Gene PSMD9 - ENSG00000110801 | NCBI Gene ID: 5715

Details for: PSMD9

Gene ID: 5715

Symbol: PSMD9

Ensembl ID: ENSG00000110801

Description: proteasome 26S subunit, non-ATPase 9

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Pten regulation
(R-HSA-6807070)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 2.56
Marker Score: 1806
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.82
Marker Score: 8919
Cell Name: Unknown (CL0002371)
Fold Change: 1.59
Marker Score: 1694
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.53
Marker Score: 1039
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.53
Marker Score: 6378.5
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.5
Marker Score: 532
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.43
Marker Score: 48820
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.42
Marker Score: 9052
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.39
Marker Score: 13980.5
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.38
Marker Score: 1660.5
Cell Name: blood cell (CL0000081)
Fold Change: 1.34
Marker Score: 15593
Cell Name: plasmablast (CL0000980)
Fold Change: 1.34
Marker Score: 1783
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.28
Marker Score: 71391
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.26
Marker Score: 3428.5
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.24
Marker Score: 1264
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.23
Marker Score: 8029
Cell Name: Unknown (CL0000548)
Fold Change: 1.22
Marker Score: 890
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.18
Marker Score: 1485
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.18
Marker Score: 1273
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.17
Marker Score: 8711
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.15
Marker Score: 370
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.14
Marker Score: 781
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.13
Marker Score: 1198
Cell Name: kidney cell (CL1000497)
Fold Change: 1.13
Marker Score: 754
Cell Name: decidual cell (CL2000002)
Fold Change: 1.13
Marker Score: 4865.5
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.13
Marker Score: 2193
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.12
Marker Score: 1732
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.11
Marker Score: 1249
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.11
Marker Score: 3297
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.09
Marker Score: 4658
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.08
Marker Score: 2264.5
Cell Name: male germ cell (CL0000015)
Fold Change: 1.08
Marker Score: 311
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.07
Marker Score: 778
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.07
Marker Score: 250
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.06
Marker Score: 794
Cell Name: thymocyte (CL0000893)
Fold Change: 1.04
Marker Score: 1091
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.04
Marker Score: 3285
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.02
Marker Score: 597
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.01
Marker Score: 638
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1
Marker Score: 1783
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1
Marker Score: 2799
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1
Marker Score: 201
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71631
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1
Marker Score: 1650
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47856
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.99
Marker Score: 996
Cell Name: osteoclast (CL0000092)
Fold Change: 0.99
Marker Score: 492
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.99
Marker Score: 2423
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.99
Marker Score: 251
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.99
Marker Score: 52120
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.98
Marker Score: 1566
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30382
Cell Name: stromal cell (CL0000499)
Fold Change: 0.98
Marker Score: 1143
Cell Name: erythroblast (CL0000765)
Fold Change: 0.97
Marker Score: 608
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.97
Marker Score: 2285
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.97
Marker Score: 1641
Cell Name: stem cell (CL0000034)
Fold Change: 0.97
Marker Score: 2292
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.96
Marker Score: 2270
Cell Name: enterocyte (CL0000584)
Fold Change: 0.96
Marker Score: 4584
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.95
Marker Score: 1471
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.95
Marker Score: 3662
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.94
Marker Score: 348
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.94
Marker Score: 431
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.94
Marker Score: 310
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2390
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.94
Marker Score: 57753
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.94
Marker Score: 8041
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.93
Marker Score: 1372
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 479.5
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.93
Marker Score: 1817
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.93
Marker Score: 1331
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 436
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.92
Marker Score: 5586
Cell Name: centroblast (CL0009112)
Fold Change: 0.92
Marker Score: 451
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.91
Marker Score: 3113.5
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.91
Marker Score: 317
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.9
Marker Score: 603.5
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.9
Marker Score: 314
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.9
Marker Score: 2482.5
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2685
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.9
Marker Score: 11811.5
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.89
Marker Score: 654
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.89
Marker Score: 2169
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.88
Marker Score: 1446
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5031
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.88
Marker Score: 2149
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.88
Marker Score: 8357.5
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.88
Marker Score: 635
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.88
Marker Score: 281
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.87
Marker Score: 886
Cell Name: malignant cell (CL0001064)
Fold Change: 0.87
Marker Score: 11728.5
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.87
Marker Score: 1235
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.87
Marker Score: 1397
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 312
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.87
Marker Score: 404.5
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.86
Marker Score: 268
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.86
Marker Score: 8124
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.86
Marker Score: 474
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5211
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.86
Marker Score: 205

Hover over a box to see details here...

**Key Characteristics:** PSMD9 is a non-ATPase regulatory subunit of the 26S proteasome, a large protein complex responsible for degrading damaged or unneeded proteins. The 26S proteasome is a critical component of the ubiquitin-proteasome pathway (UPP), which regulates protein turnover and cell signaling. PSMD9 is specifically involved in the regulation of protein degradation, cell cycle progression, and immune responses. **Pathways and Functions:** PSMD9 is involved in various cellular pathways, including: 1. **Adaptive Immune System:** PSMD9 regulates the activation and proliferation of T cells, a crucial step in the adaptive immune response. 2. **Antigen Processing-Cross Presentation:** PSMD9 is involved in the processing and presentation of antigens to T cells, a process essential for initiating an immune response. 3. **Apoptosis:** PSMD9 regulates the degradation of pro-apoptotic proteins, influencing cell survival and death. 4. **Cell Cycle:** PSMD9 is involved in the regulation of cell cycle progression, particularly in the G1/S and G2/M phases. 5. **Immune System:** PSMD9 is expressed in various immune cells, including monocytes, T cells, and dendritic cells, and plays a role in the regulation of immune responses. **Clinical Significance:** Dysregulation of PSMD9 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Abnormalities in PSMD9 expression and function have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** PSMD9 is overexpressed in certain types of cancer, including breast and lung cancer, and is associated with tumor progression and metastasis. 3. **Infectious Diseases:** PSMD9 is involved in the regulation of immune responses to viral infections, such as HIV and influenza. 4. **Neurological Disorders:** PSMD9 is implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, PSMD9 plays a critical role in regulating various cellular processes, including immune responses, cell cycle, and apoptosis. Dysregulation of PSMD9 has been implicated in various diseases, highlighting the importance of further research into its mechanisms and potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

26S proteasome non-ATPase regulatory subunit 9

Genular Protein ID: 220362401

Symbol: PSMD9_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 9

UniProtKB Accession Codes:

O00233 B2RD35 G3V1Q6 Q9BQ42

Database IDs:

Citations:

PubMed ID: 9653651

Title: cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9).

PubMed ID: 9653651

DOI: 10.1006/geno.1998.5301

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16712791

Title: Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.

PubMed ID: 16712791

DOI: 10.1016/j.bbrc.2006.04.175

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19490896

Title: Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.

PubMed ID: 19490896

DOI: 10.1016/j.cell.2009.05.008

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 223
Mass: 24682
Checksum: 98B3A623323A8F37
Sequence:

MSDEEARQSG GSSQAGVVTV SDVQELMRRK EEIEAQIKAN YDVLESQKGI GMNEPLVDCE 
GYPRSDVDLY QVRTARHNII CLQNDHKAVM KQVEEALHQL HARDKEKQAR DMAEAHKEAM 
SRKLGQSESQ GPPRAFAKVN SISPGSPASI AGLQVDDEIV EFGSVNTQNF QSLHNIGSVV 
QHSEGKPLNV TVIRRGEKHQ LRLVPTRWAG KGLLGCNIIP LQR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: PSMD9

Associated with

Cells (max top 100)

Other Information

cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9). PubMed ID: 9653651

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. PubMed ID: 16712791

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. PubMed ID: 19490896

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Initial characterization of the human central proteome. PubMed ID: 21269460