Details for: IL2RG

Gene ID: 3561

Symbol: IL2RG

Ensembl ID: ENSG00000147168

Description: interleukin 2 receptor subunit gamma

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.83
    Marker Score: 11179
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.56
    Marker Score: 9843
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.53
    Marker Score: 9906
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.44
    Marker Score: 34089
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.92
    Marker Score: 4034
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.91
    Marker Score: 1708
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.88
    Marker Score: 18443
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.8
    Marker Score: 4798
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.71
    Marker Score: 3008
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.65
    Marker Score: 1524
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.58
    Marker Score: 1957
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.56
    Marker Score: 4577
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.52
    Marker Score: 2125
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.44
    Marker Score: 1347
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.41
    Marker Score: 9874
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.4
    Marker Score: 1034
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.34
    Marker Score: 3316
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.33
    Marker Score: 2185
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.25
    Marker Score: 9640
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.24
    Marker Score: 1628
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.22
    Marker Score: 1887
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.2
    Marker Score: 1130
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.17
    Marker Score: 3189
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.16
    Marker Score: 702
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.11
    Marker Score: 559
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.07
    Marker Score: 1460
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.05
    Marker Score: 1319
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.04
    Marker Score: 4965
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2
    Marker Score: 1759
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.96
    Marker Score: 978
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.94
    Marker Score: 600
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.91
    Marker Score: 629
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.9
    Marker Score: 662
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.89
    Marker Score: 5967
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.88
    Marker Score: 1379
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.86
    Marker Score: 2011
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.84
    Marker Score: 4149
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.82
    Marker Score: 1097
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.81
    Marker Score: 630
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.74
    Marker Score: 749
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.71
    Marker Score: 17352
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.66
    Marker Score: 1637
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.64
    Marker Score: 580
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.63
    Marker Score: 1798
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.59
    Marker Score: 1250
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.59
    Marker Score: 979
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.57
    Marker Score: 2551
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.55
    Marker Score: 2697
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.54
    Marker Score: 475
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.54
    Marker Score: 81474
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.51
    Marker Score: 343
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.51
    Marker Score: 1954
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.5
    Marker Score: 1229
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.48
    Marker Score: 1490
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.46
    Marker Score: 1065
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.46
    Marker Score: 1304
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.44
    Marker Score: 1357
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.44
    Marker Score: 364
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.36
    Marker Score: 799
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.36
    Marker Score: 1053
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.32
    Marker Score: 899
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.3
    Marker Score: 1081
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.27
    Marker Score: 1123
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.26
    Marker Score: 278
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.17
    Marker Score: 784
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.16
    Marker Score: 872
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.15
    Marker Score: 872
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.12
    Marker Score: 341
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.12
    Marker Score: 808
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.11
    Marker Score: 467
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.11
    Marker Score: 617
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.11
    Marker Score: 2864
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.09
    Marker Score: 801
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.08
    Marker Score: 27773
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.07
    Marker Score: 653
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.07
    Marker Score: 771
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.06
    Marker Score: 519
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.06
    Marker Score: 899
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 667
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.05
    Marker Score: 515
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.05
    Marker Score: 695
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.04
    Marker Score: 1090
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.03
    Marker Score: 713
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.03
    Marker Score: 356
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.01
    Marker Score: 696
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.01
    Marker Score: 577
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1
    Marker Score: 609
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71675
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47903
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.99
    Marker Score: 1005
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.99
    Marker Score: 316
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.98
    Marker Score: 351
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.97
    Marker Score: 1059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.95
    Marker Score: 4575
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.94
    Marker Score: 406
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.94
    Marker Score: 894

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

## Summary The IL2RG gene encodes the IL2RG subunit of a cytokine receptor complex. This complex is expressed on various immune cells, including NKp46-positive innate lymphoid cells, human dendritic cells, and activated CD4 and CD8 T cells. The IL2RG gene is also expressed in the developing thymus and is important for the development and function of thymocytes. ## Key characteristics * The IL2RG gene is located on chromosome 1 and is approximately 28 kb in length. * The IL2RG gene is expressed in high levels in cells of the immune system, including NKp46 cells, dendritic cells, and T cells. * The IL2RG gene is also expressed in low levels in cells of the hematopoietic system. * The IL2RG gene product is a type I transmembrane receptor that is expressed on the surface of immune cells. * The IL2RG receptor complex is a heterodimeric complex that is composed of two immunoglobulin heavy chains and two immunoglobulin light chains. * The IL2RG receptor complex is a key regulator of the immune response. ## Pathways and functions * The IL2RG receptor complex is a key regulator of the immune response. * The IL2RG receptor complex is expressed on NKp46 cells, dendritic cells, and activated T cells. * The IL2RG receptor complex is activated by the cytokine interleukin-2 (IL-2). * Activation of the IL2RG receptor complex leads to the phosphorylation of its cytoplasmic domain by the cytokine receptor common signaling pathway (CRPC). * Phosphorylation of the IL2RG cytoplasmic domain leads to the dimerization of the IL2RG receptor complex, which results in the activation of the signaling pathway. * The IL2RG signaling pathway is a critical pathway for the activation of T cells and the proliferation and survival of activated T cells. ## Clinical significance * Mutations in the IL2RG gene have been linked to several human diseases, including cancer and autoimmune disorders. * Dysregulation of the IL2RG signaling pathway has been linked to the development of cancer. * Inhibition of the IL2RG signaling pathway has been shown to be effective in treating cancer.

Genular Protein ID: 3866403703

Symbol: IL2RG_HUMAN

Name: Cytokine receptor common subunit gamma

UniProtKB Accession Codes:

P31785 Q5FC12

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEMBL 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 14 EMDB 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 11 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1631559

Title: Cloning of the gamma chain of the human IL-2 receptor.

PubMed ID: 1631559

DOI: 10.1126/science.1631559

PubMed ID: 8514792

Title: Characterization of the human interleukin-2 receptor gamma chain gene.

PubMed ID: 8514792

DOI: 10.1016/s0021-9258(19)38691-0

PubMed ID: 8401490

Title: The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1.

PubMed ID: 8401490

DOI: 10.1093/hmg/2.8.1099

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8266076

Title: Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4.

PubMed ID: 8266076

DOI: 10.1126/science.8266076

PubMed ID: 8266078

Title: Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor.

PubMed ID: 8266078

DOI: 10.1126/science.8266078

PubMed ID: 8266077

Title: Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.

PubMed ID: 8266077

DOI: 10.1126/science.8266077

PubMed ID: 8648694

Title: The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.

PubMed ID: 8648694

DOI: 10.1128/jvi.70.6.3599-3605.1996

PubMed ID: 12200137

Title: IL-2 receptor signaling through the Shb adapter protein in T and NK cells.

PubMed ID: 12200137

DOI: 10.1016/s0006-291x(02)02016-8

PubMed ID: 15123770

Title: Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.

PubMed ID: 15123770

DOI: 10.1189/jlb.0605298

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 7529123

Title: The interleukin-2 and interleukin-4 receptors studied by molecular modelling.

PubMed ID: 7529123

DOI: 10.1016/s0969-2126(94)00085-9

PubMed ID: 16293754

Title: Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.

PubMed ID: 16293754

DOI: 10.1126/science.1117893

PubMed ID: 16477002

Title: Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.

PubMed ID: 16477002

DOI: 10.1073/pnas.0511161103

PubMed ID: 8299698

Title: Interleukin-2 (IL-2) receptor gamma chain mutations in X-linked severe combined immunodeficiency disease result in the loss of high-affinity IL-2 receptor binding.

PubMed ID: 8299698

DOI: 10.1002/eji.1830240232

PubMed ID: 8088810

Title: Detection of three nonsense mutations and one missense mutation in the interleukin-2 receptor gamma chain gene in SCIDX1 that differently affect the mRNA processing.

PubMed ID: 8088810

DOI: 10.1006/geno.1994.1265

PubMed ID: 8027558

Title: Impairment of ligand binding and growth signaling of mutant IL-2 receptor gamma-chains in patients with X-linked severe combined immunodeficiency.

PubMed ID: 8027558

PubMed ID: 7937790

Title: Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells.

PubMed ID: 7937790

DOI: 10.1073/pnas.91.20.9466

PubMed ID: 7668284

Title: Two mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiency.

PubMed ID: 7668284

PubMed ID: 7557965

Title: Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis.

PubMed ID: 7557965

DOI: 10.1007/bf00191801

PubMed ID: 7860773

Title: Female germ line mosaicism as the origin of a unique IL-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency.

PubMed ID: 7860773

DOI: 10.1172/jci117740

PubMed ID: 7883965

Title: Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency.

PubMed ID: 7883965

DOI: 10.1172/jci117765

PubMed ID: 8900089

Title: Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells.

PubMed ID: 8900089

DOI: 10.1056/nejm199611213352104

PubMed ID: 9150740

Title: B-cell-negative severe combined immunodeficiency associated with a common gamma chain mutation.

PubMed ID: 9150740

DOI: 10.1007/s004390050428

PubMed ID: 9049783

Title: Maternal mosaicism for a novel interleukin-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency in a Navajo kindred.

PubMed ID: 9049783

DOI: 10.1023/a:1027332327827

PubMed ID: 9399950

Title: An interleukin-2 receptor gamma chain mutation with normal thymus morphology.

PubMed ID: 9399950

DOI: 10.1172/jci119858

Sequence Information:

  • Length: 369
  • Mass: 42287
  • Checksum: 3B6215246D610215
  • Sequence:
    • MLKPSLPFTS LLFLQLPLLG VGLNTTILTP NGNEDTTADF FLTTMPTDSL SVSTLPLPEV 
QCFVFNVEYM NCTWNSSSEP QPTNLTLHYW YKNSDNDKVQ KCSHYLFSEE ITSGCQLQKK 
EIHLYQTFVV QLQDPREPRR QATQMLKLQN LVIPWAPENL TLHKLSESQL ELNWNNRFLN 
HCLEHLVQYR TDWDHSWTEQ SVDYRHKFSL PSVDGQKRYT FRVRSRFNPL CGSAQHWSEW 
SHPIHWGSNT SKENPFLFAL EAVVISVGSM GLIISLLCVY FWLERTMPRI PTLKNLEDLV 
TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP CNQHSPYWAP 
PCYTLKPET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.