Details for: IGKV1D 37

Gene ID: 28894

Symbol: IGKV1D 37

Ensembl ID: ENSG00000250036

Description: immunoglobulin kappa variable 1D-37 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0565
    Cell Significance Index: 0.6400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0073
    Cell Significance Index: -0.1000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0269
    Cell Significance Index: -0.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0309
    Cell Significance Index: -0.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0380
    Cell Significance Index: -0.4500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0405
    Cell Significance Index: -0.5200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0407
    Cell Significance Index: -0.4300
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0413
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0421
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0423
    Cell Significance Index: -0.4000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0462
    Cell Significance Index: -0.5700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0481
    Cell Significance Index: -0.3200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0482
    Cell Significance Index: -0.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0491
    Cell Significance Index: -1.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0525
    Cell Significance Index: -0.7200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0560
    Cell Significance Index: -0.6200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0591
    Cell Significance Index: -0.5400
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0598
    Cell Significance Index: -0.5300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0605
    Cell Significance Index: -0.6500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0641
    Cell Significance Index: -0.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0655
    Cell Significance Index: -1.2800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0658
    Cell Significance Index: -0.7000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0676
    Cell Significance Index: -0.7400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0693
    Cell Significance Index: -0.7300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0702
    Cell Significance Index: -0.5100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0725
    Cell Significance Index: -0.7400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0726
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0742
    Cell Significance Index: -0.7000
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0749
    Cell Significance Index: -0.6500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0760
    Cell Significance Index: -0.5000
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.0781
    Cell Significance Index: -0.4100
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0784
    Cell Significance Index: -0.6300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0787
    Cell Significance Index: -0.7500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0806
    Cell Significance Index: -0.7500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0823
    Cell Significance Index: -0.9300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0838
    Cell Significance Index: -0.5200
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: -0.0842
    Cell Significance Index: -0.6500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0852
    Cell Significance Index: -0.9800
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.0885
    Cell Significance Index: -0.6500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0973
    Cell Significance Index: -1.2800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1010
    Cell Significance Index: -0.8300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1021
    Cell Significance Index: -0.9800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1041
    Cell Significance Index: -1.2300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1092
    Cell Significance Index: -0.5800
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1095
    Cell Significance Index: -0.8800
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1110
    Cell Significance Index: -0.7800
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1151
    Cell Significance Index: -0.9500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1164
    Cell Significance Index: -1.0800
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1190
    Cell Significance Index: -0.6000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1242
    Cell Significance Index: -1.2600
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1273
    Cell Significance Index: -1.3100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1287
    Cell Significance Index: -1.2200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1297
    Cell Significance Index: -1.3100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1299
    Cell Significance Index: -1.2200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1345
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1363
    Cell Significance Index: -1.3100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1444
    Cell Significance Index: -1.2900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1449
    Cell Significance Index: -1.2500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1478
    Cell Significance Index: -1.2600
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.1622
    Cell Significance Index: -0.7600
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1641
    Cell Significance Index: -1.2600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1892
    Cell Significance Index: -1.7400
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1936
    Cell Significance Index: -1.2600
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.2279
    Cell Significance Index: -1.1400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.4003
    Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional gene**: IGKV1D-37 is a non-functional gene, meaning it does not encode for a functional protein. Despite this, it is still expressed in various stages of B-cell development. 2. **Significant expression**: IGKV1D-37 is significantly expressed in multiple B-cell subsets, including pro-B cells, pre-B cells, and mature B cells. 3. **Widespread expression**: IGKV1D-37 is expressed in various stages of B-cell development, from early pro-B cells to mature B cells. 4. **Adaptive immune response**: IGKV1D-37 is involved in the adaptive immune response, which is a complex process that involves the activation of B-lymphocytes in response to antigens. **Pathways and Functions:** 1. **Adaptive immune response**: IGKV1D-37 is involved in the adaptive immune response, which is a complex process that involves the activation of B-lymphocytes in response to antigens. 2. **Immunoglobulin complex**: IGKV1D-37 is part of the immunoglobulin complex, which is a multi-subunit complex composed of IgM, IgG, IgA, and IgE antibodies. 3. **Immunoglobulin production**: IGKV1D-37 is involved in the production of immunoglobulins, which are proteins that recognize and bind to specific antigens. 4. **Plasma membrane**: IGKV1D-37 is expressed on the surface of plasma cells, which are mature B cells that produce large quantities of immunoglobulins. **Clinical Significance:** 1. **B-cell development disorders**: IGKV1D-37's non-functional status and widespread expression make it a potential candidate for studying B-cell development disorders, such as X-linked agammaglobulinemia (XLA) and Bruton's agammaglobulinemia (BAG). 2. **Immunoglobulin disorders**: IGKV1D-37's involvement in immunoglobulin production and its expression on plasma cells make it a potential candidate for studying immunoglobulin disorders, such as IgM deficiency and IgG subclass deficiency. 3. **Cancer research**: IGKV1D-37's expression on plasma cells and its involvement in immunoglobulin production make it a potential candidate for studying cancer research, particularly in the context of B-cell lymphomas and leukemias. In conclusion, the non-functional IGKV1D-37 gene has a complex role in B-cell development and function, and its widespread expression across different B-cell subsets makes it an interesting subject for further investigation. Further studies are needed to fully understand the clinical significance of IGKV1D-37 and its potential implications in B-cell development disorders, immunoglobulin disorders, and cancer research.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.