Details for: PFN1

Gene ID: 5216

Symbol: PFN1

Ensembl ID: ENSG00000108518

Description: profilin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 735.7346
    Cell Significance Index: -114.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 441.2494
    Cell Significance Index: -111.9200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 398.0361
    Cell Significance Index: -163.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 332.7737
    Cell Significance Index: -157.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 324.0178
    Cell Significance Index: -166.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 235.5064
    Cell Significance Index: -158.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 111.2449
    Cell Significance Index: -137.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 39.3332
    Cell Significance Index: -120.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 39.2792
    Cell Significance Index: -155.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 28.0135
    Cell Significance Index: -61.3100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 27.5469
    Cell Significance Index: 73.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 13.4737
    Cell Significance Index: 249.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 12.4852
    Cell Significance Index: 366.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 9.1283
    Cell Significance Index: 1076.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 8.1761
    Cell Significance Index: 384.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.4320
    Cell Significance Index: 169.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.1751
    Cell Significance Index: 56.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.0660
    Cell Significance Index: 106.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.8843
    Cell Significance Index: 364.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.6623
    Cell Significance Index: 300.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.6582
    Cell Significance Index: 601.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.2150
    Cell Significance Index: 74.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.1820
    Cell Significance Index: 514.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.7980
    Cell Significance Index: 2074.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.6018
    Cell Significance Index: 649.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.2564
    Cell Significance Index: 447.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.9154
    Cell Significance Index: 33.1200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.8881
    Cell Significance Index: 12.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.7920
    Cell Significance Index: 1234.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.5609
    Cell Significance Index: 181.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.1211
    Cell Significance Index: 271.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1182
    Cell Significance Index: 60.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9765
    Cell Significance Index: 53.8000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.9491
    Cell Significance Index: 12.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7819
    Cell Significance Index: 47.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7707
    Cell Significance Index: 61.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2801
    Cell Significance Index: 126.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1525
    Cell Significance Index: 14.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1310
    Cell Significance Index: 9.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.0705
    Cell Significance Index: 810.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9665
    Cell Significance Index: 8.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9193
    Cell Significance Index: 42.8600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8659
    Cell Significance Index: 5.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7651
    Cell Significance Index: 151.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6415
    Cell Significance Index: 14.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5243
    Cell Significance Index: 99.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2318
    Cell Significance Index: 39.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2141
    Cell Significance Index: 11.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1960
    Cell Significance Index: 3.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0462
    Cell Significance Index: 4.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0262
    Cell Significance Index: -19.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0650
    Cell Significance Index: -122.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0658
    Cell Significance Index: -48.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0957
    Cell Significance Index: -176.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1002
    Cell Significance Index: -62.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1119
    Cell Significance Index: -172.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1276
    Cell Significance Index: -173.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1918
    Cell Significance Index: -68.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2087
    Cell Significance Index: -117.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2389
    Cell Significance Index: -151.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2845
    Cell Significance Index: -129.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3009
    Cell Significance Index: -15.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3274
    Cell Significance Index: -65.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3310
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3878
    Cell Significance Index: -81.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4168
    Cell Significance Index: -119.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4262
    Cell Significance Index: -19.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5163
    Cell Significance Index: -13.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6401
    Cell Significance Index: -20.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7359
    Cell Significance Index: -85.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7530
    Cell Significance Index: -86.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7661
    Cell Significance Index: -11.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.8628
    Cell Significance Index: -140.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9521
    Cell Significance Index: -108.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.0664
    Cell Significance Index: -155.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0685
    Cell Significance Index: -29.8600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.3790
    Cell Significance Index: -11.8500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3806
    Cell Significance Index: -23.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.4397
    Cell Significance Index: -149.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.6503
    Cell Significance Index: -130.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.9234
    Cell Significance Index: -51.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.9746
    Cell Significance Index: -52.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.9871
    Cell Significance Index: -152.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0767
    Cell Significance Index: -130.8900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.1200
    Cell Significance Index: -11.5600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -2.1316
    Cell Significance Index: -16.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.1385
    Cell Significance Index: -131.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.1391
    Cell Significance Index: -128.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.1885
    Cell Significance Index: -122.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.2537
    Cell Significance Index: -151.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.4835
    Cell Significance Index: -53.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.5791
    Cell Significance Index: -158.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.8849
    Cell Significance Index: -39.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -3.0013
    Cell Significance Index: -122.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.1162
    Cell Significance Index: -91.7900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -3.1620
    Cell Significance Index: -26.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -3.3656
    Cell Significance Index: -170.0900
  • Cell Name: centroblast (CL0009112)
    Fold Change: -3.5618
    Cell Significance Index: -8.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.6399
    Cell Significance Index: -161.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.8483
    Cell Significance Index: -141.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-binding protein**: Profilin 1 binds to actin monomers, regulating their polymerization and filament assembly. 2. **Proline-rich region**: The protein contains a proline-rich region that interacts with actin filaments, modulating their dynamics. 3. **Regulatory functions**: Profilin 1 negatively regulates actin filament bundle assembly, polymerization, and stress fiber assembly, while positively regulating actin filament bundle assembly and polymerization. 4. **Cellular localization**: Profilin 1 is localized to the cytoplasm, cell cortex, and nucleus, where it influences various cellular processes. **Pathways and Functions:** 1. **Actin cytoskeleton organization**: Profilin 1 regulates actin filament assembly, disassembly, and polymerization, maintaining cytoskeletal homeostasis. 2. **Immune cell migration**: Profilin 1 contributes to the migration of immune cells, such as T cells and monocytes, by regulating actin filament dynamics. 3. **Neurological functions**: Profilin 1 is involved in axon guidance, synapse maturation, and the regulation of neurotransmitter release. 4. **Cell signaling**: Profilin 1 interacts with various signaling molecules, including Rho GTPases, Wnt proteins, and miro GTPases, modulating cellular responses. **Clinical Significance:** 1. **Immune-related disorders**: Profilin 1 dysregulation has been implicated in various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: Profilin 1 overexpression has been observed in certain types of cancer, including leukemia and lymphoma, where it may contribute to tumor progression and metastasis. 3. **Neurological diseases**: Profilin 1 dysregulation has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 4. **Platelet activation**: Profilin 1 plays a crucial role in platelet activation, aggregation, and degranulation, highlighting its potential as a therapeutic target in cardiovascular diseases. In conclusion, profilin 1 is a multifunctional protein that plays a critical role in actin dynamics, immune cell migration, and various cellular processes. Its dysregulation has been implicated in various immune-related disorders, cancer, and neurological diseases, highlighting the importance of profilin 1 in maintaining cellular homeostasis and overall health. Further research is needed to fully elucidate the mechanisms underlying profilin 1's functions and to explore its potential as a therapeutic target.

Genular Protein ID: 761845367

Symbol: PROF1_HUMAN

Name: Profilin-1

UniProtKB Accession Codes:

P07737 Q53Y44

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 13 EMDB 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3356709

Title: Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis.

PubMed ID: 3356709

DOI: 10.1016/s0021-9258(18)60651-9

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3342873

Title: The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence.

PubMed ID: 3342873

DOI: 10.1016/0014-5793(88)80575-1

PubMed ID: 7758455

Title: Distinct biochemical characteristics of the two human profilin isoforms.

PubMed ID: 7758455

DOI: 10.1111/j.1432-1033.1995.tb20506.x

PubMed ID: 10411937

Title: A heterozygous mutation of beta-actin associated with neutrophil dysfunction and recurrent infection.

PubMed ID: 10411937

DOI: 10.1073/pnas.96.15.8693

PubMed ID: 14592989

Title: Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.

PubMed ID: 14592989

DOI: 10.1093/emboj/cdg565

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18573880

Title: Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.

PubMed ID: 18573880

DOI: 10.1128/mcb.00079-08

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34331014

Title: Adaptor SH3BGRL promotes breast cancer metastasis through PFN1 degradation by translational STUB1 upregulation.

PubMed ID: 34331014

DOI: 10.1038/s41388-021-01970-8

PubMed ID: 36173861

Title: Actin maturation requires the ACTMAP/C19orf54 protease.

PubMed ID: 36173861

DOI: 10.1126/science.abq5082

PubMed ID: 8268157

Title: Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern.

PubMed ID: 8268157

DOI: 10.1021/bi00213a010

PubMed ID: 9360613

Title: Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation.

PubMed ID: 9360613

DOI: 10.1038/nsb1197-953

PubMed ID: 10404225

Title: Profilin binds proline-rich ligands in two distinct amide backbone orientations.

PubMed ID: 10404225

DOI: 10.1038/10722

PubMed ID: 17914456

Title: Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.

PubMed ID: 17914456

DOI: 10.1038/sj.emboj.7601874

PubMed ID: 18689676

Title: Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding.

PubMed ID: 18689676

DOI: 10.1073/pnas.0805852105

PubMed ID: 22801503

Title: Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.

PubMed ID: 22801503

DOI: 10.1038/nature11280

Sequence Information:

  • Length: 140
  • Mass: 15054
  • Checksum: F725119E55A289EB
  • Sequence:
    • MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY 
VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH 
GGLINKKCYE MASHLRRSQY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.