Details for: SIT1

Gene ID: 27240

Symbol: SIT1

Ensembl ID: ENSG00000137078

Description: signaling threshold regulating transmembrane adaptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.9820
    Cell Significance Index: -7.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.6048
    Cell Significance Index: -8.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.6771
    Cell Significance Index: -9.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.4236
    Cell Significance Index: -7.9200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 6.0436
    Cell Significance Index: 14.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.2304
    Cell Significance Index: 153.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.6598
    Cell Significance Index: 55.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.9860
    Cell Significance Index: -6.1000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.8686
    Cell Significance Index: 28.9100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.7493
    Cell Significance Index: 17.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6575
    Cell Significance Index: 195.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4337
    Cell Significance Index: 31.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1020
    Cell Significance Index: 209.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8557
    Cell Significance Index: 84.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7072
    Cell Significance Index: 638.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4725
    Cell Significance Index: 7.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4029
    Cell Significance Index: 65.5200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.3781
    Cell Significance Index: 3.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3053
    Cell Significance Index: 33.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1727
    Cell Significance Index: 11.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1555
    Cell Significance Index: 10.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0249
    Cell Significance Index: 0.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0076
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0130
    Cell Significance Index: -5.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0167
    Cell Significance Index: -1.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0170
    Cell Significance Index: -0.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0194
    Cell Significance Index: -14.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0205
    Cell Significance Index: -9.2900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0293
    Cell Significance Index: -0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0411
    Cell Significance Index: -8.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0456
    Cell Significance Index: -9.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0493
    Cell Significance Index: -8.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0516
    Cell Significance Index: -6.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0529
    Cell Significance Index: -2.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0654
    Cell Significance Index: -8.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0678
    Cell Significance Index: -1.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0700
    Cell Significance Index: -8.1600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0704
    Cell Significance Index: -1.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0743
    Cell Significance Index: -2.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0747
    Cell Significance Index: -13.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0779
    Cell Significance Index: -8.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0857
    Cell Significance Index: -6.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0967
    Cell Significance Index: -14.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1014
    Cell Significance Index: -12.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1040
    Cell Significance Index: -13.4400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1148
    Cell Significance Index: -1.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1177
    Cell Significance Index: -5.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1187
    Cell Significance Index: -9.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1216
    Cell Significance Index: -12.4200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1338
    Cell Significance Index: -1.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1634
    Cell Significance Index: -4.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1670
    Cell Significance Index: -9.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1813
    Cell Significance Index: -13.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1960
    Cell Significance Index: -9.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1961
    Cell Significance Index: -5.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2127
    Cell Significance Index: -9.4100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2378
    Cell Significance Index: -2.8100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2384
    Cell Significance Index: -2.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2446
    Cell Significance Index: -8.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2485
    Cell Significance Index: -9.4100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2599
    Cell Significance Index: -1.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2846
    Cell Significance Index: -7.2700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2869
    Cell Significance Index: -2.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2892
    Cell Significance Index: -2.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2899
    Cell Significance Index: -9.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3038
    Cell Significance Index: -6.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3092
    Cell Significance Index: -8.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3103
    Cell Significance Index: -8.1600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3169
    Cell Significance Index: -3.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3206
    Cell Significance Index: -8.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3347
    Cell Significance Index: -8.3500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3469
    Cell Significance Index: -5.1900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3475
    Cell Significance Index: -5.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3740
    Cell Significance Index: -9.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3854
    Cell Significance Index: -8.9100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3877
    Cell Significance Index: -9.4600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3886
    Cell Significance Index: -3.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3909
    Cell Significance Index: -10.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4012
    Cell Significance Index: -10.0200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.4052
    Cell Significance Index: -5.0900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.4127
    Cell Significance Index: -4.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4230
    Cell Significance Index: -9.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4279
    Cell Significance Index: -14.8700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4281
    Cell Significance Index: -5.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4288
    Cell Significance Index: -12.6300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4317
    Cell Significance Index: -6.1400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4382
    Cell Significance Index: -6.1500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4396
    Cell Significance Index: -11.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4403
    Cell Significance Index: -10.9800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.4409
    Cell Significance Index: -3.4300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4413
    Cell Significance Index: -3.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4462
    Cell Significance Index: -9.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SIT1 is a transmembrane protein with a unique structure, comprising an extracellular domain, a transmembrane domain, and an intracellular domain. Its expression is restricted to various immune cells, including mature T cells, B cells, and epithelial cells. SIT1 is highly expressed in cells that undergo rapid proliferation and activation, such as alpha-beta memory T cells and germinal center B cells. Its expression is also present in enterocytes and colon goblet cells, suggesting a potential role in maintaining epithelial barrier function. **Pathways and Functions:** SIT1 is involved in multiple signaling pathways that regulate T cell activation, proliferation, and differentiation. These pathways include: 1. **Adaptive immune response:** SIT1 interacts with T cell receptors (TCRs) and co-receptors, influencing the activation and proliferation of T cells. 2. **Regulation of T cell activation:** SIT1 modulates the activity of downstream signaling molecules, such as phospholipase C gamma (PLC-γ) and protein kinase C (PKC), to regulate T cell activation. 3. **T cell homeostasis:** SIT1 helps maintain the balance between T cell activation and quiescence by regulating the expression of transcription factors, such as NF-κB and T-bet. **Clinical Significance:** Dysregulation of SIT1 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** Alterations in SIT1 expression and function have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** SIT1 has been identified as a potential biomarker for cancer diagnosis and prognosis, particularly in lymphomas and leukemias. 3. **Immunodeficiency disorders:** Defects in SIT1 have been associated with impaired T cell function and increased susceptibility to infections in individuals with immunodeficiency disorders. In conclusion, SIT1 is a critical regulator of T cell activation and homeostasis, with implications for the development and treatment of immune-related disorders. Further research is needed to fully elucidate the mechanisms by which SIT1 influences immune function and to explore its potential as a therapeutic target.

Genular Protein ID: 483576381

Symbol: SIT1_HUMAN

Name: Signaling threshold-regulating transmembrane adapter 1

UniProtKB Accession Codes:

Q9Y3P8 B2RBP9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10209036

Title: SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T-cell activation.

PubMed ID: 10209036

DOI: 10.1084/jem.189.8.1181

PubMed ID: 11491537

Title: Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT).

PubMed ID: 11491537

DOI: 10.1007/s002510100328

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11433379

Title: Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).

PubMed ID: 11433379

DOI: 10.1002/1521-4141(200106)31:6<1825::aid-immu1825>3.0.co;2-v

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16160011

Title: Transmembrane adaptor molecules: a new category of lymphoid-cell markers.

PubMed ID: 16160011

DOI: 10.1182/blood-2005-06-2273

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 196
  • Mass: 21126
  • Checksum: 2A0C48C9466F7F07
  • Sequence:
    • MNQADPRLRA VCLWTLTSAA MSRGDNCTDL LALGIPSITQ AWGLWVLLGA VTLLFLISLA 
AHLSQWTRGR SRSHPGQGRS GESVEEVPLY GNLHYLQTGR LSQDPEPDQQ DPTLGGPARA 
AEEVMCYTSL QLRPPQGRIP GPGTPVKYSE VVLDSEPKSQ ASGPEPELYA SVCAQTRRAR 
ASFPDQAYAN SQPAAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.