Details for: HOXB8

Gene ID: 3218

Symbol: HOXB8

Ensembl ID: ENSG00000120068

Description: homeobox B8

Associated with

  • Adult locomotory behavior
    (GO:0008344)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dorsal spinal cord development
    (GO:0021516)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Grooming behavior
    (GO:0007625)
  • Negative regulation of myeloid cell differentiation
    (GO:0045638)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sensory perception of pain
    (GO:0019233)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.31
    Marker Score: 45374
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.12
    Marker Score: 2750.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251798
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.94
    Marker Score: 992
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5291
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.9
    Marker Score: 2410
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.9
    Marker Score: 210
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.87
    Marker Score: 2205
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.85
    Marker Score: 1404
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 484
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.79
    Marker Score: 5281
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.79
    Marker Score: 1115
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.77
    Marker Score: 245
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.77
    Marker Score: 276
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.71
    Marker Score: 719
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.65
    Marker Score: 196
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.64
    Marker Score: 1110
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.63
    Marker Score: 598
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 391
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.57
    Marker Score: 382
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.56
    Marker Score: 484
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.54
    Marker Score: 106
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 216.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.52
    Marker Score: 267
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.51
    Marker Score: 352
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.51
    Marker Score: 736
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.49
    Marker Score: 1202
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 744
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 653
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.44
    Marker Score: 127
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 737
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.43
    Marker Score: 224
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.43
    Marker Score: 160
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.42
    Marker Score: 671
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.4
    Marker Score: 194
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.39
    Marker Score: 415
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.38
    Marker Score: 104
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.35
    Marker Score: 662
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.35
    Marker Score: 236
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.35
    Marker Score: 820
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.34
    Marker Score: 717
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.34
    Marker Score: 698
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.34
    Marker Score: 379.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.31
    Marker Score: 123
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 717
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.3
    Marker Score: 715
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.3
    Marker Score: 135
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.29
    Marker Score: 292
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.28
    Marker Score: 128
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.28
    Marker Score: 488
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 154
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.27
    Marker Score: 61
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.26
    Marker Score: 927
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.24
    Marker Score: 414
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 213
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.23
    Marker Score: 3629
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.23
    Marker Score: 217
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.22
    Marker Score: 156
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 133
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.22
    Marker Score: 53
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.2
    Marker Score: 214
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.19
    Marker Score: 382
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.18
    Marker Score: 1067
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.17
    Marker Score: 108
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 80
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.16
    Marker Score: 54
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.15
    Marker Score: 47

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Other Information

**Key characteristics:** * HOXB8 is a homeobox gene, which are a family of genes that are involved in the development and maintenance of tissues and organs. * It is expressed in a variety of cell types, including granulocyte monocyte progenitor cells, cell in vitro, glandular epithelial cell, early T lineage precursor, fallopian tube secretory epithelial cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, tuft cell of colon, absorptive cell, and BEST4+ intestinal epithelial cell. * It is involved in a variety of biological processes, including embryonic skeletal system morphogenesis, grooming behavior, and negative regulation of myeloid cell differentiation. **Pathways and functions:** * HOXB8 is involved in the development and maintenance of the embryonic skeletal system. * It is also involved in the regulation of grooming behavior. * It is involved in the negative regulation of myeloid cell differentiation. **Clinical significance:** HOXB8 is a gene that is implicated in a number of human diseases, including cancer, developmental disorders, and neurodegenerative diseases. Mutations in HOXB8 have been linked to a number of human diseases, including Wilcoyne-White syndrome, Angelman syndrome, and autism spectrum disorder.

Genular Protein ID: 2999259498

Symbol: HXB8_HUMAN

Name: Homeobox protein Hox-B8

UniProtKB Accession Codes:

P17481 Q9H1I2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 2570724

Title: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

PubMed ID: 2570724

DOI: 10.1111/j.1432-0436.1989.tb00598.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 7791786

Title: Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

PubMed ID: 7791786

DOI: 10.1128/mcb.15.7.3786

PubMed ID: 9191052

Title: The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements.

PubMed ID: 9191052

DOI: 10.1038/sj.onc.1201097

Sequence Information:

  • Length: 243
  • Mass: 27574
  • Checksum: 36982182725F121F
  • Sequence:
    • MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG 
PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE 
EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS 
HALGLTERQV KIWFQNRRMK WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG 
DKK

Genular Protein ID: 1034043485

Symbol: Q8N8T3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N8T3

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 243
  • Mass: 27672
  • Checksum: 1F40BD105D8F10E2
  • Sequence:
    • MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG 
PSSLSTAPYQ QNPCAVACHG DPDNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE 
EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS 
HALGLTERQV KIWFQNRRMK WKKENNKDKF HSSKCEQEEL EKQKLERAPE AADEGDAQKG 
DKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.