Details for: SRM

Gene ID: 6723

Symbol: SRM

Ensembl ID: ENSG00000116649

Description: spermidine synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.2785
    Cell Significance Index: -33.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 121.2332
    Cell Significance Index: -30.7500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.2123
    Cell Significance Index: -42.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.5241
    Cell Significance Index: -40.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.2293
    Cell Significance Index: -33.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.1747
    Cell Significance Index: -37.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.9220
    Cell Significance Index: -40.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.8471
    Cell Significance Index: -33.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.4715
    Cell Significance Index: -37.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3887
    Cell Significance Index: -27.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9707
    Cell Significance Index: -39.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1981
    Cell Significance Index: -25.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.5037
    Cell Significance Index: 38.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.4625
    Cell Significance Index: 92.6200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.2647
    Cell Significance Index: 17.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.2177
    Cell Significance Index: 46.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8643
    Cell Significance Index: 23.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.8036
    Cell Significance Index: 15.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7434
    Cell Significance Index: 81.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6821
    Cell Significance Index: 166.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5850
    Cell Significance Index: 45.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5529
    Cell Significance Index: 109.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5115
    Cell Significance Index: 90.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4433
    Cell Significance Index: 67.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4318
    Cell Significance Index: 92.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4316
    Cell Significance Index: 196.6000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.3662
    Cell Significance Index: 11.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2427
    Cell Significance Index: 160.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1660
    Cell Significance Index: 1052.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0712
    Cell Significance Index: 308.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0448
    Cell Significance Index: 178.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9857
    Cell Significance Index: 73.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9483
    Cell Significance Index: 154.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8405
    Cell Significance Index: 371.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7533
    Cell Significance Index: 411.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6048
    Cell Significance Index: 74.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5589
    Cell Significance Index: 110.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5359
    Cell Significance Index: 37.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5355
    Cell Significance Index: 96.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4477
    Cell Significance Index: 89.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4131
    Cell Significance Index: 7.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3448
    Cell Significance Index: 123.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3439
    Cell Significance Index: 9.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2882
    Cell Significance Index: 36.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2573
    Cell Significance Index: 6.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2394
    Cell Significance Index: 2.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1770
    Cell Significance Index: 20.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1741
    Cell Significance Index: 4.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1187
    Cell Significance Index: 3.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1000
    Cell Significance Index: 75.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0709
    Cell Significance Index: 13.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0535
    Cell Significance Index: 2.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0492
    Cell Significance Index: 1.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0359
    Cell Significance Index: 0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0114
    Cell Significance Index: -21.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0126
    Cell Significance Index: -7.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0181
    Cell Significance Index: -33.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0219
    Cell Significance Index: -16.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0234
    Cell Significance Index: -36.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0284
    Cell Significance Index: -38.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0389
    Cell Significance Index: -2.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0403
    Cell Significance Index: -25.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0435
    Cell Significance Index: -24.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0675
    Cell Significance Index: -30.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0795
    Cell Significance Index: -16.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0897
    Cell Significance Index: -9.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1146
    Cell Significance Index: -13.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1430
    Cell Significance Index: -4.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1629
    Cell Significance Index: -1.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1739
    Cell Significance Index: -6.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1922
    Cell Significance Index: -22.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1936
    Cell Significance Index: -12.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2130
    Cell Significance Index: -30.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2194
    Cell Significance Index: -25.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2356
    Cell Significance Index: -15.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2721
    Cell Significance Index: -6.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2863
    Cell Significance Index: -9.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3047
    Cell Significance Index: -13.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3765
    Cell Significance Index: -39.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3765
    Cell Significance Index: -19.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3876
    Cell Significance Index: -30.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3913
    Cell Significance Index: -30.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4051
    Cell Significance Index: -9.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4320
    Cell Significance Index: -26.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4680
    Cell Significance Index: -24.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5133
    Cell Significance Index: -28.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5460
    Cell Significance Index: -15.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5650
    Cell Significance Index: -15.1400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5859
    Cell Significance Index: -3.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5930
    Cell Significance Index: -12.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6197
    Cell Significance Index: -10.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6314
    Cell Significance Index: -27.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6483
    Cell Significance Index: -9.7700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7070
    Cell Significance Index: -4.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7583
    Cell Significance Index: -28.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8027
    Cell Significance Index: -19.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8624
    Cell Significance Index: -25.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8936
    Cell Significance Index: -32.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9103
    Cell Significance Index: -12.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Function:** SRM catalyzes the condensation of putrescine with ornithine to form spermidine, a key polyamine involved in various cellular processes, including protein synthesis, cell growth, and differentiation. 2. **Cellular Expression:** SRM is expressed in multiple cell types, including myoepithelial cells of the mammary gland, acinar cells of the salivary gland, and fibroblasts of the mammary gland, highlighting its role in maintaining tissue homeostasis. 3. **Signaling Pathways:** SRM is involved in cellular responses to leukemia inhibitory factor (LIF), a cytokine that regulates various cellular processes, including cell growth, differentiation, and apoptosis. 4. **Metabolic Pathways:** SRM is part of the metabolism of amino acids and derivatives, polyamines, and polyamine metabolic processes, underscoring its role in maintaining cellular energy balance. **Pathways and Functions:** 1. **Cytosol:** SRM is involved in the biosynthesis of spermidine, a polyamine that plays a crucial role in maintaining cellular homeostasis. 2. **Metabolism:** SRM is part of the metabolism of amino acids and derivatives, polyamines, and polyamine metabolic processes, highlighting its role in maintaining cellular energy balance. 3. **Cellular Response to Leukemia Inhibitory Factor (LIF):** SRM is involved in cellular responses to LIF, a cytokine that regulates various cellular processes, including cell growth, differentiation, and apoptosis. 4. **Polyamine Metabolic Process:** SRM is crucial in the biosynthesis of spermidine, a polyamine involved in various cellular processes, including protein synthesis, cell growth, and differentiation. **Clinical Significance:** 1. **Cancer Research:** SRM's involvement in cellular responses to LIF and its role in maintaining cellular homeostasis make it an attractive target for cancer research, particularly in the development of novel therapeutic strategies. 2. **Aging and Age-Related Diseases:** SRM's role in maintaining cellular homeostasis and its involvement in polyamine metabolic processes make it an interesting target for research on aging and age-related diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Tissue Regeneration:** SRM's expression in various cell types, including fibroblasts of the mammary gland, highlights its potential role in tissue regeneration and repair. In conclusion, SRM is a gene that plays a crucial role in maintaining cellular homeostasis and is involved in various cellular processes, including metabolism, signaling pathways, and polyamine metabolic processes. Further research on SRM is necessary to fully understand its role in human health and disease, and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 1301578435

Symbol: SPEE_HUMAN

Name: Spermidine synthase

UniProtKB Accession Codes:

P19623 B1AKP9 Q15511

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2344393

Title: Human spermidine synthase: cloning and primary structure.

PubMed ID: 2344393

DOI: 10.1089/dna.1990.9.103

PubMed ID: 2069720

Title: Human spermidine synthase gene: structure and chromosomal localization.

PubMed ID: 2069720

DOI: 10.1089/dna.1991.10.467

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 17585781

Title: Structure and mechanism of spermidine synthases.

PubMed ID: 17585781

DOI: 10.1021/bi602498k

Sequence Information:

  • Length: 302
  • Mass: 33825
  • Checksum: 3EF454D886F6425D
  • Sequence:
    • MEPGPDGPAA SGPAAIREGW FRETCSLWPG QALSLQVEQL LHHRRSRYQD ILVFRSKTYG 
NVLVLDGVIQ CTERDEFSYQ EMIANLPLCS HPNPRKVLII GGGDGGVLRE VVKHPSVESV 
VQCEIDEDVI QVSKKFLPGM AIGYSSSKLT LHVGDGFEFM KQNQDAFDVI ITDSSDPMGP 
AESLFKESYY QLMKTALKED GVLCCQGECQ WLHLDLIKEM RQFCQSLFPV VAYAYCTIPT 
YPSGQIGFML CSKNPSTNFQ EPVQPLTQQQ VAQMQLKYYN SDVHRAAFVL PEFARKALND 
VS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.