Details for: PFN1
Gene ID: 5216
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PFN1
Ensembl ID: ENSG00000108518
Description: profilin 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 131.83rCSI 87.86%PRS 7.8
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CSI 125.49rCSI 94.1%PRS 8.35
-
CSI 111rCSI 73.78%PRS 3.27
-
CSI 109.17rCSI 76.23%PRS 2.89
-
CSI 108.14rCSI 83.32%PRS 2.48
-
CSI 106.15rCSI 85.83%PRS 2.69
-
CSI 105.94rCSI 91.73%PRS 3.07
-
CSI 105.2rCSI 70.87%PRS 3.34
-
CSI 102.87rCSI 77.82%PRS 3.85
-
CSI 98.6rCSI 89.04%PRS 2.42
-
CSI 95.61rCSI 67.15%PRS 8.4
-
CSI 95.27rCSI 87.47%PRS 3.12
-
CSI 90.77rCSI 68.2%PRS 2.83
-
CSI 90.74rCSI 53.59%PRS 3.84
-
CSI 90.65rCSI 73.25%PRS 7.13
-
CSI 90.44rCSI 62.88%PRS 3.23
-
CSI 88.62rCSI 65.84%PRS 4.1
-
CSI 86.98rCSI 76.39%PRS 3.07
-
CSI 86.87rCSI 88.54%PRS 4
-
CSI 84.8rCSI 75.27%PRS 2.76
-
CSI 83.49rCSI 66.29%PRS 4.89
-
CSI 82rCSI 92.29%PRS 4.66
-
CSI 79.82rCSI 59.59%PRS 4.66
-
CSI 78.24rCSI 81.77%PRS 2.95
-
CSI 78.23rCSI 68.53%PRS 3.71
-
CSI 77.85rCSI 76.46%PRS 4.42
-
CSI 77.66rCSI 61.09%PRS 3.27
-
CSI 77.22rCSI 57.79%PRS 4.51
-
CSI 75.88rCSI 80.63%PRS 4.99
-
CSI 75.45rCSI 62.55%PRS 2.58
-
CSI 75.41rCSI 64.68%PRS 8.67
-
CSI 75.28rCSI 78.86%PRS 2.57
-
CSI 74.79rCSI 72.12%PRS 1.08
-
CSI 74.68rCSI 58.09%PRS 3.99
-
CSI 74.31rCSI 56.52%PRS 3.67
-
CSI 72.16rCSI 69.46%PRS 2.87
-
CSI 71.75rCSI 82.13%PRS 5.73
-
CSI 71.34rCSI 89.54%PRS 3.48
-
CSI 71.15rCSI 59.64%PRS 3.31
-
CSI 67.37rCSI 66.53%PRS 12.21
-
CSI 66.68rCSI 55.22%PRS 2.75
-
CSI 65.65rCSI 81.21%PRS 2.43
-
CSI 64.53rCSI 60.98%PRS 2.87
-
CSI 64.45rCSI 53.8%PRS 9.21
-
CSI 61.67rCSI 59.31%PRS 6.02
-
CSI 60.82rCSI 71.43%PRS 3.36
-
CSI 60.74rCSI 71.33%PRS 27.82
-
CSI 60.27rCSI 78.97%PRS 3.84
-
CSI 60.04rCSI 86.59%PRS 3.82
-
CSI 59.81rCSI 91.86%PRS 3.18
-
CSI 59.4rCSI 71.75%PRS 3.17
-
CSI 58.58rCSI 46.93%PRS 5.16
-
CSI 57.71rCSI 82.36%PRS 3.14
-
CSI 56.96rCSI 46.29%PRS 2.89
-
CSI 56.41rCSI 96.65%PRS 3.67
-
CSI 56.29rCSI 58.79%PRS 8.94
-
CSI 56.13rCSI 47.22%PRS 4.63
-
CSI 56rCSI 52.12%PRS 2.74
-
CSI 55.35rCSI 69.59%PRS 4.23
-
CSI 54.84rCSI 81.29%PRS 32.92
-
CSI 54.67rCSI 69.59%PRS 3.22
-
CSI 52.36rCSI 36.44%PRS 4.01
-
CSI 51.51rCSI 68.83%PRS 5.26
-
CSI 50.47rCSI 62.19%PRS 9.19
-
CSI 50.12rCSI 85.74%PRS 6.04
-
CSI 49.82rCSI 79.86%PRS 9.19
-
CSI 49.56rCSI 75.7%PRS 4.82
-
CSI 49.16rCSI 79.27%PRS 4.48
-
CSI 49.06rCSI 67.04%PRS 3.04
-
CSI 48.39rCSI 74.36%PRS 4
-
CSI 48.07rCSI 37.27%PRS 2.61
-
CSI 47.61rCSI 68.98%PRS 4.04
-
CSI 47.6rCSI 57.67%PRS 4.33
-
CSI 47.49rCSI 72.63%PRS 4.5
-
CSI 47.46rCSI 56.97%PRS 2.75
-
CSI 47.07rCSI 71.94%PRS 3.21
-
CSI 47rCSI 46.91%PRS 2.32
-
CSI 46.77rCSI 41.13%PRS 2
-
CSI 46.6rCSI 64.54%PRS 3.96
-
CSI 46.53rCSI 33.4%PRS 3.77
-
CSI 46.41rCSI 55.4%PRS 4.82
-
CSI 46.05rCSI 45.26%PRS 8.29
-
CSI 46.02rCSI 39.67%PRS 4.6
-
CSI 45.88rCSI 47.52%PRS 3.22
-
CSI 45.73rCSI 65.55%PRS 3.86
-
CSI 44.87rCSI 46.82%PRS 2.81
-
CSI 44.42rCSI 88.55%PRS 4.74
-
CSI 43.39rCSI 43.95%PRS 18.44
-
CSI 43.37rCSI 67.01%PRS 2.6
-
CSI 43.17rCSI 39.32%PRS 4.33
-
CSI 42.94rCSI 39.62%PRS 2.78
-
CSI 41.58rCSI 59.93%PRS 4.48
-
CSI 41.54rCSI 56.61%PRS 2.5
-
CSI 41.27rCSI 67.97%PRS 3.18
-
CSI 40.09rCSI 51.28%PRS 12.81
-
CSI 38.58rCSI 49.48%PRS 3.18
-
CSI 38.39rCSI 57.92%PRS 2.69
-
CSI 38.26rCSI 46.57%PRS 3.48
-
CSI 37.41rCSI 67.52%PRS 8.56
-
CSI 36.27rCSI 49.4%PRS 6.95
-
CSI -22.4rCSI -84.5%PRS 6.3%
-
CSI -15.1rCSI -28.4%PRS 2.2%
-
CSI -13.9rCSI -28.5%PRS 3.3%
-
CSI -13.3rCSI -66.9%PRS 18.4%
-
CSI -13.1rCSI -37.3%PRS 3.8%
-
CSI -12.9rCSI -24.6%PRS 4.4%
-
CSI -12.1rCSI -62.1%PRS 13.5%
-
CSI -11.8rCSI -52.1%PRS 2.9%
-
CSI -11.6rCSI -20.5%PRS 3.2%
-
CSI -9.3rCSI -15.2%PRS 2.2%
-
CSI -8.9rCSI -49.5%PRS 10.7%
-
CSI -8.9rCSI -14.2%PRS 2.4%
-
CSI -7.9rCSI -9.2%PRS 2.5%
-
CSI -7.2rCSI -21.4%PRS 3.6%
-
CSI -7.1rCSI -14.3%PRS 2.1%
-
CSI -6.5rCSI -32.3%PRS 21.9%
-
CSI -6.3rCSI -9.3%PRS 3.7%
-
CSI -6.0rCSI -100.0%PRS 14.8%
-
CSI -5.8rCSI -8.5%PRS 2.9%
-
CSI -4.8rCSI -24.2%PRS 14.6%
-
CSI -4.0rCSI -16.2%PRS 3.2%
-
CSI -3.8rCSI -12.3%PRS 4.8%
-
CSI -3.4rCSI -8.8%PRS 3.4%
-
CSI -3.3rCSI -23.7%PRS 12.2%
-
CSI -2.5rCSI -6.4%PRS 4.1%
-
CSI -2.0rCSI -4.6%PRS 3.7%
-
CSI -1.8rCSI -11.9%PRS 7.8%
-
CSI -1.8rCSI -19.6%PRS 38.2%
-
CSI -1.6rCSI -17.8%PRS 19.9%
-
CSI -1.5rCSI -7.7%PRS 7.2%
-
CSI -1.3rCSI -3.5%PRS 3.2%
-
CSI -0.8rCSI -1.0%PRS 1.6%
-
CSI -0.8rCSI -4.8%PRS 4.2%
-
CSI -0.6rCSI -5.3%PRS 26.9%
-
CSI -0.4rCSI -0.7%PRS 2.1%
-
CSI 0.0rCSI 0.0%PRS 1.8%
-
CSI 0.5rCSI 2.1%PRS 11.5%
-
CSI 0.5rCSI 16.1%PRS 46.6%
-
CSI 0.8rCSI 4.7%PRS 14.5%
-
CSI 0.9rCSI 21.5%PRS 2.9%
-
CSI 1.0rCSI 18.6%PRS 24.1%
-
CSI 1.0rCSI 1.8%PRS 2.4%
-
CSI 1.1rCSI 4.3%PRS 13.7%
-
CSI 1.1rCSI 6.9%PRS 11.4%
-
CSI 1.2rCSI 1.9%PRS 2.2%
-
CSI 1.2rCSI 5.8%PRS 4.9%
-
CSI 1.3rCSI 1.6%PRS 1.9%
-
CSI 1.3rCSI 7.4%PRS 14.4%
-
CSI 1.5rCSI 2.0%PRS 5.1%
-
CSI 1.5rCSI 30.4%PRS 61.6%
-
CSI 1.8rCSI 15.0%PRS 19.8%
-
CSI 1.8rCSI 40.6%PRS 20.8%
-
CSI 1.8rCSI 41.5%PRS 16.4%
-
CSI 2.1rCSI 17.8%PRS 7.7%
-
CSI 2.2rCSI 35.6%PRS 31.7%
-
CSI 2.3rCSI 20.2%PRS 18.2%
-
CSI 2.5rCSI 34.2%PRS 32.1%
-
CSI 2.5rCSI 77.8%PRS 37.1%
-
CSI 2.5rCSI 62.3%PRS 27.1%
-
CSI 2.6rCSI 5.4%PRS 6.2%
-
CSI 2.7rCSI 5.9%PRS 2.1%
-
CSI 2.7rCSI 38.5%PRS 43.5%
-
CSI 2.7rCSI 10.6%PRS 4.8%
-
CSI 2.8rCSI 8.8%PRS 3.4%
-
CSI 2.8rCSI 29.7%PRS 4.9%
-
CSI 2.8rCSI 6.8%PRS 4.4%
-
CSI 2.9rCSI 74.8%PRS 15.8%
-
CSI 2.9rCSI 26.7%PRS 11.0%
-
CSI 2.9rCSI 5.1%PRS 1.7%
-
CSI 3.0rCSI 89.9%PRS 6.9%
-
CSI 3.0rCSI 52.4%PRS 11.7%
-
CSI 3.1rCSI 64.7%PRS 51.0%
-
CSI 3.2rCSI 48.9%PRS 7.5%
-
CSI 3.2rCSI 61.1%PRS 10.2%
-
CSI 3.2rCSI 21.0%PRS 21.9%
-
CSI 3.2rCSI 77.3%PRS 10.7%
-
CSI 3.3rCSI 20.8%PRS 13.7%
-
CSI 3.3rCSI 26.0%PRS 33.9%
-
CSI 3.4rCSI 85.0%PRS 9.8%
-
CSI 3.6rCSI 20.5%PRS 4.5%
-
CSI 3.6rCSI 53.8%PRS 8.7%
-
CSI 3.7rCSI 40.5%PRS 5.1%
-
CSI 3.7rCSI 5.1%PRS 3.1%
-
CSI 3.8rCSI 29.5%PRS 6.8%
-
CSI 3.8rCSI 87.9%PRS 14.5%
-
CSI 3.8rCSI 37.5%PRS 8.9%
-
CSI 4.2rCSI 88.5%PRS 17.9%
-
CSI 4.6rCSI 15.6%PRS 13.1%
-
CSI 4.6rCSI 84.9%PRS 4.7%
-
CSI 4.7rCSI 12.5%PRS 2.9%
-
CSI 4.8rCSI 12.2%PRS 2.2%
-
CSI 4.8rCSI 26.3%PRS 7.4%
-
CSI 4.9rCSI 93.1%PRS 25.5%
-
CSI 4.9rCSI 78.7%PRS 18.8%
-
CSI 5.0rCSI 11.5%PRS 2.6%
-
CSI 5.1rCSI 50.4%PRS 35.1%
-
CSI 5.2rCSI 14.8%PRS 5.5%
-
CSI 5.3rCSI 12.7%PRS 3.6%
-
CSI 5.4rCSI 81.2%PRS 9.3%
-
CSI 5.4rCSI 59.0%PRS 5.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 761845367
Symbol: PROF1_HUMAN
Name: Profilin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3356709
Title: Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis.
PubMed ID: 3356709
PubMed ID: 20736409
Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.
PubMed ID: 20736409
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3342873
Title: The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence.
PubMed ID: 3342873
PubMed ID: 7758455
Title: Distinct biochemical characteristics of the two human profilin isoforms.
PubMed ID: 7758455
PubMed ID: 10411937
Title: A heterozygous mutation of beta-actin associated with neutrophil dysfunction and recurrent infection.
PubMed ID: 10411937
PubMed ID: 14592989
Title: Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.
PubMed ID: 14592989
DOI: 10.1093/emboj/cdg565
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 18573880
Title: Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.
PubMed ID: 18573880
DOI: 10.1128/mcb.00079-08
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 34331014
Title: Adaptor SH3BGRL promotes breast cancer metastasis through PFN1 degradation by translational STUB1 upregulation.
PubMed ID: 34331014
PubMed ID: 36173861
Title: Actin maturation requires the ACTMAP/C19orf54 protease.
PubMed ID: 36173861
PubMed ID: 8268157
Title: Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern.
PubMed ID: 8268157
DOI: 10.1021/bi00213a010
PubMed ID: 9360613
Title: Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation.
PubMed ID: 9360613
DOI: 10.1038/nsb1197-953
PubMed ID: 10404225
Title: Profilin binds proline-rich ligands in two distinct amide backbone orientations.
PubMed ID: 10404225
DOI: 10.1038/10722
PubMed ID: 17914456
Title: Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.
PubMed ID: 17914456
PubMed ID: 18689676
Title: Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding.
PubMed ID: 18689676
PubMed ID: 22801503
Title: Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.
PubMed ID: 22801503
DOI: 10.1038/nature11280
Sequence Information:
- Length: 140
- Mass: 15054
- Checksum: F725119E55A289EB
- Sequence:
MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY