Details for: PSMD9

Gene ID: 5715

Symbol: PSMD9

Ensembl ID: ENSG00000110801

Description: proteasome 26S subunit, non-ATPase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.5709
    Cell Significance Index: -23.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.1990
    Cell Significance Index: -24.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.0659
    Cell Significance Index: -26.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.3732
    Cell Significance Index: -26.9400
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.3391
    Cell Significance Index: -7.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.4771
    Cell Significance Index: -26.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.7190
    Cell Significance Index: -24.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.8700
    Cell Significance Index: -20.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5078
    Cell Significance Index: -25.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9802
    Cell Significance Index: -16.0200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.3161
    Cell Significance Index: 15.1000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.1378
    Cell Significance Index: 18.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9802
    Cell Significance Index: 18.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6617
    Cell Significance Index: 38.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4131
    Cell Significance Index: 41.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3018
    Cell Significance Index: 234.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2380
    Cell Significance Index: 152.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0057
    Cell Significance Index: 12.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9949
    Cell Significance Index: 28.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9243
    Cell Significance Index: 25.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9203
    Cell Significance Index: 24.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9138
    Cell Significance Index: 148.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8927
    Cell Significance Index: 16.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7641
    Cell Significance Index: 90.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6952
    Cell Significance Index: 139.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6259
    Cell Significance Index: 29.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6018
    Cell Significance Index: 41.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5986
    Cell Significance Index: 12.5300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.5923
    Cell Significance Index: 3.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5636
    Cell Significance Index: 77.4000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.5521
    Cell Significance Index: 5.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5138
    Cell Significance Index: 38.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4867
    Cell Significance Index: 62.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4546
    Cell Significance Index: 28.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4509
    Cell Significance Index: 15.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4409
    Cell Significance Index: 3.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4289
    Cell Significance Index: 22.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4021
    Cell Significance Index: 11.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3767
    Cell Significance Index: 37.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3619
    Cell Significance Index: 7.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3505
    Cell Significance Index: 154.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3323
    Cell Significance Index: 63.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3071
    Cell Significance Index: 167.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2992
    Cell Significance Index: 38.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2670
    Cell Significance Index: 12.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2583
    Cell Significance Index: 2.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2512
    Cell Significance Index: 6.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2480
    Cell Significance Index: 88.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2252
    Cell Significance Index: 15.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1973
    Cell Significance Index: 33.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1645
    Cell Significance Index: 12.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1617
    Cell Significance Index: 146.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1569
    Cell Significance Index: 10.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1278
    Cell Significance Index: 14.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0976
    Cell Significance Index: 4.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0963
    Cell Significance Index: 27.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0793
    Cell Significance Index: 2.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0788
    Cell Significance Index: 4.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0766
    Cell Significance Index: 1.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0532
    Cell Significance Index: 0.8900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0260
    Cell Significance Index: 0.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0167
    Cell Significance Index: 0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0116
    Cell Significance Index: 0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0104
    Cell Significance Index: 7.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0078
    Cell Significance Index: 0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0051
    Cell Significance Index: -3.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0129
    Cell Significance Index: -24.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0140
    Cell Significance Index: -25.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0172
    Cell Significance Index: -26.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0178
    Cell Significance Index: -1.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0191
    Cell Significance Index: -26.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0207
    Cell Significance Index: -15.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0291
    Cell Significance Index: -16.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0394
    Cell Significance Index: -25.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0458
    Cell Significance Index: -5.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0488
    Cell Significance Index: -10.2700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0509
    Cell Significance Index: -0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0566
    Cell Significance Index: -25.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0804
    Cell Significance Index: -4.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0873
    Cell Significance Index: -2.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1034
    Cell Significance Index: -12.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1148
    Cell Significance Index: -2.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1246
    Cell Significance Index: -24.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1299
    Cell Significance Index: -4.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1701
    Cell Significance Index: -24.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1726
    Cell Significance Index: -9.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1798
    Cell Significance Index: -3.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1942
    Cell Significance Index: -8.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2482
    Cell Significance Index: -9.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2484
    Cell Significance Index: -25.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2632
    Cell Significance Index: -1.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2981
    Cell Significance Index: -23.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3026
    Cell Significance Index: -3.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3296
    Cell Significance Index: -14.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3470
    Cell Significance Index: -5.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3589
    Cell Significance Index: -9.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3929
    Cell Significance Index: -26.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4069
    Cell Significance Index: -11.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4131
    Cell Significance Index: -7.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSMD9 is a non-ATPase regulatory subunit of the 26S proteasome, a large protein complex responsible for degrading damaged or unneeded proteins. The 26S proteasome is a critical component of the ubiquitin-proteasome pathway (UPP), which regulates protein turnover and cell signaling. PSMD9 is specifically involved in the regulation of protein degradation, cell cycle progression, and immune responses. **Pathways and Functions:** PSMD9 is involved in various cellular pathways, including: 1. **Adaptive Immune System:** PSMD9 regulates the activation and proliferation of T cells, a crucial step in the adaptive immune response. 2. **Antigen Processing-Cross Presentation:** PSMD9 is involved in the processing and presentation of antigens to T cells, a process essential for initiating an immune response. 3. **Apoptosis:** PSMD9 regulates the degradation of pro-apoptotic proteins, influencing cell survival and death. 4. **Cell Cycle:** PSMD9 is involved in the regulation of cell cycle progression, particularly in the G1/S and G2/M phases. 5. **Immune System:** PSMD9 is expressed in various immune cells, including monocytes, T cells, and dendritic cells, and plays a role in the regulation of immune responses. **Clinical Significance:** Dysregulation of PSMD9 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Abnormalities in PSMD9 expression and function have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** PSMD9 is overexpressed in certain types of cancer, including breast and lung cancer, and is associated with tumor progression and metastasis. 3. **Infectious Diseases:** PSMD9 is involved in the regulation of immune responses to viral infections, such as HIV and influenza. 4. **Neurological Disorders:** PSMD9 is implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, PSMD9 plays a critical role in regulating various cellular processes, including immune responses, cell cycle, and apoptosis. Dysregulation of PSMD9 has been implicated in various diseases, highlighting the importance of further research into its mechanisms and potential therapeutic applications.

Genular Protein ID: 220362401

Symbol: PSMD9_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 9

UniProtKB Accession Codes:

O00233 B2RD35 G3V1Q6 Q9BQ42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 59 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653651

Title: cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9).

PubMed ID: 9653651

DOI: 10.1006/geno.1998.5301

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16712791

Title: Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.

PubMed ID: 16712791

DOI: 10.1016/j.bbrc.2006.04.175

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19490896

Title: Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.

PubMed ID: 19490896

DOI: 10.1016/j.cell.2009.05.008

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 223
  • Mass: 24682
  • Checksum: 98B3A623323A8F37
  • Sequence:
    • MSDEEARQSG GSSQAGVVTV SDVQELMRRK EEIEAQIKAN YDVLESQKGI GMNEPLVDCE 
GYPRSDVDLY QVRTARHNII CLQNDHKAVM KQVEEALHQL HARDKEKQAR DMAEAHKEAM 
SRKLGQSESQ GPPRAFAKVN SISPGSPASI AGLQVDDEIV EFGSVNTQNF QSLHNIGSVV 
QHSEGKPLNV TVIRRGEKHQ LRLVPTRWAG KGLLGCNIIP LQR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.