Details for: OR1G1

Gene ID: 8390

Symbol: OR1G1

Ensembl ID: ENSG00000183024

Description: olfactory receptor family 1 subfamily G member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5775
    Cell Significance Index: 9.8700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3401
    Cell Significance Index: 5.5100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1433
    Cell Significance Index: 1.5200
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1115
    Cell Significance Index: 1.4700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0763
    Cell Significance Index: 0.4500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0529
    Cell Significance Index: 0.6800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0508
    Cell Significance Index: 0.6100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0264
    Cell Significance Index: 0.3400
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0185
    Cell Significance Index: 0.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0129
    Cell Significance Index: 0.1900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0050
    Cell Significance Index: 0.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0032
    Cell Significance Index: -0.6500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0058
    Cell Significance Index: -0.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0064
    Cell Significance Index: -0.0900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0083
    Cell Significance Index: -0.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0118
    Cell Significance Index: -0.3000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0132
    Cell Significance Index: -0.1600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0164
    Cell Significance Index: -0.2200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0183
    Cell Significance Index: -0.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0184
    Cell Significance Index: -1.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0224
    Cell Significance Index: -0.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0284
    Cell Significance Index: -0.9300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0288
    Cell Significance Index: -0.2700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0319
    Cell Significance Index: -0.3600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0367
    Cell Significance Index: -0.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0380
    Cell Significance Index: -1.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0387
    Cell Significance Index: -0.5600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0395
    Cell Significance Index: -0.4300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0396
    Cell Significance Index: -0.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0415
    Cell Significance Index: -1.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0430
    Cell Significance Index: -0.9300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0452
    Cell Significance Index: -0.5600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0457
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0464
    Cell Significance Index: -1.3300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0469
    Cell Significance Index: -0.5600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0518
    Cell Significance Index: -0.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0553
    Cell Significance Index: -1.3800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0561
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0568
    Cell Significance Index: -1.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0575
    Cell Significance Index: -1.2200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0617
    Cell Significance Index: -0.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0618
    Cell Significance Index: -1.2400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0639
    Cell Significance Index: -0.6800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0640
    Cell Significance Index: -0.7600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0698
    Cell Significance Index: -0.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0698
    Cell Significance Index: -1.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0699
    Cell Significance Index: -0.9200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0774
    Cell Significance Index: -0.9300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0791
    Cell Significance Index: -0.9300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0810
    Cell Significance Index: -1.4000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0826
    Cell Significance Index: -0.9200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0858
    Cell Significance Index: -0.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0936
    Cell Significance Index: -0.9000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1041
    Cell Significance Index: -1.2300
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1120
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1173
    Cell Significance Index: -1.1900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1200
    Cell Significance Index: -1.1700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1284
    Cell Significance Index: -1.6200
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1352
    Cell Significance Index: -1.6800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1406
    Cell Significance Index: -1.2300
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.1579
    Cell Significance Index: -1.7000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1593
    Cell Significance Index: -1.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR1G1 is a G protein-coupled receptor that is part of the olfactory receptor family 1 subfamily G. It is characterized by its ability to detect chemical stimuli involved in sensory perception of smell. OR1G1 is significantly expressed in various cell types, including erythrocytes, pericytes, cardiac endothelial cells, and hematopoietic stem cells. Its expression is also observed in other tissues, such as the lung and nasal epithelium, where it plays a crucial role in the detection of odorant molecules. **Pathways and Functions:** OR1G1 is involved in the detection of chemical stimuli involved in sensory perception of smell through its activation of G protein-coupled receptors. This activation leads to the regulation of various signaling pathways, including the G protein-coupled receptor signaling pathway and the olfactory signaling pathway. OR1G1 is also involved in the expression and translocation of olfactory receptors, which is essential for the detection of odorant molecules. Additionally, OR1G1 is involved in the regulation of various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance:** OR1G1 has been implicated in various diseases, including olfactory dysfunction, respiratory diseases, and cardiovascular diseases. For example, studies have shown that OR1G1 is involved in the regulation of nasal epithelial cell function and is associated with olfactory dysfunction in patients with respiratory diseases. Additionally, OR1G1 has been shown to play a role in the regulation of cardiac function and is associated with cardiovascular disease. In conclusion, OR1G1 is a novel olfactory receptor that plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. Its expression and translocation of olfactory receptors are essential for the detection of odorant molecules, and its regulation of various cellular processes, including cell proliferation, differentiation, and survival. OR1G1 has been implicated in various diseases, including olfactory dysfunction, respiratory diseases, and cardiovascular diseases, highlighting its potential as a therapeutic target for the treatment of these conditions. **Clinical Implications:** 1. **Olfactory Dysfunction:** OR1G1 has been implicated in the regulation of nasal epithelial cell function and is associated with olfactory dysfunction in patients with respiratory diseases. 2. **Respiratory Diseases:** OR1G1 has been shown to play a role in the regulation of nasal epithelial cell function and is associated with respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). 3. **Cardiovascular Diseases:** OR1G1 has been shown to play a role in the regulation of cardiac function and is associated with cardiovascular disease. 4. **Neurological Disorders:** OR1G1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of olfactory function. **Future Research Directions:** 1. **Functional Studies:** Further functional studies are needed to elucidate the mechanisms by which OR1G1 regulates sensory perception of smell and its role in various diseases. 2. **Therapeutic Targeting:** OR1G1 may serve as a therapeutic target for the treatment of olfactory dysfunction, respiratory diseases, and cardiovascular diseases. 3. **Genetic Studies:** Genetic studies are needed to further understand the role of OR1G1 in various diseases and to identify genetic variants associated with olfactory dysfunction and other diseases. In conclusion, OR1G1 is a novel olfactory receptor that plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. Its expression and translocation of olfactory receptors are essential for the detection of odorant molecules, and its regulation of various cellular processes, including cell proliferation, differentiation, and survival. Further research is needed to elucidate the mechanisms by which OR1G1 regulates sensory perception of smell and its role in various diseases, and to identify potential therapeutic targets for the treatment of these conditions.

Genular Protein ID: 1139530908

Symbol: OR1G1_HUMAN

Name: Olfactory receptor 1G1

UniProtKB Accession Codes:

P47890 Q4VBM1 Q6IFL9 Q9UM76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8004088

Title: Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

PubMed ID: 8004088

DOI: 10.1093/hmg/3.2.229

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 313
  • Mass: 34924
  • Checksum: 556C28EB731FD003
  • Sequence:
    • MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII TDTQLHTPMY 
FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ LYFFMLFVML EAFLLAVMAY 
DCYVAICHPL HYILIMSPGL CIFLVSASWI MNALHSLLHT LLMNSLSFCA NHEIPHFFCD 
INPLLSLSCT DPFTNELVIF ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST 
CSSHLSVVSL FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS 
LRKLIWVRKI HSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.