Details for: MRPL13

Gene ID: 28998

Symbol: MRPL13

Ensembl ID: ENSG00000172172

Description: mitochondrial ribosomal protein L13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 183.6765
    Cell Significance Index: -28.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.2118
    Cell Significance Index: -29.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 89.1618
    Cell Significance Index: -36.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.4847
    Cell Significance Index: -39.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.7771
    Cell Significance Index: -32.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.8454
    Cell Significance Index: -37.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.7611
    Cell Significance Index: -39.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.5119
    Cell Significance Index: -32.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.2768
    Cell Significance Index: -37.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6915
    Cell Significance Index: -31.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9720
    Cell Significance Index: -39.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.2009
    Cell Significance Index: -28.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3248
    Cell Significance Index: 68.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2838
    Cell Significance Index: 10.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2714
    Cell Significance Index: 694.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1833
    Cell Significance Index: 145.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1185
    Cell Significance Index: 10.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0293
    Cell Significance Index: 185.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0079
    Cell Significance Index: 45.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9825
    Cell Significance Index: 159.7900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.9454
    Cell Significance Index: 10.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9140
    Cell Significance Index: 107.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8938
    Cell Significance Index: 31.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7964
    Cell Significance Index: 37.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7705
    Cell Significance Index: 54.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7616
    Cell Significance Index: 336.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7538
    Cell Significance Index: 19.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7288
    Cell Significance Index: 21.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7275
    Cell Significance Index: 99.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7045
    Cell Significance Index: 139.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6634
    Cell Significance Index: 9.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5986
    Cell Significance Index: 12.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5600
    Cell Significance Index: 112.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5374
    Cell Significance Index: 25.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5341
    Cell Significance Index: 14.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5133
    Cell Significance Index: 38.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4318
    Cell Significance Index: 9.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3927
    Cell Significance Index: 38.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3794
    Cell Significance Index: 72.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3544
    Cell Significance Index: 319.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3228
    Cell Significance Index: 20.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3126
    Cell Significance Index: 8.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2844
    Cell Significance Index: 36.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2695
    Cell Significance Index: 7.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2642
    Cell Significance Index: 13.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2588
    Cell Significance Index: 2.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2560
    Cell Significance Index: 32.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2125
    Cell Significance Index: 2.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1879
    Cell Significance Index: 67.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1817
    Cell Significance Index: 5.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1645
    Cell Significance Index: 3.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1535
    Cell Significance Index: 9.9000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1199
    Cell Significance Index: 1.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0506
    Cell Significance Index: 37.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0183
    Cell Significance Index: 13.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0046
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0071
    Cell Significance Index: -13.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0237
    Cell Significance Index: -43.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0281
    Cell Significance Index: -43.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0293
    Cell Significance Index: -2.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0323
    Cell Significance Index: -43.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0337
    Cell Significance Index: -21.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0339
    Cell Significance Index: -25.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0371
    Cell Significance Index: -2.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0415
    Cell Significance Index: -1.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0436
    Cell Significance Index: -19.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0538
    Cell Significance Index: -9.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0576
    Cell Significance Index: -32.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0716
    Cell Significance Index: -44.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0837
    Cell Significance Index: -6.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0973
    Cell Significance Index: -28.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1038
    Cell Significance Index: -5.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1327
    Cell Significance Index: -15.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1527
    Cell Significance Index: -1.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1568
    Cell Significance Index: -9.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1723
    Cell Significance Index: -19.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1948
    Cell Significance Index: -15.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1985
    Cell Significance Index: -28.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2166
    Cell Significance Index: -45.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2265
    Cell Significance Index: -3.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2359
    Cell Significance Index: -6.3100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2514
    Cell Significance Index: -2.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2775
    Cell Significance Index: -18.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3064
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3648
    Cell Significance Index: -37.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3856
    Cell Significance Index: -2.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4573
    Cell Significance Index: -13.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4602
    Cell Significance Index: -11.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4634
    Cell Significance Index: -9.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5064
    Cell Significance Index: -22.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5317
    Cell Significance Index: -32.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5549
    Cell Significance Index: -13.8700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5982
    Cell Significance Index: -3.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6164
    Cell Significance Index: -23.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6465
    Cell Significance Index: -8.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6573
    Cell Significance Index: -19.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7242
    Cell Significance Index: -12.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7941
    Cell Significance Index: -40.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8067
    Cell Significance Index: -14.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8417
    Cell Significance Index: -7.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL13 is a mitochondrial ribosomal protein that belongs to the L13 family of ribosomal proteins. It is a highly conserved protein across species, with high sequence identity among mammals. MRPL13 is a 39S ribosomal protein, which is a subunit of the mitochondrial large ribosomal subunit. This subunit is responsible for the translation of mitochondrial mRNAs into proteins. MRPL13 is also known as RM13_HUMAN, and its human homolog is encoded by the ENSG00000172172 gene. **Pathways and Functions:** MRPL13 is involved in various mitochondrial translation processes, including: 1. **Mitochondrial translation elongation**: MRPL13 plays a crucial role in the elongation phase of mitochondrial translation, where it interacts with other ribosomal proteins to facilitate the assembly of the mitochondrial ribosome. 2. **Mitochondrial translation initiation**: MRPL13 is also involved in the initiation phase of mitochondrial translation, where it helps to recruit the ribosome to the mRNA and position it correctly for translation. 3. **Mitochondrial translation termination**: MRPL13 participates in the termination phase of mitochondrial translation, where it interacts with other ribosomal proteins to facilitate the release of the completed protein. 4. **Negative regulation of translation**: MRPL13 can also act as a negative regulator of translation, where it inhibits the translation of certain mRNAs by interacting with other proteins. MRPL13 is also involved in various other cellular processes, including: 1. **Metabolism of proteins**: MRPL13 is involved in the regulation of protein synthesis and degradation, which is critical for cellular homeostasis. 2. **RNA binding**: MRPL13 can bind to various RNAs, including mRNAs, tRNAs, and rRNAs, which is essential for the regulation of translation and other cellular processes. 3. **Protein binding**: MRPL13 can interact with various proteins, including other ribosomal proteins, chaperones, and transcription factors, which is critical for the regulation of translation and other cellular processes. **Clinical Significance:** Dysregulation of MRPL13 has been implicated in various human diseases, including: 1. **Mitochondrial diseases**: Mutations in the MRPL13 gene have been linked to various mitochondrial diseases, including hypertrophic cardiomyopathy and muscular dystrophy. 2. **Cancer**: MRPL13 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumorigenesis. 3. **Neurodegenerative diseases**: MRPL13 has been implicated in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it may contribute to the development of these diseases. In conclusion, MRPL13 is a critical component of the mitochondrial ribosome, playing a vital role in the translation of mitochondrial mRNAs into proteins. Its dysregulation has been implicated in various human diseases, highlighting the importance of MRPL13 in maintaining cellular homeostasis. Further research is needed to fully understand the biology of MRPL13 and its role in human disease.

Genular Protein ID: 3852564861

Symbol: RM13_HUMAN

Name: 39S ribosomal protein L13, mitochondrial

UniProtKB Accession Codes:

Q9BYD1 B2R4R8 Q9UI04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 57 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11279069

Title: Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.

PubMed ID: 11279069

DOI: 10.1074/jbc.m100432200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 178
  • Mass: 20692
  • Checksum: AF4FD524CC234D52
  • Sequence:
    • MSSFSRAPQQ WATFARIWYL LDGKMQPPGK LAAMASIRLQ GLHKPVYHAL SDCGDHVVIM 
NTRHIAFSGN KWEQKVYSSH TGYPGGFRQV TAAQLHLRDP VAIVKLAIYG MLPKNLHRRT 
MMERLHLFPD EYIPEDILKN LVEELPQPRK IPKRLDEYTQ EEIDAFPRLW TPPEDYRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.