Gene HDAC2 - ENSG00000196591 | NCBI Gene ID: 3066

Details for: HDAC2

Gene ID: 3066

Symbol: HDAC2

Ensembl ID: ENSG00000196591

Description: histone deacetylase 2

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Death receptor signaling
(R-HSA-73887)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Egr2 and sox10-mediated initiation of schwann cell myelination
(R-HSA-9619665)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of oxidative stress, metabolic and neuronal genes
(R-HSA-9615017)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdacs deacetylate histones
(R-HSA-3214815)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mecp2 regulates neuronal receptors and channels
(R-HSA-9022699)
Metabolism of proteins
(R-HSA-392499)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nervous system development
(R-HSA-9675108)
Norc negatively regulates rrna expression
(R-HSA-427413)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
P75ntr negatively regulates cell cycle via sc1
(R-HSA-193670)
Pip3 activates akt signaling
(R-HSA-1257604)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Potential therapeutics for sars
(R-HSA-9679191)
Pten regulation
(R-HSA-6807070)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of pten gene transcription
(R-HSA-8943724)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through acetylation
(R-HSA-6804758)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Sars-cov infections
(R-HSA-9679506)
Signaling by alk
(R-HSA-201556)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Stat3 nuclear events downstream of alk signaling
(R-HSA-9701898)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation by tp53
(R-HSA-3700989)
Viral infection pathways
(R-HSA-9824446)
Cardiac muscle hypertrophy
(GO:0003300)
Cellular response to heat
(GO:0034605)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Circadian regulation of gene expression
(GO:0032922)
Dendrite development
(GO:0016358)
Enzyme binding
(GO:0019899)
Epidermal cell differentiation
(GO:0009913)
Heat shock protein binding
(GO:0031072)
Heterochromatin formation
(GO:0031507)
Histone binding
(GO:0042393)
Histone deacetylase activity
(GO:0004407)
Histone deacetylase binding
(GO:0042826)
Histone decrotonylase activity
(GO:0160009)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of transcription by competitive promoter binding
(GO:0010944)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nf-kappab binding
(GO:0051059)
Nucleosomal dna binding
(GO:0031492)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of interleukin-1 production
(GO:0032732)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein de-2-hydroxyisobutyrylase activity
(GO:0160010)
Protein lysine deacetylase activity
(GO:0033558)
Response to amphetamine
(GO:0001975)
Response to caffeine
(GO:0031000)
Response to lipopolysaccharide
(GO:0032496)
Response to xenobiotic stimulus
(GO:0009410)
Rna binding
(GO:0003723)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.97
Marker Score: 39207
Cell Name: oogonial cell (CL0000024)
Fold Change: 2.64
Marker Score: 3794
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.6
Marker Score: 1635
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.6
Marker Score: 5430
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.59
Marker Score: 2903
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.58
Marker Score: 16772
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.49
Marker Score: 2658
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.48
Marker Score: 2335
Cell Name: Unknown (CL0002371)
Fold Change: 2.33
Marker Score: 2475
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 2.32
Marker Score: 9691
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.32
Marker Score: 3935
Cell Name: motor neuron (CL0000100)
Fold Change: 2.31
Marker Score: 1373
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 2.25
Marker Score: 8719
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.22
Marker Score: 6045.5
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 2.21
Marker Score: 2225
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.21
Marker Score: 22204
Cell Name: kidney cell (CL1000497)
Fold Change: 2.16
Marker Score: 1442
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.13
Marker Score: 8726
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 2.12
Marker Score: 1001
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.1
Marker Score: 2970
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.05
Marker Score: 689
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.05
Marker Score: 2164
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.98
Marker Score: 4669
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.95
Marker Score: 2083.5
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.92
Marker Score: 7543
Cell Name: male germ cell (CL0000015)
Fold Change: 1.9
Marker Score: 547
Cell Name: decidual cell (CL2000002)
Fold Change: 1.89
Marker Score: 8130
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.86
Marker Score: 2009.5
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.83
Marker Score: 1009
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.81
Marker Score: 885
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.79
Marker Score: 4854
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.78
Marker Score: 2505
Cell Name: oocyte (CL0000023)
Fold Change: 1.78
Marker Score: 440
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.77
Marker Score: 1666.5
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.76
Marker Score: 61057
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.72
Marker Score: 2024
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.71
Marker Score: 2050
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.7
Marker Score: 2132
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.69
Marker Score: 2483
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.67
Marker Score: 536
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.67
Marker Score: 18818
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.65
Marker Score: 8661
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.64
Marker Score: 9737
Cell Name: stem cell (CL0000034)
Fold Change: 1.63
Marker Score: 3877
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.63
Marker Score: 2513
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.6
Marker Score: 376
Cell Name: enteric neuron (CL0007011)
Fold Change: 1.59
Marker Score: 848.5
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.59
Marker Score: 1078
Cell Name: glial cell (CL0000125)
Fold Change: 1.57
Marker Score: 1730
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.57
Marker Score: 13552.5
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.56
Marker Score: 2561
Cell Name: theca cell (CL0000503)
Fold Change: 1.55
Marker Score: 1112
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.55
Marker Score: 525
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.53
Marker Score: 5659.5
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.53
Marker Score: 3103
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.52
Marker Score: 1104
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.52
Marker Score: 3708
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.52
Marker Score: 531
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.51
Marker Score: 11216.5
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.49
Marker Score: 709
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.48
Marker Score: 514
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.48
Marker Score: 1425
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.47
Marker Score: 1100
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.46
Marker Score: 509
Cell Name: osteoclast (CL0000092)
Fold Change: 1.46
Marker Score: 725
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.45
Marker Score: 1787.5
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 165839
Cell Name: neural cell (CL0002319)
Fold Change: 1.44
Marker Score: 695
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.43
Marker Score: 2537
Cell Name: supporting cell (CL0000630)
Fold Change: 1.42
Marker Score: 2677
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.42
Marker Score: 279
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.42
Marker Score: 403
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.42
Marker Score: 12476
Cell Name: Unknown (CL0000548)
Fold Change: 1.42
Marker Score: 1034
Cell Name: basal cell (CL0000646)
Fold Change: 1.41
Marker Score: 1822
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.41
Marker Score: 1472
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.41
Marker Score: 1326
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.4
Marker Score: 1688
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.39
Marker Score: 1468
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.39
Marker Score: 355
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.39
Marker Score: 947
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.39
Marker Score: 14085
Cell Name: erythroblast (CL0000765)
Fold Change: 1.38
Marker Score: 862.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.38
Marker Score: 2398
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.37
Marker Score: 2741
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.36
Marker Score: 1172
Cell Name: neuron (CL0000540)
Fold Change: 1.32
Marker Score: 5370
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.32
Marker Score: 499
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.32
Marker Score: 11429
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.31
Marker Score: 313.5
Cell Name: osteoblast (CL0000062)
Fold Change: 1.31
Marker Score: 703.5
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.31
Marker Score: 1181
Cell Name: stromal cell (CL0000499)
Fold Change: 1.3
Marker Score: 1528
Cell Name: promyelocyte (CL0000836)
Fold Change: 1.3
Marker Score: 644
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.3
Marker Score: 1609
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.3
Marker Score: 1349
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.3
Marker Score: 1023
Cell Name: plasmablast (CL0000980)
Fold Change: 1.29
Marker Score: 1721
Cell Name: club cell (CL0000158)
Fold Change: 1.29
Marker Score: 1504
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 1.28
Marker Score: 663

Hover over a box to see details here...

**Key characteristics:** - HDAC2 is a histone deacetylase, an enzyme that removes acetyl groups from histones. - It is found in a variety of cell types, including mesodermal cells, oogonial cells, and neural crest cells. - It is involved in a variety of cellular processes, including cell differentiation, proliferation, and apoptosis. **Pathways and functions:** - HDAC2 is involved in the regulation of gene expression by deacetylating histones on DNA. - It is involved in the regulation of cell differentiation by deacetylating histones on genes that are expressed in certain cell types but not in others. - It is involved in the regulation of cell proliferation by deacetylating histones on genes that are expressed in proliferating cells. - It is involved in the regulation of cell apoptosis by deacetylating histones on pro-apoptotic genes. - It is involved in the regulation of inflammation by deacetylating histones on inflammatory genes. **Clinical significance:** - Mutations in HDAC2 have been linked to a number of human diseases, including cancer, developmental disorders, and neurological disorders. - Inhibitors of HDAC2 have been shown to be effective in treating these diseases. **Additional information:** - HDAC2 is a highly conserved protein, with a similar protein found in other mammals. - It is a member of the HDAC family of histone deacetylases. - It is a highly regulated gene, with its expression being controlled by a variety of factors, including growth factors, cytokines, and other signaling molecules.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

HDAC2_HUMAN

Genular Protein ID: 2675874660

Symbol: HDAC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92769 B3KRS5 B4DL58 E1P561 Q5SRI8 Q5SZ86 Q8NEH4

Database IDs:

Citations:

PubMed ID: 8917507

Title: Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.

PubMed ID: 8917507

DOI: 10.1073/pnas.93.23.12845

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10545197

Title: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.

PubMed ID: 10545197

DOI: 10.1021/bi991614n

PubMed ID: 10644367

Title: A role for SKIP in EBNA2 activation of CBF1-repressed promoters.

PubMed ID: 10644367

DOI: 10.1128/jvi.74.4.1939-1947.2000

PubMed ID: 10888872

Title: DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.

PubMed ID: 10888872

DOI: 10.1038/77023

PubMed ID: 10904264

Title: NuRD and SIN3 histone deacetylase complexes in development.

PubMed ID: 10904264

DOI: 10.1016/s0168-9525(00)02066-7

PubMed ID: 11331609

Title: Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.

PubMed ID: 11331609

DOI: 10.1101/gad.871201

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 11739383

Title: Isolation and characterization of a novel class II histone deacetylase, HDAC10.

PubMed ID: 11739383

DOI: 10.1074/jbc.m108055200

PubMed ID: 12176973

Title: The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.

PubMed ID: 12176973

DOI: 10.1074/jbc.c200378200

PubMed ID: 12140263

Title: Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.

PubMed ID: 12140263

DOI: 10.1242/jcs.115.16.3319

PubMed ID: 12402037

Title: Acetylation inactivates the transcriptional repressor BCL6.

PubMed ID: 12402037

DOI: 10.1038/ng1018

PubMed ID: 14633989

Title: Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.

PubMed ID: 14633989

DOI: 10.1093/emboj/cdg595

PubMed ID: 12670868

Title: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

PubMed ID: 12670868

DOI: 10.1101/gad.252103

PubMed ID: 12493763

Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

PubMed ID: 12493763

DOI: 10.1074/jbc.m208992200

PubMed ID: 12724404

Title: Identification and characterization of three new components of the mSin3A corepressor complex.

PubMed ID: 12724404

DOI: 10.1128/mcb.23.10.3456-3467.2003

PubMed ID: 15456770

Title: The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains.

PubMed ID: 15456770

DOI: 10.1074/jbc.m406831200

PubMed ID: 15060175

Title: Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition.

PubMed ID: 15060175

DOI: 10.1093/nar/gkh524

PubMed ID: 15701600

Title: MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

PubMed ID: 15701600

DOI: 10.1074/jbc.m413492200

PubMed ID: 15927959

Title: Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

PubMed ID: 15927959

DOI: 10.1074/jbc.m413687200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16428440

Title: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

PubMed ID: 16428440

DOI: 10.1128/mcb.26.3.843-851.2006

PubMed ID: 16820529

Title: SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.

PubMed ID: 16820529

DOI: 10.1093/nar/gkl401

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19061646

Title: CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.

PubMed ID: 19061646

DOI: 10.1016/j.molcel.2008.10.025

PubMed ID: 18212045

Title: CtBP is an essential corepressor for BCL6 autoregulation.

PubMed ID: 18212045

DOI: 10.1128/mcb.01400-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18757745

Title: RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.

PubMed ID: 18757745

DOI: 10.1073/pnas.0709227105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19433865

Title: Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

PubMed ID: 19433865

DOI: 10.1074/jbc.m109.007237

PubMed ID: 19343227

Title: FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

PubMed ID: 19343227

DOI: 10.1371/journal.pone.0005071

PubMed ID: 19182791

Title: Chfr is linked to tumour metastasis through the downregulation of HDAC1.

PubMed ID: 19182791

DOI: 10.1038/ncb1837

PubMed ID: 19729656

Title: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

PubMed ID: 19729656

DOI: 10.1126/science.1176709

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20523938

Title: CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.

PubMed ID: 20523938

DOI: 10.1039/c004108d

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21965678

Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

PubMed ID: 21965678

DOI: 10.1074/jbc.m111.267237

PubMed ID: 21914818

Title: A BEN-domain-containing protein associates with heterochromatin and represses transcription.

PubMed ID: 21914818

DOI: 10.1242/jcs.086603

PubMed ID: 21549307

Title: Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

PubMed ID: 21549307

DOI: 10.1016/j.molcel.2011.02.036

PubMed ID: 21573134

Title: Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.

PubMed ID: 21573134

DOI: 10.1371/journal.pgen.1002065

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22926524

Title: RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene.

PubMed ID: 22926524

DOI: 10.1038/onc.2012.386

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 24970816

Title: The subcellular distribution and function of MTA1 in cancer differentiation.

PubMed ID: 24970816

DOI: 10.18632/oncotarget.2095

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28497810

Title: Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

PubMed ID: 28497810

DOI: 10.1038/cr.2017.68

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28977666

Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PubMed ID: 28977666

DOI: 10.1093/nar/gkx711

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 33283408

Title: Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.

PubMed ID: 33283408

DOI: 10.1111/febs.15650

PubMed ID: 20392638

Title: Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.

PubMed ID: 20392638

DOI: 10.1016/j.bmcl.2010.03.091

Sequence Information:

Length: 488
Mass: 55364
Checksum: 775419CCCDAE07FA
Sequence:

MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA 
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA 
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH 
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ 
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG 
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM 
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE 
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT 
KSEQLSNP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HDAC2

Associated with

Cells (max top 100)

Other Information

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. PubMed ID: 8917507

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. PubMed ID: 10545197

A role for SKIP in EBNA2 activation of CBF1-repressed promoters. PubMed ID: 10644367

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. PubMed ID: 10888872

NuRD and SIN3 histone deacetylase complexes in development. PubMed ID: 10904264

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. PubMed ID: 11331609

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. PubMed ID: 11533236

Isolation and characterization of a novel class II histone deacetylase, HDAC10. PubMed ID: 11739383

The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. PubMed ID: 12176973

Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. PubMed ID: 12140263

Acetylation inactivates the transcriptional repressor BCL6. PubMed ID: 12402037

Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. PubMed ID: 14633989

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. PubMed ID: 12670868

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. PubMed ID: 12493763

Identification and characterization of three new components of the mSin3A corepressor complex. PubMed ID: 12724404

The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains. PubMed ID: 15456770

Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. PubMed ID: 15060175

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing. PubMed ID: 15701600

Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. PubMed ID: 15927959

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. PubMed ID: 16428440

SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. PubMed ID: 16820529

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. PubMed ID: 19061646

CtBP is an essential corepressor for BCL6 autoregulation. PubMed ID: 18212045

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition. PubMed ID: 18757745

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. PubMed ID: 19433865

FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. PubMed ID: 19343227

Chfr is linked to tumour metastasis through the downregulation of HDAC1. PubMed ID: 19182791

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. PubMed ID: 19729656

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. PubMed ID: 20523938

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. PubMed ID: 21965678

A BEN-domain-containing protein associates with heterochromatin and represses transcription. PubMed ID: 21914818

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. PubMed ID: 21549307

Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. PubMed ID: 21573134

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. PubMed ID: 22926524

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

The subcellular distribution and function of MTA1 in cancer differentiation. PubMed ID: 24970816

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination. PubMed ID: 25593309

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. PubMed ID: 28497810

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. PubMed ID: 28977666

Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. PubMed ID: 29192674

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. PubMed ID: 32051553

Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex. PubMed ID: 33283408

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. PubMed ID: 20392638