Details for: IGHV1 67

Gene ID: 28463

Symbol: IGHV1 67

Ensembl ID: ENSG00000253274

Description: immunoglobulin heavy variable 1-67 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4445
    Cell Significance Index: 34.9900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3711
    Cell Significance Index: 4.8700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2646
    Cell Significance Index: 3.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2456
    Cell Significance Index: 3.5800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1373
    Cell Significance Index: 1.7400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0627
    Cell Significance Index: 0.9500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0100
    Cell Significance Index: -0.0900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0157
    Cell Significance Index: -0.1800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0206
    Cell Significance Index: -0.2100
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0227
    Cell Significance Index: -0.2300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0233
    Cell Significance Index: -0.2600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0294
    Cell Significance Index: -0.3800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0300
    Cell Significance Index: -0.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0304
    Cell Significance Index: -1.3800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0327
    Cell Significance Index: -0.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0341
    Cell Significance Index: -0.6300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0344
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0371
    Cell Significance Index: -0.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0379
    Cell Significance Index: -1.7700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0429
    Cell Significance Index: -0.2800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0463
    Cell Significance Index: -0.4700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0467
    Cell Significance Index: -0.2900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0521
    Cell Significance Index: -0.5600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0541
    Cell Significance Index: -0.5700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0596
    Cell Significance Index: -0.6600
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0608
    Cell Significance Index: -0.5300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0611
    Cell Significance Index: -0.9900
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0612
    Cell Significance Index: -0.5600
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0623
    Cell Significance Index: -0.3000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0644
    Cell Significance Index: -0.6000
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0654
    Cell Significance Index: -0.7000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0661
    Cell Significance Index: -0.6700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0707
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0716
    Cell Significance Index: -0.6700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0719
    Cell Significance Index: -0.6800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0722
    Cell Significance Index: -0.6700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0751
    Cell Significance Index: -0.6400
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0762
    Cell Significance Index: -0.6800
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0765
    Cell Significance Index: -0.5500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0767
    Cell Significance Index: -0.6800
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0780
    Cell Significance Index: -0.6800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0789
    Cell Significance Index: -0.4200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0842
    Cell Significance Index: -0.7900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0878
    Cell Significance Index: -1.0400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0907
    Cell Significance Index: -0.9700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0939
    Cell Significance Index: -1.1100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0956
    Cell Significance Index: -1.0300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0999
    Cell Significance Index: -1.1500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1020
    Cell Significance Index: -1.0800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1054
    Cell Significance Index: -0.6600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1103
    Cell Significance Index: -1.5000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1151
    Cell Significance Index: -1.1600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1152
    Cell Significance Index: -1.3600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1182
    Cell Significance Index: -1.0200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1256
    Cell Significance Index: -1.0700
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1315
    Cell Significance Index: -1.0100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1615
    Cell Significance Index: -1.6500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1704
    Cell Significance Index: -1.8500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1709
    Cell Significance Index: -2.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2210
    Cell Significance Index: -2.5100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2321
    Cell Significance Index: -2.3600
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.3299
    Cell Significance Index: -2.1500
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.3892
    Cell Significance Index: -2.7500
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.4758
    Cell Significance Index: -2.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGHV1-67 is a member of the immunoglobulin heavy chain locus (IGHV) family, which is a group of genes responsible for encoding the variable region of the heavy chain of immunoglobulins. The IGHV1-67 gene is characterized by its high degree of polymorphism, with a high frequency of mutations and rearrangements. This polymorphism allows for the generation of a diverse repertoire of antibodies, which is essential for the immune system's ability to recognize and respond to pathogens. IGHV1-67 is expressed in a wide range of cells, including IgA plasma cells, plasmablasts, IgG plasma cells, B cells, plasma cells, stromal cells, naive B cells, memory B cells, and megakaryocytes. Its expression is not limited to mature B cells, as it is also detected in early B cell development stages. **Pathways and Functions** IGHV1-67 plays a crucial role in the development and function of the immune system. The expression of IGHV1-67 is regulated by a complex interplay of transcriptional and post-transcriptional mechanisms. The gene is activated by the rearrangement of the immunoglobulin heavy chain locus during B cell development, which leads to the expression of a functional antibody. The IGHV1-67 gene is involved in several key pathways, including: 1. **Antibody production**: IGHV1-67 is responsible for encoding a variable region of the heavy chain of immunoglobulins, which is essential for the production of antibodies. 2. **B cell development**: The expression of IGHV1-67 is required for the development of mature B cells, which is a critical step in the immune system's ability to recognize and respond to pathogens. 3. **Immune tolerance**: IGHV1-67 is also involved in the regulation of immune tolerance, which is the ability of the immune system to distinguish between self and non-self antigens. **Clinical Significance** IGHV1-67 has significant clinical implications, particularly in the context of autoimmune diseases and cancers. The expression of IGHV1-67 has been associated with several diseases, including: 1. **Multiple sclerosis**: Studies have shown that IGHV1-67 is overexpressed in patients with multiple sclerosis, a chronic autoimmune disease that affects the central nervous system. 2. **Rheumatoid arthritis**: IGHV1-67 has also been linked to rheumatoid arthritis, a chronic autoimmune disease that affects the joints. 3. **Cancer**: The expression of IGHV1-67 has been detected in various types of cancer, including lymphoma and leukemia. In conclusion, IGHV1-67 is a highly expressed and polymorphic gene that plays a crucial role in the development and function of the immune system. Its clinical significance is evident in the context of autoimmune diseases and cancers, highlighting the need for further research into the mechanisms underlying its expression and function.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.