Details for: TMEM230

Gene ID: 29058

Symbol: TMEM230

Ensembl ID: ENSG00000089063

Description: transmembrane protein 230

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 375.7107
    Cell Significance Index: -58.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 204.2632
    Cell Significance Index: -51.8100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 173.9299
    Cell Significance Index: -71.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 147.6405
    Cell Significance Index: -59.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 147.4087
    Cell Significance Index: -69.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 129.0667
    Cell Significance Index: -66.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 104.0130
    Cell Significance Index: -69.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 63.6297
    Cell Significance Index: -60.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.2307
    Cell Significance Index: -69.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.0008
    Cell Significance Index: -58.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.3982
    Cell Significance Index: -72.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.8650
    Cell Significance Index: -42.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.9028
    Cell Significance Index: 100.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3239
    Cell Significance Index: 319.1300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9000
    Cell Significance Index: 15.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5540
    Cell Significance Index: 199.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4097
    Cell Significance Index: 254.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4072
    Cell Significance Index: 104.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4009
    Cell Significance Index: 172.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3748
    Cell Significance Index: 272.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3721
    Cell Significance Index: 36.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2986
    Cell Significance Index: 709.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2922
    Cell Significance Index: 83.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2763
    Cell Significance Index: 26.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1803
    Cell Significance Index: 61.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0224
    Cell Significance Index: 64.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0020
    Cell Significance Index: 46.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9370
    Cell Significance Index: 44.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8254
    Cell Significance Index: 296.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8023
    Cell Significance Index: 160.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7828
    Cell Significance Index: 101.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7238
    Cell Significance Index: 19.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6841
    Cell Significance Index: 6.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6818
    Cell Significance Index: 35.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6623
    Cell Significance Index: 78.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6380
    Cell Significance Index: 7.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6112
    Cell Significance Index: 17.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5093
    Cell Significance Index: 13.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5047
    Cell Significance Index: 86.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4342
    Cell Significance Index: 191.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4173
    Cell Significance Index: 7.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3842
    Cell Significance Index: 38.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3450
    Cell Significance Index: 24.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2852
    Cell Significance Index: 6.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2402
    Cell Significance Index: 45.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2324
    Cell Significance Index: 2.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1507
    Cell Significance Index: 4.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1283
    Cell Significance Index: 1.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1213
    Cell Significance Index: 2.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0814
    Cell Significance Index: 61.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0555
    Cell Significance Index: 40.7000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0539
    Cell Significance Index: 0.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0197
    Cell Significance Index: 37.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0083
    Cell Significance Index: -15.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0087
    Cell Significance Index: -0.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0115
    Cell Significance Index: -17.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0265
    Cell Significance Index: -19.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0382
    Cell Significance Index: -3.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0400
    Cell Significance Index: -54.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0482
    Cell Significance Index: -30.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0555
    Cell Significance Index: -34.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0773
    Cell Significance Index: -35.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0880
    Cell Significance Index: -49.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1246
    Cell Significance Index: -20.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1439
    Cell Significance Index: -30.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1765
    Cell Significance Index: -50.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1895
    Cell Significance Index: -22.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2084
    Cell Significance Index: -12.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2116
    Cell Significance Index: -11.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2839
    Cell Significance Index: -21.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2898
    Cell Significance Index: -8.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2905
    Cell Significance Index: -33.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3135
    Cell Significance Index: -8.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3224
    Cell Significance Index: -46.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3439
    Cell Significance Index: -9.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3620
    Cell Significance Index: -12.7200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3802
    Cell Significance Index: -2.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4028
    Cell Significance Index: -12.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4040
    Cell Significance Index: -32.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4526
    Cell Significance Index: -4.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5069
    Cell Significance Index: -13.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5861
    Cell Significance Index: -66.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5935
    Cell Significance Index: -10.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6002
    Cell Significance Index: -40.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6656
    Cell Significance Index: -69.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8123
    Cell Significance Index: -21.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8216
    Cell Significance Index: -14.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8413
    Cell Significance Index: -24.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0280
    Cell Significance Index: -8.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.1130
    Cell Significance Index: -50.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.1132
    Cell Significance Index: -16.6800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -1.1327
    Cell Significance Index: -7.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1328
    Cell Significance Index: -69.4500
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.1540
    Cell Significance Index: -6.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2963
    Cell Significance Index: -33.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3354
    Cell Significance Index: -59.0700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.3577
    Cell Significance Index: -19.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.4789
    Cell Significance Index: -54.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5586
    Cell Significance Index: -59.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.6121
    Cell Significance Index: -46.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM230 is a transmembrane protein, consisting of a single transmembrane domain and a short cytoplasmic tail. Its expression is widespread, with notable presence in cells of the kidney, retina, and immune system. The protein's structure and localization suggest it may play a role in cellular signaling, trafficking, or membrane organization. **Pathways and Functions:** TMEM230 has been implicated in various cellular processes, including: 1. **Autophagy**: TMEM230 has been associated with the autophagosome pathway, which is crucial for cellular degradation and recycling of damaged or dysfunctional organelles. 2. **Endomembrane system**: TMEM230 is also involved in the regulation of the endoplasmic reticulum, Golgi apparatus, and late endosomes, which are essential for protein synthesis, modification, and transport. 3. **Synaptic vesicle transport**: TMEM230 has been linked to the regulation of synaptic vesicle trafficking, which is critical for neuronal communication and learning. 4. **Cell signaling**: TMEM230 may act as a receptor or co-receptor for various signaling molecules, influencing cellular responses to external stimuli. **Clinical Significance:** While the functional significance of TMEM230 is still unclear, its widespread expression and involvement in critical cellular processes suggest potential implications for various diseases: 1. **Autophagy-related disorders**: Mutations in TMEM230 may contribute to autophagy-related disorders, such as type 2 diabetes, neurodegenerative diseases, or cancer. 2. **Neurological disorders**: TMEM230's involvement in synaptic vesicle transport and cell signaling may be linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, or schizophrenia. 3. **Cancer**: TMEM230's role in endomembrane system regulation and cell signaling may contribute to cancer development and progression. 4. **Kidney disease**: TMEM230's expression in kidney cells suggests a potential role in kidney function and disease, such as nephropathy or renal failure. In conclusion, while TMEM230's functional significance is still an open question, its widespread expression and involvement in critical cellular processes suggest a potential role in various diseases. Further research is necessary to elucidate the mechanisms by which TMEM230 contributes to disease and to explore its therapeutic potential.

Genular Protein ID: 2672087033

Symbol: TM230_HUMAN

Name: Transmembrane protein 230

UniProtKB Accession Codes:

Q96A57 B2RDM8 D3DVZ9 Q0VGC8 Q5TDS5 Q96ES2 Q9P0A7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 7 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 8 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27270108

Title: Identification of TMEM230 mutations in familial Parkinson's disease.

PubMed ID: 27270108

DOI: 10.1038/ng.3589

Sequence Information:

  • Length: 120
  • Mass: 13188
  • Checksum: 18A4A556330D77CE
  • Sequence:
    • MMPSRTNLAT GIPSSKVKYS RLSSTDDGYI DLQFKKTPPK IPYKAIALAT VLFLIGAFLI 
IIGSLLLSGY ISKGGADRAV PVLIIGILVF LPGFYHLRIA YYASKGYRGY SYDDIPDFDD

Genular Protein ID: 2571582055

Symbol: A0A087WTT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WTT2

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 3 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 127
  • Mass: 13586
  • Checksum: F00D9339CBC06800
  • Sequence:
    • MMPSRTNLAT GIPSSKVKYS RLSSTDDGYI DLQFKKTPPK IPYKAIALAT VLFLIGAFLI 
IIGSLLLSGY ISKGSLESTS REQKKADHKH LPASRGYMMG GISGRSPEGG LSSRLPEGRG 
TQVSSPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.