Details for: ZAP70

Gene ID: 7535

Symbol: ZAP70

Ensembl ID: ENSG00000115085

Description: zeta chain of T cell receptor associated protein kinase 70

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 35.3595
    Cell Significance Index: -5.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.9750
    Cell Significance Index: -9.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.9743
    Cell Significance Index: -5.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.6071
    Cell Significance Index: -10.6000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 11.3667
    Cell Significance Index: 30.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.4933
    Cell Significance Index: -5.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.3975
    Cell Significance Index: 99.7800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.5462
    Cell Significance Index: 7.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.9795
    Cell Significance Index: -6.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6054
    Cell Significance Index: 34.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5281
    Cell Significance Index: -6.0300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.4608
    Cell Significance Index: 14.6500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.0968
    Cell Significance Index: 11.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9769
    Cell Significance Index: 185.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8691
    Cell Significance Index: 85.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6504
    Cell Significance Index: 587.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6370
    Cell Significance Index: 17.0400
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.6328
    Cell Significance Index: 1.6200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.4934
    Cell Significance Index: 4.8100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.4755
    Cell Significance Index: 4.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3957
    Cell Significance Index: 64.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3356
    Cell Significance Index: 36.5100
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.3197
    Cell Significance Index: 2.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2109
    Cell Significance Index: 41.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2007
    Cell Significance Index: 4.2800
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.1786
    Cell Significance Index: 0.4400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.1784
    Cell Significance Index: 1.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1711
    Cell Significance Index: 11.0400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1620
    Cell Significance Index: 1.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1554
    Cell Significance Index: 10.7500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0750
    Cell Significance Index: 0.5400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0612
    Cell Significance Index: 0.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0611
    Cell Significance Index: 7.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0468
    Cell Significance Index: 0.4500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0293
    Cell Significance Index: 0.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0283
    Cell Significance Index: 1.7000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.0045
    Cell Significance Index: 0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0018
    Cell Significance Index: 0.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0013
    Cell Significance Index: 0.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0017
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -5.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0039
    Cell Significance Index: -1.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0042
    Cell Significance Index: -5.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0062
    Cell Significance Index: -0.0900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0071
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0086
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0093
    Cell Significance Index: -5.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0102
    Cell Significance Index: -5.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0111
    Cell Significance Index: -6.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0125
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0152
    Cell Significance Index: -11.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0165
    Cell Significance Index: -10.4500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0182
    Cell Significance Index: -0.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0190
    Cell Significance Index: -8.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0246
    Cell Significance Index: -7.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0253
    Cell Significance Index: -0.8100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0278
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0302
    Cell Significance Index: -6.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0307
    Cell Significance Index: -1.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0311
    Cell Significance Index: -0.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0313
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0316
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0326
    Cell Significance Index: -5.5600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0400
    Cell Significance Index: -0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0401
    Cell Significance Index: -5.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0442
    Cell Significance Index: -7.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0444
    Cell Significance Index: -5.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0510
    Cell Significance Index: -2.5800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0528
    Cell Significance Index: -0.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0531
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0544
    Cell Significance Index: -6.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0551
    Cell Significance Index: -6.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0566
    Cell Significance Index: -5.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0604
    Cell Significance Index: -0.9100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0618
    Cell Significance Index: -0.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0624
    Cell Significance Index: -4.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0649
    Cell Significance Index: -8.3800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0651
    Cell Significance Index: -0.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0672
    Cell Significance Index: -8.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0684
    Cell Significance Index: -9.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0717
    Cell Significance Index: -3.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0793
    Cell Significance Index: -4.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0795
    Cell Significance Index: -3.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0805
    Cell Significance Index: -6.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0847
    Cell Significance Index: -8.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0894
    Cell Significance Index: -1.2800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0896
    Cell Significance Index: -1.1400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1062
    Cell Significance Index: -0.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1077
    Cell Significance Index: -3.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1090
    Cell Significance Index: -5.0800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1094
    Cell Significance Index: -1.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1143
    Cell Significance Index: -8.5200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1193
    Cell Significance Index: -1.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1235
    Cell Significance Index: -6.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Tyrosine kinase activity**: ZAP70 is a non-membrane spanning protein tyrosine kinase, which means it possesses the ability to phosphorylate tyrosine residues on target proteins. 2. **TCR signaling**: ZAP70 is specifically associated with the TCR complex and is crucial for the transmission of signals from the TCR to downstream effectors, leading to T cell activation and proliferation. 3. **Adaptive immune response**: ZAP70 is essential for the adaptive immune response, which involves the activation, differentiation, and proliferation of T cells in response to specific antigens. 4. **Diverse expression**: ZAP70 is expressed in various immune cells, including mature gamma-delta T cells, alpha-beta T cells, and natural killer cells. **Pathways and Functions** 1. **TCR signaling pathway**: ZAP70 is involved in the signaling of the TCR complex, which leads to the activation of downstream effectors, including the activation of NF-κB, MAP kinases, and other transcription factors. 2. **Calcium-mediated signaling**: ZAP70 is also involved in calcium-mediated signaling, which is essential for the activation of T cells. 3. **Phosphorylation of tyrosine residues**: ZAP70 phosphorylates tyrosine residues on target proteins, which leads to the activation of downstream effectors and the modulation of cellular processes. 4. **Regulation of T cell differentiation**: ZAP70 is involved in the regulation of T cell differentiation, particularly in the differentiation of alpha-beta T cells into effector T cells. **Clinical Significance** 1. **Autoimmune diseases**: Dysregulation of ZAP70 has been implicated in several autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer**: ZAP70 has been found to be overexpressed in certain types of cancer, including T cell lymphoma and leukemia. 3. **Immunodeficiency disorders**: Defects in ZAP70 have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID) and Wiskott-Aldrich syndrome. 4. **Vaccine development**: ZAP70 is a potential target for vaccine development, as it is involved in the activation and differentiation of T cells. In conclusion, ZAP70 is a critical protein kinase involved in the signaling of T cell receptors and is essential for the adaptive immune response. Its dysregulation has been implicated in several immune-related disorders, including autoimmune diseases and cancer. Further research is needed to fully understand the role of ZAP70 in the immune system and its potential as a therapeutic target.

Genular Protein ID: 3145938041

Symbol: ZAP70_HUMAN

Name: Tyrosine-protein kinase ZAP-70

UniProtKB Accession Codes:

P43403 A6NFP4 Q6PIA4 Q8IXD6 Q9UBS6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 DrugCentral 1 EC 2 ELM 1 EMBL 5 Ensembl 6 EvolutionaryTrace 1 GO 34 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 2 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1423621

Title: ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.

PubMed ID: 1423621

DOI: 10.1016/0092-8674(92)90598-7

PubMed ID: 14985102

Title: Identification of a novel isoform of ZAP-70, truncated ZAP kinase.

PubMed ID: 14985102

DOI: 10.1016/j.bbrc.2004.01.127

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8124727

Title: Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase.

PubMed ID: 8124727

DOI: 10.1016/0092-8674(94)90368-9

PubMed ID: 7528772

Title: ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

PubMed ID: 7528772

DOI: 10.1084/jem.181.1.375

PubMed ID: 7781602

Title: Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

PubMed ID: 7781602

DOI: 10.1002/j.1460-2075.1995.tb07247.x

PubMed ID: 8702662

Title: Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.

PubMed ID: 8702662

DOI: 10.1074/jbc.271.33.19641

PubMed ID: 8943331

Title: Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.

PubMed ID: 8943331

DOI: 10.1128/mcb.16.12.6765

PubMed ID: 9151714

Title: The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction.

PubMed ID: 9151714

DOI: 10.1084/jem.185.10.1877

PubMed ID: 9378960

Title: In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and p21 phospho-zeta molecules in human CD3+ thymocytes.

PubMed ID: 9378960

PubMed ID: 9489702

Title: LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

PubMed ID: 9489702

DOI: 10.1016/s0092-8674(00)80901-0

PubMed ID: 9813084

Title: ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation.

PubMed ID: 9813084

DOI: 10.1083/jcb.143.3.613

PubMed ID: 10037717

Title: Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

PubMed ID: 10037717

DOI: 10.1074/jbc.274.10.6285

PubMed ID: 10449770

Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.

PubMed ID: 10449770

DOI: 10.1073/pnas.96.17.9775

PubMed ID: 11353765

Title: Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.

PubMed ID: 11353765

DOI: 10.1074/jbc.m010738200

PubMed ID: 12051764

Title: SPAP2, an Ig family receptor containing both ITIMs and ITAMs.

PubMed ID: 12051764

DOI: 10.1016/s0006-291x(02)00332-7

PubMed ID: 11828374

Title: Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.

PubMed ID: 11828374

DOI: 10.1002/1521-4141(200202)32:2<568::aid-immu568>3.0.co;2-q

PubMed ID: 12084069

Title: Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.

PubMed ID: 12084069

DOI: 10.1046/j.1432-1033.2002.03008.x

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15143214

Title: NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling.

PubMed ID: 15143214

DOI: 10.1073/pnas.0401119101

PubMed ID: 16339550

Title: T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315.

PubMed ID: 16339550

DOI: 10.4049/jimmunol.175.12.8123

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16467082

Title: ZAP-70 expression in normal pro/pre B cells, mature B cells, and in B-cell acute lymphoblastic leukemia.

PubMed ID: 16467082

DOI: 10.1158/1078-0432.ccr-05-1531

PubMed ID: 16461343

Title: Identification of substrates of human protein-tyrosine phosphatase PTPN22.

PubMed ID: 16461343

DOI: 10.1074/jbc.m600498200

PubMed ID: 19290920

Title: The structure, regulation, and function of ZAP-70.

PubMed ID: 19290920

DOI: 10.1111/j.1600-065x.2008.00753.x

PubMed ID: 19843936

Title: FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.

PubMed ID: 19843936

DOI: 10.4049/jimmunol.0901982

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20135127

Title: ZAP70: a master regulator of adaptive immunity.

PubMed ID: 20135127

DOI: 10.1007/s00281-010-0196-x

PubMed ID: 26903241

Title: Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.

PubMed ID: 26903241

DOI: 10.1084/jem.20151426

PubMed ID: 7659156

Title: Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor.

PubMed ID: 7659156

DOI: 10.1038/377032a0

PubMed ID: 10078535

Title: Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.

PubMed ID: 10078535

DOI: 10.1038/18050

PubMed ID: 10966114

Title: Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.

PubMed ID: 10966114

DOI: 10.1016/s0092-8674(00)00057-x

PubMed ID: 12450381

Title: Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem.

PubMed ID: 12450381

DOI: 10.1021/bi026465e

PubMed ID: 15292186

Title: The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.

PubMed ID: 15292186

DOI: 10.1074/jbc.m407096200

PubMed ID: 17512407

Title: Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.

PubMed ID: 17512407

DOI: 10.1016/j.cell.2007.03.039

PubMed ID: 8202713

Title: ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.

PubMed ID: 8202713

DOI: 10.1126/science.8202713

PubMed ID: 11412303

Title: Specific immunoglobulin E responses in ZAP-70-deficient patients are mediated by Syk-dependent T-cell receptor signalling.

PubMed ID: 11412303

DOI: 10.1046/j.1365-2567.2001.01246.x

PubMed ID: 11123350

Title: Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.

PubMed ID: 11123350

DOI: 10.4049/jimmunol.166.1.656

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18509675

Title: Clinical heterogeneity can hamper the diagnosis of patients with ZAP70 deficiency.

PubMed ID: 18509675

DOI: 10.1007/s00431-008-0718-x

PubMed ID: 26783323

Title: A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.

PubMed ID: 26783323

DOI: 10.1084/jem.20150888

Sequence Information:

  • Length: 619
  • Mass: 69872
  • Checksum: D1E1A8EC66FA116F
  • Sequence:
    • MPDPAAHLPF FYGSISRAEA EEHLKLAGMA DGLFLLRQCL RSLGGYVLSL VHDVRFHHFP 
IERQLNGTYA IAGGKAHCGP AELCEFYSRD PDGLPCNLRK PCNRPSGLEP QPGVFDCLRD 
AMVRDYVRQT WKLEGEALEQ AIISQAPQVE KLIATTAHER MPWYHSSLTR EEAERKLYSG 
AQTDGKFLLR PRKEQGTYAL SLIYGKTVYH YLISQDKAGK YCIPEGTKFD TLWQLVEYLK 
LKADGLIYCL KEACPNSSAS NASGAAAPTL PAHPSTLTHP QRRIDTLNSD GYTPEPARIT 
SPDKPRPMPM DTSVYESPYS DPEELKDKKL FLKRDNLLIA DIELGCGNFG SVRQGVYRMR 
KKQIDVAIKV LKQGTEKADT EEMMREAQIM HQLDNPYIVR LIGVCQAEAL MLVMEMAGGG 
PLHKFLVGKR EEIPVSNVAE LLHQVSMGMK YLEEKNFVHR DLAARNVLLV NRHYAKISDF 
GLSKALGADD SYYTARSAGK WPLKWYAPEC INFRKFSSRS DVWSYGVTMW EALSYGQKPY 
KKMKGPEVMA FIEQGKRMEC PPECPPELYA LMSDCWIYKW EDRPDFLTVE QRMRACYYSL 
ASKVEGPPGS TQKAEAACA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.