Details for: HOXA11

Gene ID: 3207

Symbol: HOXA11

Ensembl ID: ENSG00000005073

Description: homeobox A11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.24
    Marker Score: 4072.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.09
    Marker Score: 2105
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.81
    Marker Score: 20406
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.66
    Marker Score: 1143
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.46
    Marker Score: 1764
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.16
    Marker Score: 1107
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7574
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 655
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.97
    Marker Score: 403.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.96
    Marker Score: 1252
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 649.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5331
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.92
    Marker Score: 347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 481
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8
    Marker Score: 3440
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.78
    Marker Score: 518.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.77
    Marker Score: 522.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.66
    Marker Score: 1242
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.55
    Marker Score: 227
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.45
    Marker Score: 232
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.44
    Marker Score: 1028
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 247
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.43
    Marker Score: 5652
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.43
    Marker Score: 171
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.42
    Marker Score: 721
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.4
    Marker Score: 698
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.4
    Marker Score: 641
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.4
    Marker Score: 444
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.39
    Marker Score: 784
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.37
    Marker Score: 183
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.36
    Marker Score: 748
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 145.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.34
    Marker Score: 157
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.34
    Marker Score: 246.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.33
    Marker Score: 93
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.29
    Marker Score: 312
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 552
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.27
    Marker Score: 82.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.27
    Marker Score: 85
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.26
    Marker Score: 249
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.25
    Marker Score: 178
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.25
    Marker Score: 132
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.24
    Marker Score: 356
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.24
    Marker Score: 240
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.24
    Marker Score: 154
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 110
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2
    Marker Score: 1226
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.2
    Marker Score: 173
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3116.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.2
    Marker Score: 46
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.19
    Marker Score: 372
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.18
    Marker Score: 172
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.17
    Marker Score: 115
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 97
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.15
    Marker Score: 171
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.13
    Marker Score: 27
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.13
    Marker Score: 25.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.13
    Marker Score: 151
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.13
    Marker Score: 28
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.13
    Marker Score: 50
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.12
    Marker Score: 195
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.12
    Marker Score: 172
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.12
    Marker Score: 297
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.12
    Marker Score: 56
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.12
    Marker Score: 180
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.12
    Marker Score: 274
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.11
    Marker Score: 47

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Other Information

**Key characteristics:** - HOXA11 is a transcription factor that is expressed in a wide range of cell types. - It is involved in the development of the neural tube, heart, kidney, and other organs. - HOXA11 is a key regulator of gene expression and is involved in the regulation of cell fate and differentiation. **Pathways and functions:** - HOXA11 is involved in the specification of the anterior/posterior (A/P) pattern of the human body. - It is also involved in the development of the male reproductive tract and the formation of the kidney. - HOXA11 is a key regulator of mesodermal cell fate specification, and its deficiency leads to the formation of teratomas, which are tumors that develop from the same cells that would form the brain and other neural tissues. **Clinical significance:** - Mutations in HOXA11 have been linked to a number of human diseases, including kidney cancer, cardiovascular disease, and urogenital disorders. - These diseases are often caused by defects in the specification of cell fate, which can be due to mutations in HOXA11 or other genes that regulate cell fate. - Targeting HOXA11 has been investigated as a therapeutic strategy for these diseases. **Additional information:** - HOXA11 is a member of the HOX family of homeobox genes. - It is expressed in a pattern that is characteristic of early-stage neural tube cells. - HOXA11 is a highly conserved gene, with a similar gene found in other vertebrates.

Genular Protein ID: 1856665698

Symbol: HXA11_HUMAN

Name: Homeobox protein Hox-A11

UniProtKB Accession Codes:

P31270 A4D190

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9745033

Title: Evolutionary conservation and tissue-specific processing of hoxa 11 antisense transcripts.

PubMed ID: 9745033

DOI: 10.1007/s003359900870

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 11101832

Title: Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation.

PubMed ID: 11101832

DOI: 10.1038/82511

Sequence Information:

  • Length: 313
  • Mass: 34486
  • Checksum: B345B987816AB9FB
  • Sequence:
    • MDFDERGPCS SNMYLPSCTY YVSGPDFSSL PSFLPQTPSS RPMTYSYSSN LPQVQPVREV 
TFREYAIEPA TKWHPRGNLA HCYSAEELVH RDCLQAPSAA GVPGDVLAKS SANVYHHPTP 
AVSSNFYSTV GRNGVLPQAF DQFFETAYGT PENLASSDYP GDKSAEKGPP AATATSAAAA 
AAATGAPATS SSDSGGGGGC RETAAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSSGQR 
TRKKRCPYTK YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN 
RDRLQYYSAN PLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.