Details for: HBZP1

Gene ID: 3051

Symbol: HBZP1

Ensembl ID: ENSG00000206178

Description: hemoglobin subunit zeta pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.7760
    Cell Significance Index: 11.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1463
    Cell Significance Index: 2.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0122
    Cell Significance Index: 0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0026
    Cell Significance Index: -0.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0044
    Cell Significance Index: -0.1500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0047
    Cell Significance Index: -0.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0090
    Cell Significance Index: -0.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0108
    Cell Significance Index: -0.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0110
    Cell Significance Index: -0.2200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0114
    Cell Significance Index: -0.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0117
    Cell Significance Index: -0.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0135
    Cell Significance Index: -0.4300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0142
    Cell Significance Index: -0.1700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0176
    Cell Significance Index: -0.1900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0218
    Cell Significance Index: -0.2400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0218
    Cell Significance Index: -0.2900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0222
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0232
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0234
    Cell Significance Index: -0.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0238
    Cell Significance Index: -0.4700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0271
    Cell Significance Index: -0.3800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0366
    Cell Significance Index: -0.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0372
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0379
    Cell Significance Index: -0.4000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0418
    Cell Significance Index: -0.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0448
    Cell Significance Index: -1.2000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0559
    Cell Significance Index: -0.6700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0561
    Cell Significance Index: -0.5100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0578
    Cell Significance Index: -0.5900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0584
    Cell Significance Index: -0.3800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0640
    Cell Significance Index: -0.3800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0682
    Cell Significance Index: -0.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0874
    Cell Significance Index: -1.2900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0889
    Cell Significance Index: -1.1100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0893
    Cell Significance Index: -1.1300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0899
    Cell Significance Index: -1.0500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0979
    Cell Significance Index: -1.0000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0979
    Cell Significance Index: -1.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0990
    Cell Significance Index: -1.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1016
    Cell Significance Index: -1.2000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1172
    Cell Significance Index: -1.5300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1192
    Cell Significance Index: -1.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1312
    Cell Significance Index: -1.5500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1321
    Cell Significance Index: -2.1400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1390
    Cell Significance Index: -1.5700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1417
    Cell Significance Index: -1.6300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1774
    Cell Significance Index: -2.1800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1781
    Cell Significance Index: -1.3700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1852
    Cell Significance Index: -2.0600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1893
    Cell Significance Index: -1.9600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1902
    Cell Significance Index: -1.5700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.2576
    Cell Significance Index: -2.3300
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: -0.2715
    Cell Significance Index: -1.5700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2772
    Cell Significance Index: -3.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogenic nature:** HBZP1 is a pseudogene, meaning it has been inactivated through mutations or deletions, rendering it non-functional in terms of encoding a protein. 2. **Wide tissue expression:** HBZP1 is significantly expressed in various cell types, including erythroid lineage cells, macrophages, fibroblasts, epithelial cells, and dendritic cells. 3. **Cell-type specific expression:** The expression levels of HBZP1 vary across different cell types, suggesting a possible role in regulating gene expression or cellular differentiation. 4. **Conservation across species:** The HBZP1 gene is conserved across different species, including humans, mice, and rats, indicating its evolutionary significance. **Pathways and Functions:** 1. **Gene regulation:** HBZP1 may play a role in regulating gene expression by influencing the activity of transcription factors or epigenetic modifiers. 2. **Cellular differentiation:** The expression of HBZP1 in erythroid lineage cells and other cell types may be involved in regulating cellular differentiation and development. 3. **Immunomodulation:** The presence of HBZP1 in dendritic cells and macrophages suggests a possible role in modulating immune responses. 4. **Stress response:** HBZP1 may be involved in the cellular response to stress, such as oxidative stress or hypoxia, by regulating the expression of stress-related genes. **Clinical Significance:** 1. **Cancer association:** The overexpression of HBZP1 has been linked to various types of cancer, including leukemia, lymphoma, and solid tumors, suggesting a potential role in tumorigenesis. 2. **Inflammatory diseases:** The expression of HBZP1 in macrophages and dendritic cells may contribute to the development of inflammatory diseases, such as atherosclerosis and arthritis. 3. **Neurological disorders:** The presence of HBZP1 in retinal pigment epithelial cells and dendritic cells may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and multiple sclerosis. 4. **Personalized medicine:** The study of HBZP1 expression patterns may provide valuable insights into the development of targeted therapies for various diseases. In conclusion, the HBZP1 gene is a complex and enigmatic element that challenges our understanding of pseudogenes and their role in the human genome. Further research is needed to elucidate the pathways and functions associated with HBZP1 and its clinical significance, ultimately leading to the development of novel therapeutic strategies for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.