Details for: DYRK4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 86.5986
Cell Significance Index: -13.4700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 41.3967
Cell Significance Index: -10.5000 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 35.7570
Cell Significance Index: -14.7300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 32.6398
Cell Significance Index: -15.4100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 22.8606
Cell Significance Index: -15.3400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.9388
Cell Significance Index: -14.7200 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 7.7937
Cell Significance Index: 128.4300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.7670
Cell Significance Index: -12.7700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.8342
Cell Significance Index: -15.1300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.5130
Cell Significance Index: -10.7900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.2631
Cell Significance Index: 368.0800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.7632
Cell Significance Index: 105.8500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.6465
Cell Significance Index: 179.0900 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.2493
Cell Significance Index: 16.0000 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.0191
Cell Significance Index: 8.5600 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.9156
Cell Significance Index: 7.3100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.8837
Cell Significance Index: 61.1200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.8816
Cell Significance Index: 102.7400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.8517
Cell Significance Index: 53.6800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.8451
Cell Significance Index: 17.6900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.6111
Cell Significance Index: 16.3800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5947
Cell Significance Index: 81.6700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5299
Cell Significance Index: 27.5300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4517
Cell Significance Index: 12.3000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4399
Cell Significance Index: 43.5200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4225
Cell Significance Index: 84.7500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3717
Cell Significance Index: 17.4700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3357
Cell Significance Index: 15.6500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3313
Cell Significance Index: 180.9500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2949
Cell Significance Index: 7.7600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2842
Cell Significance Index: 125.6300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2784
Cell Significance Index: 19.6900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2769
Cell Significance Index: 250.0500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2446
Cell Significance Index: 12.8400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2388
Cell Significance Index: 30.8500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2382
Cell Significance Index: 30.5400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2360
Cell Significance Index: 8.2000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2320
Cell Significance Index: 41.8200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2247
Cell Significance Index: 80.6100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2235
Cell Significance Index: 16.6600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2213
Cell Significance Index: 6.5000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2164
Cell Significance Index: 9.8100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2145
Cell Significance Index: 26.3700 - Cell Name: peg cell (CL4033014)
Fold Change: 0.1967
Cell Significance Index: 4.5500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1395
Cell Significance Index: 9.0000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1230
Cell Significance Index: 14.5100 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.1121
Cell Significance Index: 0.5900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1049
Cell Significance Index: 19.9600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0906
Cell Significance Index: 1.9300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0755
Cell Significance Index: 0.9000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0727
Cell Significance Index: 2.3300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0359
Cell Significance Index: 0.6000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0273
Cell Significance Index: 20.6400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0032
Cell Significance Index: -2.3400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0039
Cell Significance Index: -7.3000 - Cell Name: germ cell (CL0000586)
Fold Change: -0.0053
Cell Significance Index: -0.0400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0075
Cell Significance Index: -13.8400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0091
Cell Significance Index: -14.0500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0118
Cell Significance Index: -1.2100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0118
Cell Significance Index: -15.9900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0136
Cell Significance Index: -10.0500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0181
Cell Significance Index: -1.3900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0199
Cell Significance Index: -12.6300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0202
Cell Significance Index: -4.0000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0205
Cell Significance Index: -3.5000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0216
Cell Significance Index: -12.1900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0295
Cell Significance Index: -18.4100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0315
Cell Significance Index: -14.3100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0326
Cell Significance Index: -9.3900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0346
Cell Significance Index: -0.8800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0369
Cell Significance Index: -2.0700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0452
Cell Significance Index: -2.2900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0475
Cell Significance Index: -1.2700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0751
Cell Significance Index: -8.6000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0760
Cell Significance Index: -3.3600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0766
Cell Significance Index: -16.1300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0792
Cell Significance Index: -11.5100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0856
Cell Significance Index: -2.1400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0914
Cell Significance Index: -5.6200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0963
Cell Significance Index: -2.7600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1041
Cell Significance Index: -1.4200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1088
Cell Significance Index: -3.0400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1140
Cell Significance Index: -3.2900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1208
Cell Significance Index: -1.8100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1432
Cell Significance Index: -14.9100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1491
Cell Significance Index: -11.8100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1523
Cell Significance Index: -1.7300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1531
Cell Significance Index: -1.4100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1558
Cell Significance Index: -6.3800 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.1583
Cell Significance Index: -1.2200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1601
Cell Significance Index: -1.7400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1690
Cell Significance Index: -6.4000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1789
Cell Significance Index: -10.9700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2011
Cell Significance Index: -3.0300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2214
Cell Significance Index: -14.8900 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.2332
Cell Significance Index: -1.4600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2487
Cell Significance Index: -6.6400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2509
Cell Significance Index: -13.0700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2630
Cell Significance Index: -9.2400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2753
Cell Significance Index: -8.1100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1868102776
Symbol: DYRK4_HUMAN
Name: Dual specificity tyrosine-phosphorylation-regulated kinase 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11062477
Title: Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.
PubMed ID: 11062477
DOI: 10.1038/81664
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9748265
Title: Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.
PubMed ID: 9748265
PubMed ID: 17292540
Title: The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice.
PubMed ID: 17292540
PubMed ID: 21127067
Title: Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.
PubMed ID: 21127067
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 520
- Mass: 59608
- Checksum: 33FECD8249DDB223
- Sequence:
MPASELKASE IPFHPSIKTQ DPKAEEKSPK KQKVTLTAAE ALKLFKNQLS PYEQSEILGY AELWFLGLEA KKLDTAPEKF SKTSFDDEHG FYLKVLHDHI AYRYEVLETI GKGSFGQVAK CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ KGQASVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDVAIDMWSL GCITAELYTG YPLFPGENEV EQLACIMEVL GLPPAGFIQT ASRRQTFFDS KGFPKNITNN RGKKRYPDSK DLTMVLKTYD TSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSRNLKPQP RPQTLRKSNS FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV
Genular Protein ID: 3316185404
Symbol: B4E1A4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 233
- Mass: 26300
- Checksum: 7BB4A385E91391CB
- Sequence:
MWSLGCITAE LYTGYPLFPG ENEVEQLACI MEVLGLPPAG FIQTASRRQT FFDSKGFPKN ITNNRGKKRY PDSKDLTMVL KTYDTSFLDF LRRCLVWEPS LRMTPDQALK HAWIHQSRNL KPQPRPQTLR KSNSFFPSET RKDKVQGCHH SSRKDEITKE TTEKTKDSPT KHVQHSGDQQ DCLQHGADTV QLPQLVDAPK KSEAAVGAEV SMTSPGQSKN FSLKNTNVLP PIV
Genular Protein ID: 3521716462
Symbol: D3JEN2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 254
- Mass: 28688
- Checksum: 2B99D84367AFE681
- Sequence:
SRFYRSPEVI LGHPYDVAID MWSLGCITAE LYTGYPLFPG ENEVEQLACI MEVLGLPPAG FIQTASRRQT FFDSKGFPKN ITNNRGKKRY PDSKDLTMVL KTYDTSFLDF LRRCLVWEPS LRMTPDQALK HAWIHQSRNL KPQPRPQTLR KSNSFFPSET RKDKVQGCHH SSRKADEITK ETTEKTKDSP TKHVQHSGDQ QDCLQHGADT VQLPQLVDAP KKSEAAVGAE VSMTSPGQSK NFSLKNTNVL PPIV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.