Details for: OR1G1

Gene ID: 8390

Symbol: OR1G1

Ensembl ID: ENSG00000183024

Description: olfactory receptor family 1 subfamily G member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.12
    Marker Score: 622
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.88
    Marker Score: 515.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5
    Marker Score: 949
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 884
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.43
    Marker Score: 226
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.25
    Marker Score: 3952
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.21
    Marker Score: 128
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1245
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 81
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.14
    Marker Score: 190
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.02
    Marker Score: 42
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.01
    Marker Score: 44
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 13

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Other Information

**Key Characteristics:** OR1G1 is a G protein-coupled receptor that is part of the olfactory receptor family 1 subfamily G. It is characterized by its ability to detect chemical stimuli involved in sensory perception of smell. OR1G1 is significantly expressed in various cell types, including erythrocytes, pericytes, cardiac endothelial cells, and hematopoietic stem cells. Its expression is also observed in other tissues, such as the lung and nasal epithelium, where it plays a crucial role in the detection of odorant molecules. **Pathways and Functions:** OR1G1 is involved in the detection of chemical stimuli involved in sensory perception of smell through its activation of G protein-coupled receptors. This activation leads to the regulation of various signaling pathways, including the G protein-coupled receptor signaling pathway and the olfactory signaling pathway. OR1G1 is also involved in the expression and translocation of olfactory receptors, which is essential for the detection of odorant molecules. Additionally, OR1G1 is involved in the regulation of various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance:** OR1G1 has been implicated in various diseases, including olfactory dysfunction, respiratory diseases, and cardiovascular diseases. For example, studies have shown that OR1G1 is involved in the regulation of nasal epithelial cell function and is associated with olfactory dysfunction in patients with respiratory diseases. Additionally, OR1G1 has been shown to play a role in the regulation of cardiac function and is associated with cardiovascular disease. In conclusion, OR1G1 is a novel olfactory receptor that plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. Its expression and translocation of olfactory receptors are essential for the detection of odorant molecules, and its regulation of various cellular processes, including cell proliferation, differentiation, and survival. OR1G1 has been implicated in various diseases, including olfactory dysfunction, respiratory diseases, and cardiovascular diseases, highlighting its potential as a therapeutic target for the treatment of these conditions. **Clinical Implications:** 1. **Olfactory Dysfunction:** OR1G1 has been implicated in the regulation of nasal epithelial cell function and is associated with olfactory dysfunction in patients with respiratory diseases. 2. **Respiratory Diseases:** OR1G1 has been shown to play a role in the regulation of nasal epithelial cell function and is associated with respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). 3. **Cardiovascular Diseases:** OR1G1 has been shown to play a role in the regulation of cardiac function and is associated with cardiovascular disease. 4. **Neurological Disorders:** OR1G1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of olfactory function. **Future Research Directions:** 1. **Functional Studies:** Further functional studies are needed to elucidate the mechanisms by which OR1G1 regulates sensory perception of smell and its role in various diseases. 2. **Therapeutic Targeting:** OR1G1 may serve as a therapeutic target for the treatment of olfactory dysfunction, respiratory diseases, and cardiovascular diseases. 3. **Genetic Studies:** Genetic studies are needed to further understand the role of OR1G1 in various diseases and to identify genetic variants associated with olfactory dysfunction and other diseases. In conclusion, OR1G1 is a novel olfactory receptor that plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. Its expression and translocation of olfactory receptors are essential for the detection of odorant molecules, and its regulation of various cellular processes, including cell proliferation, differentiation, and survival. Further research is needed to elucidate the mechanisms by which OR1G1 regulates sensory perception of smell and its role in various diseases, and to identify potential therapeutic targets for the treatment of these conditions.

Genular Protein ID: 1139530908

Symbol: OR1G1_HUMAN

Name: Olfactory receptor 1G1

UniProtKB Accession Codes:

P47890 Q4VBM1 Q6IFL9 Q9UM76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8004088

Title: Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

PubMed ID: 8004088

DOI: 10.1093/hmg/3.2.229

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 313
  • Mass: 34924
  • Checksum: 556C28EB731FD003
  • Sequence:
    • MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII TDTQLHTPMY 
FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ LYFFMLFVML EAFLLAVMAY 
DCYVAICHPL HYILIMSPGL CIFLVSASWI MNALHSLLHT LLMNSLSFCA NHEIPHFFCD 
INPLLSLSCT DPFTNELVIF ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST 
CSSHLSVVSL FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS 
LRKLIWVRKI HSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.