Details for: EOMES

Gene ID: 8320

Symbol: EOMES

Ensembl ID: ENSG00000163508

Description: eomesodermin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 14.9988
    Cell Significance Index: 40.1800
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.6368
    Cell Significance Index: 28.6200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.8008
    Cell Significance Index: 8.5200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.7590
    Cell Significance Index: 7.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4742
    Cell Significance Index: 12.6900
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.4416
    Cell Significance Index: 3.6200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.3302
    Cell Significance Index: 3.4400
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.2586
    Cell Significance Index: 1.8800
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.2187
    Cell Significance Index: 0.5600
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.0793
    Cell Significance Index: 0.4600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0431
    Cell Significance Index: 0.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0233
    Cell Significance Index: 0.4000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0139
    Cell Significance Index: 0.1000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.0123
    Cell Significance Index: 0.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0013
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.4200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0045
    Cell Significance Index: -0.0400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0051
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0104
    Cell Significance Index: -5.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0115
    Cell Significance Index: -5.2400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0140
    Cell Significance Index: -0.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0193
    Cell Significance Index: -5.5400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0242
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0247
    Cell Significance Index: -4.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0253
    Cell Significance Index: -5.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0286
    Cell Significance Index: -5.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0297
    Cell Significance Index: -5.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0347
    Cell Significance Index: -4.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0360
    Cell Significance Index: -5.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0364
    Cell Significance Index: -5.0000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0376
    Cell Significance Index: -0.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0400
    Cell Significance Index: -2.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0404
    Cell Significance Index: -4.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0404
    Cell Significance Index: -5.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0423
    Cell Significance Index: -4.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0424
    Cell Significance Index: -4.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0424
    Cell Significance Index: -4.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0458
    Cell Significance Index: -5.2500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0501
    Cell Significance Index: -0.3900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0515
    Cell Significance Index: -0.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0553
    Cell Significance Index: -2.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0594
    Cell Significance Index: -0.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0636
    Cell Significance Index: -3.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0698
    Cell Significance Index: -5.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0712
    Cell Significance Index: -1.9900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0742
    Cell Significance Index: -1.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0742
    Cell Significance Index: -4.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0781
    Cell Significance Index: -1.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0820
    Cell Significance Index: -6.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0824
    Cell Significance Index: -5.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0839
    Cell Significance Index: -5.4100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0854
    Cell Significance Index: -0.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0889
    Cell Significance Index: -4.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0908
    Cell Significance Index: -6.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0991
    Cell Significance Index: -4.6200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1007
    Cell Significance Index: -1.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1044
    Cell Significance Index: -4.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1135
    Cell Significance Index: -2.7500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1260
    Cell Significance Index: -1.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1341
    Cell Significance Index: -5.9300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1360
    Cell Significance Index: -0.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1378
    Cell Significance Index: -5.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1402
    Cell Significance Index: -2.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1437
    Cell Significance Index: -5.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1459
    Cell Significance Index: -5.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1498
    Cell Significance Index: -4.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1504
    Cell Significance Index: -4.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1519
    Cell Significance Index: -4.4600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1542
    Cell Significance Index: -1.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1555
    Cell Significance Index: -5.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1612
    Cell Significance Index: -5.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1774
    Cell Significance Index: -5.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1795
    Cell Significance Index: -4.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1797
    Cell Significance Index: -5.1500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1827
    Cell Significance Index: -3.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1841
    Cell Significance Index: -9.3000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1856
    Cell Significance Index: -5.8700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1860
    Cell Significance Index: -2.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1891
    Cell Significance Index: -3.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1902
    Cell Significance Index: -4.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1911
    Cell Significance Index: -5.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1925
    Cell Significance Index: -5.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1978
    Cell Significance Index: -3.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1989
    Cell Significance Index: -5.2300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2002
    Cell Significance Index: -5.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2007
    Cell Significance Index: -4.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2010
    Cell Significance Index: -4.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2043
    Cell Significance Index: -5.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2064
    Cell Significance Index: -5.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2112
    Cell Significance Index: -4.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2149
    Cell Significance Index: -5.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2152
    Cell Significance Index: -5.2500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2196
    Cell Significance Index: -2.4800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2208
    Cell Significance Index: -2.2400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.2248
    Cell Significance Index: -2.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Eomesodermin is a member of the SOX family of transcription factors, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is highly expressed in various cell types, including neural progenitor cells, cardiac endothelial cells, and immune cells, such as CD8+ T cells and natural killer cells. EOMES is also involved in the regulation of gene expression in stem cells and progenitor cells, playing a crucial role in maintaining the pluripotency of these cells. The expression of EOMES is tightly regulated by other transcription factors, such as OCT4, SOX2, and NANOG, which are essential for maintaining the undifferentiated state of embryonic stem cells. **Pathways and Functions** EOMES is involved in various biological pathways, including: 1. **Adaptive Immune Response**: EOMES plays a crucial role in the differentiation of CD8+ T cells, a subset of T cells that recognize and kill infected cells or tumor cells. 2. **Cell Differentiation**: EOMES regulates the differentiation of various cell types, including neural progenitor cells, cardiac endothelial cells, and immune cells. 3. **Embryonic Development**: EOMES is involved in the formation of definitive endoderm and mesoderm during embryonic development. 4. **Stem Cell Maintenance**: EOMES regulates the maintenance of stem cells and progenitor cells, maintaining their pluripotency and preventing their differentiation. **Clinical Significance** Dysregulation of EOMES has been implicated in various diseases, including: 1. **Autoimmune Disorders**: Altered expression of EOMES has been observed in autoimmune disorders, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: EOMES has been shown to be involved in the development and progression of various cancers, including leukemia and lymphoma. 3. **Immune-Related Disorders**: EOMES has been implicated in immune-related disorders, such as graft-versus-host disease and immune-mediated tissue damage. In conclusion, EOMES is a critical transcription factor involved in various biological processes, including immune response, development, and cell differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of EOMES in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 1672297350

Symbol: EOMES_HUMAN

Name: Eomesodermin homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10407135

Title: A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain.

PubMed ID: 10407135

DOI: 10.1016/s0165-3806(99)00064-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18316326

Title: Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products.

PubMed ID: 18316326

DOI: 10.1093/dnares/dsn004

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9888994

Title: Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19.

PubMed ID: 9888994

DOI: 10.1006/geno.1998.5632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17566017

Title: The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer.

PubMed ID: 17566017

DOI: 10.1136/gut.2006.117812

PubMed ID: 17353897

Title: Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis.

PubMed ID: 17353897

DOI: 10.1038/ng1993

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 686
  • Mass: 72732
  • Checksum: 1A6BA0763C5A6681
  • Sequence:
  • MQLGEQLLVS SVNLPGAHFY PLESARGGSG GSAGHLPSAA PSPQKLDLDK ASKKFSGSLS 
    CEAVSGEPAA ASAGAPAAML SDTDAGDAFA SAAAVAKPGP PDGRKGSPCG EEELPSAAAA 
    AAAAAAAAAA TARYSMDSLS SERYYLQSPG PQGSELAAPC SLFPYQAAAG APHGPVYPAP 
    NGARYPYGSM LPPGGFPAAV CPPGRAQFGP GAGAGSGAGG SSGGGGGPGT YQYSQGAPLY 
    GPYPGAAAAG SCGGLGGLGV PGSGFRAHVY LCNRPLWLKF HRHQTEMIIT KQGRRMFPFL 
    SFNINGLNPT AHYNVFVEVV LADPNHWRFQ GGKWVTCGKA DNNMQGNKMY VHPESPNTGS 
    HWMRQEISFG KLKLTNNKGA NNNNTQMIVL QSLHKYQPRL HIVEVTEDGV EDLNEPSKTQ 
    TFTFSETQFI AVTAYQNTDI TQLKIDHNPF AKGFRDNYDS SHQIVPGGRY GVQSFFPEPF 
    VNTLPQARYY NGERTVPQTN GLLSPQQSEE VANPPQRWLV TPVQQPGTNK LDISSYESEY 
    TSSTLLPYGI KSLPLQTSHA LGYYPDPTFP AMAGWGGRGS YQRKMAAGLP WTSRTSPTVF 
    SEDQLSKEKV KEEIGSSWIE TPPSIKSLDS NDSGVYTSAC KRRRLSPSNS SNENSPSIKC 
    EDINAEEYSK DTSKGMGGYY AFYTTP

Genular Protein ID: 3345280733

Symbol: B7Z4K0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 590
  • Mass: 61659
  • Checksum: ED45B734FD522570
  • Sequence:
  • MQLGEQLLVS SVNLPGAHFY PLESARGGSG GSAGHLPSAA PSPQKLDLDK ASKKFSGSLS 
    CEAVSGEPAA ASAGAPATML SDTDAGDAFA SAAAVAKPGP PDGRKGSPCG EEELPSAAAG 
    AAAAAAAAAA AATARYSMDS LSSERYYLQS PGPQGSELAA PCSLFPYQAA AGAPHGPVYP 
    APNGARYPYG SMLPPGGFPA AVCPPGRAQF GPGAGAGSGA GGSSGGGGGP GTYQYSQGAP 
    LYGPYPGAAA AGSCGGLGGL GVPGSGFRAH VYLCNRPLWL KFHRHQTEMI ITKQGRRMFP 
    FLSFNINGLN PTAHYNVFVE VVLADPNHWR FQGGKWVTCG KADNNMQGNK MYVHPESPNT 
    GSHWMRQEIS FGKLKLTNNK GANNNNTLPQ ARYYNGERTV PQTNGLLSPQ QSEEVANPPQ 
    RWLVTPVQQP GTNKLDISSY ESEYTSSTLL PYGIKSLPLQ TSHALGYYPD PTFPAMAGWG 
    GRGSYQRKMA AGLPWTSRTS PTVFSEDQLS KEKVKEEIGS SWIETPPSIK SLDSNDSGVY 
    TSACKRRRLS PSNSSNENSP SIKCEDINAE EYSKDTSKGM GGYYAFYTTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.