Details for: TRBJ1 5

Gene ID: 28631

Symbol: TRBJ1 5

Ensembl ID: ENSG00000282173

Description: T cell receptor beta joining 1-5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.1501
    Cell Significance Index: 52.0800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5544
    Cell Significance Index: 8.0800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2641
    Cell Significance Index: 1.4400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0817
    Cell Significance Index: 0.8800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0260
    Cell Significance Index: 0.3300
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.0158
    Cell Significance Index: 0.1300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0133
    Cell Significance Index: 0.1500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0159
    Cell Significance Index: -0.3100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0224
    Cell Significance Index: -0.3800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0253
    Cell Significance Index: -0.3300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0266
    Cell Significance Index: -0.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0306
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0314
    Cell Significance Index: -0.5400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0401
    Cell Significance Index: -0.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0406
    Cell Significance Index: -0.7500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0415
    Cell Significance Index: -0.4900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0456
    Cell Significance Index: -0.7800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0520
    Cell Significance Index: -0.4400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0559
    Cell Significance Index: -0.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0573
    Cell Significance Index: -0.7500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0591
    Cell Significance Index: -0.5600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0598
    Cell Significance Index: -0.7400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0602
    Cell Significance Index: -0.8000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0612
    Cell Significance Index: -0.5700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0623
    Cell Significance Index: -0.6900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0633
    Cell Significance Index: -0.7700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0672
    Cell Significance Index: -0.5800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0672
    Cell Significance Index: -0.7800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0700
    Cell Significance Index: -0.7100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0704
    Cell Significance Index: -0.8100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0711
    Cell Significance Index: -0.7400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0716
    Cell Significance Index: -0.8000
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0718
    Cell Significance Index: -0.6000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0723
    Cell Significance Index: -0.7300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0726
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0730
    Cell Significance Index: -0.7700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0743
    Cell Significance Index: -0.8600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0744
    Cell Significance Index: -0.7500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0749
    Cell Significance Index: -0.7300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0755
    Cell Significance Index: -0.8000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0756
    Cell Significance Index: -0.7100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0758
    Cell Significance Index: -0.7800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0779
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0780
    Cell Significance Index: -0.7500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0793
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0799
    Cell Significance Index: -0.7800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0799
    Cell Significance Index: -0.8700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0802
    Cell Significance Index: -0.8000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0829
    Cell Significance Index: -0.7000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0829
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0831
    Cell Significance Index: -0.7800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0837
    Cell Significance Index: -0.7500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0838
    Cell Significance Index: -0.7800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0848
    Cell Significance Index: -0.7900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0862
    Cell Significance Index: -0.8000
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0866
    Cell Significance Index: -0.8000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0898
    Cell Significance Index: -0.7900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0923
    Cell Significance Index: -0.7800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0926
    Cell Significance Index: -0.7500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0951
    Cell Significance Index: -0.7400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1008
    Cell Significance Index: -0.7500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1085
    Cell Significance Index: -0.8700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1090
    Cell Significance Index: -0.7500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1274
    Cell Significance Index: -1.5100
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.1367
    Cell Significance Index: -1.1200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1569
    Cell Significance Index: -0.8400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2526
    Cell Significance Index: -0.7700
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.4797
    Cell Significance Index: -1.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The TRBJ1 gene is located on chromosome 14q32.11, a region known for its high density of immune-related genes. 2. **Structure:** The TRBJ1 gene encodes for a protein that consists of 5 exons, which are joined by alternative splicing to form a mature protein. 3. **Expression:** TRBJ1 is expressed in a wide range of immune cells, including mature gamma-delta T cells, alpha-beta T cells, and natural killer cells. 4. **Function:** TRBJ1 plays a crucial role in the assembly and maturation of TCR complexes, which are essential for recognizing and responding to antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBJ1 is involved in the adaptive immune response, which involves the activation of immune cells in response to specific antigens. 2. **T Cell Receptor Complex Assembly:** TRBJ1 is essential for the assembly and maturation of TCR complexes, which are critical for the recognition and response to antigens. 3. **Immune Cell Development:** TRBJ1 is also involved in the development of immune cells, including alpha-beta T cells and gamma-delta T cells. 4. **Regulation of Immune Responses:** TRBJ1 plays a role in regulating immune responses, including the activation and proliferation of immune cells. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the TRBJ1 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Autoimmune Diseases:** Alterations in TRBJ1 expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer Immunotherapy:** TRBJ1 is being investigated as a potential target for cancer immunotherapy, as it plays a critical role in the recognition and response to tumor antigens. 4. **Vaccine Development:** TRBJ1 is also being explored as a potential component of vaccine development, as it can be used to enhance the recognition and response to vaccine antigens. In conclusion, the TRBJ1 gene plays a critical role in the regulation of T cell receptor function and immune response. Its widespread expression across various immune cells highlights its importance in the adaptive immune system. Further research is needed to fully elucidate the mechanisms by which TRBJ1 regulates immune responses and to explore its potential applications in immunotherapy and vaccine development.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.