Details for: HOXB8

Gene ID: 3218

Symbol: HOXB8

Ensembl ID: ENSG00000120068

Description: homeobox B8

Associated with

  • Adult locomotory behavior
    (GO:0008344)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dorsal spinal cord development
    (GO:0021516)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Grooming behavior
    (GO:0007625)
  • Negative regulation of myeloid cell differentiation
    (GO:0045638)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sensory perception of pain
    (GO:0019233)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.8209
    Cell Significance Index: -9.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 14.6344
    Cell Significance Index: -9.8200
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.3082
    Cell Significance Index: 13.1200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.0337
    Cell Significance Index: 23.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2941
    Cell Significance Index: 27.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2678
    Cell Significance Index: 65.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9339
    Cell Significance Index: 843.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9195
    Cell Significance Index: 502.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7588
    Cell Significance Index: 45.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7331
    Cell Significance Index: 79.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6912
    Cell Significance Index: 68.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6222
    Cell Significance Index: 101.2000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4233
    Cell Significance Index: 3.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3792
    Cell Significance Index: 26.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3266
    Cell Significance Index: 62.1500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2462
    Cell Significance Index: 3.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1822
    Cell Significance Index: 3.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1475
    Cell Significance Index: 5.1300
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.1347
    Cell Significance Index: 1.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1303
    Cell Significance Index: 1.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0579
    Cell Significance Index: 10.4300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0354
    Cell Significance Index: 0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0350
    Cell Significance Index: 1.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0316
    Cell Significance Index: 0.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0282
    Cell Significance Index: 20.7000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0187
    Cell Significance Index: 0.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0126
    Cell Significance Index: -2.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0143
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0163
    Cell Significance Index: -9.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0164
    Cell Significance Index: -2.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0435
    Cell Significance Index: -4.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0461
    Cell Significance Index: -6.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0492
    Cell Significance Index: -1.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0508
    Cell Significance Index: -4.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0513
    Cell Significance Index: -10.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0526
    Cell Significance Index: -1.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0708
    Cell Significance Index: -8.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0805
    Cell Significance Index: -9.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0836
    Cell Significance Index: -10.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0873
    Cell Significance Index: -1.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0950
    Cell Significance Index: -4.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1352
    Cell Significance Index: -3.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1382
    Cell Significance Index: -5.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1398
    Cell Significance Index: -1.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1445
    Cell Significance Index: -10.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1559
    Cell Significance Index: -2.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1597
    Cell Significance Index: -9.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1676
    Cell Significance Index: -4.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1724
    Cell Significance Index: -2.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1755
    Cell Significance Index: -5.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1821
    Cell Significance Index: -9.4900
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1940
    Cell Significance Index: -1.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1980
    Cell Significance Index: -8.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2087
    Cell Significance Index: -3.5800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2200
    Cell Significance Index: -1.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2229
    Cell Significance Index: -10.4800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2432
    Cell Significance Index: -1.4900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2623
    Cell Significance Index: -1.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2676
    Cell Significance Index: -9.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2758
    Cell Significance Index: -12.8600
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2968
    Cell Significance Index: -2.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3208
    Cell Significance Index: -8.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3357
    Cell Significance Index: -9.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3360
    Cell Significance Index: -6.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3394
    Cell Significance Index: -9.0800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.3414
    Cell Significance Index: -4.3000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3459
    Cell Significance Index: -8.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3470
    Cell Significance Index: -8.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3493
    Cell Significance Index: -8.0700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3626
    Cell Significance Index: -3.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3681
    Cell Significance Index: -9.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3708
    Cell Significance Index: -9.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3743
    Cell Significance Index: -10.7300
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.3786
    Cell Significance Index: -2.6400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.3984
    Cell Significance Index: -3.5900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.3984
    Cell Significance Index: -3.1700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4033
    Cell Significance Index: -9.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4183
    Cell Significance Index: -5.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4314
    Cell Significance Index: -10.4500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4335
    Cell Significance Index: -7.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4517
    Cell Significance Index: -9.8900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4528
    Cell Significance Index: -5.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4668
    Cell Significance Index: -9.1100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.4715
    Cell Significance Index: -5.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4733
    Cell Significance Index: -10.0500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4749
    Cell Significance Index: -5.0100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5095
    Cell Significance Index: -4.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5281
    Cell Significance Index: -10.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5356
    Cell Significance Index: -9.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5565
    Cell Significance Index: -9.3600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.5643
    Cell Significance Index: -6.1100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5689
    Cell Significance Index: -8.6400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5727
    Cell Significance Index: -8.3200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.5738
    Cell Significance Index: -4.1700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5762
    Cell Significance Index: -9.8500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5874
    Cell Significance Index: -9.6800
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.5879
    Cell Significance Index: -4.7600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5926
    Cell Significance Index: -10.0700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5969
    Cell Significance Index: -10.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXB8 is a member of the homeobox gene family, which encodes transcription factors that regulate embryonic development and tissue patterning. This gene is characterized by its unique binding specificity to RNA polymerase II transcription regulatory regions, allowing it to modulate transcriptional activity. HOXB8 is also known for its role in regulating myeloid cell differentiation and negative regulation of pain perception, highlighting its complex and multifaceted functions. **Pathways and Functions:** HOXB8 is involved in several critical pathways, including: 1. **Anterior/posterior pattern specification**: HOXB8 plays a crucial role in establishing the anterior-posterior axis during embryonic development, regulating the expression of other homeobox genes and patterning the body plan. 2. **Chromatin remodeling**: HOXB8 interacts with chromatin-modifying enzymes, influencing chromatin structure and gene expression. 3. **RNA polymerase II-specific transcriptional regulation**: HOXB8 binds to RNA polymerase II transcription regulatory regions, modulating transcriptional activity and regulating the expression of target genes. 4. **Negative regulation of myeloid cell differentiation**: HOXB8 inhibits myeloid cell differentiation, highlighting its role in maintaining stem cell populations and preventing premature differentiation. **Clinical Significance:** HOXB8 has been implicated in various diseases and disorders, including: 1. **Cancer**: HOXB8 is overexpressed in several types of cancer, including leukemia, lymphoma, and breast cancer, suggesting its potential as a therapeutic target. 2. **Neurological disorders**: HOXB8 has been linked to neurological diseases, such as autism and schizophrenia, highlighting its role in brain development and function. 3. **Pain perception**: HOXB8 modulates pain perception, suggesting its potential as a therapeutic target for pain management. 4. **Regenerative medicine**: HOXB8 has been used as a stem cell marker, highlighting its potential in regenerative medicine and tissue engineering. In conclusion, HOXB8 is a critical gene that plays a multifaceted role in development, transcriptional regulation, and cell differentiation. Its clinical significance in various diseases and disorders underscores its importance as a therapeutic target and potential biomarker. Further research is needed to fully elucidate the functions and mechanisms of HOXB8, but its significance in human biology and disease is already clear.

Genular Protein ID: 2999259498

Symbol: HXB8_HUMAN

Name: Homeobox protein Hox-B8

UniProtKB Accession Codes:

P17481 Q9H1I2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 2570724

Title: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

PubMed ID: 2570724

DOI: 10.1111/j.1432-0436.1989.tb00598.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 7791786

Title: Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

PubMed ID: 7791786

DOI: 10.1128/mcb.15.7.3786

PubMed ID: 9191052

Title: The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subset of Pbx-recognition elements.

PubMed ID: 9191052

DOI: 10.1038/sj.onc.1201097

Sequence Information:

  • Length: 243
  • Mass: 27574
  • Checksum: 36982182725F121F
  • Sequence:
    • MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG 
PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE 
EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS 
HALGLTERQV KIWFQNRRMK WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG 
DKK

Genular Protein ID: 1034043485

Symbol: Q8N8T3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N8T3

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 243
  • Mass: 27672
  • Checksum: 1F40BD105D8F10E2
  • Sequence:
    • MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG 
PSSLSTAPYQ QNPCAVACHG DPDNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE 
EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS 
HALGLTERQV KIWFQNRRMK WKKENNKDKF HSSKCEQEEL EKQKLERAPE AADEGDAQKG 
DKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.