Details for: TCEAL7

Gene ID: 56849

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TCEAL7

Ensembl ID: ENSG00000182916

Description: transcription elongation factor A like 7

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • peripheral nervous system neuron CL2000032
    CSI 25.46
    rCSI 34.7%
    PRS 88.54
  • progenitor cell CL0011026
    CSI 13.66
    rCSI 29.06%
    PRS 88.05
  • retina horizontal cell CL0000745
    CSI 11.66
    rCSI 17.78%
    PRS 91.21
  • retinal ganglion cell CL0000740
    CSI 9.92
    rCSI 21.91%
    PRS 85.69
  • retinal blood vessel endothelial cell CL0002585
    CSI 8.55
    rCSI 13.65%
    PRS 95.42
  • rod bipolar cell CL0000751
    CSI 8.33
    rCSI 14.97%
    PRS 89.94
  • enteric smooth muscle cell CL0002504
    CSI 6.85
    rCSI 9.77%
    PRS 93.58
  • forebrain radial glial cell CL0013000
    CSI 6.52
    rCSI 20.92%
    PRS 93.3
  • cerebellar granule cell CL0001031
    CSI 6.25
    rCSI 9.18%
    PRS 89.93
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 6.13
    rCSI 7.07%
    PRS 87.46
  • myofibroblast cell CL0000186
    CSI 5.72
    rCSI 7.92%
    PRS 91.16
  • neural cell CL0002319
    CSI 5.65
    rCSI 21.33%
    PRS 81.98
  • interneuron CL0000099
    CSI 5.1
    rCSI 10.24%
    PRS 89.34
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 4.88
    rCSI 14.39%
    PRS 93.3
  • ON-bipolar cell CL0000749
    CSI 4.82
    rCSI 7.16%
    PRS 92.43
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 4.53
    rCSI 5.63%
    PRS 82.01
  • neural crest cell CL0011012
    CSI 4.4
    rCSI 3.47%
    PRS 88.59
  • bronchus fibroblast of lung CL2000093
    CSI 4.3
    rCSI 3.49%
    PRS 93.26
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 4.22
    rCSI 5.41%
    PRS 90.5
  • perivascular cell CL4033054
    CSI 4.1
    rCSI 5.61%
    PRS 95.99
  • vascular associated smooth muscle cell CL0000359
    CSI 4.04
    rCSI 13.1%
    PRS 92.32
  • glioblast CL0000030
    CSI 3.98
    rCSI 6.34%
    PRS 87.69
  • cerebral cortex neuron CL0010012
    CSI 3.96
    rCSI 16.14%
    PRS 87.91
  • interstitial cell of Cajal CL0002088
    CSI 3.94
    rCSI 5.02%
    PRS 96.08
  • Cajal-Retzius cell CL0000695
    CSI 3.91
    rCSI 30.63%
    PRS 94.22
  • radial glial cell CL0000681
    CSI 3.64
    rCSI 5.06%
    PRS 92.31
  • inhibitory interneuron CL0000498
    CSI 3.6
    rCSI 8.31%
    PRS 86.83
  • mesodermal cell CL0000222
    CSI 3.37
    rCSI 4.05%
    PRS 92.93
  • myeloid leukocyte CL0000766
    CSI 3.04
    rCSI 2.8%
    PRS 94.87
  • cerebral cortex endothelial cell CL1001602
    CSI 3.01
    rCSI 5.2%
    PRS 89.92
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.97
    rCSI 3.55%
    PRS 84.13
  • glutamatergic neuron CL0000679
    CSI 2.75
    rCSI 5.64%
    PRS 84.06
  • lung neuroendocrine cell CL1000223
    CSI 2.68
    rCSI 3.97%
    PRS 94.57
  • pancreatic D cell CL0000173
    CSI 2.66
    rCSI 2.61%
    PRS 94.7
  • muscle cell CL0000187
    CSI 2.61
    rCSI 5.36%
    PRS 95.13
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.27
    rCSI 2.92%
    PRS 85.05
  • sncg GABAergic cortical interneuron CL4023015
    CSI 2.16
    rCSI 3.47%
    PRS 85.1
  • OFF-bipolar cell CL0000750
    CSI 2.12
    rCSI 2.89%
    PRS 91.91
  • mesenchymal cell CL0008019
    CSI 2.08
    rCSI 5.29%
    PRS 89.99
  • basal cell CL0000646
    CSI 2.06
    rCSI 2.75%
    PRS 91.25
  • lung pericyte CL0009089
    CSI 2.02
    rCSI 5.33%
    PRS 96.43
  • enteric neuron CL0007011
    CSI 1.89
    rCSI 28%
    PRS 93.89
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.85
    rCSI 3.11%
    PRS 84.23
  • glial cell CL0000125
    CSI 1.64
    rCSI 6.26%
    PRS 88.42
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.61
    rCSI 4.67%
    PRS 93.12
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.52
    rCSI 4.76%
    PRS 86.84
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.42
    rCSI 2.5%
    PRS 83.55
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.34
    rCSI 4.83%
    PRS 82.28
  • neural progenitor cell CL0011020
    CSI 1.23
    rCSI 5.41%
    PRS 84.61
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.2
    rCSI 2.92%
    PRS 81.96
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.18
    rCSI 3.69%
    PRS 85.06
  • podocyte CL0000653
    CSI 1.15
    rCSI 5.1%
    PRS 93.89
  • stromal cell of ovary CL0002132
    CSI 1.06
    rCSI 2.92%
    PRS 95.79
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.97
    rCSI 5.72%
    PRS 84.4
  • neuroplacodal cell CL0000032
    CSI 0.9
    rCSI 8.3%
    PRS 90.05
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.88
    rCSI 3.33%
    PRS 84.23
  • blood vessel smooth muscle cell CL0019018
    CSI 0.78
    rCSI 6.35%
    PRS 92.41
  • pancreatic stellate cell CL0002410
    CSI 0.76
    rCSI 4.45%
    PRS 94.81

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [TCEAL7](/details-gene/56849) (transcription elongation factor A like 7) is a protein-coding gene located on the X chromosome at position Xq22.2. Functionally, it is characterized as a nuclear protein involved in the negative regulation of gene expression. Research indicates it acts as a putative tumor suppressor by inhibiting the transcriptional activity of key oncoproteins, including c-Myc and NF-kappaB [Link](https://doi.org/10.1038/onc.2008.360) [Link](https://doi.org/10.1038/onc.2009.431). Expression data from the **Overall** context reveals that [TCEAL7](/details-gene/56849) is a highly significant gene in various neuronal cell types, such as the [peripheral nervous system neuron](/details-cell/CL2000032) and retinal cells, as well as in [progenitor cell](/details-cell/CL0011026) populations, suggesting a role in neural development, function, and cell fate determination. An association with disease has been noted in OMIM ([300771](https://omim.org/entry/300771)). ## Cellular Roles and Expression Landscape The expression profile of [TCEAL7](/details-gene/56849) points to a specialized role within the nervous system and in developmental contexts. **Overall**, its most significant expression is observed in [peripheral nervous system neuron](/details-cell/CL2000032) (CSI: 25.46), highlighting a potentially crucial function in mature neurons. This neuronal signature is further reinforced by its high significance in multiple retinal cell types, including [retina horizontal cell](/details-cell/CL0000745) (CSI: 11.66), [retinal ganglion cell](/details-cell/CL0000740) (CSI: 9.92), and [rod bipolar cell](/details-cell/CL0000751) (CSI: 8.33). Beyond mature neurons, [TCEAL7](/details-gene/56849) shows high significance in precursor and developing cell populations, such as [progenitor cell](/details-cell/CL0011026) (CSI: 13.66), [forebrain radial glial cell](/details-cell/CL0013000) (CSI: 6.52), and [neuroblast (sensu Nematoda and Protostomia)](/details-cell/CL0000338) (CSI: 6.13). This pattern suggests that in addition to its functions in the terminally differentiated nervous system, [TCEAL7](/details-gene/56849) may be involved in regulating the transition from proliferation to differentiation during neurogenesis. Its expression in [myofibroblast cell](/details-cell/CL0000186) and [enteric smooth muscle cell](/details-cell/CL0002504) indicates its role is not exclusively limited to the central nervous system but extends to other specialized cell types. ## Pathways and Molecular Function The molecular function of [TCEAL7](/details-gene/56849) is centered on the negative regulation of transcription, consistent with its localization to the [nucleus](/details-cell/GO:0005634) and [nucleoplasm](/details-cell/GO:0005654). Gene Ontology annotations confirm its involvement in the *negative regulation of dna-templated transcription* ([GO:0045892](https://www.ebi.ac.uk/QuickGO/term/GO:0045892)). Specific molecular pathways have been elucidated through targeted research. Studies have demonstrated that [TCEAL7](/details-gene/56849) functions as a transcriptional repressor by directly targeting major signaling hubs. It negatively regulates the *NF-kappaB transcription factor activity* ([GO:0032088](https://www.ebi.ac.uk/QuickGO/term/GO:0032088)), a critical pathway in inflammation and cell survival [Link](https://doi.org/10.1038/onc.2009.431). Furthermore, [TCEAL7](/details-gene/56849) has been shown to inhibit the activity of the c-Myc oncoprotein, thereby regulating cyclin D1 levels and cellular transformation [Link](https://doi.org/10.1038/onc.2008.360). This anti-proliferative function is also linked to its ability to modulate hTERT expression in the context of alternative lengthening of telomeres [Link](https://doi.org/10.1593/neo.10180). These repressive functions align with its proposed role as a tumor suppressor gene. ## Research Directions The established role of [TCEAL7](/details-gene/56849) as a tumor suppressor that inhibits oncogenic transcription factors, combined with its specific expression pattern, suggests several avenues for future research. **Proposed Hypotheses:** 1. Given its high significance in both [progenitor cell](/details-cell/CL0011026) populations and mature, post-mitotic neurons, [TCEAL7](/details-gene/56849) may function as a key regulator of neuronal differentiation by repressing c-Myc-driven proliferative programs, thereby facilitating cell cycle exit. 2. The silencing or downregulation of [TCEAL7](/details-gene/56849) in specific neuronal cancers, such as neuroblastoma or glioblastoma, could be a critical event that permits uncontrolled proliferation via the de-repression of NF-kappaB and c-Myc target genes. **Experimental Approach:** To test the first hypothesis, one could employ a human neural progenitor cell (NPC) model. Using CRISPR-Cas9 to knock out [TCEAL7](/details-gene/56849) in NPCs, researchers could then induce differentiation and compare the outcomes to wild-type controls. Key readouts would include assays for proliferation (e.g., Ki67 staining), analysis of differentiation efficiency via immunofluorescence for mature neuronal markers (e.g., Tuj1, MAP2), and neurite outgrowth measurements. RNA-sequencing at different time points during differentiation would reveal the global transcriptional changes, specifically assessing the expression of c-Myc target genes related to the cell cycle. **Therapeutic Potential:** As a putative tumor suppressor, [TCEAL7](/details-gene/56849) is an attractive candidate for therapeutic intervention aimed at **activation or restoration** of function, rather than inhibition. In cancers characterized by its loss or epigenetic silencing, strategies could involve gene therapies to re-introduce a functional copy of the gene. Alternatively, the development of small-molecule drugs that mimic the inhibitory effect of [TCEAL7](/details-gene/56849) on c-Myc or NF-kappaB protein-protein interactions could represent a viable therapeutic approach.

Genular Protein ID: 2096346712

Symbol: TCAL7_HUMAN

Name: Transcription elongation factor A protein-like 7

UniProtKB Accession Codes:

Q9BRU2 B3KSV2 Q96AT4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18806825

Title: A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation.

PubMed ID: 18806825

DOI: 10.1038/onc.2008.360

PubMed ID: 20454512

Title: TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.

PubMed ID: 20454512

DOI: 10.1593/neo.10180

PubMed ID: 19966855

Title: TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway.

PubMed ID: 19966855

DOI: 10.1038/onc.2009.431

Sequence Information:

  • Length: 100
  • Mass: 12324
  • Checksum: 84AF23BD169606D0
  • Sequence:
    • MQKPCKENEG KPKCSVPKRE EKRPYGEFER QQTEGNFRQR LLQSLEEFKE DIDYRHFKDE 
EMTREGDEME RCLEEIRGLR KKFRALHSNH RHSRDRPYPI