Details for: HOXD12

Gene ID: 3238

Symbol: HOXD12

Ensembl ID: ENSG00000170178

Description: homeobox D12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 2.67
    Marker Score: 693
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.17
    Marker Score: 698
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.72
    Marker Score: 540
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.56
    Marker Score: 495
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.51
    Marker Score: 547
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.49
    Marker Score: 551
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.37
    Marker Score: 548
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.28
    Marker Score: 584
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.26
    Marker Score: 610
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.24
    Marker Score: 711
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.2
    Marker Score: 550
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.18
    Marker Score: 492
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7678
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.15
    Marker Score: 511
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.11
    Marker Score: 616
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.08
    Marker Score: 516
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.03
    Marker Score: 554
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30260
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.98
    Marker Score: 514
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.93
    Marker Score: 539
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5072
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 533.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1438
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5260
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.85
    Marker Score: 499
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.83
    Marker Score: 544
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.81
    Marker Score: 535
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.8
    Marker Score: 499
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.78
    Marker Score: 554
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.73
    Marker Score: 383
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.7
    Marker Score: 743.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 530
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 539
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.67
    Marker Score: 378
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.65
    Marker Score: 758
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.61
    Marker Score: 1035
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.6
    Marker Score: 574.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.59
    Marker Score: 456
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.55
    Marker Score: 494
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.54
    Marker Score: 519
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.53
    Marker Score: 1098
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.4
    Marker Score: 404
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.39
    Marker Score: 555
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.38
    Marker Score: 523
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.38
    Marker Score: 421
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.36
    Marker Score: 553
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.35
    Marker Score: 496
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.35
    Marker Score: 450
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.34
    Marker Score: 710
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.33
    Marker Score: 577.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.33
    Marker Score: 579.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.26
    Marker Score: 694.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.23
    Marker Score: 542
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.22
    Marker Score: 354
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.21
    Marker Score: 392
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.18
    Marker Score: 325
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.18
    Marker Score: 356
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.17
    Marker Score: 2627
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 389
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.15
    Marker Score: 519
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1
    Marker Score: 603
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.09
    Marker Score: 604
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.04
    Marker Score: 467

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Other Information

**Key characteristics:** * HOXD12 is a highly conserved gene with a predicted protein of 437 amino acids. * It is involved in the regulation of embryonic digit morphogenesis, the specification of tissue fate, and the development of various tissues, including the skin, eyes, and skeleton. * HOXD12 is a key regulator of the development of the skeletal system. * It is expressed in a variety of cell types, including connective tissue cells, mononuclear cells, kidney capillary endothelial cells, renal beta-intercalated cells, and other cell types. **Pathways and functions:** * HOXD12 is a key regulator of the development of the skeletal system. * It is required for the specification of mesoderm, which is the group of cells that gives rise to connective tissue, muscles, and bone. * HOXD12 is also involved in the regulation of the development of the cardiovascular system, the nervous system, and the immune system. * The protein encoded by HOXD12 is a transcription factor that binds to DNA sequences in a sequence-specific manner. * This binding triggers a cascade of events that leads to the activation of transcription factors that promote the expression of genes involved in skeletal development. **Clinical significance:** HOXD12 mutations have been linked to a number of human diseases, including skeletal disorders, cardiovascular disorders, and cancer. These mutations can disrupt the normal function of HOXD12, leading to a variety of developmental abnormalities and health problems.

Genular Protein ID: 1775155720

Symbol: HXD12_HUMAN

Name: Homeobox protein Hox-D12

UniProtKB Accession Codes:

P35452 B5MCP0 Q0VAD7 Q0VAD8 Q9NS03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1675198

Title: EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2.

PubMed ID: 1675198

DOI: 10.1016/0888-7543(91)90482-t

Sequence Information:

  • Length: 270
  • Mass: 29031
  • Checksum: 224D53783405A162
  • Sequence:
    • MCERSLYRAG YVGSLLNLQS PDSFYFSNLR PNGGQLAALP PISYPRGALP WAATPASCAP 
AQPAGATAFG GFSQPYLAGS GPLGLQPPTA KDGPEEQAKF YAPEAAAGPE ERGRTRPSFA 
PESSLAPAVA ALKAAKYDYA GVGRATPGST TLLQGAPCAP GFKDDTKGPL NLNMTVQAAG 
VASCLRPSLP DGLPWGAAPG RARKKRKPYT KQQIAELENE FLVNEFINRQ KRKELSNRLN 
LSDQQVKIWF QNRRMKKKRV VLREQALALY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.