Details for: EOMES

Gene ID: 8320

Symbol: EOMES

Ensembl ID: ENSG00000163508

Description: eomesodermin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.95
    Marker Score: 13237
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2
    Marker Score: 7723
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.67
    Marker Score: 3157
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.66
    Marker Score: 800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.6
    Marker Score: 4493
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.57
    Marker Score: 4338
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.38
    Marker Score: 449
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2566
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 730
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7679
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2424
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.87
    Marker Score: 2547
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12844
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.78
    Marker Score: 656
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.77
    Marker Score: 332
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.76
    Marker Score: 419
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.75
    Marker Score: 7423
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.69
    Marker Score: 175
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.66
    Marker Score: 382
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.65
    Marker Score: 964
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 310
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.65
    Marker Score: 473
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.64
    Marker Score: 5375
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.63
    Marker Score: 514
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.62
    Marker Score: 169
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.6
    Marker Score: 1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.6
    Marker Score: 776
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.58
    Marker Score: 180
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.55
    Marker Score: 427
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.54
    Marker Score: 189
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.54
    Marker Score: 178
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.53
    Marker Score: 162
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.51
    Marker Score: 448
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 213
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.48
    Marker Score: 377
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.47
    Marker Score: 266
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 197
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.44
    Marker Score: 222
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.42
    Marker Score: 374
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.41
    Marker Score: 255
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.41
    Marker Score: 988
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.4
    Marker Score: 349
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.36
    Marker Score: 747
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.36
    Marker Score: 304
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.35
    Marker Score: 482.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.34
    Marker Score: 325
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.32
    Marker Score: 523
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.31
    Marker Score: 71
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.27
    Marker Score: 123
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.26
    Marker Score: 279
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.26
    Marker Score: 282
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.26
    Marker Score: 252
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.24
    Marker Score: 267
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.24
    Marker Score: 162
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.24
    Marker Score: 111
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.22
    Marker Score: 82
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.21
    Marker Score: 92
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.19
    Marker Score: 235
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.19
    Marker Score: 64
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.18
    Marker Score: 133
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.17
    Marker Score: 806
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.17
    Marker Score: 883
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.16
    Marker Score: 152
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 83
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 87
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.15
    Marker Score: 107
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.15
    Marker Score: 84.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.14
    Marker Score: 146
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.13
    Marker Score: 694
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 208.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.12
    Marker Score: 234
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.12
    Marker Score: 26
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.12
    Marker Score: 1356
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.12
    Marker Score: 27
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.11
    Marker Score: 37

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Other Information

**Key Characteristics** Eomesodermin is a member of the SOX family of transcription factors, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is highly expressed in various cell types, including neural progenitor cells, cardiac endothelial cells, and immune cells, such as CD8+ T cells and natural killer cells. EOMES is also involved in the regulation of gene expression in stem cells and progenitor cells, playing a crucial role in maintaining the pluripotency of these cells. The expression of EOMES is tightly regulated by other transcription factors, such as OCT4, SOX2, and NANOG, which are essential for maintaining the undifferentiated state of embryonic stem cells. **Pathways and Functions** EOMES is involved in various biological pathways, including: 1. **Adaptive Immune Response**: EOMES plays a crucial role in the differentiation of CD8+ T cells, a subset of T cells that recognize and kill infected cells or tumor cells. 2. **Cell Differentiation**: EOMES regulates the differentiation of various cell types, including neural progenitor cells, cardiac endothelial cells, and immune cells. 3. **Embryonic Development**: EOMES is involved in the formation of definitive endoderm and mesoderm during embryonic development. 4. **Stem Cell Maintenance**: EOMES regulates the maintenance of stem cells and progenitor cells, maintaining their pluripotency and preventing their differentiation. **Clinical Significance** Dysregulation of EOMES has been implicated in various diseases, including: 1. **Autoimmune Disorders**: Altered expression of EOMES has been observed in autoimmune disorders, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: EOMES has been shown to be involved in the development and progression of various cancers, including leukemia and lymphoma. 3. **Immune-Related Disorders**: EOMES has been implicated in immune-related disorders, such as graft-versus-host disease and immune-mediated tissue damage. In conclusion, EOMES is a critical transcription factor involved in various biological processes, including immune response, development, and cell differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of EOMES in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 1672297350

Symbol: EOMES_HUMAN

Name: Eomesodermin homolog

UniProtKB Accession Codes:

O95936 B7Z4I2 B7ZA51 G3XAI5 Q8TAZ2 Q9UPM7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 5 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10407135

Title: A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain.

PubMed ID: 10407135

DOI: 10.1016/s0165-3806(99)00064-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18316326

Title: Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products.

PubMed ID: 18316326

DOI: 10.1093/dnares/dsn004

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9888994

Title: Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19.

PubMed ID: 9888994

DOI: 10.1006/geno.1998.5632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17566017

Title: The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer.

PubMed ID: 17566017

DOI: 10.1136/gut.2006.117812

PubMed ID: 17353897

Title: Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis.

PubMed ID: 17353897

DOI: 10.1038/ng1993

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 686
  • Mass: 72732
  • Checksum: 1A6BA0763C5A6681
  • Sequence:
    • MQLGEQLLVS SVNLPGAHFY PLESARGGSG GSAGHLPSAA PSPQKLDLDK ASKKFSGSLS 
CEAVSGEPAA ASAGAPAAML SDTDAGDAFA SAAAVAKPGP PDGRKGSPCG EEELPSAAAA 
AAAAAAAAAA TARYSMDSLS SERYYLQSPG PQGSELAAPC SLFPYQAAAG APHGPVYPAP 
NGARYPYGSM LPPGGFPAAV CPPGRAQFGP GAGAGSGAGG SSGGGGGPGT YQYSQGAPLY 
GPYPGAAAAG SCGGLGGLGV PGSGFRAHVY LCNRPLWLKF HRHQTEMIIT KQGRRMFPFL 
SFNINGLNPT AHYNVFVEVV LADPNHWRFQ GGKWVTCGKA DNNMQGNKMY VHPESPNTGS 
HWMRQEISFG KLKLTNNKGA NNNNTQMIVL QSLHKYQPRL HIVEVTEDGV EDLNEPSKTQ 
TFTFSETQFI AVTAYQNTDI TQLKIDHNPF AKGFRDNYDS SHQIVPGGRY GVQSFFPEPF 
VNTLPQARYY NGERTVPQTN GLLSPQQSEE VANPPQRWLV TPVQQPGTNK LDISSYESEY 
TSSTLLPYGI KSLPLQTSHA LGYYPDPTFP AMAGWGGRGS YQRKMAAGLP WTSRTSPTVF 
SEDQLSKEKV KEEIGSSWIE TPPSIKSLDS NDSGVYTSAC KRRRLSPSNS SNENSPSIKC 
EDINAEEYSK DTSKGMGGYY AFYTTP

Genular Protein ID: 3345280733

Symbol: B7Z4K0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z4K0

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 6 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 590
  • Mass: 61659
  • Checksum: ED45B734FD522570
  • Sequence:
    • MQLGEQLLVS SVNLPGAHFY PLESARGGSG GSAGHLPSAA PSPQKLDLDK ASKKFSGSLS 
CEAVSGEPAA ASAGAPATML SDTDAGDAFA SAAAVAKPGP PDGRKGSPCG EEELPSAAAG 
AAAAAAAAAA AATARYSMDS LSSERYYLQS PGPQGSELAA PCSLFPYQAA AGAPHGPVYP 
APNGARYPYG SMLPPGGFPA AVCPPGRAQF GPGAGAGSGA GGSSGGGGGP GTYQYSQGAP 
LYGPYPGAAA AGSCGGLGGL GVPGSGFRAH VYLCNRPLWL KFHRHQTEMI ITKQGRRMFP 
FLSFNINGLN PTAHYNVFVE VVLADPNHWR FQGGKWVTCG KADNNMQGNK MYVHPESPNT 
GSHWMRQEIS FGKLKLTNNK GANNNNTLPQ ARYYNGERTV PQTNGLLSPQ QSEEVANPPQ 
RWLVTPVQQP GTNKLDISSY ESEYTSSTLL PYGIKSLPLQ TSHALGYYPD PTFPAMAGWG 
GRGSYQRKMA AGLPWTSRTS PTVFSEDQLS KEKVKEEIGS SWIETPPSIK SLDSNDSGVY 
TSACKRRRLS PSNSSNENSP SIKCEDINAE EYSKDTSKGM GGYYAFYTTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.