Details for: ITGA4

Gene ID: 3676

Symbol: ITGA4

Ensembl ID: ENSG00000115232

Description: integrin subunit alpha 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.47
    Marker Score: 3575
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.64
    Marker Score: 26718.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.49
    Marker Score: 6971
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.4
    Marker Score: 1036.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.3
    Marker Score: 3388
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.28
    Marker Score: 3150
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.28
    Marker Score: 26457
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.22
    Marker Score: 6991
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.11
    Marker Score: 1531
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.04
    Marker Score: 3973
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 2.03
    Marker Score: 650
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.98
    Marker Score: 497
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.97
    Marker Score: 12625.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.95
    Marker Score: 1198
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.92
    Marker Score: 4035
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.92
    Marker Score: 7870.5
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.87
    Marker Score: 917
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.87
    Marker Score: 655
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.85
    Marker Score: 1786
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.82
    Marker Score: 478
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.79
    Marker Score: 2109
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.75
    Marker Score: 17343
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.75
    Marker Score: 853
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.75
    Marker Score: 1190
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.74
    Marker Score: 2095.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.73
    Marker Score: 91595
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.7
    Marker Score: 469
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.69
    Marker Score: 1774
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.65
    Marker Score: 2340
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.64
    Marker Score: 2856.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.62
    Marker Score: 502
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.58
    Marker Score: 1489
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.58
    Marker Score: 1237
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.56
    Marker Score: 3066
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.55
    Marker Score: 1128
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.53
    Marker Score: 85560.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.49
    Marker Score: 6402
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.48
    Marker Score: 1608
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.47
    Marker Score: 4006.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167663
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.42
    Marker Score: 1884
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.36
    Marker Score: 3294
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.34
    Marker Score: 783
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.33
    Marker Score: 464
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.33
    Marker Score: 3876
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.32
    Marker Score: 335
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.32
    Marker Score: 1173
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.31
    Marker Score: 986
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.3
    Marker Score: 955
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.29
    Marker Score: 360
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.29
    Marker Score: 296
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.28
    Marker Score: 738
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.28
    Marker Score: 1076
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.28
    Marker Score: 931
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.28
    Marker Score: 967
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.28
    Marker Score: 1256
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.27
    Marker Score: 441
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.23
    Marker Score: 723.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.21
    Marker Score: 822
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.19
    Marker Score: 1111
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.18
    Marker Score: 1056
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.18
    Marker Score: 1204
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.18
    Marker Score: 1306
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.17
    Marker Score: 744
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.16
    Marker Score: 699
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.16
    Marker Score: 381
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.15
    Marker Score: 570
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.15
    Marker Score: 261
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.15
    Marker Score: 589
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.14
    Marker Score: 494
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.14
    Marker Score: 827
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.12
    Marker Score: 4717
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.12
    Marker Score: 2001
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.11
    Marker Score: 737
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.06
    Marker Score: 799
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.05
    Marker Score: 635
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.05
    Marker Score: 552
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.04
    Marker Score: 446
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.03
    Marker Score: 336
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.03
    Marker Score: 9043.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.02
    Marker Score: 565
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.01
    Marker Score: 417
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1211
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71695.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1
    Marker Score: 282
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47920
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.99
    Marker Score: 842
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.98
    Marker Score: 706
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.95
    Marker Score: 656
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.95
    Marker Score: 288
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.94
    Marker Score: 1221
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.94
    Marker Score: 1614
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.94
    Marker Score: 2430
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.93
    Marker Score: 334
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.93
    Marker Score: 425.5

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Other Information

**Key characteristics:** * ITGA4 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels on blood cells, including monocytes, macrophages, and dendritic cells. * ITGA4 is also expressed on activated T cells, natural killer (NK) cells, and B cells. * It is a key molecule for the adhesion of immune cells to extracellular matrix proteins. **Pathways and functions:** * ITGA4 is involved in cell adhesion to extracellular matrix proteins, which is essential for the migration, adhesion, and signaling of immune cells. * It is also involved in the regulation of immune responses by interacting with other adhesion molecules, cytokines, and signaling pathways. * ITGA4 is a key regulator of inflammation and immune responses. It is expressed on macrophages and dendritic cells, which are key cells in inflammation. * ITGA4 binds to various extracellular matrix proteins, including fibronectin, collagen, and elastin. * It is involved in the regulation of leukocyte migration, adhesion, and activation. **Clinical significance:** * Mutations in ITGA4 have been linked to several immune disorders, including immune thrombocytopenia, autoimmune disorders, and cancer. * ITGA4 is a potential therapeutic target for these disorders. * Inhibition of ITGA4 has been shown to inhibit inflammation and promote the resolution of inflammation. **Additional notes:** * ITGA4 is a highly conserved protein, with a similar sequence found in mammals, birds, and reptiles. * It is a member of the integrin family of adhesion molecules, which are expressed in various cell types. * ITGA4 is a key molecule for the adhesion of immune cells to extracellular matrix proteins, which is essential for the migration, adhesion, and signaling of immune cells.

Genular Protein ID: 3421694821

Symbol: ITA4_HUMAN

Name: Integrin alpha-4

UniProtKB Accession Codes:

P13612 D3DPG4 Q7Z4L6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 44 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2788572

Title: The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

PubMed ID: 2788572

DOI: 10.1002/j.1460-2075.1989.tb03516.x

PubMed ID: 1551405

Title: A single mRNA encodes the alpha 150 and alpha 80/70 forms of the alpha subunit of VLA4.

PubMed ID: 1551405

DOI: 10.1002/eji.1830220434

PubMed ID: 8643114

Title: Identification of two variants of the human integrin alpha 4 subunit.

PubMed ID: 8643114

DOI: 10.1016/0161-5890(96)00001-6

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2034655

Title: Characterization of the alpha 4 integrin gene promoter.

PubMed ID: 2034655

DOI: 10.1073/pnas.88.10.4094

PubMed ID: 3033641

Title: The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

PubMed ID: 3033641

DOI: 10.1073/pnas.84.10.3239

PubMed ID: 1730718

Title: Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage.

PubMed ID: 1730718

DOI: 10.1016/s0021-9258(18)46014-0

PubMed ID: 9488735

Title: A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion.

PubMed ID: 9488735

DOI: 10.1074/jbc.273.10.5955

PubMed ID: 10604475

Title: Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses.

PubMed ID: 10604475

DOI: 10.1038/45264

PubMed ID: 11533025

Title: Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding.

PubMed ID: 11533025

DOI: 10.1074/jbc.m102665200

PubMed ID: 15466886

Title: alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.

PubMed ID: 15466886

DOI: 10.1242/jcs.01423

PubMed ID: 18635536

Title: Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.

PubMed ID: 18635536

DOI: 10.1074/jbc.m804835200

PubMed ID: 19064666

Title: JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.

PubMed ID: 19064666

DOI: 10.1083/jcb.200805061

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23125415

Title: Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.

PubMed ID: 23125415

DOI: 10.4049/jimmunol.1200889

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25398877

Title: Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins alphavbeta3, alpha4beta1, and alpha5beta1.

PubMed ID: 25398877

DOI: 10.1074/jbc.m114.579946

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 35802072

Title: The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins alpha9beta1 and alpha4beta1.

PubMed ID: 35802072

DOI: 10.1111/bph.15921

Sequence Information:

  • Length: 1032
  • Mass: 114900
  • Checksum: 73EC1204DE78CD35
  • Sequence:
    • MAWEARREPG PRRAAVRETV MLLLCLGVPT GRPYNVDTES ALLYQGPHNT LFGYSVVLHS 
HGANRWLLVG APTANWLANA SVINPGAIYR CRIGKNPGQT CEQLQLGSPN GEPCGKTCLE 
ERDNQWLGVT LSRQPGENGS IVTCGHRWKN IFYIKNENKL PTGGCYGVPP DLRTELSKRI 
APCYQDYVKK FGENFASCQA GISSFYTKDL IVMGAPGSSY WTGSLFVYNI TTNKYKAFLD 
KQNQVKFGSY LGYSVGAGHF RSQHTTEVVG GAPQHEQIGK AYIFSIDEKE LNILHEMKGK 
KLGSYFGASV CAVDLNADGF SDLLVGAPMQ STIREEGRVF VYINSGSGAV MNAMETNLVG 
SDKYAARFGE SIVNLGDIDN DGFEDVAIGA PQEDDLQGAI YIYNGRADGI SSTFSQRIEG 
LQISKSLSMF GQSISGQIDA DNNGYVDVAV GAFRSDSAVL LRTRPVVIVD ASLSHPESVN 
RTKFDCVENG WPSVCIDLTL CFSYKGKEVP GYIVLFYNMS LDVNRKAESP PRFYFSSNGT 
SDVITGSIQV SSREANCRTH QAFMRKDVRD ILTPIQIEAA YHLGPHVISK RSTEEFPPLQ 
PILQQKKEKD IMKKTINFAR FCAHENCSAD LQVSAKIGFL KPHENKTYLA VGSMKTLMLN 
VSLFNAGDDA YETTLHVKLP VGLYFIKILE LEEKQINCEV TDNSGVVQLD CSIGYIYVDH 
LSRIDISFLL DVSSLSRAEE DLSITVHATC ENEEEMDNLK HSRVTVAIPL KYEVKLTVHG 
FVNPTSFVYG SNDENEPETC MVEKMNLTFH VINTGNSMAP NVSVEIMVPN SFSPQTDKLF 
NILDVQTTTG ECHFENYQRV CALEQQKSAM QTLKGIVRFL SKTDKRLLYC IKADPHCLNF 
LCNFGKMESG KEASVHIQLE GRPSILEMDE TSALKFEIRA TGFPEPNPRV IELNKDENVA 
HVLLEGLHHQ RPKRYFTIVI ISSSLLLGLI VLLLISYVMW KAGFFKRQYK SILQEENRRD 
SWSYINSKSN DD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.