Details for: C11orf21

Gene ID: 29125

Symbol: C11orf21

Ensembl ID: ENSG00000110665

Description: chromosome 11 open reading frame 21

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7,219
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16,954
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,338
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.92
    Marker Score: 1,737
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.89
    Marker Score: 1,737
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.86
    Marker Score: 372
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.86
    Marker Score: 2,140
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.8
    Marker Score: 400
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.78
    Marker Score: 2,447
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.77
    Marker Score: 788
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.74
    Marker Score: 364
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.73
    Marker Score: 40,632
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.69
    Marker Score: 1,018
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.67
    Marker Score: 711
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.66
    Marker Score: 1,923
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.61
    Marker Score: 7,147
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.61
    Marker Score: 1,467
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.6
    Marker Score: 196
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.59
    Marker Score: 1,626
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.58
    Marker Score: 370
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 346
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.57
    Marker Score: 431
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.54
    Marker Score: 138
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.53
    Marker Score: 1,286
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.52
    Marker Score: 461
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 218
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.48
    Marker Score: 394
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.47
    Marker Score: 493
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.44
    Marker Score: 192
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.44
    Marker Score: 1,822
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 115
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.42
    Marker Score: 2,715
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.42
    Marker Score: 288
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.42
    Marker Score: 136
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.41
    Marker Score: 294
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4
    Marker Score: 212
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.39
    Marker Score: 507
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 184
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.38
    Marker Score: 187
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.37
    Marker Score: 267
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.36
    Marker Score: 127
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.36
    Marker Score: 934
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.35
    Marker Score: 486
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.35
    Marker Score: 311
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.35
    Marker Score: 79
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.34
    Marker Score: 189
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.34
    Marker Score: 17,895
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.34
    Marker Score: 174
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 222
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.34
    Marker Score: 296
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.33
    Marker Score: 3,382
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 330
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.32
    Marker Score: 110
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.31
    Marker Score: 605
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.31
    Marker Score: 150
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.31
    Marker Score: 546
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.29
    Marker Score: 133
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.29
    Marker Score: 199
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.29
    Marker Score: 73
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.29
    Marker Score: 244
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.28
    Marker Score: 168
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.27
    Marker Score: 176
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.27
    Marker Score: 292
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.27
    Marker Score: 1,107
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.26
    Marker Score: 85
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.26
    Marker Score: 727
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.25
    Marker Score: 144
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.24
    Marker Score: 152
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.24
    Marker Score: 56
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.24
    Marker Score: 183
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.24
    Marker Score: 182
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.23
    Marker Score: 80
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.23
    Marker Score: 178
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.23
    Marker Score: 68
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.23
    Marker Score: 141
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.22
    Marker Score: 94
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.22
    Marker Score: 115
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.22
    Marker Score: 144
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 96
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.22
    Marker Score: 5,529
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 444
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.21
    Marker Score: 433

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** C11orf21 is a non-coding gene, which implies that it does not encode a protein that can be easily characterized. However, its presence on the chromosome suggests that it may have regulatory functions, influencing gene expression or cellular behavior. The gene's expression in specific cell types, such as goblet cells, cardiac muscle myoblasts, and immune cells, highlights its potential involvement in tissue development and immune homeostasis. **Pathways and Functions:** The C11orf21 gene is primarily localized to the cytoplasm, which suggests that it may be involved in regulating cellular processes that occur outside the nucleus. Its expression in GABAergic interneurons and forebrain radial glial cells implies a role in neuronal development and function. Additionally, its presence in immune cells, such as monocytes and endothelial cells, suggests a potential involvement in immune regulation and inflammation. The C11orf21 gene may act as a regulator of gene expression, influencing the transcription of other genes involved in immune responses or cellular differentiation. Its unique expression profile and cellular localization suggest that it may be involved in the regulation of cellular behavior, such as cell proliferation, differentiation, or survival. **Clinical Significance:** The identification of C11orf21 as an immune-regulatory gene has significant implications for our understanding of immune-related disorders. Dysregulation of immune responses has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancer. Further studies on C11orf21 may reveal its role in modulating immune responses and its potential as a therapeutic target for immune-related diseases. Moreover, the C11orf21 gene's expression in various cell types, including those involved in tissue development and regeneration, suggests that it may have implications for understanding and treating diseases related to tissue injury or degeneration, such as cardiovascular disease or neurodegenerative disorders. In conclusion, the C11orf21 gene is a novel player in the regulation of immune responses and tissue development. Further research is needed to fully elucidate its functional significance and potential therapeutic applications. As an expert immunologist, I believe that C11orf21 holds great promise for advancing our understanding of immune regulation and developing novel therapeutic strategies for immune-related diseases.

Genular Protein ID: 3231752919

Symbol: CK021_HUMAN

Name: Uncharacterized protein C11orf21

UniProtKB Accession Codes:

Q9P2W6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 RNAct 1 RefSeq 2 SAM 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11054561

Title: C11orf21, a novel gene within the Beckwith-Wiedemann syndrome region in human chromosome 11p15.5.

PubMed ID: 11054561

DOI: 10.1016/s0378-1119(00)00377-2

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 132
  • Mass: 14447
  • Checksum: 3D8A2246EC0A7683
  • Sequence:
    • MGRTWCGMWR RRRPGRRSAV PRWPHLSSQS GVEPPDRWTG TPGWPSRDQE APGSMMPPAA 
AQPSAHGALV PPATAHEPVD HPALHWLACC CCLSLPGQLP LAIRLGWDLD LEAGPSSGKL 
CPRARRWQPL PS

Genular Protein ID: 3451272737

Symbol: E9PAM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PAM5

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 2 SAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 178
  • Mass: 18563
  • Checksum: 8D713E4EE64CCD6E
  • Sequence:
    • MASFLVWPLR TALRGGKSWA GPGVGCGGDG ARGGGELSLS NLDLPGAGEA GLEHHPLLGH 
LFISAVPRWP HLSSQSGVEP PDRWTGTPGW PSRDQEAPGS MMPPAAAQPS AHGALVPPAT 
AHEPVDHPAL HWLACCCCLS LPGQLPLAIR LGWDLDLEAG PSSGKLCPRA RRWQPLPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.