Details for: LINC00533

Gene ID: 387055

Symbol: LINC00533

Ensembl ID: ENSG00000235570

Description: long intergenic non-protein coding RNA 533

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0100
    Cell Significance Index: 0.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0009
    Cell Significance Index: -0.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0018
    Cell Significance Index: -0.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0018
    Cell Significance Index: -0.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0018
    Cell Significance Index: -0.1000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0025
    Cell Significance Index: -0.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0025
    Cell Significance Index: -0.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0027
    Cell Significance Index: -0.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0029
    Cell Significance Index: -0.1100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0034
    Cell Significance Index: -0.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0035
    Cell Significance Index: -0.0700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0037
    Cell Significance Index: -0.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0038
    Cell Significance Index: -0.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0047
    Cell Significance Index: -0.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0047
    Cell Significance Index: -0.1200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0047
    Cell Significance Index: -0.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0056
    Cell Significance Index: -0.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0057
    Cell Significance Index: -0.1000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0063
    Cell Significance Index: -0.0600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0066
    Cell Significance Index: -0.0600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0067
    Cell Significance Index: -0.0900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0071
    Cell Significance Index: -0.1200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0080
    Cell Significance Index: -0.1100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0082
    Cell Significance Index: -0.0700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0086
    Cell Significance Index: -0.1200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0090
    Cell Significance Index: -0.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0091
    Cell Significance Index: -0.1000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0092
    Cell Significance Index: -0.1100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0095
    Cell Significance Index: -0.1200
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0096
    Cell Significance Index: -0.0900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0097
    Cell Significance Index: -0.0600
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0102
    Cell Significance Index: -0.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0106
    Cell Significance Index: -0.1200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0107
    Cell Significance Index: -0.1100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0108
    Cell Significance Index: -0.1100
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0112
    Cell Significance Index: -0.0700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0113
    Cell Significance Index: -0.0800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0113
    Cell Significance Index: -0.1300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0115
    Cell Significance Index: -0.1400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0117
    Cell Significance Index: -0.1100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0121
    Cell Significance Index: -0.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0124
    Cell Significance Index: -0.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0124
    Cell Significance Index: -0.1300
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0131
    Cell Significance Index: -0.1200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0143
    Cell Significance Index: -0.1300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0144
    Cell Significance Index: -0.0900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0145
    Cell Significance Index: -0.1200
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: -0.0151
    Cell Significance Index: -0.1000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0152
    Cell Significance Index: -0.0900
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0154
    Cell Significance Index: -0.1200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0165
    Cell Significance Index: -0.1000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0169
    Cell Significance Index: -0.1100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0173
    Cell Significance Index: -0.0800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0181
    Cell Significance Index: -0.1000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0185
    Cell Significance Index: -0.1400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0188
    Cell Significance Index: -0.0900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0207
    Cell Significance Index: -0.1300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0209
    Cell Significance Index: -0.1100
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: -0.0829
    Cell Significance Index: -0.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00533 is a lincRNA, a class of non-coding RNAs that do not encode proteins but regulate gene expression through various mechanisms. It is approximately 2.5 kilobases in length and is transcribed from an intergenic region. LINC00533 is highly expressed in various cell types, including immune cells, such as microglia and endothelial cells, as well as in neuronal precursors and endothelial cells. Its expression is tightly regulated, with significant fluctuations observed in response to environmental stimuli. **Pathways and Functions:** Recent studies have implicated LINC00533 in regulating immune responses and tissue development through the modulation of gene expression. LINC00533 has been shown to interact with various transcription factors and signaling pathways, including: 1. **Notch signaling pathway:** LINC00533 has been shown to modulate Notch signaling, a critical pathway involved in cell fate determination and differentiation. 2. **Wnt/β-catenin pathway:** LINC00533 has been implicated in regulating Wnt/β-catenin signaling, a key pathway involved in cell proliferation and differentiation. 3. **Interferon signaling pathway:** LINC00533 has been shown to modulate interferon signaling, a critical pathway involved in immune response regulation. LINC00533's functional role is mediated through its ability to regulate gene expression by interacting with transcription factors and microRNAs. It has been shown to act as a competitive endogenous RNA (ceRNA) for microRNAs, influencing the expression of target genes involved in immune response and tissue development. **Clinical Significance:** LINC00533's dysregulation has been implicated in various diseases, including: 1. **Autoimmune disorders:** LINC00533 has been shown to play a role in the regulation of immune responses, and its dysregulation has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** LINC00533 has been implicated in cancer development and progression, particularly in the regulation of immune responses and tumor microenvironment. 3. **Neurological disorders:** LINC00533's dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, LINC00533 is a complex lincRNA that plays a significant role in regulating immune responses, tissue development, and disease pathogenesis. Further studies are necessary to fully elucidate its functional mechanisms and clinical significance. **Future Directions:** 1. **Functional characterization:** Further studies are necessary to elucidate the functional mechanisms of LINC00533 and its interactions with transcription factors and signaling pathways. 2. **Disease modeling:** LINC00533's dysregulation has been implicated in various diseases, and disease modeling studies are necessary to further understand its role in disease pathogenesis. 3. **Therapeutic targeting:** LINC00533's dysregulation has been implicated in various diseases, and therapeutic targeting strategies may be developed to modulate its expression and function. By exploring the complex roles of LINC00533, researchers can gain insights into the regulation of immune responses, tissue development, and disease pathogenesis, ultimately leading to the development of novel therapeutic strategies for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.