Details for: ITGA4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 45.7715
Cell Significance Index: -18.6000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 37.6566
Cell Significance Index: -19.3700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 32.1527
Cell Significance Index: -15.1800 - Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 16.3297
Cell Significance Index: -2.5400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.4164
Cell Significance Index: -11.6100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 6.0715
Cell Significance Index: -1.5400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.5770
Cell Significance Index: -14.9400 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 5.5732
Cell Significance Index: 14.9300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.5697
Cell Significance Index: 294.8200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.4604
Cell Significance Index: -13.7000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.7594
Cell Significance Index: 110.4100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.3439
Cell Significance Index: -13.2000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 2.5002
Cell Significance Index: 66.8800 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 1.9785
Cell Significance Index: 12.6300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.3603
Cell Significance Index: 29.4700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.2888
Cell Significance Index: 67.1300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8641
Cell Significance Index: 15.9700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.8112
Cell Significance Index: 23.1500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5106
Cell Significance Index: 97.1800 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.4131
Cell Significance Index: 4.4000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4041
Cell Significance Index: 39.9700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3329
Cell Significance Index: 42.6800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2786
Cell Significance Index: 32.4700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2562
Cell Significance Index: 30.2100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2386
Cell Significance Index: 215.4800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1961
Cell Significance Index: 31.9000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1893
Cell Significance Index: 4.0300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1319
Cell Significance Index: 14.3500 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.0626
Cell Significance Index: 0.6100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0548
Cell Significance Index: 3.2900 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.0511
Cell Significance Index: 0.5300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0499
Cell Significance Index: 31.1400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0455
Cell Significance Index: 9.1200 - Cell Name: mature T cell (CL0002419)
Fold Change: 0.0278
Cell Significance Index: 0.2000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0250
Cell Significance Index: 0.7200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0076
Cell Significance Index: 0.1300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0035
Cell Significance Index: 0.7000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0013
Cell Significance Index: 0.9200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0013
Cell Significance Index: -0.5700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0017
Cell Significance Index: -0.1200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0037
Cell Significance Index: -2.7400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0050
Cell Significance Index: -0.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0053
Cell Significance Index: -2.9800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0057
Cell Significance Index: -10.7700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0072
Cell Significance Index: -13.2400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0073
Cell Significance Index: -11.3000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0100
Cell Significance Index: -13.6000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0125
Cell Significance Index: -6.8400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0148
Cell Significance Index: -0.3700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0189
Cell Significance Index: -3.9900 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0205
Cell Significance Index: -0.2600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0209
Cell Significance Index: -7.5000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0239
Cell Significance Index: -3.2800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0242
Cell Significance Index: -1.2300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0264
Cell Significance Index: -11.9800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0278
Cell Significance Index: -20.3800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0302
Cell Significance Index: -19.2100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0312
Cell Significance Index: -5.3300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0329
Cell Significance Index: -0.8400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0444
Cell Significance Index: -2.7200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0465
Cell Significance Index: -13.3700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0512
Cell Significance Index: -2.3200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0660
Cell Significance Index: -3.4700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0691
Cell Significance Index: -7.0600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0697
Cell Significance Index: -4.3900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0713
Cell Significance Index: -1.4800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0844
Cell Significance Index: -15.2200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0863
Cell Significance Index: -5.8000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0969
Cell Significance Index: -11.1000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0972
Cell Significance Index: -11.0900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1225
Cell Significance Index: -1.4600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1252
Cell Significance Index: -13.0400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1259
Cell Significance Index: -18.3000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1277
Cell Significance Index: -15.7000 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.1279
Cell Significance Index: -1.8700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1311
Cell Significance Index: -4.2000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1312
Cell Significance Index: -16.9500 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1404
Cell Significance Index: -2.4200 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1440
Cell Significance Index: -2.8100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1478
Cell Significance Index: -11.3400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1488
Cell Significance Index: -8.3500 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1514
Cell Significance Index: -1.5700 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.1540
Cell Significance Index: -0.8400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1579
Cell Significance Index: -2.3800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1602
Cell Significance Index: -11.3300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1615
Cell Significance Index: -7.5900 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: -0.1903
Cell Significance Index: -0.5800 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.2033
Cell Significance Index: -3.4200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2276
Cell Significance Index: -16.9700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2449
Cell Significance Index: -11.4200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2463
Cell Significance Index: -15.1400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2592
Cell Significance Index: -7.4300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2618
Cell Significance Index: -13.6000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2672
Cell Significance Index: -11.6200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2672
Cell Significance Index: -9.3600 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.2726
Cell Significance Index: -4.6300 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.2727
Cell Significance Index: -3.8300 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.2841
Cell Significance Index: -2.2100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3104
Cell Significance Index: -13.7300 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.3145
Cell Significance Index: -2.8000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3421694821
Symbol: ITA4_HUMAN
Name: Integrin alpha-4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2788572
Title: The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.
PubMed ID: 2788572
PubMed ID: 1551405
Title: A single mRNA encodes the alpha 150 and alpha 80/70 forms of the alpha subunit of VLA4.
PubMed ID: 1551405
PubMed ID: 8643114
Title: Identification of two variants of the human integrin alpha 4 subunit.
PubMed ID: 8643114
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2034655
Title: Characterization of the alpha 4 integrin gene promoter.
PubMed ID: 2034655
PubMed ID: 3033641
Title: The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.
PubMed ID: 3033641
PubMed ID: 1730718
Title: Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage.
PubMed ID: 1730718
PubMed ID: 9488735
Title: A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion.
PubMed ID: 9488735
PubMed ID: 10604475
Title: Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses.
PubMed ID: 10604475
DOI: 10.1038/45264
PubMed ID: 11533025
Title: Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding.
PubMed ID: 11533025
PubMed ID: 15466886
Title: alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.
PubMed ID: 15466886
DOI: 10.1242/jcs.01423
PubMed ID: 18635536
Title: Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.
PubMed ID: 18635536
PubMed ID: 19064666
Title: JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.
PubMed ID: 19064666
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23125415
Title: Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.
PubMed ID: 23125415
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25398877
Title: Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins alphavbeta3, alpha4beta1, and alpha5beta1.
PubMed ID: 25398877
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 35802072
Title: The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins alpha9beta1 and alpha4beta1.
PubMed ID: 35802072
DOI: 10.1111/bph.15921
PubMed ID: 37184585
Title: The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand.
PubMed ID: 37184585
Sequence Information:
- Length: 1032
- Mass: 114900
- Checksum: 73EC1204DE78CD35
- Sequence:
MAWEARREPG PRRAAVRETV MLLLCLGVPT GRPYNVDTES ALLYQGPHNT LFGYSVVLHS HGANRWLLVG APTANWLANA SVINPGAIYR CRIGKNPGQT CEQLQLGSPN GEPCGKTCLE ERDNQWLGVT LSRQPGENGS IVTCGHRWKN IFYIKNENKL PTGGCYGVPP DLRTELSKRI APCYQDYVKK FGENFASCQA GISSFYTKDL IVMGAPGSSY WTGSLFVYNI TTNKYKAFLD KQNQVKFGSY LGYSVGAGHF RSQHTTEVVG GAPQHEQIGK AYIFSIDEKE LNILHEMKGK KLGSYFGASV CAVDLNADGF SDLLVGAPMQ STIREEGRVF VYINSGSGAV MNAMETNLVG SDKYAARFGE SIVNLGDIDN DGFEDVAIGA PQEDDLQGAI YIYNGRADGI SSTFSQRIEG LQISKSLSMF GQSISGQIDA DNNGYVDVAV GAFRSDSAVL LRTRPVVIVD ASLSHPESVN RTKFDCVENG WPSVCIDLTL CFSYKGKEVP GYIVLFYNMS LDVNRKAESP PRFYFSSNGT SDVITGSIQV SSREANCRTH QAFMRKDVRD ILTPIQIEAA YHLGPHVISK RSTEEFPPLQ PILQQKKEKD IMKKTINFAR FCAHENCSAD LQVSAKIGFL KPHENKTYLA VGSMKTLMLN VSLFNAGDDA YETTLHVKLP VGLYFIKILE LEEKQINCEV TDNSGVVQLD CSIGYIYVDH LSRIDISFLL DVSSLSRAEE DLSITVHATC ENEEEMDNLK HSRVTVAIPL KYEVKLTVHG FVNPTSFVYG SNDENEPETC MVEKMNLTFH VINTGNSMAP NVSVEIMVPN SFSPQTDKLF NILDVQTTTG ECHFENYQRV CALEQQKSAM QTLKGIVRFL SKTDKRLLYC IKADPHCLNF LCNFGKMESG KEASVHIQLE GRPSILEMDE TSALKFEIRA TGFPEPNPRV IELNKDENVA HVLLEGLHHQ RPKRYFTIVI ISSSLLLGLI VLLLISYVMW KAGFFKRQYK SILQEENRRD SWSYINSKSN DD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.