Details for: DYRK4

Gene ID: 8798

Symbol: DYRK4

Ensembl ID: ENSG00000010219

Description: dual specificity tyrosine phosphorylation regulated kinase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.5986
    Cell Significance Index: -13.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.3967
    Cell Significance Index: -10.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 35.7570
    Cell Significance Index: -14.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.6398
    Cell Significance Index: -15.4100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 22.8606
    Cell Significance Index: -15.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9388
    Cell Significance Index: -14.7200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 7.7937
    Cell Significance Index: 128.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7670
    Cell Significance Index: -12.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8342
    Cell Significance Index: -15.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.5130
    Cell Significance Index: -10.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2631
    Cell Significance Index: 368.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7632
    Cell Significance Index: 105.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6465
    Cell Significance Index: 179.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2493
    Cell Significance Index: 16.0000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0191
    Cell Significance Index: 8.5600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9156
    Cell Significance Index: 7.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8837
    Cell Significance Index: 61.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8816
    Cell Significance Index: 102.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8517
    Cell Significance Index: 53.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8451
    Cell Significance Index: 17.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6111
    Cell Significance Index: 16.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5947
    Cell Significance Index: 81.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5299
    Cell Significance Index: 27.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4517
    Cell Significance Index: 12.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4399
    Cell Significance Index: 43.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4225
    Cell Significance Index: 84.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3717
    Cell Significance Index: 17.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3357
    Cell Significance Index: 15.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3313
    Cell Significance Index: 180.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2949
    Cell Significance Index: 7.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2842
    Cell Significance Index: 125.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2784
    Cell Significance Index: 19.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2769
    Cell Significance Index: 250.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2446
    Cell Significance Index: 12.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2388
    Cell Significance Index: 30.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2382
    Cell Significance Index: 30.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2360
    Cell Significance Index: 8.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2320
    Cell Significance Index: 41.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2247
    Cell Significance Index: 80.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2235
    Cell Significance Index: 16.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2213
    Cell Significance Index: 6.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2164
    Cell Significance Index: 9.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2145
    Cell Significance Index: 26.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1967
    Cell Significance Index: 4.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1395
    Cell Significance Index: 9.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1230
    Cell Significance Index: 14.5100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1121
    Cell Significance Index: 0.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1049
    Cell Significance Index: 19.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0906
    Cell Significance Index: 1.9300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0755
    Cell Significance Index: 0.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0727
    Cell Significance Index: 2.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0359
    Cell Significance Index: 0.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0273
    Cell Significance Index: 20.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.3000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0053
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -14.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0118
    Cell Significance Index: -1.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0118
    Cell Significance Index: -15.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0181
    Cell Significance Index: -1.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0199
    Cell Significance Index: -12.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0202
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0205
    Cell Significance Index: -3.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0216
    Cell Significance Index: -12.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0295
    Cell Significance Index: -18.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0315
    Cell Significance Index: -14.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0326
    Cell Significance Index: -9.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0346
    Cell Significance Index: -0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0369
    Cell Significance Index: -2.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0452
    Cell Significance Index: -2.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0475
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0751
    Cell Significance Index: -8.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0760
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0766
    Cell Significance Index: -16.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0792
    Cell Significance Index: -11.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0856
    Cell Significance Index: -2.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0914
    Cell Significance Index: -5.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0963
    Cell Significance Index: -2.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1041
    Cell Significance Index: -1.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1088
    Cell Significance Index: -3.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1140
    Cell Significance Index: -3.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1208
    Cell Significance Index: -1.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1432
    Cell Significance Index: -14.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1491
    Cell Significance Index: -11.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1523
    Cell Significance Index: -1.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1531
    Cell Significance Index: -1.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1558
    Cell Significance Index: -6.3800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1583
    Cell Significance Index: -1.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1601
    Cell Significance Index: -1.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1690
    Cell Significance Index: -6.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1789
    Cell Significance Index: -10.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2011
    Cell Significance Index: -3.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2214
    Cell Significance Index: -14.8900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2332
    Cell Significance Index: -1.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2487
    Cell Significance Index: -6.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2509
    Cell Significance Index: -13.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2630
    Cell Significance Index: -9.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2753
    Cell Significance Index: -8.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DYRK4 exhibits several key characteristics that distinguish it from other kinases. These include: * Dual specificity: DYRK4 has the ability to phosphorylate both serine and tyrosine residues on target proteins, which is a unique feature of this kinase family. * Tyrosine phosphorylation regulation: DYRK4 is regulated by tyrosine phosphorylation, which modulates its activity and substrate specificity. * Cell-type specificity: DYRK4 is highly expressed in specific cell types, including pancreatic A cells, male germ cells, and Leydig cells, suggesting a role in cell-specific signaling pathways. * Protein kinase activity: DYRK4 is a member of the protein kinase family and exhibits kinase activity, which is essential for its function. **Pathways and Functions** DYRK4 is involved in several cellular pathways, including: * Cell proliferation: DYRK4 regulates cell proliferation by phosphorylating proteins involved in the cell cycle, such as cyclin-dependent kinases. * Differentiation: DYRK4 is involved in the regulation of cell differentiation by phosphorylating proteins involved in the signaling pathways that control cell fate decisions. * Survival: DYRK4 regulates cell survival by phosphorylating proteins involved in the apoptotic pathway. * Signal transduction: DYRK4 is involved in signal transduction pathways, including those that regulate cell growth, differentiation, and survival. **Clinical Significance** DYRK4 has been implicated in various diseases and disorders, including: * Cancer: DYRK4 is overexpressed in several types of cancer, including pancreatic cancer, and is associated with poor prognosis. * Neurological disorders: DYRK4 is involved in the regulation of neuronal function and is implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. * Reproductive disorders: DYRK4 is involved in the regulation of reproductive processes, including spermatogenesis and follicular development, and is implicated in reproductive disorders, such as infertility and polycystic ovary syndrome (PCOS). * Cardiovascular disease: DYRK4 is involved in the regulation of cardiovascular function and is implicated in cardiovascular disease, including hypertension and atherosclerosis. In conclusion, DYRK4 is a serine/threonine/tyrosine kinase enzyme that plays a critical role in various cellular processes, including cell proliferation, differentiation, and survival. Its involvement in disease pathways, including cancer, neurological disorders, reproductive disorders, and cardiovascular disease, highlights the importance of DYRK4 in human health and disease. Further research is needed to fully elucidate the mechanisms of DYRK4 and its role in disease pathology.

Genular Protein ID: 1868102776

Symbol: DYRK4_HUMAN

Name: Dual specificity tyrosine-phosphorylation-regulated kinase 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11062477

Title: Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.

PubMed ID: 11062477

DOI: 10.1038/81664

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9748265

Title: Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.

PubMed ID: 9748265

DOI: 10.1074/jbc.273.40.25893

PubMed ID: 17292540

Title: The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice.

PubMed ID: 17292540

DOI: 10.1016/j.mce.2006.12.041

PubMed ID: 21127067

Title: Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.

PubMed ID: 21127067

DOI: 10.1074/jbc.m110.157909

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 520
  • Mass: 59608
  • Checksum: 33FECD8249DDB223
  • Sequence:
  • MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY 
    AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK 
    CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC 
    ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ 
    KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG 
    YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK 
    DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS 
    FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP 
    QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV

Genular Protein ID: 3316185404

Symbol: B4E1A4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 233
  • Mass: 26300
  • Checksum: 7BB4A385E91391CB
  • Sequence:
  • MWSLGCITAE LYTGYPLFPG ENEVEQLACI MEVLGLPPAG FIQTASRRQT FFDSKGFPKN 
    ITNNRGKKRY PDSKDLTMVL KTYDTSFLDF LRRCLVWEPS LRMTPDQALK HAWIHQSRNL 
    KPQPRPQTLR KSNSFFPSET RKDKVQGCHH SSRKDEITKE TTEKTKDSPT KHVQHSGDQQ 
    DCLQHGADTV QLPQLVDAPK KSEAAVGAEV SMTSPGQSKN FSLKNTNVLP PIV

Genular Protein ID: 3521716462

Symbol: D3JEN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 254
  • Mass: 28688
  • Checksum: 2B99D84367AFE681
  • Sequence:
  • SRFYRSPEVI LGHPYDVAID MWSLGCITAE LYTGYPLFPG ENEVEQLACI MEVLGLPPAG 
    FIQTASRRQT FFDSKGFPKN ITNNRGKKRY PDSKDLTMVL KTYDTSFLDF LRRCLVWEPS 
    LRMTPDQALK HAWIHQSRNL KPQPRPQTLR KSNSFFPSET RKDKVQGCHH SSRKADEITK 
    ETTEKTKDSP TKHVQHSGDQ QDCLQHGADT VQLPQLVDAP KKSEAAVGAE VSMTSPGQSK 
    NFSLKNTNVL PPIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.