Details for: C11orf21

Gene ID: 29125

Symbol: C11orf21

Ensembl ID: ENSG00000110665

Description: chromosome 11 open reading frame 21

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 8.4956
    Cell Significance Index: -4.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.9389
    Cell Significance Index: -1.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.7738
    Cell Significance Index: -3.4200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.4577
    Cell Significance Index: 15.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.1348
    Cell Significance Index: -3.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.0948
    Cell Significance Index: -4.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.9181
    Cell Significance Index: -2.8200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.6645
    Cell Significance Index: 1.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4796
    Cell Significance Index: 12.8300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4724
    Cell Significance Index: 6.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4624
    Cell Significance Index: 13.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4089
    Cell Significance Index: -0.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3601
    Cell Significance Index: 9.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3047
    Cell Significance Index: 19.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2478
    Cell Significance Index: 4.5800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.2457
    Cell Significance Index: 1.6300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1469
    Cell Significance Index: 2.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1385
    Cell Significance Index: 10.6300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.1182
    Cell Significance Index: 0.8500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0924
    Cell Significance Index: 0.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0239
    Cell Significance Index: 3.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0025
    Cell Significance Index: -0.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0051
    Cell Significance Index: -2.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0061
    Cell Significance Index: -4.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0092
    Cell Significance Index: -4.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0099
    Cell Significance Index: -3.5500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0100
    Cell Significance Index: -0.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0140
    Cell Significance Index: -0.7100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0168
    Cell Significance Index: -0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0169
    Cell Significance Index: -3.3900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0180
    Cell Significance Index: -0.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0190
    Cell Significance Index: -1.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0206
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0210
    Cell Significance Index: -3.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0211
    Cell Significance Index: -0.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0219
    Cell Significance Index: -3.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0234
    Cell Significance Index: -3.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0255
    Cell Significance Index: -3.7100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0281
    Cell Significance Index: -1.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0311
    Cell Significance Index: -4.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0324
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0326
    Cell Significance Index: -3.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0344
    Cell Significance Index: -0.9600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0352
    Cell Significance Index: -0.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0372
    Cell Significance Index: -3.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0422
    Cell Significance Index: -0.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0455
    Cell Significance Index: -1.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0464
    Cell Significance Index: -2.1800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0499
    Cell Significance Index: -0.6400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0513
    Cell Significance Index: -0.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0541
    Cell Significance Index: -4.0300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0584
    Cell Significance Index: -0.7400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0595
    Cell Significance Index: -0.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0605
    Cell Significance Index: -2.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0623
    Cell Significance Index: -3.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0731
    Cell Significance Index: -1.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0743
    Cell Significance Index: -3.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0748
    Cell Significance Index: -4.2000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0782
    Cell Significance Index: -0.6600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0813
    Cell Significance Index: -0.9200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0853
    Cell Significance Index: -1.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0909
    Cell Significance Index: -4.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0920
    Cell Significance Index: -4.1700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0941
    Cell Significance Index: -1.8400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0948
    Cell Significance Index: -1.6100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0958
    Cell Significance Index: -1.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0962
    Cell Significance Index: -3.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0992
    Cell Significance Index: -2.7000
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.1024
    Cell Significance Index: -0.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1072
    Cell Significance Index: -4.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1100
    Cell Significance Index: -1.5800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1195
    Cell Significance Index: -0.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1204
    Cell Significance Index: -4.4200
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1223
    Cell Significance Index: -1.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1235
    Cell Significance Index: -3.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1252
    Cell Significance Index: -4.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1280
    Cell Significance Index: -3.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1294
    Cell Significance Index: -4.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1302
    Cell Significance Index: -1.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1321
    Cell Significance Index: -4.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1330
    Cell Significance Index: -2.6000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1375
    Cell Significance Index: -1.0700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1375
    Cell Significance Index: -1.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1392
    Cell Significance Index: -3.9900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1404
    Cell Significance Index: -1.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1414
    Cell Significance Index: -2.9600
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.1445
    Cell Significance Index: -0.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1445
    Cell Significance Index: -3.6100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1446
    Cell Significance Index: -2.3200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1492
    Cell Significance Index: -2.0300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1517
    Cell Significance Index: -1.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1531
    Cell Significance Index: -4.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1532
    Cell Significance Index: -3.8200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1543
    Cell Significance Index: -2.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1552
    Cell Significance Index: -3.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** C11orf21 is a non-coding gene, which implies that it does not encode a protein that can be easily characterized. However, its presence on the chromosome suggests that it may have regulatory functions, influencing gene expression or cellular behavior. The gene's expression in specific cell types, such as goblet cells, cardiac muscle myoblasts, and immune cells, highlights its potential involvement in tissue development and immune homeostasis. **Pathways and Functions:** The C11orf21 gene is primarily localized to the cytoplasm, which suggests that it may be involved in regulating cellular processes that occur outside the nucleus. Its expression in GABAergic interneurons and forebrain radial glial cells implies a role in neuronal development and function. Additionally, its presence in immune cells, such as monocytes and endothelial cells, suggests a potential involvement in immune regulation and inflammation. The C11orf21 gene may act as a regulator of gene expression, influencing the transcription of other genes involved in immune responses or cellular differentiation. Its unique expression profile and cellular localization suggest that it may be involved in the regulation of cellular behavior, such as cell proliferation, differentiation, or survival. **Clinical Significance:** The identification of C11orf21 as an immune-regulatory gene has significant implications for our understanding of immune-related disorders. Dysregulation of immune responses has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancer. Further studies on C11orf21 may reveal its role in modulating immune responses and its potential as a therapeutic target for immune-related diseases. Moreover, the C11orf21 gene's expression in various cell types, including those involved in tissue development and regeneration, suggests that it may have implications for understanding and treating diseases related to tissue injury or degeneration, such as cardiovascular disease or neurodegenerative disorders. In conclusion, the C11orf21 gene is a novel player in the regulation of immune responses and tissue development. Further research is needed to fully elucidate its functional significance and potential therapeutic applications. As an expert immunologist, I believe that C11orf21 holds great promise for advancing our understanding of immune regulation and developing novel therapeutic strategies for immune-related diseases.

Genular Protein ID: 3231752919

Symbol: CK021_HUMAN

Name: Uncharacterized protein C11orf21

UniProtKB Accession Codes:

Q9P2W6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11054561

Title: C11orf21, a novel gene within the Beckwith-Wiedemann syndrome region in human chromosome 11p15.5.

PubMed ID: 11054561

DOI: 10.1016/s0378-1119(00)00377-2

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 132
  • Mass: 14447
  • Checksum: 3D8A2246EC0A7683
  • Sequence:
    • MGRTWCGMWR RRRPGRRSAV PRWPHLSSQS GVEPPDRWTG TPGWPSRDQE APGSMMPPAA 
AQPSAHGALV PPATAHEPVD HPALHWLACC CCLSLPGQLP LAIRLGWDLD LEAGPSSGKL 
CPRARRWQPL PS

Genular Protein ID: 3451272737

Symbol: E9PAM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PAM5

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 2 SAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 178
  • Mass: 18563
  • Checksum: 8D713E4EE64CCD6E
  • Sequence:
    • MASFLVWPLR TALRGGKSWA GPGVGCGGDG ARGGGELSLS NLDLPGAGEA GLEHHPLLGH 
LFISAVPRWP HLSSQSGVEP PDRWTGTPGW PSRDQEAPGS MMPPAAAQPS AHGALVPPAT 
AHEPVDHPAL HWLACCCCLS LPGQLPLAIR LGWDLDLEAG PSSGKLCPRA RRWQPLPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.