Details for: DDT

Gene ID: 1652

Symbol: DDT

Ensembl ID: ENSG00000099977

Description: D-dopachrome tautomerase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.02
    Marker Score: 10604
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 4.85
    Marker Score: 4749
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 3.75
    Marker Score: 1631.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.33
    Marker Score: 3471
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.09
    Marker Score: 10976
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.99
    Marker Score: 8014
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.94
    Marker Score: 4880
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.78
    Marker Score: 7011
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.78
    Marker Score: 13318
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.58
    Marker Score: 4151
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.57
    Marker Score: 6280
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.55
    Marker Score: 21947
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.55
    Marker Score: 88208
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.52
    Marker Score: 19684
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.46
    Marker Score: 16038.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.45
    Marker Score: 1929
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.4
    Marker Score: 5454
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.4
    Marker Score: 7539
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.38
    Marker Score: 3375
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.37
    Marker Score: 3656
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.37
    Marker Score: 945
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.33
    Marker Score: 31370
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.31
    Marker Score: 14767
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.31
    Marker Score: 1347
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.31
    Marker Score: 17159
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.3
    Marker Score: 2434.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.28
    Marker Score: 23155
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.28
    Marker Score: 8452
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.28
    Marker Score: 1173.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.26
    Marker Score: 2019.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.24
    Marker Score: 938
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.21
    Marker Score: 9027
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.2
    Marker Score: 2236
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.18
    Marker Score: 717
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.16
    Marker Score: 9333
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.16
    Marker Score: 8320
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.15
    Marker Score: 2065
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.15
    Marker Score: 4040
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.14
    Marker Score: 3407
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.14
    Marker Score: 1519
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.13
    Marker Score: 3705
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.08
    Marker Score: 3723
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.08
    Marker Score: 116436
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.08
    Marker Score: 23450
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.08
    Marker Score: 4938
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.07
    Marker Score: 11155
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.06
    Marker Score: 3767
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.06
    Marker Score: 840
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.01
    Marker Score: 1213
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.99
    Marker Score: 703
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.99
    Marker Score: 747.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.98
    Marker Score: 628
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.97
    Marker Score: 7754
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.97
    Marker Score: 2211
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.97
    Marker Score: 699
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.97
    Marker Score: 5432
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.96
    Marker Score: 1974
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.95
    Marker Score: 1072
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.91
    Marker Score: 3811
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.91
    Marker Score: 711
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.91
    Marker Score: 1276
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9
    Marker Score: 64600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.88
    Marker Score: 2668
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.88
    Marker Score: 3932.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.88
    Marker Score: 649
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.88
    Marker Score: 3657
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.87
    Marker Score: 11953
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.87
    Marker Score: 1977
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.86
    Marker Score: 1832
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.84
    Marker Score: 1230.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.84
    Marker Score: 16007
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.83
    Marker Score: 1115
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.83
    Marker Score: 669
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.83
    Marker Score: 1951
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.82
    Marker Score: 9556
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.81
    Marker Score: 5382
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.81
    Marker Score: 385
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.79
    Marker Score: 4203
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.79
    Marker Score: 4860
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.78
    Marker Score: 882
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.78
    Marker Score: 1677
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.78
    Marker Score: 885
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.76
    Marker Score: 4780.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.76
    Marker Score: 2881
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.76
    Marker Score: 909
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.75
    Marker Score: 1188
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.75
    Marker Score: 44843
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.75
    Marker Score: 505
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.74
    Marker Score: 1070
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.73
    Marker Score: 2973
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.73
    Marker Score: 525
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.72
    Marker Score: 416
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.71
    Marker Score: 574
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.71
    Marker Score: 1453
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.7
    Marker Score: 399
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.7
    Marker Score: 1239
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7
    Marker Score: 406
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.69
    Marker Score: 543
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.68
    Marker Score: 330
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.68
    Marker Score: 1059

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Other Information

**Key characteristics:** * The D-dopachrome tautomerase gene is located on chromosome 17q21.1. * It is a protein of approximately 120 kDa. * It is a transmembrane protein that is expressed in the cytoplasm. * It is a key enzyme in the production of dopachrome, which is a signaling molecule that is involved in the regulation of inflammation and cell growth. **Pathways and functions:** * The D-dopachrome tautomerase gene is involved in the regulation of inflammation. It is expressed in cells that are activated in inflammation, such as macrophages and dendritic cells. * Dopachrome is a signaling molecule that is involved in the regulation of inflammation and cell growth. It acts by binding to receptors on immune cells and activating signaling pathways that lead to the production of cytokines and chemokines. * The D-dopachrome tautomerase gene is also involved in the regulation of cell growth. It is expressed in cells that are undergoing growth, such as epithelial cells and cancer cells. * The D-dopachrome tautomerase gene is a key regulator of inflammation and cell growth. Its expression and activity can be modulated by a variety of factors, including cytokines, growth factors, and hormones. **Clinical significance:** * Mutations in the D-dopachrome tautomerase gene have been linked to a number of human diseases, including cancer and autoimmune disorders. * The D-dopachrome tautomerase gene is a potential target for the development of new drugs for cancer and autoimmune disorders.

Genular Protein ID: 770504349

Symbol: DOPD_HUMAN

Name: D-dopachrome decarboxylase

UniProtKB Accession Codes:

P30046 B7Z522 O00774 O60787 Q13534

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 2 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 14 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 9 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9480844

Title: Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation.

PubMed ID: 9480844

DOI: 10.1006/bbrc.1998.8123

PubMed ID: 9716662

Title: Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF.

PubMed ID: 9716662

DOI: 10.1007/s003359900858

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 8267597

Title: Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole.

PubMed ID: 8267597

DOI: 10.1006/bbrc.1993.2524

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 10079069

Title: Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54-A resolution.

PubMed ID: 10079069

DOI: 10.1021/bi982184o

Sequence Information:

  • Length: 118
  • Mass: 12712
  • Checksum: 12FEF51908F342B7
  • Sequence:
    • MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL SGSTEPCAQL 
SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRILIRF FPLESWQIGK IGTVMTFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.