BCL2L11 | ENSG00000153094 | NCBI 10018

Details for: BCL2L11

Gene ID: 10018

Symbol: BCL2L11

Ensembl ID: ENSG00000153094

Description: BCL2 like 11

Associated with

Activation of bh3-only proteins
(R-HSA-114452)
Activation of bim and translocation to mitochondria
(R-HSA-111446)
Apoptosis
(R-HSA-109581)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-HSA-111453)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Flt3 signaling
(R-HSA-9607240)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell death genes
(R-HSA-9614657)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Neurodegenerative diseases
(R-HSA-8863678)
Nrage signals death through jnk
(R-HSA-193648)
Oncogenic mapk signaling
(R-HSA-6802957)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Programmed cell death
(R-HSA-5357801)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates bcl2l11 (bim) transcription
(R-HSA-8952158)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx3
(R-HSA-8878159)
Apoptotic process
(GO:0006915)
Apoptotic process involved in embryonic digit morphogenesis
(GO:1902263)
B cell homeostasis
(GO:0001782)
Bcl-2 family protein complex
(GO:0097136)
Cell-matrix adhesion
(GO:0007160)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cytosol
(GO:0005829)
Developmental pigmentation
(GO:0048066)
Ear development
(GO:0043583)
Endomembrane system
(GO:0012505)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Male gonad development
(GO:0008584)
Mammary gland development
(GO:0030879)
Meiosis i
(GO:0007127)
Microtubule binding
(GO:0008017)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Molecular adaptor activity
(GO:0060090)
Myeloid cell homeostasis
(GO:0002262)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902237)
Positive regulation of fibroblast apoptotic process
(GO:2000271)
Positive regulation of ire1-mediated unfolded protein response
(GO:1903896)
Positive regulation of mitochondrial membrane permeability involved in apoptotic process
(GO:1902110)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of release of cytochrome c from mitochondria
(GO:0090200)
Positive regulation of t cell apoptotic process
(GO:0070234)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of apoptotic process
(GO:0042981)
Regulation of developmental pigmentation
(GO:0048070)
Regulation of organ growth
(GO:0046620)
Response to endoplasmic reticulum stress
(GO:0034976)
Spermatogenesis
(GO:0007283)
Spleen development
(GO:0048536)
T cell homeostasis
(GO:0043029)
Thymocyte apoptotic process
(GO:0070242)
Thymus development
(GO:0048538)
Tube formation
(GO:0035148)

Other Information

Proteins

Bcl-2-like protein 11
A0A0C4DH20_HUMAN

Genular Protein ID: 1322573751

Symbol: B2L11_HUMAN

Name: Bcl-2-like protein 11

UniProtKB Accession Codes:

O43521 A8K2W2 O43522 Q0MSE7 Q0MSE8 Q0MSE9 Q53R28 Q6JTU6 Q6T851 Q6TE14 Q6TE15 Q6TE16 Q6V402 Q8WYL6 Q8WYL7 Q8WYL8 Q8WYL9 Q8WYM0 Q8WYM1

Database IDs:

Citations:

PubMed ID: 9430630

Title: Bim: a novel member of the Bcl-2 family that promotes apoptosis.

PubMed ID: 9430630

DOI: 10.1093/emboj/17.2.384

PubMed ID: 11734221

Title: Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family.

PubMed ID: 11734221

DOI: 10.1016/s0014-5793(01)03145-3

PubMed ID: 12019181

Title: Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim.

PubMed ID: 12019181

PubMed ID: 11997495

Title: Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

PubMed ID: 11997495

DOI: 10.1128/mcb.22.11.3577-3589.2002

PubMed ID: 15147734

Title: Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis.

PubMed ID: 15147734

DOI: 10.1016/j.biocel.2003.12.015

PubMed ID: 17503221

Title: Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas.

PubMed ID: 17503221

DOI: 10.1007/s10495-007-0093-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15486195

Title: BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors.

PubMed ID: 15486195

DOI: 10.1158/1535-7163.1281.3.10

PubMed ID: 15661735

Title: Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL.

PubMed ID: 15661735

DOI: 10.1074/jbc.m413062200

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17289999

Title: Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

PubMed ID: 17289999

DOI: 10.1126/science.1133289

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21478148

Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.

PubMed ID: 21478148

DOI: 10.1074/jbc.m110.197707

PubMed ID: 22498477

Title: The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

PubMed ID: 22498477

DOI: 10.4161/auto.19084

PubMed ID: 22761832

Title: CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress.

PubMed ID: 22761832

DOI: 10.1371/journal.pone.0039586

PubMed ID: 23563182

Title: Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.

PubMed ID: 23563182

DOI: 10.1038/onc.2013.99

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27013495

Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

PubMed ID: 27013495

DOI: 10.15252/embr.201541392

PubMed ID: 17389404

Title: Structural insights into the degradation of Mcl-1 induced by BH3 domains.

PubMed ID: 17389404

DOI: 10.1073/pnas.0701297104

PubMed ID: 18812174

Title: Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

PubMed ID: 18812174

DOI: 10.1016/j.febslet.2008.09.028

PubMed ID: 23235460

Title: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

PubMed ID: 23235460

DOI: 10.1038/cddis.2012.178

Sequence Information:

Length: 198
Mass: 22171
Checksum: D75735E469CA6997
Sequence:

MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP 
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP 
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR 
MVILRLLRYI VRLVWRMH

Genular Protein ID: 3546150739

Symbol: A0A0C4DH20_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DH20

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 75
Mass: 8171
Checksum: B461A639D86F9B06
Sequence:

MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QVSLCHPGWS ALVRSWLTAT 
SNSQVQAVLL PQPPK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BCL2L11

Associated with

Other Information

Bim: a novel member of the Bcl-2 family that promotes apoptosis. PubMed ID: 9430630

Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family. PubMed ID: 11734221

Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. PubMed ID: 12019181

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. PubMed ID: 11997495

Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis. PubMed ID: 15147734

Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas. PubMed ID: 17503221

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors. PubMed ID: 15486195

Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL. PubMed ID: 15661735

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. PubMed ID: 17289999

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. PubMed ID: 21478148

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. PubMed ID: 22498477

CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PubMed ID: 22761832

Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B. PubMed ID: 23563182

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. PubMed ID: 27013495

Structural insights into the degradation of Mcl-1 induced by BH3 domains. PubMed ID: 17389404

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. PubMed ID: 18812174

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist. PubMed ID: 23235460

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Database document:

PubMed ID: 9430630

PubMed ID: 11734221

PubMed ID: 12019181

PubMed ID: 11997495

PubMed ID: 15147734

PubMed ID: 17503221

PubMed ID: 14702039

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 15486195

PubMed ID: 15661735

PubMed ID: 16509771

PubMed ID: 17289999

PubMed ID: 19690332

PubMed ID: 21478148

PubMed ID: 22498477

PubMed ID: 22761832

PubMed ID: 23563182

PubMed ID: 23186163

PubMed ID: 27013495

PubMed ID: 17389404

PubMed ID: 18812174

PubMed ID: 23235460

PubMed ID: 15815621