Details for: HOXA11

Gene ID: 3207

Symbol: HOXA11

Ensembl ID: ENSG00000005073

Description: homeobox A11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.0303
    Cell Significance Index: -18.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6274
    Cell Significance Index: -18.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.1687
    Cell Significance Index: 104.2100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 3.3390
    Cell Significance Index: 28.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.9073
    Cell Significance Index: 62.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1767
    Cell Significance Index: 298.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2489
    Cell Significance Index: 43.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0255
    Cell Significance Index: 195.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6655
    Cell Significance Index: 65.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5438
    Cell Significance Index: 490.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4549
    Cell Significance Index: 23.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4167
    Cell Significance Index: 8.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4109
    Cell Significance Index: 8.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3713
    Cell Significance Index: 60.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3190
    Cell Significance Index: 34.7000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: 0.2487
    Cell Significance Index: 2.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2215
    Cell Significance Index: 10.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1861
    Cell Significance Index: 11.1700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.1721
    Cell Significance Index: 1.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1587
    Cell Significance Index: 1.7300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1534
    Cell Significance Index: 2.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1476
    Cell Significance Index: 10.2100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.1012
    Cell Significance Index: 0.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0099
    Cell Significance Index: 1.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0045
    Cell Significance Index: 0.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0042
    Cell Significance Index: 0.1200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0039
    Cell Significance Index: -0.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0042
    Cell Significance Index: -0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0061
    Cell Significance Index: -0.2500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0073
    Cell Significance Index: -0.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0151
    Cell Significance Index: -11.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0184
    Cell Significance Index: -2.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0295
    Cell Significance Index: -13.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0374
    Cell Significance Index: -20.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0396
    Cell Significance Index: -2.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0612
    Cell Significance Index: -0.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0694
    Cell Significance Index: -13.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0818
    Cell Significance Index: -16.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0837
    Cell Significance Index: -5.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0911
    Cell Significance Index: -1.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0920
    Cell Significance Index: -13.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1085
    Cell Significance Index: -4.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1424
    Cell Significance Index: -4.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1425
    Cell Significance Index: -16.3200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1445
    Cell Significance Index: -1.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1468
    Cell Significance Index: -15.0000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1484
    Cell Significance Index: -1.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1539
    Cell Significance Index: -4.9300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1581
    Cell Significance Index: -2.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1661
    Cell Significance Index: -13.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1708
    Cell Significance Index: -22.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1788
    Cell Significance Index: -3.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1913
    Cell Significance Index: -4.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1945
    Cell Significance Index: -3.9100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1972
    Cell Significance Index: -3.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1982
    Cell Significance Index: -3.9200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2155
    Cell Significance Index: -2.3800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2183
    Cell Significance Index: -2.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2601
    Cell Significance Index: -7.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2780
    Cell Significance Index: -2.5600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2854
    Cell Significance Index: -3.6600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2953
    Cell Significance Index: -4.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2973
    Cell Significance Index: -22.1600
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.3040
    Cell Significance Index: -2.4200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.3361
    Cell Significance Index: -2.0800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.3406
    Cell Significance Index: -3.7200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3477
    Cell Significance Index: -3.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3582
    Cell Significance Index: -6.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3748
    Cell Significance Index: -21.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3820
    Cell Significance Index: -17.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3866
    Cell Significance Index: -4.0100
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.3987
    Cell Significance Index: -3.7000
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.4195
    Cell Significance Index: -3.9300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.4249
    Cell Significance Index: -3.9300
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.4333
    Cell Significance Index: -3.9200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4347
    Cell Significance Index: -6.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4404
    Cell Significance Index: -11.7600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4411
    Cell Significance Index: -4.5700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4470
    Cell Significance Index: -3.2100
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.4650
    Cell Significance Index: -2.9000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.4742
    Cell Significance Index: -3.9300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5292
    Cell Significance Index: -3.4500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.5390
    Cell Significance Index: -6.8200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.5396
    Cell Significance Index: -5.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5563
    Cell Significance Index: -20.4200
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.5664
    Cell Significance Index: -3.0700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.5670
    Cell Significance Index: -5.6100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.5709
    Cell Significance Index: -9.1800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.5759
    Cell Significance Index: -9.2400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.5936
    Cell Significance Index: -3.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6009
    Cell Significance Index: -16.1000
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.6023
    Cell Significance Index: -4.2000
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: -0.6152
    Cell Significance Index: -2.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6184
    Cell Significance Index: -13.5400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6274
    Cell Significance Index: -3.9400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6311
    Cell Significance Index: -16.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6486
    Cell Significance Index: -17.3500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6488
    Cell Significance Index: -11.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Conservation:** HOXA11 is highly conserved across species, with orthologs present in mammals, birds, and reptiles, indicating its essential role in evolutionarily conserved developmental processes. 2. **Transcriptional regulation:** HOXA11 acts as a transcription factor, regulating gene expression by binding to specific DNA sequences, thereby influencing the development and maintenance of various tissues and organs. 3. **Cellular specificity:** HOXA11 is expressed in a wide range of cell types, including microglial cells, blood vessel endothelial cells, and stromal cells of the ovary, suggesting its role in regulating cellular differentiation and homeostasis. 4. **Heterodimerization:** HOXA11 can form heterodimers with other homeobox proteins, such as HOXA4 and HOXA5, to regulate gene expression and tissue development. **Pathways and Functions:** HOXA11 is involved in various developmental pathways, including: 1. **Anatomical structure development:** HOXA11 regulates the development of various anatomical structures, such as the kidney, gonads, and limb buds, by controlling the expression of target genes involved in cell proliferation, differentiation, and morphogenesis. 2. **Anterior/posterior patterning:** HOXA11 plays a critical role in establishing the anterior-posterior axis during embryonic development, influencing the specification of cell fates and tissue organization. 3. **Dorsal/ventral patterning:** HOXA11 is involved in regulating the dorsal/ventral axis during embryonic development, influencing the specification of cell fates and tissue organization. 4. **Cell differentiation:** HOXA11 regulates the differentiation of various cell types, including chondrocytes, osteoblasts, and myoblasts, by controlling the expression of target genes involved in cellular differentiation and morphogenesis. **Clinical Significance:** Dysregulation of HOXA11 has been implicated in various human diseases, including: 1. **Genetic disorders:** HOXA11 mutations have been associated with genetic disorders, such as Axenfeld-Rieger syndrome, a disorder characterized by abnormalities in the development of the eye and kidney. 2. **Cancer:** HOXA11 is overexpressed in various types of cancer, including prostate cancer, breast cancer, and lung cancer, suggesting its potential role as a oncogene. 3. **Reproductive disorders:** HOXA11 is involved in the development of the gonads, and dysregulation of HOXA11 has been implicated in reproductive disorders, such as infertility and abnormal gonadal development. 4. **Developmental abnormalities:** HOXA11 plays a critical role in embryonic development, and dysregulation of HOXA11 has been implicated in developmental abnormalities, such as limb defects and organ malformations. In conclusion, HOXA11 is a highly conserved transcription factor that plays a critical role in various developmental processes, including embryonic patterning, organogenesis, and tissue homeostasis. Its dysregulation has been implicated in various human diseases, highlighting the importance of understanding the molecular mechanisms underlying HOXA11 function and its role in human disease.

Genular Protein ID: 1856665698

Symbol: HXA11_HUMAN

Name: Homeobox protein Hox-A11

UniProtKB Accession Codes:

P31270 A4D190

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9745033

Title: Evolutionary conservation and tissue-specific processing of hoxa 11 antisense transcripts.

PubMed ID: 9745033

DOI: 10.1007/s003359900870

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 11101832

Title: Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation.

PubMed ID: 11101832

DOI: 10.1038/82511

Sequence Information:

  • Length: 313
  • Mass: 34486
  • Checksum: B345B987816AB9FB
  • Sequence:
    • MDFDERGPCS SNMYLPSCTY YVSGPDFSSL PSFLPQTPSS RPMTYSYSSN LPQVQPVREV 
TFREYAIEPA TKWHPRGNLA HCYSAEELVH RDCLQAPSAA GVPGDVLAKS SANVYHHPTP 
AVSSNFYSTV GRNGVLPQAF DQFFETAYGT PENLASSDYP GDKSAEKGPP AATATSAAAA 
AAATGAPATS SSDSGGGGGC RETAAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSSGQR 
TRKKRCPYTK YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN 
RDRLQYYSAN PLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.