmentation. **Clinical significance:** - Mutations in HOXA2 have been linked to various human diseases, including lissencephaly, microcephaly, and intellectual disability. - HOXA2 is a potential therapeutic target for these disorders.

Genular Protein ID: 2184616326

Symbol: HXA2_HUMAN

Name: Homeobox protein Hox-A2

UniProtKB Accession Codes:

O43364 A1L4K3 B2RMW3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23775976

Title: HOXA2 haploinsufficiency in dominant bilateral microtia and hearing loss.

PubMed ID: 23775976

DOI: 10.1002/humu.22367

PubMed ID: 18394579

Title: A mutation in HOXA2 is responsible for autosomal-recessive microtia in an Iranian family.

PubMed ID: 18394579

DOI: 10.1016/j.ajhg.2008.02.015

Sequence Information:

  • Length: 376
  • Mass: 41002
  • Checksum: 78EB388FE1EEAD72
  • Sequence:
    • MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 
PGSHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE KKAAKKTALL PAAAAAATAA 
ATGPACLSHK ESLEIADGSG GGSRRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL 
DLTERQVKVW FQNRRMKHKR QTQCKENQNS EGKCKSLEDS EKVEEDEEEK TLFEQALSVS 
GALLEREGYT FQQNALSQQQ APNGHNGDSQ SFPVSPLTSN EKNLKHFQHQ SPTVPNCLST 
MGQNCGAGLN NDSPEALEVP SLQDFSVFST DSCLQLSDAV SPSLPGSLDS PVDISADSLD 
FFTDTLTTID LQHLNY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.