Details for: BCL2L11

Gene ID: 10018

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: BCL2L11

Ensembl ID: ENSG00000153094

Description: BCL2 like 11

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • ciliated epithelial cell CL0000067
    CSI 11.01
    rCSI 9.68%
    PRS 73.82
  • retinal rod cell CL0000604
    CSI 8.9
    rCSI 15.69%
    PRS 79.32
  • dendritic cell, human CL0001056
    CSI 7.74
    rCSI 11.89%
    PRS 90.93
  • erythrocyte CL0000232
    CSI 6.53
    rCSI 14.81%
    PRS 83.82
  • plasmacytoid dendritic cell, human CL0001058
    CSI 4.89
    rCSI 3.41%
    PRS 87.31
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 4.38
    rCSI 8.73%
    PRS 93.36
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.89
    rCSI 2.79%
    PRS 94.36
  • erythroblast CL0000765
    CSI 3.81
    rCSI 10.1%
    PRS 87.88
  • class switched memory B cell CL0000972
    CSI 3.75
    rCSI 2.8%
    PRS 93.63
  • double negative thymocyte CL0002489
    CSI 3.7
    rCSI 2.57%
    PRS 93.64
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 3.47
    rCSI 4.54%
    PRS 92.66
  • squamous epithelial cell CL0000076
    CSI 3.43
    rCSI 8.13%
    PRS 83.1
  • club cell CL0000158
    CSI 3.33
    rCSI 4.88%
    PRS 78.8
  • endothelial cell of artery CL1000413
    CSI 3.19
    rCSI 4.68%
    PRS 88.64
  • goblet cell CL0000160
    CSI 3.16
    rCSI 2.99%
    PRS 82.15
  • T-helper 17 cell CL0000899
    CSI 3.1
    rCSI 2.47%
    PRS 96.7
  • blood vessel endothelial cell CL0000071
    CSI 2.93
    rCSI 6.07%
    PRS 80.96
  • plasmablast CL0000980
    CSI 2.86
    rCSI 2.25%
    PRS 88.04
  • pro-B cell CL0000826
    CSI 2.82
    rCSI 2.33%
    PRS 86.11
  • respiratory suprabasal cell CL4033048
    CSI 2.79
    rCSI 3.57%
    PRS 86.56
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 2.76
    rCSI 1.86%
    PRS 94.52
  • IgA plasma cell CL0000987
    CSI 2.7
    rCSI 2.76%
    PRS 89.44
  • precursor B cell CL0000817
    CSI 2.66
    rCSI 2.33%
    PRS 89.96
  • mature B cell CL0000785
    CSI 2.61
    rCSI 2.27%
    PRS 91.8
  • basal cell CL0000646
    CSI 2.61
    rCSI 3.49%
    PRS 81.9
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.46
    rCSI 2.41%
    PRS 94.54
  • ependymal cell CL0000065
    CSI 2.42
    rCSI 4.92%
    PRS 63.52
  • CD4-positive helper T cell CL0000492
    CSI 2.39
    rCSI 1.8%
    PRS 93.96
  • lung interstitial macrophage CL4033043
    CSI 2.37
    rCSI 5.32%
    PRS 93.38
  • conjunctival epithelial cell CL1000432
    CSI 2.36
    rCSI 3.6%
    PRS 83.82
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.35
    rCSI 1.81%
    PRS 87.13
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.34
    rCSI 3.73%
    PRS 87.1
  • group 3 innate lymphoid cell CL0001071
    CSI 2.34
    rCSI 1.75%
    PRS 89.07
  • IgG plasma cell CL0000985
    CSI 2.23
    rCSI 2.67%
    PRS 91.52
  • elicited macrophage CL0000861
    CSI 2.18
    rCSI 2%
    PRS 90.57
  • ionocyte CL0005006
    CSI 2.17
    rCSI 2.33%
    PRS 85.7
  • lung ciliated cell CL1000271
    CSI 2.16
    rCSI 2.5%
    PRS 76.93
  • alternatively activated macrophage CL0000890
    CSI 2.1
    rCSI 2.64%
    PRS 91.66
  • hepatocyte CL0000182
    CSI 2.06
    rCSI 3.69%
    PRS 83.03
  • corneal epithelial cell CL0000575
    CSI 2.04
    rCSI 5.84%
    PRS 88.43
  • mononuclear phagocyte CL0000113
    CSI 2
    rCSI 4.41%
    PRS 87.18
  • CD14-positive monocyte CL0001054
    CSI 1.96
    rCSI 2.44%
    PRS 91.51
  • Langerhans cell CL0000453
    CSI 1.91
    rCSI 2.91%
    PRS 92.68
  • myeloid dendritic cell, human CL0001057
    CSI 1.8
    rCSI 10.15%
    PRS 94.29
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.78
    rCSI 2.22%
    PRS 65.09
  • granulocyte CL0000094
    CSI 1.73
    rCSI 2.65%
    PRS 89.98
  • colon epithelial cell CL0011108
    CSI 1.7
    rCSI 1.78%
    PRS 81.35
  • T-helper 1 cell CL0000545
    CSI 1.64
    rCSI 2.96%
    PRS 95.4
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 1.58
    rCSI 2.69%
    PRS 93.79
  • myeloid dendritic cell CL0000782
    CSI 1.57
    rCSI 2.28%
    PRS 94.19
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.57
    rCSI 1.89%
    PRS 90.53
  • Hofbauer cell CL3000001
    CSI 1.56
    rCSI 2.94%
    PRS 90.65
  • fallopian tube secretory epithelial cell CL4030006
    CSI 1.42
    rCSI 1.37%
    PRS 83.26
  • respiratory basal cell CL0002633
    CSI 1.35
    rCSI 1.39%
    PRS 87.03
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.33
    rCSI 3.82%
    PRS 96.6
  • promonocyte CL0000559
    CSI 1.33
    rCSI 2.28%
    PRS 88.55
  • vascular associated smooth muscle cell CL0000359
    CSI 1.32
    rCSI 4.27%
    PRS 82.05
  • lung macrophage CL1001603
    CSI 1.16
    rCSI 2.6%
    PRS 90.18
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 1.15
    rCSI 6.94%
    PRS 92.63
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.11
    rCSI 2.81%
    PRS 75.21
  • enterocyte of epithelium of large intestine CL0002071
    CSI 1.1
    rCSI 5.8%
    PRS 87.94
  • mature alpha-beta T cell CL0000791
    CSI 1.08
    rCSI 3.92%
    PRS 96.09
  • intermediate monocyte CL0002393
    CSI 1.08
    rCSI 1.63%
    PRS 88.79
  • innate lymphoid cell CL0001065
    CSI 0.85
    rCSI 1.75%
    PRS 80.01
  • colon macrophage CL0009038
    CSI 0.79
    rCSI 3.66%
    PRS 93.57
  • endothelial cell of placenta CL0009092
    CSI 0.63
    rCSI 3.1%
    PRS 90.04

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [BCL2L11](/details-gene/10018), also known as Bim, is a protein-coding gene located on chromosome 2q13. It is a member of the B-cell lymphoma 2 (Bcl-2) family of proteins and functions as a critical pro-apoptotic BH3-only protein. [BCL2L11](/details-gene/10018) plays a central role in initiating the intrinsic pathway of apoptosis by binding to and neutralizing anti-apoptotic Bcl-2 family members, thereby promoting programmed cell death. Expression data from the **Overall** context indicates its high significance in a diverse range of cell types, including [ciliated epithelial cells](/details-cell/CL0000067), [retinal rod cells](/details-cell/CL0000604), and multiple lymphocyte populations such as [dendritic cells](/details-cell/CL0001056) and T cells, underscoring its fundamental role in tissue homeostasis, immune regulation, and developmental processes. ## Cellular Roles and Expression Landscape The expression profile of [BCL2L11](/details-gene/10018) highlights its widespread importance in regulating cell survival and death across various tissues. **Overall**, the gene shows the highest significance in [ciliated epithelial cells](/details-cell/CL0000067) (CSI: 11.01) and [retinal rod cells](/details-cell/CL0000604) (CSI: 8.90), suggesting a crucial function in the maintenance and turnover of cells in the respiratory tract and the retina. A prominent role for [BCL2L11](/details-gene/10018) is observed within the immune system. It is a significant marker in both the innate and adaptive immune compartments, with high CSI values in [dendritic cells](/details-cell/CL0001056) (CSI: 7.74) and [plasmacytoid dendritic cells](/details-cell/CL0001058) (CSI: 4.89). Furthermore, its importance extends to lymphocyte populations, including [CD8-positive, CD28-negative, alpha-beta regulatory T cells](/details-cell/CL0000920), [CD4-positive, alpha-beta memory T cells](/details-cell/CL0000897), [class switched memory B cells](/details-cell/CL0000972), and [double negative thymocytes](/details-cell/CL0002489). This pattern is consistent with its established role in shaping immune repertoires through the deletion of autoreactive lymphocytes and maintaining lymphocyte homeostasis. The gene's significance is also noted in hematopoietic precursors, such as [erythroblasts](/details-cell/CL0000765), indicating its involvement in regulating the development of red blood cells. ## Pathways and Molecular Function Functional annotation confirms the role of [BCL2L11](/details-gene/10018) as a key initiator of programmed cell death. The gene is heavily involved in the '[Apoptotic process](/details-go/GO:0006915)' ([GO:0006915](https://www.ebi.ac.uk/QuickGO/term/GO:0006915)) and specifically in the '[Intrinsic pathway for apoptosis](/details-pathway/R-HSA-109606)' ([R-HSA-109606](https://reactome.org/content/detail/R-HSA-109606)), as originally described in early research on the protein ([Link](https://doi.org/10.1093/emboj/17.2.384)). As a BH3-only protein, its primary mechanism involves the '[Activation of bh3-only proteins](/details-pathway/R-HSA-114452)' ([R-HSA-114452](https://reactome.org/content/detail/R-HSA-114452)), leading to the neutralization of anti-apoptotic Bcl-2 members ([Link](https://doi.org/10.1126/science.1133289)). Its molecular functions include binding to other proteins ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)) and forming complexes with Bcl-2 and Bcl-xL ([GO:0097141](https://www.ebi.ac.uk/QuickGO/term/GO:0097141), [GO:0097140](https://www.ebi.ac.uk/QuickGO/term/GO:0097140)), which are critical steps for initiating apoptosis. This function is essential for processes like '[T cell homeostasis](/details-go/GO:0043029)' ([GO:0043029](https://www.ebi.ac.uk/QuickGO/term/GO:0043029)), '[B cell homeostasis](/details-go/GO:0001782)' ([GO:0001782](https://www.ebi.ac.uk/QuickGO/term/GO:0001782)), and the apoptotic process in [thymocytes](/details-cell/CL0000811) ([GO:0070242](https://www.ebi.ac.uk/QuickGO/term/GO:0070242)). Reactome pathways further connect [BCL2L11](/details-gene/10018) to '[Cytokine signaling in immune system](/details-pathway/R-HSA-1280215)' ([R-HSA-1280215](https://reactome.org/content/detail/R-HSA-1280215)) and transcriptional regulation by factors such as FOXO and RUNX3, illustrating the complex signaling networks that control its expression and activity. ## Research Directions The function of [BCL2L11](/details-gene/10018) as a central apoptotic regulator makes it a gene of significant interest in both physiology and pathology. Based on its expression profile and known functions, several research avenues can be proposed. **Proposed Hypotheses:** 1. Given its high significance in [ciliated epithelial cells](/details-cell/CL0000067) and [club cells](/details-cell/CL0000158), [BCL2L11](/details-gene/10018) likely functions as a key sensor and mediator of cellular stress and damage in the airway epithelium. Its dysregulation may contribute to the pathogenesis of chronic inflammatory lung diseases, such as COPD or asthma, by altering the threshold for apoptosis in response to environmental insults. 2. The high CSI score in [retinal rod cells](/details-cell/CL0000604) suggests that [BCL2L11](/details-gene/10018) is a critical executioner of photoreceptor cell death. Variations in its expression or regulation could be a key factor determining the rate of progression in retinal degenerative diseases like retinitis pigmentosa. **Experimental Approach:** To test the first hypothesis regarding its role in the respiratory epithelium, a valuable experiment would be to use an *in vitro* air-liquid interface (ALI) culture system with primary human bronchial epithelial cells. [BCL2L11](/details-gene/10018) expression could be knocked down using shRNA. These cultures would then be exposed to relevant stressors like cigarette smoke extract or viral mimics (e.g., poly(I:C)). The impact of [BCL2L11](/details-gene/10018) deficiency on cell viability, apoptosis rates (measured by TUNEL or cleaved caspase-3 staining), and inflammatory cytokine release (measured by ELISA) would be quantified to determine its necessity in the epithelial damage-response pathway. **Therapeutic Potential:** As a pro-apoptotic protein, [BCL2L11](/details-gene/10018) itself is a challenging direct target. However, its functional pathway is highly relevant for therapy. In oncology, where apoptosis is often evaded, therapeutic strategies aim to **activate** its downstream effects. BH3-mimetic drugs, which functionally replicate the action of [BCL2L11](/details-gene/10018) by inhibiting anti-apoptotic proteins like BCL-2, are already in clinical use for hematological malignancies. Conversely, in conditions characterized by excessive cell death, such as neurodegenerative diseases ([R-HSA-8863678](https://reactome.org/content/detail/R-HSA-8863678)), **inhibition** of the [BCL2L11](/details-gene/10018) pathway could be a viable neuroprotective strategy, potentially by preventing its activation or blocking its interaction with other Bcl-2 family members.

Genular Protein ID: 1322573751

Symbol: B2L11_HUMAN

Name: Bcl-2-like protein 11

UniProtKB Accession Codes:

O43521 A8K2W2 O43522 Q0MSE7 Q0MSE8 Q0MSE9 Q53R28 Q6JTU6 Q6T851 Q6TE14 Q6TE15 Q6TE16 Q6V402 Q8WYL6 Q8WYL7 Q8WYL8 Q8WYL9 Q8WYM0 Q8WYM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 11 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 30 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 48 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 45 PDBsum 45 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 20 Pumba 1 RNAct 1 Reactome 8 RefSeq 19 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9430630

Title: Bim: a novel member of the Bcl-2 family that promotes apoptosis.

PubMed ID: 9430630

DOI: 10.1093/emboj/17.2.384

PubMed ID: 11734221

Title: Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family.

PubMed ID: 11734221

DOI: 10.1016/s0014-5793(01)03145-3

PubMed ID: 12019181

Title: Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim.

PubMed ID: 12019181

PubMed ID: 11997495

Title: Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

PubMed ID: 11997495

DOI: 10.1128/mcb.22.11.3577-3589.2002

PubMed ID: 15147734

Title: Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis.

PubMed ID: 15147734

DOI: 10.1016/j.biocel.2003.12.015

PubMed ID: 17503221

Title: Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas.

PubMed ID: 17503221

DOI: 10.1007/s10495-007-0093-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15486195

Title: BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors.

PubMed ID: 15486195

DOI: 10.1158/1535-7163.1281.3.10

PubMed ID: 15661735

Title: Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL.

PubMed ID: 15661735

DOI: 10.1074/jbc.m413062200

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17289999

Title: Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

PubMed ID: 17289999

DOI: 10.1126/science.1133289

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21478148

Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.

PubMed ID: 21478148

DOI: 10.1074/jbc.m110.197707

PubMed ID: 22498477

Title: The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

PubMed ID: 22498477

DOI: 10.4161/auto.19084

PubMed ID: 22761832

Title: CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress.

PubMed ID: 22761832

DOI: 10.1371/journal.pone.0039586

PubMed ID: 23563182

Title: Polyubiquitination and proteasomal turnover controls the anti-apoptotic activity of Bcl-B.

PubMed ID: 23563182

DOI: 10.1038/onc.2013.99

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27013495

Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

PubMed ID: 27013495

DOI: 10.15252/embr.201541392

PubMed ID: 17389404

Title: Structural insights into the degradation of Mcl-1 induced by BH3 domains.

PubMed ID: 17389404

DOI: 10.1073/pnas.0701297104

PubMed ID: 18812174

Title: Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

PubMed ID: 18812174

DOI: 10.1016/j.febslet.2008.09.028

PubMed ID: 23235460

Title: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.

PubMed ID: 23235460

DOI: 10.1038/cddis.2012.178

Sequence Information:

  • Length: 198
  • Mass: 22171
  • Checksum: D75735E469CA6997
  • Sequence:
    • MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP 
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP 
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR 
MVILRLLRYI VRLVWRMH

Genular Protein ID: 550602877

Symbol: H7BZE5_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7BZE5

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 98
  • Mass: 10801
  • Checksum: F56CACE255B31688
  • Sequence:
    • MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QDRSPAPMSC DKSTQTPSPP 
CQAFNHYLSA MDDSAGSSLR IALHREVQWP LKWLAKSS

Genular Protein ID: 3546150739

Symbol: A0A0C4DH20_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DH20

Database IDs:

AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 75
  • Mass: 8171
  • Checksum: B461A639D86F9B06
  • Sequence:
    • MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QVSLCHPGWS ALVRSWLTAT 
SNSQVQAVLL PQPPK