HDAC2 | ENSG00000196591 | NCBI 3066

Details for: HDAC2

Gene ID: 3066

Symbol: HDAC2

Ensembl ID: ENSG00000196591

Description: histone deacetylase 2

Associated with

Adipogenesis
(R-HSA-9843745)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Death receptor signaling
(R-HSA-73887)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Egr2 and sox10-mediated initiation of schwann cell myelination
(R-HSA-9619665)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdacs deacetylate histones
(R-HSA-3214815)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mecp2 regulates neuronal receptors and channels
(R-HSA-9022699)
Metabolism of proteins
(R-HSA-392499)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nervous system development
(R-HSA-9675108)
Norc negatively regulates rrna expression
(R-HSA-427413)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
P75ntr negatively regulates cell cycle via sc1
(R-HSA-193670)
Pip3 activates akt signaling
(R-HSA-1257604)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Potential therapeutics for sars
(R-HSA-9679191)
Pten regulation
(R-HSA-6807070)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of pten gene transcription
(R-HSA-8943724)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through acetylation
(R-HSA-6804758)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Sars-cov infections
(R-HSA-9679506)
Signaling by alk
(R-HSA-201556)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Stat3 nuclear events downstream of alk signaling
(R-HSA-9701898)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcriptional regulation of brown and beige adipocyte differentiation
(R-HSA-9843743)
Transcriptional regulation of brown and beige adipocyte differentiation by ebf2
(R-HSA-9844594)
Viral infection pathways
(R-HSA-9824446)
Cardiac muscle hypertrophy
(GO:0003300)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Dendrite development
(GO:0016358)
Enzyme binding
(GO:0019899)
Epidermal cell differentiation
(GO:0009913)
Heat shock protein binding
(GO:0031072)
Heterochromatin formation
(GO:0031507)
Histone binding
(GO:0042393)
Histone deacetylase activity
(GO:0004407)
Histone deacetylase binding
(GO:0042826)
Histone decrotonylase activity
(GO:0160009)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of transcription by competitive promoter binding
(GO:0010944)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nf-kappab binding
(GO:0051059)
Nucleosomal dna binding
(GO:0031492)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein de-2-hydroxyisobutyrylase activity
(GO:0160010)
Protein lysine deacetylase activity
(GO:0033558)
Response to amphetamine
(GO:0001975)
Response to caffeine
(GO:0031000)
Response to xenobiotic stimulus
(GO:0009410)
Rna binding
(GO:0003723)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 248.4808
Cell Significance Index: -38.6500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 160.5798
Cell Significance Index: -40.7300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 124.9040
Cell Significance Index: -58.9700
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 124.5547
Cell Significance Index: -51.3100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 118.1025
Cell Significance Index: -47.9800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 108.9845
Cell Significance Index: -56.0600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 88.2236
Cell Significance Index: -59.2000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 50.6524
Cell Significance Index: -48.3600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 42.8320
Cell Significance Index: -52.8100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.4776
Cell Significance Index: -46.8200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.3409
Cell Significance Index: -56.5900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.4083
Cell Significance Index: -35.0400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.1622
Cell Significance Index: -15.6800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 5.6957
Cell Significance Index: 61.9200
Cell Name: kidney cell (CL1000497)
Fold Change: 5.2391
Cell Significance Index: 41.8300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.5185
Cell Significance Index: 94.5800
Cell Name: germ cell (CL0000586)
Fold Change: 3.8513
Cell Significance Index: 29.0800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.8392
Cell Significance Index: 133.4100
Cell Name: granulosa cell (CL0000501)
Fold Change: 3.8049
Cell Significance Index: 100.0500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.6219
Cell Significance Index: 46.3900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.3117
Cell Significance Index: 31.5400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.9420
Cell Significance Index: 211.2400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.7879
Cell Significance Index: 100.3300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.5111
Cell Significance Index: 207.5100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.4891
Cell Significance Index: 39.7600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3371
Cell Significance Index: 265.3500
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2690
Cell Significance Index: 693.0300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1636
Cell Significance Index: 143.0800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.1553
Cell Significance Index: 60.1800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1465
Cell Significance Index: 206.6700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0667
Cell Significance Index: 213.9800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9343
Cell Significance Index: 48.5400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8800
Cell Significance Index: 56.7800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8575
Cell Significance Index: 23.3400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.8557
Cell Significance Index: 52.6000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.8329
Cell Significance Index: 43.7300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7846
Cell Significance Index: 346.8800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.6829
Cell Significance Index: 88.2200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.6575
Cell Significance Index: 6.0600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6247
Cell Significance Index: 80.0800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5980
Cell Significance Index: 28.1100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5613
Cell Significance Index: 39.7000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5494
Cell Significance Index: 197.0700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4592
Cell Significance Index: 31.7600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4315
Cell Significance Index: 42.6800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4009
Cell Significance Index: 47.2800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3951
Cell Significance Index: 11.3900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3820
Cell Significance Index: 17.8100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3769
Cell Significance Index: 28.0900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3690
Cell Significance Index: 60.0200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3296
Cell Significance Index: 7.1400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2791
Cell Significance Index: 47.6500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2188
Cell Significance Index: 151.3400
Cell Name: peg cell (CL4033014)
Fold Change: 0.1831
Cell Significance Index: 4.2300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1247
Cell Significance Index: 23.7400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1238
Cell Significance Index: 3.4600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1189
Cell Significance Index: 107.3200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0789
Cell Significance Index: 1.3200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0330
Cell Significance Index: 62.1700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0228
Cell Significance Index: 0.3900
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.0043
Cell Significance Index: 0.0600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0004
Cell Significance Index: 0.6800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0002
Cell Significance Index: -0.4100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0078
Cell Significance Index: -4.9300
Cell Name: theca cell (CL0000503)
Fold Change: -0.0119
Cell Significance Index: -0.0700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0126
Cell Significance Index: -7.8500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0181
Cell Significance Index: -24.5700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0198
Cell Significance Index: -15.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0269
Cell Significance Index: -19.9500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0300
Cell Significance Index: -22.0300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0477
Cell Significance Index: -21.6700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0586
Cell Significance Index: -1.7200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0623
Cell Significance Index: -2.1900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0702
Cell Significance Index: -39.5700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0784
Cell Significance Index: -11.3900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0854
Cell Significance Index: -8.7200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1101
Cell Significance Index: -4.8700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1208
Cell Significance Index: -25.4400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1211
Cell Significance Index: -3.8800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1541
Cell Significance Index: -17.6600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1639
Cell Significance Index: -12.5800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1655
Cell Significance Index: -1.0000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1666
Cell Significance Index: -47.9300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2342
Cell Significance Index: -8.8700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2509
Cell Significance Index: -6.4100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2573
Cell Significance Index: -29.9800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3114
Cell Significance Index: -19.6300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3131
Cell Significance Index: -21.0500
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3169
Cell Significance Index: -7.6000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3550
Cell Significance Index: -7.5600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3600
Cell Significance Index: -41.0900
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.4196
Cell Significance Index: -2.7300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5126
Cell Significance Index: -53.3700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5553
Cell Significance Index: -6.6200
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.5744
Cell Significance Index: -4.8200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5836
Cell Significance Index: -46.2200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5942
Cell Significance Index: -6.7500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6036
Cell Significance Index: -16.1500
Cell Name: sensory neuron (CL0000101)
Fold Change: -0.6263
Cell Significance Index: -3.5600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.6593
Cell Significance Index: -18.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Histone Deacetylase Activity**: HDAC2 possesses histone deacetylase activity, which allows it to remove acetyl groups from histones, leading to chromatin compaction and transcriptional repression. 2. **Chromatin Binding**: HDAC2 interacts with chromatin, facilitating its remodeling and reorganization. 3. **Regulation of Gene Expression**: HDAC2 modulates gene expression by influencing the activity of transcription factors, DNA methylation, and histone modifications. 4. **Signaling Pathways**: HDAC2 is involved in multiple signaling pathways, including Notch, Wnt, and Hedgehog, which are crucial for development, cell fate determination, and tissue homeostasis. 5. **Cellular Location**: HDAC2 is primarily found in the nucleus, where it regulates gene expression and interacts with chromatin. **Pathways and Functions** 1. **Cardiac Muscle Hypertrophy**: HDAC2 regulates cardiac muscle hypertrophy by modulating the expression of genes involved in cardiac development and function. 2. **Circadian Regulation of Gene Expression**: HDAC2 plays a role in the regulation of circadian rhythms by influencing the expression of genes involved in the body's internal clock. 3. **Chromatin Remodeling**: HDAC2 participates in chromatin remodeling, which is essential for gene expression regulation and cellular differentiation. 4. **Infectious Disease**: HDAC2 has been implicated in the regulation of immune responses to viral infections, such as HIV and SARS-CoV. 5. **Neurological Disorders**: HDAC2 is involved in the regulation of gene expression in the nervous system, and its dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. **Clinical Significance** 1. **Cancer Therapy**: HDAC2 is a potential target for cancer therapy, as its inhibition has been shown to induce apoptosis and inhibit tumor growth in various cancer types. 2. **Neurological Disorders**: HDAC2 inhibitors have been investigated as potential treatments for neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Infectious Disease**: HDAC2 inhibitors have been explored as potential therapeutic agents for the treatment of infectious diseases, such as HIV and SARS-CoV. 4. **Cardiovascular Disease**: HDAC2 has been implicated in the regulation of cardiac function and has been investigated as a potential target for the treatment of cardiovascular disease. 5. **Regenerative Medicine**: HDAC2 has been shown to play a role in the regulation of stem cell differentiation and has been investigated as a potential target for regenerative medicine. In conclusion, HDAC2 is a multifunctional enzyme that plays a critical role in regulating gene expression, cellular differentiation, and response to environmental stimuli. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic intervention.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

HDAC2_HUMAN

Genular Protein ID: 2675874660

Symbol: HDAC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92769 B3KRS5 B4DL58 E1P561 Q5SRI8 Q5SZ86 Q8NEH4

Database IDs:

Citations:

PubMed ID: 8917507

Title: Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.

PubMed ID: 8917507

DOI: 10.1073/pnas.93.23.12845

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10545197

Title: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.

PubMed ID: 10545197

DOI: 10.1021/bi991614n

PubMed ID: 10644367

Title: A role for SKIP in EBNA2 activation of CBF1-repressed promoters.

PubMed ID: 10644367

DOI: 10.1128/jvi.74.4.1939-1947.2000

PubMed ID: 10888872

Title: DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.

PubMed ID: 10888872

DOI: 10.1038/77023

PubMed ID: 10904264

Title: NuRD and SIN3 histone deacetylase complexes in development.

PubMed ID: 10904264

DOI: 10.1016/s0168-9525(00)02066-7

PubMed ID: 11331609

Title: Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.

PubMed ID: 11331609

DOI: 10.1101/gad.871201

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 11739383

Title: Isolation and characterization of a novel class II histone deacetylase, HDAC10.

PubMed ID: 11739383

DOI: 10.1074/jbc.m108055200

PubMed ID: 12176973

Title: The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.

PubMed ID: 12176973

DOI: 10.1074/jbc.c200378200

PubMed ID: 12140263

Title: Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.

PubMed ID: 12140263

DOI: 10.1242/jcs.115.16.3319

PubMed ID: 12402037

Title: Acetylation inactivates the transcriptional repressor BCL6.

PubMed ID: 12402037

DOI: 10.1038/ng1018

PubMed ID: 14633989

Title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

PubMed ID: 14633989

DOI: 10.1093/emboj/cdg595

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 12493763

Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

PubMed ID: 12493763

DOI: 10.1074/jbc.m208992200

PubMed ID: 12724404

Title: Identification and characterization of three new components of the mSin3A corepressor complex.

PubMed ID: 12724404

DOI: 10.1128/mcb.23.10.3456-3467.2003

PubMed ID: 15456770

Title: The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains.

PubMed ID: 15456770

DOI: 10.1074/jbc.m406831200

PubMed ID: 15060175

Title: Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.

PubMed ID: 15060175

DOI: 10.1093/nar/gkh524

PubMed ID: 15701600

Title: MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

PubMed ID: 15701600

DOI: 10.1074/jbc.m413492200

PubMed ID: 15927959

Title: Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

PubMed ID: 15927959

DOI: 10.1074/jbc.m413687200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 16820529

Title: SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.

PubMed ID: 16820529

DOI: 10.1093/nar/gkl401

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19061646

Title: CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.

PubMed ID: 19061646

DOI: 10.1016/j.molcel.2008.10.025

PubMed ID: 18212045

Title: CtBP is an essential corepressor for BCL6 autoregulation.

PubMed ID: 18212045

DOI: 10.1128/mcb.01400-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18757745

Title: RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.

PubMed ID: 18757745

DOI: 10.1073/pnas.0709227105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19433865

Title: Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

PubMed ID: 19433865

DOI: 10.1074/jbc.m109.007237

PubMed ID: 19343227

Title: FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

PubMed ID: 19343227

DOI: 10.1371/journal.pone.0005071

PubMed ID: 19182791

Title: Chfr is linked to tumour metastasis through the downregulation of HDAC1.

PubMed ID: 19182791

DOI: 10.1038/ncb1837

PubMed ID: 19729656

Title: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

PubMed ID: 19729656

DOI: 10.1126/science.1176709

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20523938

Title: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.

PubMed ID: 20523938

DOI: 10.1039/c004108d

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21965678

Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

PubMed ID: 21965678

DOI: 10.1074/jbc.m111.267237

PubMed ID: 21914818

Title: A BEN-domain-containing protein associates with heterochromatin and represses transcription.

PubMed ID: 21914818

DOI: 10.1242/jcs.086603

PubMed ID: 21549307

Title: Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

PubMed ID: 21549307

DOI: 10.1016/j.molcel.2011.02.036

PubMed ID: 21573134

Title: Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.

PubMed ID: 21573134

DOI: 10.1371/journal.pgen.1002065

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22926524

Title: RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.

PubMed ID: 22926524

DOI: 10.1038/onc.2012.386

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24970816

Title: The subcellular distribution and function of MTA1 in cancer differentiation.

PubMed ID: 24970816

DOI: 10.18632/oncotarget.2095

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28497810

Title: Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

PubMed ID: 28497810

DOI: 10.1038/cr.2017.68

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 20392638

Title: Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.

PubMed ID: 20392638

DOI: 10.1016/j.bmcl.2010.03.091

PubMed ID: 37137925

Title: Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.

PubMed ID: 37137925

DOI: 10.1038/s41467-023-38276-0

Sequence Information:

Length: 488
Mass: 55364
Checksum: 775419CCCDAE07FA
Sequence:

MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG 
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT 
KSEQLSNP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HDAC2

Associated with

Cells (max top 100)

Other Information

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. PubMed ID: 8917507

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. PubMed ID: 10545197

A role for SKIP in EBNA2 activation of CBF1-repressed promoters. PubMed ID: 10644367

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. PubMed ID: 10888872

NuRD and SIN3 histone deacetylase complexes in development. PubMed ID: 10904264

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. PubMed ID: 11331609

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. PubMed ID: 11533236

Isolation and characterization of a novel class II histone deacetylase, HDAC10. PubMed ID: 11739383

The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. PubMed ID: 12176973

Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. PubMed ID: 12140263

Acetylation inactivates the transcriptional repressor BCL6. PubMed ID: 12402037

Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. PubMed ID: 14633989

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. PubMed ID: 12670868

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. PubMed ID: 12493763

Identification and characterization of three new components of the mSin3A corepressor complex. PubMed ID: 12724404

The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains. PubMed ID: 15456770

Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. PubMed ID: 15060175

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. PubMed ID: 15701600

Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. PubMed ID: 15927959

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. PubMed ID: 16428440

SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. PubMed ID: 16820529

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. PubMed ID: 19061646

CtBP is an essential corepressor for BCL6 autoregulation. PubMed ID: 18212045

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition. PubMed ID: 18757745

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. PubMed ID: 19433865

FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PubMed ID: 19343227

Chfr is linked to tumour metastasis through the downregulation of HDAC1. PubMed ID: 19182791

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. PubMed ID: 19729656

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. PubMed ID: 20523938

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. PubMed ID: 21965678

A BEN-domain-containing protein associates with heterochromatin and represses transcription. PubMed ID: 21914818

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. PubMed ID: 21549307

Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. PubMed ID: 21573134

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. PubMed ID: 22926524

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

The subcellular distribution and function of MTA1 in cancer differentiation. PubMed ID: 24970816

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. PubMed ID: 25593309

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. PubMed ID: 28497810

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PubMed ID: 28977666

Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. PubMed ID: 29192674

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. PubMed ID: 32051553

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. PubMed ID: 33283408

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. PubMed ID: 20392638

Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. PubMed ID: 37137925