PSMA6 | ENSG00000100902 | NCBI 5687

Details for: PSMA6

Gene ID: 5687

Symbol: PSMA6

Ensembl ID: ENSG00000100902

Description: proteasome 20S subunit alpha 6

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 243.7233
Cell Significance Index: -37.9100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 147.7271
Cell Significance Index: -37.4700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 100.2075
Cell Significance Index: -40.7100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 94.5040
Cell Significance Index: -44.6200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 89.8937
Cell Significance Index: -46.2400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 43.4148
Cell Significance Index: -41.4500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 33.0020
Cell Significance Index: -40.6900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.9149
Cell Significance Index: -39.9600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.7474
Cell Significance Index: -33.0100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.4890
Cell Significance Index: -41.3900
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 5.4079
Cell Significance Index: 46.4700
Cell Name: peg cell (CL4033014)
Fold Change: 3.5445
Cell Significance Index: 81.8900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.8884
Cell Significance Index: 84.8300
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.3601
Cell Significance Index: 16.9500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.2215
Cell Significance Index: 41.0600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.1219
Cell Significance Index: 19.5400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.0301
Cell Significance Index: 239.4100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.9019
Cell Significance Index: 342.8500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.8803
Cell Significance Index: 53.9000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.7965
Cell Significance Index: 220.9000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.6987
Cell Significance Index: 184.7700
Cell Name: germ cell (CL0000586)
Fold Change: 1.6701
Cell Significance Index: 12.6100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4390
Cell Significance Index: 288.6700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.3233
Cell Significance Index: 33.0800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.2772
Cell Significance Index: 14.5100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9291
Cell Significance Index: 151.1100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.8894
Cell Significance Index: 61.5100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8656
Cell Significance Index: 55.8500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.8633
Cell Significance Index: 110.6700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.8476
Cell Significance Index: 44.1500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.7467
Cell Significance Index: 9.5600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7256
Cell Significance Index: 260.2700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6854
Cell Significance Index: 52.6000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5700
Cell Significance Index: 56.3900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4416
Cell Significance Index: 27.1400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3323
Cell Significance Index: 9.5800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2639
Cell Significance Index: 14.8100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2523
Cell Significance Index: 5.4700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2354
Cell Significance Index: 162.8400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2077
Cell Significance Index: 5.5700
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2033
Cell Significance Index: 5.3500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1681
Cell Significance Index: 31.9900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1681
Cell Significance Index: 23.0800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1678
Cell Significance Index: 74.2100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1488
Cell Significance Index: 7.5200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1250
Cell Significance Index: 68.2700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0513
Cell Significance Index: 1.3700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0502
Cell Significance Index: 2.3600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0127
Cell Significance Index: -0.4500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0180
Cell Significance Index: -13.6600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0221
Cell Significance Index: -41.5800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0252
Cell Significance Index: -46.5100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0302
Cell Significance Index: -46.5100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0342
Cell Significance Index: -46.5300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0344
Cell Significance Index: -25.4600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0414
Cell Significance Index: -0.2500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0476
Cell Significance Index: -3.5500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0490
Cell Significance Index: -35.9400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0546
Cell Significance Index: -2.4200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0603
Cell Significance Index: -6.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0635
Cell Significance Index: -35.8100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0673
Cell Significance Index: -8.7000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0701
Cell Significance Index: -44.5400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0822
Cell Significance Index: -1.7500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0867
Cell Significance Index: -2.3600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0984
Cell Significance Index: -44.6800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1084
Cell Significance Index: -6.8300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1183
Cell Significance Index: -4.4800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1239
Cell Significance Index: -8.7600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1258
Cell Significance Index: -36.2000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1466
Cell Significance Index: -17.0900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1857
Cell Significance Index: -31.7200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1873
Cell Significance Index: -4.7900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2095
Cell Significance Index: -44.1300
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.2131
Cell Significance Index: -2.1500
Cell Name: perivascular cell (CL4033054)
Fold Change: -0.2252
Cell Significance Index: -1.0400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2308
Cell Significance Index: -4.8300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2595
Cell Significance Index: -13.4800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2638
Cell Significance Index: -8.4500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2899
Cell Significance Index: -33.2200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3051
Cell Significance Index: -44.3500
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3548
Cell Significance Index: -8.5100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3786
Cell Significance Index: -17.6500
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.3846
Cell Significance Index: -2.3900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3875
Cell Significance Index: -10.3700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4025
Cell Significance Index: -41.9100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4434
Cell Significance Index: -23.2800
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.4473
Cell Significance Index: -2.9100
Cell Name: glioblast (CL0000030)
Fold Change: -0.4730
Cell Significance Index: -2.9700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5541
Cell Significance Index: -43.8900
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5775
Cell Significance Index: -12.6500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6407
Cell Significance Index: -39.2800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6695
Cell Significance Index: -45.0200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7166
Cell Significance Index: -23.4600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7369
Cell Significance Index: -23.4700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.7461
Cell Significance Index: -33.8200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.8278
Cell Significance Index: -33.9200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.8368
Cell Significance Index: -14.0100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8420
Cell Significance Index: -24.8000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.8709
Cell Significance Index: -30.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PSMA6 is a member of the proteasome alpha subunit family, which consists of seven subunits (PSMA1-PSMA7) that form the 20S proteasome. The PSMA6 subunit is specifically involved in the assembly and function of the 20S proteasome, and its expression is restricted to certain cell types, including monocytes, dendritic cells, and neurons. The PSMA6 subunit is also highly conserved across species, suggesting its importance in fundamental cellular processes. **Pathways and Functions** The PSMA6 gene is involved in several cellular pathways, including: 1. **Proteasome-mediated protein degradation**: PSMA6 is essential for the assembly and function of the 20S proteasome, which degrades and processes proteins within the cell. 2. **Antigen processing and presentation**: PSMA6 is involved in the processing and presentation of antigens to the immune system, which is critical for immune response and tolerance. 3. **Cell cycle regulation**: The 20S proteasome, and by extension PSMA6, plays a role in regulating the cell cycle by degrading and processing proteins involved in cell cycle progression. 4. **Signaling pathways**: PSMA6 is involved in several signaling pathways, including Hedgehog, Wnt, and Notch signaling, which are critical for development, growth, and differentiation. **Clinical Significance** Dysregulation of the PSMA6 gene has been implicated in several diseases, including: 1. **Cancer**: Overexpression of PSMA6 has been observed in certain types of cancer, including prostate cancer, and has been associated with poor prognosis. 2. **Neurodegenerative disorders**: PSMA6 has been implicated in several neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, where its dysregulation is thought to contribute to protein aggregation and cell death. 3. **Immune system disorders**: PSMA6 is involved in the processing and presentation of antigens to the immune system, and dysregulation of PSMA6 has been implicated in autoimmune disorders, such as rheumatoid arthritis. In conclusion, the PSMA6 gene plays a critical role in various cellular processes, including protein degradation, antigen processing, and cell cycle regulation. Its dysregulation has been implicated in several diseases, including cancer, neurodegenerative disorders, and immune system disorders. Further research is needed to fully understand the role of PSMA6 in human disease and to develop effective therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

27 kDa prosomal protein

Genular Protein ID: 1775819576

Symbol: PSA6_HUMAN

Name: 27 kDa prosomal protein

UniProtKB Accession Codes:

P60900 B2R7J9 B4DQR4 B4DXJ9 P34062 Q6IB60

Database IDs:

Citations:

PubMed ID: 7681138

Title: The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family.

PubMed ID: 7681138

DOI: 10.1007/bf00282801

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1888762

Title: The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous.

PubMed ID: 1888762

DOI: 10.1016/0167-4838(91)90020-z

PubMed ID: 7811265

Title: Human proteasome subunits from 2-dimensional gels identified by partial sequencing.

PubMed ID: 7811265

DOI: 10.1006/bbrc.1994.2876

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23145062

Title: Human ALKBH4 interacts with proteins associated with transcription.

PubMed ID: 23145062

DOI: 10.1371/journal.pone.0049045

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

Length: 246
Mass: 27399
Checksum: 94D1FD3C0A7CC72A
Sequence:

MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQGGLTSV AVRGKDCAVI VTQKKVPDKL 
LDSSTVTHLF KITENIGCVM TGMTADSRSQ VQRARYEAAN WKYKYGYEIP VDMLCKRIAD 
ISQVYTQNAE MRPLGCCMIL IGIDEEQGPQ VYKCDPAGYY CGFKATAAGV KQTESTSFLE 
KKVKKKFDWT FEQTVETAIT CLSTVLSIDF KPSEIEVGVV TVENPKFRIL TEAEIDAHLV 
ALAERD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMA6

Associated with

Cells (max top 100)

Other Information

The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family. PubMed ID: 7681138

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. PubMed ID: 1888762

Human proteasome subunits from 2-dimensional gels identified by partial sequencing. PubMed ID: 7811265

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Human ALKBH4 interacts with proteins associated with transcription. PubMed ID: 23145062

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951