Details for: IGLV3 6

Gene ID: 28806

Symbol: IGLV3 6

Ensembl ID: ENSG00000253448

Description: immunoglobulin lambda variable 3-6 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0828
    Cell Significance Index: 0.9300
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.0174
    Cell Significance Index: 0.2000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0031
    Cell Significance Index: 0.0500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0124
    Cell Significance Index: -0.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0186
    Cell Significance Index: -0.5000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0206
    Cell Significance Index: -0.2100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0276
    Cell Significance Index: -0.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0333
    Cell Significance Index: -0.5400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0379
    Cell Significance Index: -0.4700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0382
    Cell Significance Index: -0.3900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0394
    Cell Significance Index: -0.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0406
    Cell Significance Index: -0.7500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0474
    Cell Significance Index: -0.6300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0483
    Cell Significance Index: -0.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0486
    Cell Significance Index: -0.6400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0488
    Cell Significance Index: -0.5400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0488
    Cell Significance Index: -0.6400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0503
    Cell Significance Index: -0.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0535
    Cell Significance Index: -1.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0549
    Cell Significance Index: -0.7100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0555
    Cell Significance Index: -0.7500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0556
    Cell Significance Index: -0.3700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0559
    Cell Significance Index: -0.6300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0567
    Cell Significance Index: -0.6700
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0621
    Cell Significance Index: -0.5400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0634
    Cell Significance Index: -0.6800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0646
    Cell Significance Index: -0.7600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0650
    Cell Significance Index: -0.7200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0665
    Cell Significance Index: -0.7000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0679
    Cell Significance Index: -0.7300
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0683
    Cell Significance Index: -0.6100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0684
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0695
    Cell Significance Index: -0.6500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0700
    Cell Significance Index: -0.6500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0703
    Cell Significance Index: -0.8500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0739
    Cell Significance Index: -0.6300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0739
    Cell Significance Index: -0.7500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0749
    Cell Significance Index: -0.7100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0752
    Cell Significance Index: -0.7000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0771
    Cell Significance Index: -0.7300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0772
    Cell Significance Index: -0.8200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0776
    Cell Significance Index: -0.7100
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0790
    Cell Significance Index: -0.7100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0803
    Cell Significance Index: -0.8300
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0839
    Cell Significance Index: -0.7500
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.0924
    Cell Significance Index: -0.6400
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0951
    Cell Significance Index: -0.7300
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1033
    Cell Significance Index: -0.8300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1041
    Cell Significance Index: -0.8800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1066
    Cell Significance Index: -1.2600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1074
    Cell Significance Index: -1.1400
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1082
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1087
    Cell Significance Index: -1.0200
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1090
    Cell Significance Index: -0.7700
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1140
    Cell Significance Index: -0.9900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1391
    Cell Significance Index: -1.1800
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1519
    Cell Significance Index: -0.7600
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.1932
    Cell Significance Index: -1.0300
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.2106
    Cell Significance Index: -0.9900
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.2213
    Cell Significance Index: -1.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene:** IGLV3-6 is a pseudogene, meaning it does not encode a protein-coding sequence. Instead, it is thought to be a remnant of a functional gene that has been lost through evolution. 2. **Widespread expression:** IGLV3-6 is expressed in a variety of immune cells, including macrophages, conventional dendritic cells, monocytes, granulocytes, and megakaryocytes. 3. **Cell-type specificity:** The expression of IGLV3-6 is cell-type specific, with some immune cells expressing it at higher levels than others. 4. **Evolutionary conservation:** IGLV3-6 has been conserved across species, suggesting that it may play a functional role in the immune system. **Pathways and Functions:** IGLV3-6 has been implicated in several pathways that are critical for immune function. These include: 1. **Antigen presentation:** IGLV3-6 has been shown to interact with major histocompatibility complex (MHC) class II molecules, facilitating the presentation of antigens to T-cells. 2. **Immune regulation:** IGLV3-6 has been implicated in the regulation of immune responses, including the modulation of cytokine production and the activation of immune cells. 3. **Cell signaling:** IGLV3-6 has been shown to interact with various signaling molecules, including cytokines and chemokines, to regulate immune cell function. **Clinical Significance:** The clinical significance of IGLV3-6 is an area of active research. While its pseudogene status may suggest that it is not directly involved in immune function, its widespread expression and cell-type specificity suggest that it may play a role in immune regulation. Further studies are needed to fully elucidate the functional role of IGLV3-6 in the immune system. Potential applications of IGLV3-6 research include: 1. **Immunotherapy:** Understanding the role of IGLV3-6 in immune regulation may lead to the development of novel immunotherapies that target specific immune cells or pathways. 2. **Autoimmune disease:** IGLV3-6 may play a role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis or lupus. Further studies are needed to determine its involvement in these diseases. 3. **Cancer immunology:** IGLV3-6 may be involved in the modulation of immune responses in cancer, leading to the development of novel cancer therapies. In conclusion, IGLV3-6 is a pseudogene that has been found to play a role in the development and function of immune cells. Further research is needed to fully elucidate its functional role in the immune system and to explore its potential applications in immunotherapy, autoimmune disease, and cancer immunology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.