HDAC2 | ENSG00000196591 | NCBI 3066

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Analyzed for its expression specificity (CSI Z-SCORE), histone deacetylase 2 ([HDAC2](/details-gene/3066)) demonstrates a broad and non-specific expression profile, suggesting a fundamental and ubiquitous role in chromatin regulation across diverse cell lineages. Its function is not as a defining marker for a specific cell type but rather as a core component of the transcriptional machinery responsible for epigenetic modulation. Evidence points to its consistent expression in a wide range of progenitor and stem cells, implicating it in the fundamental processes of development, cell fate specification, and the maintenance of cellular identity. ## Cellular Roles and Expression Landscape The expression analysis, based on specificity (CSI Z-SCORE), reveals that [HDAC2](/details-gene/3066) does not serve as a unique identifier for any particular cell population. The uniformly low CSI (Z-SCORE) of 0.00 and non-significant p-values across all top-ranked cells indicate that its expression is widespread rather than concentrated in a specific cell type. This pattern is characteristic of genes involved in essential, or 'housekeeping,' cellular functions. Despite the lack of specificity, the data highlights its consistent presence in a variety of progenitor and stem cell populations within the **Overall** context. These include hematopoietic precursors such as [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), [common myeloid progenitor](/details-cell/CL0000049), and [hematopoietic stem cell](/details-cell/CL0000037), as well as neural precursors like [neuroblast (sensu Vertebrata)](/details-cell/CL0000031) and [radial glial cell](/details-cell/CL0000681). This broad expression in undifferentiated and actively differentiating cells underscores its likely role in governing the dynamic changes in gene expression required for lineage commitment and development. The consistent expression across these diverse progenitors suggests that [HDAC2](/details-gene/3066) is a key enzymatic component for modulating chromatin accessibility, a process crucial for both maintaining pluripotency and enabling differentiation programs. ## Pathways and Molecular Function The functional annotations for [HDAC2](/details-gene/3066) strongly support its role as a master epigenetic regulator, which explains its broad cellular expression pattern. As a histone deacetylase, its primary molecular function is to remove acetyl groups from lysine residues on histones, leading to more compact chromatin and transcriptional repression. This is captured by Gene Ontology terms such as '[Histone deacetylase activity](/details-go/GO:0004407)' and its localization to the '[Nucleus](/details-go/GO:0005634)' and '[Chromatin](/details-go/GO:0000785)'. [HDAC2](/details-gene/3066) is a core component of several major transcriptional repressor complexes, including the NuRD and Sin3 complexes, as supported by published research (PubMed: [10904264](https://pubmed.ncbi.nlm.nih.gov/10904264/)) and GO annotations '[Nurd complex](/details-go/GO:0016581)' and '[Sin3-type complex](/details-go/GO:0070822)'. These complexes are critical for global gene regulation. Its involvement in high-level biological processes is extensive, as shown by its annotation in Reactome pathways like '[Chromatin modifying enzymes](https://reactome.org/content/detail/R-HSA-3247509)', '[Gene expression (transcription)](https://reactome.org/content/detail/R-HSA-74160)', and '[Developmental biology](https://reactome.org/content/detail/R-HSA-1266738)'. The breadth of these pathways aligns perfectly with the expression data, indicating that [HDAC2](/details-gene/3066) is a pleiotropic regulator integral to the cellular machinery of numerous, if not all, cell types, particularly during dynamic developmental states. Its interaction with key transcription factors like YY1 (PubMed: [8917507](https://pubmed.ncbi.nlm.nih.gov/8917507/)) and its role in regulating TP53 activity (Reactome: '[R-HSA-5633007](https://reactome.org/content/detail/R-HSA-5633007)') further cement its status as a central hub in the gene regulatory network. ## Research Directions The ubiquitous expression of [HDAC2](/details-gene/3066), particularly in progenitor cells, suggests that its function is highly context-dependent, likely dictated by its protein interaction partners rather than its sheer presence. Future research should focus on dissecting the composition and targets of HDAC2-containing complexes in different cell lineages. ### Testable Hypotheses: 1. **Hypothesis 1: In hematopoietic progenitors, [HDAC2](/details-gene/3066) maintains stemness by forming a complex with lineage-specific transcription factors to repress key differentiation genes.** The consistent expression in [hematopoietic stem cell](/details-cell/CL0000037) and other progenitors suggests a role in preventing premature differentiation. * **Experimental Approach:** Perform conditional knockout or CRISPRi-mediated knockdown of `HDAC2` in primary human CD34+ hematopoietic stem and progenitor cells. Analyze the resulting changes in differentiation trajectories towards myeloid and lymphoid lineages using single-cell RNA sequencing and flow cytometry. Concurrently, use ChIP-seq to identify genomic sites where HDAC2 binding is lost and correlate these with upregulated differentiation-associated genes. 2. **Hypothesis 2: The enzymatic activity of [HDAC2](/details-gene/3066) is differentially regulated in neural versus hematopoietic progenitors to control distinct developmental programs.** While expressed in both [neuroblasts](/details-cell/CL0000031) and [common myeloid progenitors](/details-cell/CL0000049), its functional output is likely tailored to each lineage. * **Experimental Approach:** Employ proximity-dependent biotinylation (BioID) in both a neural progenitor cell line and a hematopoietic progenitor cell line to identify differential protein interactors of [HDAC2](/details-gene/3066). This will reveal lineage-specific complex compositions that can be validated by co-immunoprecipitation. 3. **Hypothesis 3: Cellular stress signals, such as oxidative stress or DNA damage, cause a genome-wide redistribution of [HDAC2](/details-gene/3066) binding in stem cells to prioritize survival and repair pathways over differentiation.** This is suggested by its annotated roles in responding to stimuli like hydrogen peroxide ('[GO:0070301](https://www.ebi.ac.uk/QuickGO/term/GO:0070301)') and its association with DNA repair proteins (PubMed: [10545197](https://pubmed.ncbi.nlm.nih.gov/10545197/)). * **Experimental Approach:** Expose a [stem cell](/details-cell/CL0000034) population (e.g., iPSCs) to a sublethal dose of H2O2. Perform time-course ChIP-seq for [HDAC2](/details-gene/3066) to map its dynamic relocalization from developmental gene promoters to stress-response gene loci. Correlate these binding changes with transcriptional output measured by RNA-seq. ### Therapeutic Potential: The central role of [HDAC2](/details-gene/3066) in gene regulation has made it a target for therapeutic intervention, particularly in cancer, where epigenetic dysregulation is common. Non-specific HDAC inhibitors (HDACi) are already in clinical use. However, the ubiquitous expression of [HDAC2](/details-gene/3066) leads to significant off-target effects. The therapeutic frontier lies in developing strategies to target HDAC2 activity in a cell-type or disease-specific manner. This could involve creating inhibitors that disrupt specific protein-protein interactions (e.g., blocking HDAC2 from binding to an oncogenic transcription factor) rather than its catalytic site, or developing cell-type-specific delivery systems for existing HDACi. Such approaches could increase efficacy while minimizing the toxicity associated with broad epigenetic modulation.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

HDAC2_HUMAN

Genular Protein ID: 2675874660

Symbol: HDAC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92769 B3KRS5 B4DL58 E1P561 Q5SRI8 Q5SZ86 Q8NEH4

Database IDs:

Citations:

PubMed ID: 8917507

Title: Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.

PubMed ID: 8917507

DOI: 10.1073/pnas.93.23.12845

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10545197

Title: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.

PubMed ID: 10545197

DOI: 10.1021/bi991614n

PubMed ID: 10644367

Title: A role for SKIP in EBNA2 activation of CBF1-repressed promoters.

PubMed ID: 10644367

DOI: 10.1128/jvi.74.4.1939-1947.2000

PubMed ID: 10888872

Title: DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.

PubMed ID: 10888872

DOI: 10.1038/77023

PubMed ID: 10904264

Title: NuRD and SIN3 histone deacetylase complexes in development.

PubMed ID: 10904264

DOI: 10.1016/s0168-9525(00)02066-7

PubMed ID: 11331609

Title: Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.

PubMed ID: 11331609

DOI: 10.1101/gad.871201

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 11739383

Title: Isolation and characterization of a novel class II histone deacetylase, HDAC10.

PubMed ID: 11739383

DOI: 10.1074/jbc.m108055200

PubMed ID: 12176973

Title: The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.

PubMed ID: 12176973

DOI: 10.1074/jbc.c200378200

PubMed ID: 12140263

Title: Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.

PubMed ID: 12140263

DOI: 10.1242/jcs.115.16.3319

PubMed ID: 12402037

Title: Acetylation inactivates the transcriptional repressor BCL6.

PubMed ID: 12402037

DOI: 10.1038/ng1018

PubMed ID: 14633989

Title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

PubMed ID: 14633989

DOI: 10.1093/emboj/cdg595

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 12493763

Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

PubMed ID: 12493763

DOI: 10.1074/jbc.m208992200

PubMed ID: 12724404

Title: Identification and characterization of three new components of the mSin3A corepressor complex.

PubMed ID: 12724404

DOI: 10.1128/mcb.23.10.3456-3467.2003

PubMed ID: 15456770

Title: The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains.

PubMed ID: 15456770

DOI: 10.1074/jbc.m406831200

PubMed ID: 15060175

Title: Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.

PubMed ID: 15060175

DOI: 10.1093/nar/gkh524

PubMed ID: 15701600

Title: MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

PubMed ID: 15701600

DOI: 10.1074/jbc.m413492200

PubMed ID: 15927959

Title: Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

PubMed ID: 15927959

DOI: 10.1074/jbc.m413687200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 16820529

Title: SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.

PubMed ID: 16820529

DOI: 10.1093/nar/gkl401

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19061646

Title: CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.

PubMed ID: 19061646

DOI: 10.1016/j.molcel.2008.10.025

PubMed ID: 18212045

Title: CtBP is an essential corepressor for BCL6 autoregulation.

PubMed ID: 18212045

DOI: 10.1128/mcb.01400-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18757745

Title: RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.

PubMed ID: 18757745

DOI: 10.1073/pnas.0709227105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19433865

Title: Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

PubMed ID: 19433865

DOI: 10.1074/jbc.m109.007237

PubMed ID: 19343227

Title: FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

PubMed ID: 19343227

DOI: 10.1371/journal.pone.0005071

PubMed ID: 19182791

Title: Chfr is linked to tumour metastasis through the downregulation of HDAC1.

PubMed ID: 19182791

DOI: 10.1038/ncb1837

PubMed ID: 19729656

Title: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

PubMed ID: 19729656

DOI: 10.1126/science.1176709

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20523938

Title: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.

PubMed ID: 20523938

DOI: 10.1039/c004108d

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21965678

Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

PubMed ID: 21965678

DOI: 10.1074/jbc.m111.267237

PubMed ID: 21914818

Title: A BEN-domain-containing protein associates with heterochromatin and represses transcription.

PubMed ID: 21914818

DOI: 10.1242/jcs.086603

PubMed ID: 21549307

Title: Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

PubMed ID: 21549307

DOI: 10.1016/j.molcel.2011.02.036

PubMed ID: 21573134

Title: Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.

PubMed ID: 21573134

DOI: 10.1371/journal.pgen.1002065

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22926524

Title: RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.

PubMed ID: 22926524

DOI: 10.1038/onc.2012.386

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24970816

Title: The subcellular distribution and function of MTA1 in cancer differentiation.

PubMed ID: 24970816

DOI: 10.18632/oncotarget.2095

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28497810

Title: Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

PubMed ID: 28497810

DOI: 10.1038/cr.2017.68

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 20392638

Title: Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.

PubMed ID: 20392638

DOI: 10.1016/j.bmcl.2010.03.091

PubMed ID: 37137925

Title: Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.

PubMed ID: 37137925

DOI: 10.1038/s41467-023-38276-0

Sequence Information:

Length: 488
Mass: 55364
Checksum: 775419CCCDAE07FA
Sequence:

MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG 
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT 
KSEQLSNP

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Axilla UBERON0009472
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: HDAC2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. PubMed ID: 8917507

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. PubMed ID: 10545197

A role for SKIP in EBNA2 activation of CBF1-repressed promoters. PubMed ID: 10644367

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. PubMed ID: 10888872

NuRD and SIN3 histone deacetylase complexes in development. PubMed ID: 10904264

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. PubMed ID: 11331609

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. PubMed ID: 11533236

Isolation and characterization of a novel class II histone deacetylase, HDAC10. PubMed ID: 11739383

The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. PubMed ID: 12176973

Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. PubMed ID: 12140263

Acetylation inactivates the transcriptional repressor BCL6. PubMed ID: 12402037

Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. PubMed ID: 14633989

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. PubMed ID: 12670868

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. PubMed ID: 12493763

Identification and characterization of three new components of the mSin3A corepressor complex. PubMed ID: 12724404

The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains. PubMed ID: 15456770

Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. PubMed ID: 15060175

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. PubMed ID: 15701600

Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. PubMed ID: 15927959

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. PubMed ID: 16428440

SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. PubMed ID: 16820529

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. PubMed ID: 19061646

CtBP is an essential corepressor for BCL6 autoregulation. PubMed ID: 18212045

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition. PubMed ID: 18757745

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. PubMed ID: 19433865

FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PubMed ID: 19343227

Chfr is linked to tumour metastasis through the downregulation of HDAC1. PubMed ID: 19182791

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. PubMed ID: 19729656

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. PubMed ID: 20523938

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. PubMed ID: 21965678

A BEN-domain-containing protein associates with heterochromatin and represses transcription. PubMed ID: 21914818

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. PubMed ID: 21549307

Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. PubMed ID: 21573134

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. PubMed ID: 22926524

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

The subcellular distribution and function of MTA1 in cancer differentiation. PubMed ID: 24970816

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. PubMed ID: 25593309

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. PubMed ID: 28497810

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PubMed ID: 28977666

Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. PubMed ID: 29192674

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. PubMed ID: 32051553

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. PubMed ID: 33283408

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. PubMed ID: 20392638

Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex. PubMed ID: 37137925