Details for: TRBJ1 5

Gene ID: 28631

Symbol: TRBJ1 5

Ensembl ID: ENSG00000282173

Description: T cell receptor beta joining 1-5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.26
    Marker Score: 819
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.17
    Marker Score: 339
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.09
    Marker Score: 76
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.09
    Marker Score: 4,697
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.05
    Marker Score: 86
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.05
    Marker Score: 41
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.03
    Marker Score: 74
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 43
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 72
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 4

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The TRBJ1 gene is located on chromosome 14q32.11, a region known for its high density of immune-related genes. 2. **Structure:** The TRBJ1 gene encodes for a protein that consists of 5 exons, which are joined by alternative splicing to form a mature protein. 3. **Expression:** TRBJ1 is expressed in a wide range of immune cells, including mature gamma-delta T cells, alpha-beta T cells, and natural killer cells. 4. **Function:** TRBJ1 plays a crucial role in the assembly and maturation of TCR complexes, which are essential for recognizing and responding to antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBJ1 is involved in the adaptive immune response, which involves the activation of immune cells in response to specific antigens. 2. **T Cell Receptor Complex Assembly:** TRBJ1 is essential for the assembly and maturation of TCR complexes, which are critical for the recognition and response to antigens. 3. **Immune Cell Development:** TRBJ1 is also involved in the development of immune cells, including alpha-beta T cells and gamma-delta T cells. 4. **Regulation of Immune Responses:** TRBJ1 plays a role in regulating immune responses, including the activation and proliferation of immune cells. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the TRBJ1 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Autoimmune Diseases:** Alterations in TRBJ1 expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer Immunotherapy:** TRBJ1 is being investigated as a potential target for cancer immunotherapy, as it plays a critical role in the recognition and response to tumor antigens. 4. **Vaccine Development:** TRBJ1 is also being explored as a potential component of vaccine development, as it can be used to enhance the recognition and response to vaccine antigens. In conclusion, the TRBJ1 gene plays a critical role in the regulation of T cell receptor function and immune response. Its widespread expression across various immune cells highlights its importance in the adaptive immune system. Further research is needed to fully elucidate the mechanisms by which TRBJ1 regulates immune responses and to explore its potential applications in immunotherapy and vaccine development.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.