Details for: VBP1

Gene ID: 7411

Symbol: VBP1

Ensembl ID: ENSG00000155959

Description: VHL binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.0254
    Cell Significance Index: -30.1900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.4432
    Cell Significance Index: -17.4900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 101.3478
    Cell Significance Index: -41.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.6165
    Cell Significance Index: -42.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.0478
    Cell Significance Index: -34.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.3545
    Cell Significance Index: -39.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.7088
    Cell Significance Index: -42.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.1851
    Cell Significance Index: -34.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.6037
    Cell Significance Index: -36.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.8442
    Cell Significance Index: -29.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3749
    Cell Significance Index: -40.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.5883
    Cell Significance Index: -29.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.4590
    Cell Significance Index: 286.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.7346
    Cell Significance Index: 13.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6905
    Cell Significance Index: 183.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6881
    Cell Significance Index: 88.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6574
    Cell Significance Index: 57.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.4429
    Cell Significance Index: 12.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4225
    Cell Significance Index: 29.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2059
    Cell Significance Index: 196.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9833
    Cell Significance Index: 10.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8903
    Cell Significance Index: 109.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8462
    Cell Significance Index: 116.2000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8241
    Cell Significance Index: 6.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7906
    Cell Significance Index: 21.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7292
    Cell Significance Index: 19.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6852
    Cell Significance Index: 374.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6834
    Cell Significance Index: 43.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6552
    Cell Significance Index: 118.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6372
    Cell Significance Index: 281.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6007
    Cell Significance Index: 70.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5914
    Cell Significance Index: 75.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5843
    Cell Significance Index: 17.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5247
    Cell Significance Index: 15.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5245
    Cell Significance Index: 39.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5068
    Cell Significance Index: 26.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4894
    Cell Significance Index: 23.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4683
    Cell Significance Index: 33.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4597
    Cell Significance Index: 23.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4487
    Cell Significance Index: 28.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4004
    Cell Significance Index: 80.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2936
    Cell Significance Index: 13.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2840
    Cell Significance Index: 32.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2766
    Cell Significance Index: 52.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2394
    Cell Significance Index: 30.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2114
    Cell Significance Index: 6.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2107
    Cell Significance Index: 41.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2013
    Cell Significance Index: 72.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1997
    Cell Significance Index: 2.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1882
    Cell Significance Index: 8.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1536
    Cell Significance Index: 15.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1381
    Cell Significance Index: 1.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0810
    Cell Significance Index: 4.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0093
    Cell Significance Index: 6.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0016
    Cell Significance Index: 1.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0010
    Cell Significance Index: 0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0124
    Cell Significance Index: -23.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0131
    Cell Significance Index: -0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0209
    Cell Significance Index: -38.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0228
    Cell Significance Index: -35.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0265
    Cell Significance Index: -35.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0343
    Cell Significance Index: -25.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0393
    Cell Significance Index: -24.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0424
    Cell Significance Index: -4.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0564
    Cell Significance Index: -31.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0671
    Cell Significance Index: -30.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0740
    Cell Significance Index: -46.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0852
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0985
    Cell Significance Index: -16.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1020
    Cell Significance Index: -2.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1195
    Cell Significance Index: -4.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1212
    Cell Significance Index: -6.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1284
    Cell Significance Index: -3.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1608
    Cell Significance Index: -2.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1776
    Cell Significance Index: -25.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1901
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2074
    Cell Significance Index: -43.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2147
    Cell Significance Index: -6.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2266
    Cell Significance Index: -5.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2382
    Cell Significance Index: -7.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2509
    Cell Significance Index: -4.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2674
    Cell Significance Index: -6.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2731
    Cell Significance Index: -18.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3447
    Cell Significance Index: -26.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3472
    Cell Significance Index: -27.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3625
    Cell Significance Index: -6.0700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3631
    Cell Significance Index: -2.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3968
    Cell Significance Index: -41.3200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5072
    Cell Significance Index: -3.3000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5591
    Cell Significance Index: -5.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5610
    Cell Significance Index: -7.1900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.6116
    Cell Significance Index: -5.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6437
    Cell Significance Index: -18.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6492
    Cell Significance Index: -14.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6656
    Cell Significance Index: -29.4400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6754
    Cell Significance Index: -5.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6756
    Cell Significance Index: -41.4200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.6887
    Cell Significance Index: -7.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7088
    Cell Significance Index: -17.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7108
    Cell Significance Index: -12.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VBP1 is a protein that interacts with the von Hippel-Lindau (VHL) protein, a well-established tumor suppressor. The VBP1-VHL complex is involved in the regulation of protein degradation and the modulation of cellular stress responses. VBP1 is also a subunit of the prefoldin complex, which is composed of multiple subunits that work together to facilitate the correct folding of proteins. The prefoldin complex is essential for the proper folding of actin and tubulin proteins, which are critical components of the cytoskeleton and microtubule networks, respectively. **Pathways and Functions:** VBP1 is involved in several key pathways that regulate protein folding and amyloid regulation: 1. **Chaperone-mediated protein folding:** VBP1 collaborates with the prefoldin complex to facilitate the correct folding of actin and tubulin proteins. 2. **Amyloid-beta binding:** VBP1 interacts with amyloid-beta peptides, which are associated with neurodegenerative diseases, such as Alzheimer's disease. 3. **Negative regulation of amyloid fibril formation:** VBP1 inhibits the formation of amyloid fibrils, which are characteristic of neurodegenerative diseases. 4. **Metabolism of proteins:** VBP1 is involved in the regulation of protein degradation and metabolism. **Clinical Significance:** VBP1 has been implicated in various diseases, including: 1. **Neurodegenerative diseases:** VBP1 has been shown to play a role in the regulation of amyloid-beta peptides and the prevention of amyloid fibril formation, which may contribute to the development of neurodegenerative diseases, such as Alzheimer's disease. 2. **Cancer:** The VBP1-VHL complex has been implicated in the regulation of protein degradation and the modulation of cellular stress responses, which may contribute to the development and progression of cancer. 3. **Muscle disorders:** VBP1 has been shown to play a role in the regulation of protein folding and the prevention of muscle disorders, such as muscular dystrophy. In conclusion, VBP1 is a critical component of the prefoldin complex, which plays a pivotal role in protein folding and quality control within cells. Its interaction with amyloid-beta peptides and the regulation of amyloid fibril formation make it a potential therapeutic target for neurodegenerative diseases. Further research is needed to fully elucidate the role of VBP1 in human disease and to explore its potential as a therapeutic agent.

Genular Protein ID: 776996288

Symbol: PFD3_HUMAN

Name: Prefoldin subunit 3

UniProtKB Accession Codes:

P61758 B2R8L5 B4DWR3 F5H2A7 O55228 Q15765 Q5JT81 Q86X96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 6 Ensembl 3 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9339366

Title: Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue.

PubMed ID: 9339366

DOI: 10.1006/geno.1997.4902

PubMed ID: 9630229

Title: Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.

PubMed ID: 9630229

DOI: 10.1016/s0092-8674(00)81446-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8674032

Title: Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product.

PubMed ID: 8674032

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 197
  • Mass: 22626
  • Checksum: 973BA048048D948E
  • Sequence:
    • MAAVKDSCGK GEMATGNGRR LHLGIPEAVF VEDVDSFMKQ PGNETADTVL KKLDEQYQKY 
KFMELNLAQK KRRLKGQIPE IKQTLEILKY MQKKKESTNS METRFLLADN LYCKASVPPT 
DKVCLWLGAN VMLEYDIDEA QALLEKNLST ATKNLDSLEE DLDFLRDQFT TTEVNMARVY 
NWDVKRRNKD DSTKNKA

Genular Protein ID: 2167695789

Symbol: Q6FH24_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6FH24

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 6 Gene3D 1 IntAct 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 160
  • Mass: 18735
  • Checksum: FC32B59AAB33F0AC
  • Sequence:
    • MKQPGNETAD TVLKKLDEQY QKYKFMELNL AQKKRRLKGQ IPEIKQTLEI LKYMQKKKES 
TNSMETRFLL ADNLYCKASV PPTDKVCLWL GANVMLEYDI DEAQALLEKN LSTATKNLDS 
LEEDLDFLRD QFTTTEVNMA RVYNWDVKRR NKDDSTKNKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.