Details for: RCN2

Gene ID: 5955

Symbol: RCN2

Ensembl ID: ENSG00000117906

Description: reticulocalbin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 352.9520
    Cell Significance Index: -54.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 235.0939
    Cell Significance Index: -59.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 152.8592
    Cell Significance Index: -62.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 140.2178
    Cell Significance Index: -66.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 132.6131
    Cell Significance Index: -53.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 122.4083
    Cell Significance Index: -62.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.8111
    Cell Significance Index: -54.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.4187
    Cell Significance Index: -64.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.7771
    Cell Significance Index: -52.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.3208
    Cell Significance Index: -53.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7180
    Cell Significance Index: -65.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0149
    Cell Significance Index: -19.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.7719
    Cell Significance Index: 200.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.6561
    Cell Significance Index: 542.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.5004
    Cell Significance Index: 94.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.8838
    Cell Significance Index: 89.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.5397
    Cell Significance Index: 185.8500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.2857
    Cell Significance Index: 35.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4978
    Cell Significance Index: 65.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2507
    Cell Significance Index: 1229.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1239
    Cell Significance Index: 57.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.0907
    Cell Significance Index: 26.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9522
    Cell Significance Index: 268.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8637
    Cell Significance Index: 229.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5977
    Cell Significance Index: 288.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5650
    Cell Significance Index: 12.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4944
    Cell Significance Index: 83.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4029
    Cell Significance Index: 90.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3471
    Cell Significance Index: 270.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2543
    Cell Significance Index: 11.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1955
    Cell Significance Index: 153.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1272
    Cell Significance Index: 404.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0821
    Cell Significance Index: 214.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0801
    Cell Significance Index: 66.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9753
    Cell Significance Index: 431.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9130
    Cell Significance Index: 47.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8913
    Cell Significance Index: 61.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7203
    Cell Significance Index: 117.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5598
    Cell Significance Index: 39.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4817
    Cell Significance Index: 22.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4409
    Cell Significance Index: 10.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4148
    Cell Significance Index: 19.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4037
    Cell Significance Index: 52.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4024
    Cell Significance Index: 47.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3190
    Cell Significance Index: 31.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2881
    Cell Significance Index: 260.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2449
    Cell Significance Index: 18.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2014
    Cell Significance Index: 139.3100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1741
    Cell Significance Index: 2.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1159
    Cell Significance Index: 19.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1132
    Cell Significance Index: 1.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1010
    Cell Significance Index: 1.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0847
    Cell Significance Index: 5.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0581
    Cell Significance Index: 109.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0464
    Cell Significance Index: 34.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0382
    Cell Significance Index: 1.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0197
    Cell Significance Index: 3.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0194
    Cell Significance Index: 0.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0070
    Cell Significance Index: 10.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0067
    Cell Significance Index: 4.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0022
    Cell Significance Index: 4.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0094
    Cell Significance Index: -7.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0253
    Cell Significance Index: -34.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0422
    Cell Significance Index: -31.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0484
    Cell Significance Index: -30.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0643
    Cell Significance Index: -29.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0678
    Cell Significance Index: -3.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0812
    Cell Significance Index: -2.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0828
    Cell Significance Index: -46.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0830
    Cell Significance Index: -2.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0835
    Cell Significance Index: -1.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0993
    Cell Significance Index: -6.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1008
    Cell Significance Index: -2.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1314
    Cell Significance Index: -13.4300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1531
    Cell Significance Index: -1.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1729
    Cell Significance Index: -49.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1858
    Cell Significance Index: -21.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2018
    Cell Significance Index: -42.5000
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2077
    Cell Significance Index: -1.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2204
    Cell Significance Index: -6.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2469
    Cell Significance Index: -12.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2777
    Cell Significance Index: -40.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3246
    Cell Significance Index: -3.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3507
    Cell Significance Index: -10.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4536
    Cell Significance Index: -34.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4968
    Cell Significance Index: -21.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5439
    Cell Significance Index: -32.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5533
    Cell Significance Index: -63.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5607
    Cell Significance Index: -6.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5793
    Cell Significance Index: -60.3200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5828
    Cell Significance Index: -3.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5981
    Cell Significance Index: -22.6500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.5982
    Cell Significance Index: -3.4000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6351
    Cell Significance Index: -5.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6752
    Cell Significance Index: -14.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6756
    Cell Significance Index: -17.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6850
    Cell Significance Index: -54.2500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.7270
    Cell Significance Index: -4.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7832
    Cell Significance Index: -22.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9043
    Cell Significance Index: -55.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium Ion Binding:** RCN2 is known to bind to calcium ions, which is essential for maintaining calcium homeostasis within the cell. This function is critical for various cellular processes, including muscle contraction, neurotransmission, and cell signaling. 2. **Endoplasmic Reticulum (ER) Association:** RCN2 is localized to the ER, where it interacts with other proteins to regulate protein folding, transport, and degradation. This association is crucial for maintaining ER homeostasis and preventing protein misfolding. 3. **Protein Binding:** RCN2 exhibits a high degree of protein binding specificity, interacting with various proteins involved in calcium signaling, protein folding, and cell migration. 4. **Cell Type-Specific Expression:** RCN2 is significantly expressed in mesodermal cells, GABAergic neurons, and neural crest cells, highlighting its importance in specific cellular contexts. **Pathways and Functions:** 1. **Calcium Signaling:** RCN2 plays a critical role in regulating calcium ion binding, which is essential for various cellular processes, including muscle contraction, neurotransmission, and cell signaling. 2. **Protein Quality Control:** RCN2 is involved in regulating protein folding, transport, and degradation within the ER, ensuring the proper functioning of ER-resident proteins. 3. **Cell Migration:** RCN2 is required for the migration of neural crest cells, a process critical for the development of the peripheral nervous system. 4. **Endoplasmic Reticulum Lumen:** RCN2 is localized to the ER lumen, where it interacts with other proteins to regulate protein transport and degradation. **Clinical Significance:** 1. **Neurological Disorders:** RCN2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Dysregulation of RCN2 may contribute to the development of these diseases. 2. **Muscular Dystrophy:** RCN2 has been shown to play a critical role in maintaining calcium homeostasis in muscle cells, highlighting its potential as a therapeutic target for muscular dystrophy. 3. **Cancer:** RCN2 has been identified as a potential biomarker for cancer, with altered expression levels observed in various types of cancer. 4. **Neurodevelopmental Disorders:** RCN2 is required for the proper development of the nervous system, and dysregulation of RCN2 may contribute to neurodevelopmental disorders, including autism and schizophrenia. In conclusion, RCN2 is a multifaceted protein involved in various cellular processes, including calcium signaling, protein quality control, and cell migration. Its dysregulation has been implicated in various diseases, including neurological disorders, muscular dystrophy, and cancer. Further research is necessary to fully elucidate the role of RCN2 in maintaining cellular homeostasis and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 852075058

Symbol: RCN2_HUMAN

Name: Reticulocalbin-2

UniProtKB Accession Codes:

Q14257 A8MTG6 F8WCY5 Q53XN8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 25 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8034671

Title: The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif.

PubMed ID: 8034671

DOI: 10.1016/s0021-9258(17)32286-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 317
  • Mass: 36876
  • Checksum: E7C0A4211DBF04AB
  • Sequence:
    • MRLGPRTAAL GLLLLCAAAA GAGKAEELHY PLGERRSDYD REALLGVQED VDEYVKLGHE 
EQQKRLQAII KKIDLDSDGF LTESELSSWI QMSFKHYAMQ EAKQQFVEYD KNSDDTVTWD 
EYNIQMYDRV IDFDENTALD DAEEESFRKL HLKDKKRFEK ANQDSGPGLS LEEFIAFEHP 
EEVDYMTEFV IQEALEEHDK NGDGFVSLEE FLGDYRWDPT ANEDPEWILV EKDRFVNDYD 
KDNDGRLDPQ ELLPWVVPNN QGIAQEEALH LIDEMDLNGD KKLSEEEILE NPDLFLTSEA 
TDYGRQLHDD YFYHDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.