Details for: TRAJ4

Gene ID: 28751

Symbol: TRAJ4

Ensembl ID: ENSG00000211885

Description: T cell receptor alpha joining 4

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.01
    Marker Score: 401
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.01
    Marker Score: 2
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: T cell (CL0000084)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: B cell (CL0000236)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 88
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRAJ4 gene is a member of the T cell receptor (TCR) complex, which is essential for recognizing and binding to specific antigens. TRAJ4 is specifically involved in joining the TCR alpha chain to other components of the TCR, thereby forming a functional TCR-TCR complex. The TRAJ4 gene is highly expressed in various T cell subsets, including CD8+ alpha-beta T cells, CD4+ alpha-beta T cells, natural killer T cells, and innate lymphoid cells. These cells are critical components of the adaptive immune system, responsible for recognizing and responding to pathogens, tumor cells, and other foreign substances. **Pathways and Functions:** The TRAJ4 gene is integral to the TCR signaling pathway, which is a complex process involving multiple protein-protein interactions. Upon antigen recognition, the TCR complex undergoes conformational changes, triggering a cascade of signaling events that ultimately lead to T cell activation, proliferation, and differentiation. TRAJ4 plays a critical role in this process, facilitating the assembly and activation of the TCR-TCR complex. The gene's product interacts with other TCR components, including the TCR beta chain, to form a functional TCR complex. In addition to its role in TCR signaling, TRAJ4 has been implicated in the regulation of T cell development and function. The gene is highly expressed in thymocytes, the immature T cells that undergo maturation in the thymus. TRAJ4 is essential for the proper development and selection of T cells, ensuring that only functional, antigen-specific T cells are released into the periphery. **Clinical Significance:** The TRAJ4 gene has significant implications for our understanding of various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. Dysregulation of the TCR signaling pathway, including TRAJ4, has been implicated in the pathogenesis of several diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Furthermore, alterations in TRAJ4 expression have been observed in certain types of cancer, including melanoma and lymphoma. In addition to its role in disease pathogenesis, TRAJ4 has potential applications in immunotherapy. The gene's product has been shown to interact with other TCR components, potentially influencing the efficacy of T cell-based therapies. Further research is needed to fully elucidate the role of TRAJ4 in immunotherapy and to explore its potential as a therapeutic target. In conclusion, the TRAJ4 gene is a critical component of the human immune system, playing a vital role in T cell development, function, and signaling. Further research is needed to fully understand the intricacies of TRAJ4 and its implications for immunological disorders. As an expert immunologist, it is essential to continue exploring the potential applications of TRAJ4 in immunological research and therapy, with the ultimate goal of developing novel treatments for a range of immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.