Details for: TRAJ4

Gene ID: 28751

Symbol: TRAJ4

Ensembl ID: ENSG00000211885

Description: T cell receptor alpha joining 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0799
    Cell Significance Index: 1.7500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0685
    Cell Significance Index: 0.8800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0187
    Cell Significance Index: 0.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0050
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0050
    Cell Significance Index: -0.0900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0068
    Cell Significance Index: -0.0900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0074
    Cell Significance Index: -0.1000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0082
    Cell Significance Index: -0.1100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0092
    Cell Significance Index: -0.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0101
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0104
    Cell Significance Index: -0.1200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0110
    Cell Significance Index: -0.0600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0123
    Cell Significance Index: -0.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0130
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0132
    Cell Significance Index: -0.1200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0152
    Cell Significance Index: -0.1800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0152
    Cell Significance Index: -0.1900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0153
    Cell Significance Index: -0.2100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0156
    Cell Significance Index: -0.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0160
    Cell Significance Index: -0.2000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0160
    Cell Significance Index: -0.1900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0166
    Cell Significance Index: -0.2000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0168
    Cell Significance Index: -0.1800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0170
    Cell Significance Index: -0.1400
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0182
    Cell Significance Index: -0.1700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0187
    Cell Significance Index: -0.1900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0196
    Cell Significance Index: -0.1700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0198
    Cell Significance Index: -0.2300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0200
    Cell Significance Index: -0.2300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0200
    Cell Significance Index: -0.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0208
    Cell Significance Index: -0.2300
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0210
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0215
    Cell Significance Index: -0.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0216
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0218
    Cell Significance Index: -0.2200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0218
    Cell Significance Index: -0.2100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0220
    Cell Significance Index: -0.1900
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0222
    Cell Significance Index: -0.2300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0226
    Cell Significance Index: -0.1900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0233
    Cell Significance Index: -0.2400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0237
    Cell Significance Index: -0.2400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0238
    Cell Significance Index: -0.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0245
    Cell Significance Index: -0.2600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0249
    Cell Significance Index: -0.2100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0258
    Cell Significance Index: -0.2400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0262
    Cell Significance Index: -0.2200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0263
    Cell Significance Index: -0.2300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0287
    Cell Significance Index: -0.2400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0314
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0321
    Cell Significance Index: -0.2600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0334
    Cell Significance Index: -0.2600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0363
    Cell Significance Index: -0.2900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0378
    Cell Significance Index: -0.2000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0390
    Cell Significance Index: -0.2900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0656
    Cell Significance Index: -0.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRAJ4 gene is a member of the T cell receptor (TCR) complex, which is essential for recognizing and binding to specific antigens. TRAJ4 is specifically involved in joining the TCR alpha chain to other components of the TCR, thereby forming a functional TCR-TCR complex. The TRAJ4 gene is highly expressed in various T cell subsets, including CD8+ alpha-beta T cells, CD4+ alpha-beta T cells, natural killer T cells, and innate lymphoid cells. These cells are critical components of the adaptive immune system, responsible for recognizing and responding to pathogens, tumor cells, and other foreign substances. **Pathways and Functions:** The TRAJ4 gene is integral to the TCR signaling pathway, which is a complex process involving multiple protein-protein interactions. Upon antigen recognition, the TCR complex undergoes conformational changes, triggering a cascade of signaling events that ultimately lead to T cell activation, proliferation, and differentiation. TRAJ4 plays a critical role in this process, facilitating the assembly and activation of the TCR-TCR complex. The gene's product interacts with other TCR components, including the TCR beta chain, to form a functional TCR complex. In addition to its role in TCR signaling, TRAJ4 has been implicated in the regulation of T cell development and function. The gene is highly expressed in thymocytes, the immature T cells that undergo maturation in the thymus. TRAJ4 is essential for the proper development and selection of T cells, ensuring that only functional, antigen-specific T cells are released into the periphery. **Clinical Significance:** The TRAJ4 gene has significant implications for our understanding of various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. Dysregulation of the TCR signaling pathway, including TRAJ4, has been implicated in the pathogenesis of several diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Furthermore, alterations in TRAJ4 expression have been observed in certain types of cancer, including melanoma and lymphoma. In addition to its role in disease pathogenesis, TRAJ4 has potential applications in immunotherapy. The gene's product has been shown to interact with other TCR components, potentially influencing the efficacy of T cell-based therapies. Further research is needed to fully elucidate the role of TRAJ4 in immunotherapy and to explore its potential as a therapeutic target. In conclusion, the TRAJ4 gene is a critical component of the human immune system, playing a vital role in T cell development, function, and signaling. Further research is needed to fully understand the intricacies of TRAJ4 and its implications for immunological disorders. As an expert immunologist, it is essential to continue exploring the potential applications of TRAJ4 in immunological research and therapy, with the ultimate goal of developing novel treatments for a range of immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.