Details for: TBX3

Gene ID: 6926

Symbol: TBX3

Ensembl ID: ENSG00000135111

Description: T-box transcription factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 41.0489
    Cell Significance Index: -16.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 38.5281
    Cell Significance Index: -18.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.5859
    Cell Significance Index: -16.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 11.8781
    Cell Significance Index: 73.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 10.5705
    Cell Significance Index: 283.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4584
    Cell Significance Index: -19.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.5203
    Cell Significance Index: 120.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.4317
    Cell Significance Index: 40.8100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.0429
    Cell Significance Index: 42.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.7632
    Cell Significance Index: 678.3800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 3.5243
    Cell Significance Index: 13.1400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.4135
    Cell Significance Index: 21.0600
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 3.1623
    Cell Significance Index: 2.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.1182
    Cell Significance Index: 161.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4174
    Cell Significance Index: 65.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2775
    Cell Significance Index: 169.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1502
    Cell Significance Index: 426.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0925
    Cell Significance Index: 60.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8277
    Cell Significance Index: 224.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7545
    Cell Significance Index: 38.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.7470
    Cell Significance Index: 50.0800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.6245
    Cell Significance Index: 14.4200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.5247
    Cell Significance Index: 7.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4676
    Cell Significance Index: 30.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4226
    Cell Significance Index: 182.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3606
    Cell Significance Index: 258.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2532
    Cell Significance Index: 172.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1260
    Cell Significance Index: 122.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9119
    Cell Significance Index: 148.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8653
    Cell Significance Index: 45.0700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.8053
    Cell Significance Index: 10.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6748
    Cell Significance Index: 66.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6645
    Cell Significance Index: 16.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4647
    Cell Significance Index: 32.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4509
    Cell Significance Index: 407.1400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4310
    Cell Significance Index: 3.6200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4178
    Cell Significance Index: 4.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4142
    Cell Significance Index: 18.7800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4030
    Cell Significance Index: 4.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3709
    Cell Significance Index: 7.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3464
    Cell Significance Index: 16.1500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2797
    Cell Significance Index: 1.6900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2749
    Cell Significance Index: 3.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2647
    Cell Significance Index: 5.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2497
    Cell Significance Index: 13.1100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2322
    Cell Significance Index: 3.3400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2301
    Cell Significance Index: 2.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2004
    Cell Significance Index: 9.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1502
    Cell Significance Index: 7.5900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0750
    Cell Significance Index: 0.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0415
    Cell Significance Index: 3.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0370
    Cell Significance Index: 4.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0335
    Cell Significance Index: 0.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0144
    Cell Significance Index: 6.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0078
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0091
    Cell Significance Index: -17.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0112
    Cell Significance Index: -20.5900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0131
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0247
    Cell Significance Index: -18.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0255
    Cell Significance Index: -18.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0257
    Cell Significance Index: -19.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0269
    Cell Significance Index: -17.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0323
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0323
    Cell Significance Index: -20.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0328
    Cell Significance Index: -18.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0335
    Cell Significance Index: -18.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0407
    Cell Significance Index: -2.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0546
    Cell Significance Index: -1.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0605
    Cell Significance Index: -17.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0892
    Cell Significance Index: -10.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0921
    Cell Significance Index: -19.4000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0971
    Cell Significance Index: -0.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0972
    Cell Significance Index: -19.4900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1021
    Cell Significance Index: -0.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1069
    Cell Significance Index: -10.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1127
    Cell Significance Index: -19.2400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1258
    Cell Significance Index: -1.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1260
    Cell Significance Index: -18.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1318
    Cell Significance Index: -4.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1332
    Cell Significance Index: -2.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1630
    Cell Significance Index: -9.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1665
    Cell Significance Index: -19.0700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1786
    Cell Significance Index: -1.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1798
    Cell Significance Index: -18.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2236
    Cell Significance Index: -6.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2362
    Cell Significance Index: -18.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2586
    Cell Significance Index: -6.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2864
    Cell Significance Index: -19.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2886
    Cell Significance Index: -4.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3068
    Cell Significance Index: -18.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3114
    Cell Significance Index: -19.1400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3327
    Cell Significance Index: -0.7500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3516
    Cell Significance Index: -3.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3738
    Cell Significance Index: -9.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3799
    Cell Significance Index: -11.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3859
    Cell Significance Index: -13.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3864
    Cell Significance Index: -15.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3937
    Cell Significance Index: -17.1200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.4021
    Cell Significance Index: -3.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TBX3 is a highly conserved transcription factor that belongs to the T-box family of transcription factors. It is characterized by its ability to bind to specific DNA sequences and regulate gene expression. TBX3's expression is widespread in various tissues, including the adrenal gland, respiratory system, liver, and reproductive organs. Its expression pattern suggests a role in embryonic development, tissue homeostasis, and organogenesis. **Pathways and Functions:** TBX3's involvement in multiple developmental pathways highlights its multifaceted role in embryonic development and adult tissue homeostasis. Some of the key pathways and functions of TBX3 include: 1. **Embryonic development:** TBX3 plays a crucial role in regulating embryonic development, including anterior/posterior axis specification, heart looping, and limb morphogenesis. 2. **Cardiac development:** TBX3 is involved in cardiac development, including atrioventricular bundle cell differentiation, atrioventricular canal development, and ventricular septum morphogenesis. 3. **Cell fate specification:** TBX3 regulates cell fate specification in various tissues, including cardiac muscle cell fate commitment and smooth muscle cell differentiation. 4. **Tissue homeostasis:** TBX3 maintains tissue homeostasis by regulating cell proliferation, differentiation, and apoptosis in various tissues, including the liver, respiratory system, and reproductive organs. 5. **Adult organogenesis:** TBX3 is involved in the development and maintenance of adult organs, including the heart, liver, and reproductive organs. **Clinical Significance:** TBX3's involvement in multiple developmental pathways and tissue homeostasis makes it a potential target for the treatment of various diseases, including: 1. **Congenital heart defects:** TBX3's role in cardiac development suggests its potential as a therapeutic target for congenital heart defects. 2. **Cancer:** TBX3's involvement in cell proliferation and differentiation makes it a potential target for cancer therapy. 3. **Neurological disorders:** TBX3's role in limb morphogenesis and neural crest cell development suggests its potential as a therapeutic target for neurological disorders, such as limb abnormalities and neural crest-derived tumors. 4. **Reproductive disorders:** TBX3's involvement in reproductive organ development and maintenance makes it a potential target for the treatment of reproductive disorders, such as infertility and reproductive tract abnormalities. In conclusion, TBX3 is a multifaceted transcriptional regulator that plays a crucial role in embryonic development, tissue homeostasis, and adult organogenesis. Its involvement in multiple developmental pathways underscores its importance in shaping the structure and function of various organs and tissues. Further research is needed to elucidate TBX3's role in disease and to identify potential therapeutic targets for the treatment of various diseases.

Genular Protein ID: 2956653309

Symbol: TBX3_HUMAN

Name: T-box transcription factor TBX3

UniProtKB Accession Codes:

O15119 Q8TB20 Q9UKF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 64 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10468588

Title: Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.

PubMed ID: 10468588

DOI: 10.1073/pnas.96.18.10212

PubMed ID: 9207801

Title: Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome.

PubMed ID: 9207801

DOI: 10.1038/ng0797-311

PubMed ID: 10330342

Title: The spectrum of mutations in TBX3: genotype/phenotype relationship in ulnar-mammary syndrome.

PubMed ID: 10330342

DOI: 10.1086/302417

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12000749

Title: The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.

PubMed ID: 12000749

DOI: 10.1074/jbc.m200403200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22002537

Title: Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.

PubMed ID: 22002537

DOI: 10.1038/emboj.2011.370

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12005433

Title: Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome.

PubMed ID: 12005433

DOI: 10.1016/s0969-2126(02)00722-0

Sequence Information:

  • Length: 743
  • Mass: 79389
  • Checksum: D5572F9CF871E89F
  • Sequence:
    • MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG AAALSLPGAL 
AKPIMDQLVG AAETGIPFSS LGPQAHLRPL KTMEPEEEVE DDPKVHLEAK ELWDQFHKRG 
TEMVITKSGR RMFPPFKVRC SGLDKKAKYI LLMDIIAADD CRYKFHNSRW MVAGKADPEM 
PKRMYIHPDS PATGEQWMSK VVTFHKLKLT NNISDKHGFT LAFPSDHATW QGNYSFGTQT 
ILNSMHKYQP RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA 
KGFRDTGNGR REKRKQLTLQ SMRVFDERHK KENGTSDESS SEQAAFNCFA QASSPAASTV 
GTSNLKDLCP SEGESDAEAE SKEEHGPEAC DAAKISTTTS EEPCRDKGSP AVKAHLFAAE 
RPRDSGRLDK ASPDSRHSPA TISSSTRGLG AEERRSPVRE GTAPAKVEEA RALPGKEAFA 
PLTVQTDAAA AHLAQGPLPG LGFAPGLAGQ QFFNGHPLFL HPSQFAMGGA FSSMAAAGMG 
PLLATVSGAS TGVSGLDSTA MASAAAAQGL SGASAATLPF HLQQHVLASQ GLAMSPFGSL 
FPYPYTYMAA AAAASSAAAS SSVHRHPFLN LNTMRPRLRY SPYSIPVPVP DGSSLLTTAL 
PSMAAAAGPL DGKVAALAAS PASVAVDSGS ELNSRSSTLS SSSMSLSPKL CAEKEAATSE 
LQSIQRLVSG LEAKPDRSRS ASP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.