Details for: AVPI1

Gene ID: 60370

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: AVPI1

Ensembl ID: ENSG00000119986

Description: arginine vasopressin induced 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • respiratory suprabasal cell CL4033048
    CSI 11.27
    rCSI 14.46%
    PRS 93.66
  • intestinal epithelial cell CL0002563
    CSI 10.54
    rCSI 11.02%
    PRS 90.31
  • vascular associated smooth muscle cell CL0000359
    CSI 8.5
    rCSI 27.58%
    PRS 90.82
  • conjunctival epithelial cell CL1000432
    CSI 5.53
    rCSI 8.44%
    PRS 91.52
  • mucous neck cell CL0000651
    CSI 4.87
    rCSI 7.01%
    PRS 94.5
  • myoepithelial cell CL0000185
    CSI 4.57
    rCSI 11.57%
    PRS 94.17
  • lung ciliated cell CL1000271
    CSI 3.95
    rCSI 4.57%
    PRS 87.8
  • epithelial cell of lung CL0000082
    CSI 3.79
    rCSI 3.14%
    PRS 93.32
  • colon epithelial cell CL0011108
    CSI 3.69
    rCSI 3.87%
    PRS 90.34
  • epithelial cell of lower respiratory tract CL0002632
    CSI 3.59
    rCSI 2.78%
    PRS 94.23
  • secretory cell CL0000151
    CSI 3.18
    rCSI 3.31%
    PRS 91.53
  • melanocyte CL0000148
    CSI 3.17
    rCSI 2.34%
    PRS 89.64
  • skin fibroblast CL0002620
    CSI 3.07
    rCSI 2.65%
    PRS 91.91
  • colonocyte CL1000347
    CSI 3.06
    rCSI 4.39%
    PRS 90.62
  • intermediate monocyte CL0002393
    CSI 2.91
    rCSI 4.39%
    PRS 95.76
  • ionocyte CL0005006
    CSI 2.62
    rCSI 2.81%
    PRS 93.51
  • placental villous trophoblast CL2000060
    CSI 2.61
    rCSI 4.04%
    PRS 90.76
  • lung secretory cell CL1000272
    CSI 2.61
    rCSI 6.47%
    PRS 93.4
  • respiratory hillock cell CL4030023
    CSI 2.61
    rCSI 4.65%
    PRS 95.32
  • alternatively activated macrophage CL0000890
    CSI 2.6
    rCSI 3.26%
    PRS 96.73
  • foveolar cell of stomach CL0002179
    CSI 2.55
    rCSI 5.42%
    PRS 93.83
  • lung macrophage CL1001603
    CSI 2.5
    rCSI 5.59%
    PRS 96.13
  • elicited macrophage CL0000861
    CSI 2.48
    rCSI 2.27%
    PRS 96.03
  • keratinocyte CL0000312
    CSI 2.44
    rCSI 2.04%
    PRS 92.19
  • respiratory basal cell CL0002633
    CSI 2.39
    rCSI 2.48%
    PRS 93.64
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.35
    rCSI 2.92%
    PRS 79.37
  • duct epithelial cell CL0000068
    CSI 2.28
    rCSI 3.34%
    PRS 95.13
  • club cell CL0000158
    CSI 2.24
    rCSI 3.29%
    PRS 88.66
  • stem cell CL0000034
    CSI 2.24
    rCSI 2.16%
    PRS 89.01
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 2.24
    rCSI 2.93%
    PRS 97.22
  • transit amplifying cell CL0009010
    CSI 2.23
    rCSI 3.41%
    PRS 95.17
  • Mueller cell CL0000636
    CSI 2.21
    rCSI 5.04%
    PRS 86.94
  • BEST4+ enteroycte CL4030026
    CSI 2.19
    rCSI 2.72%
    PRS 91.98
  • nasal mucosa goblet cell CL0002480
    CSI 2.14
    rCSI 2.48%
    PRS 92.57
  • transit amplifying cell of colon CL0009011
    CSI 2
    rCSI 2.35%
    PRS 92.35
  • intestine goblet cell CL0019031
    CSI 1.99
    rCSI 1.77%
    PRS 90.27
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.99
    rCSI 2.4%
    PRS 96.1
  • alveolar adventitial fibroblast CL4028006
    CSI 1.79
    rCSI 2.83%
    PRS 93.37
  • squamous epithelial cell CL0000076
    CSI 1.78
    rCSI 4.23%
    PRS 89.58
  • corneal epithelial cell CL0000575
    CSI 1.77
    rCSI 5.06%
    PRS 93.41
  • Langerhans cell CL0000453
    CSI 1.73
    rCSI 2.65%
    PRS 96.89
  • chondrocyte CL0000138
    CSI 1.73
    rCSI 2.75%
    PRS 88.59
  • enterocyte CL0000584
    CSI 1.69
    rCSI 2.73%
    PRS 89.81
  • tracheal goblet cell CL1000329
    CSI 1.52
    rCSI 3.32%
    PRS 94.08
  • alveolar macrophage CL0000583
    CSI 1.41
    rCSI 2.32%
    PRS 94.12
  • stromal cell of ovary CL0002132
    CSI 1.31
    rCSI 3.61%
    PRS 94.86
  • paneth cell of epithelium of small intestine CL1000343
    CSI 1.12
    rCSI 3.14%
    PRS 94.61
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.07
    rCSI 2.89%
    PRS 94.09
  • glial cell CL0000125
    CSI 0.85
    rCSI 3.25%
    PRS 86.95
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.76
    rCSI 5.74%
    PRS 95.93
  • basal cell of epithelium of trachea CL1000348
    CSI 0.69
    rCSI 4.89%
    PRS 92.92
  • tracheobronchial serous cell CL0019001
    CSI 0.65
    rCSI 2.82%
    PRS 94.2
  • hair follicular keratinocyte CL2000092
    CSI 0.44
    rCSI 7.65%
    PRS 94.66
  • bronchiolar smooth muscle cell CL4033017
    CSI 0.4
    rCSI 5.95%
    PRS 95.7
  • paneth cell of colon CL0009009
    CSI 0.34
    rCSI 3.38%
    PRS 94.74

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [AVPI1](/details-gene/60370) (arginine vasopressin induced 1) is a protein-coding gene located on chromosome 10q24.2. Functionally, it is annotated as being involved in [protein binding](/details-go/GO:0005515) and the [positive regulation of mapk cascade](/details-go/GO:0043410). Expression data indicates that [AVPI1](/details-gene/60370) is a significant gene in various epithelial and secretory cell types. **Overall**, it shows the highest significance in cells of the respiratory and intestinal tracts, such as [respiratory suprabasal cells](/details-cell/CL4033048) and [intestinal epithelial cells](/details-cell/CL0002563), as well as in contractile cells like [vascular associated smooth muscle cells](/details-cell/CL0000359). This expression pattern suggests a role in maintaining epithelial barrier function, cellular signaling, and potentially smooth muscle physiology. ## Cellular Roles and Expression Landscape The expression profile of [AVPI1](/details-gene/60370) points to a prominent role in mucosal and epithelial tissues. Its highest significance scores are observed in [respiratory suprabasal cells](/details-cell/CL4033048) (CSI: 11.27) and [intestinal epithelial cells](/details-cell/CL0002563) (CSI: 10.54), establishing its importance in these critical barrier tissues. This is further supported by high significance in a range of related cell types, including [lung ciliated cells](/details-cell/CL1000271), [colon epithelial cells](/details-cell/CL0011108), and [secretory cells](/details-cell/CL0000151). Beyond its epithelial roles, [AVPI1](/details-gene/60370) demonstrates notable significance in contractile cell lineages, including [vascular associated smooth muscle cells](/details-cell/CL0000359) (CSI: 8.50) and [myoepithelial cells](/details-cell/CL0000185) (CSI: 4.57). This suggests a potential function in cellular contractility or tissue architecture. The gene also shows moderate significance in [melanocytes](/details-cell/CL0000148) and [skin fibroblasts](/details-cell/CL0002620), indicating a broader role in various mesenchymal and ectodermal-derived cell types. A minor but present signal in [intermediate monocytes](/details-cell/CL0002393) suggests a possible, though less central, role in the immune system. ## Pathways and Molecular Function The known molecular functions of [AVPI1](/details-gene/60370) are consistent with its observed cellular expression pattern. Its involvement in the [positive regulation of mapk cascade](/details-go/GO:0043410) provides a mechanistic basis for its potential role in cell proliferation, differentiation, and response to external stimuli, all of which are critical processes in the highly regenerative epithelial tissues where it is prominently expressed. The MAPK pathway is a central signaling cascade that governs a wide array of cellular functions. Furthermore, its annotation for [protein binding](/details-go/GO:0005515) suggests it likely functions as an adaptor or scaffold protein, mediating interactions within signaling complexes to execute its regulatory functions. An early study identified [AVPI1](/details-gene/60370) in a large-scale screen for genes related to cancer development, which aligns with its role in regulating a key growth-related pathway ([Link](https://doi.org/10.1073/pnas.0404089101)). ## Research Directions The functional annotations and expression landscape of [AVPI1](/details-gene/60370) suggest several avenues for future investigation. **Proposed Hypotheses:** 1. Given its name ("arginine vasopressin induced 1") and its high significance in [vascular associated smooth muscle cells](/details-cell/CL0000359), [AVPI1](/details-gene/60370) may function as a downstream mediator of vasopressin signaling, regulating vascular tone through modulation of the MAPK pathway in these cells. 2. The high expression of [AVPI1](/details-gene/60370) in diverse epithelial cells of the respiratory tract ([respiratory suprabasal cell](/details-cell/CL4033048), [lung ciliated cell](/details-cell/CL1000271)) suggests it is a key regulator of epithelial homeostasis. It may be involved in the differentiation of basal cells or in coordinating the cellular response to environmental stressors or pathogens. **Key Experimental Approach:** To test the second hypothesis regarding its role in respiratory epithelial homeostasis, a valuable experiment would be to utilize an *in vitro* air-liquid interface (ALI) culture system with primary human bronchial epithelial cells. By knocking down [AVPI1](/details-gene/60370) expression using shRNA or CRISPR interference, researchers could assess its impact on epithelial differentiation. Changes in cell populations (e.g., ciliated, secretory, basal cells) could be quantified via immunofluorescence staining for specific markers (e.g., acetylated tubulin for cilia, MUC5AC for goblet cells) and RNA sequencing to analyze transcriptomic shifts. Furthermore, barrier function could be measured by transepithelial electrical resistance (TEER) to determine if [AVPI1](/details-gene/60370) is essential for maintaining airway integrity. **Therapeutic Potential:** The therapeutic potential of targeting [AVPI1](/details-gene/60370) is currently unclear. Its broad expression across multiple essential healthy tissues, such as respiratory and intestinal epithelia, suggests that systemic inhibition could lead to significant off-target toxicity. However, given its association with a cancer development screen ([Link](https://doi.org/10.1073/pnas.0404089101)) and its function in the pro-proliferative MAPK pathway, it could represent a context-dependent therapeutic target. If [AVPI1](/details-gene/60370) is found to be specifically overexpressed in certain malignancies (e.g., lung or colon cancer), developing inhibitors, potentially small molecules targeting its protein-binding interface, could be a viable strategy. In such a scenario, inhibition would be the desired therapeutic action to curb uncontrolled cell growth.

Genular Protein ID: 1960870972

Symbol: AVPI1_HUMAN

Name: Arginine vasopressin-induced protein 1

UniProtKB Accession Codes:

Q5T686 Q53G32 Q9H2R9 Q9HBN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 6 Ensembl 1 GO 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 147
  • Mass: 16773
  • Checksum: E01AEFEEF3F9006B
  • Sequence:
    • MGTPASVVSE PPPWQAPIEA RGRKQASANI FQDAELLQIQ ALFQRSGDQL AEERAQIIWE 
CAGDHRVAEA LKRLRRKRPP RQKPLGHSLH HCSRLRILEP HSALANPQSA TETASSEQYL 
HSRKKSARIR RNWRKSGPTS YLHQIRH